Latest Research

  • Letter |

    Laboratory experiments with the brine shrimp Artemia salina illustrate the potential for turbulence generated by the diurnal vertical migrations of aggregations of centimetre-scale zooplankton to affect the physical and biogeochemical structure of oceanic water columns.

    • Isabel A. Houghton
    • , Jeffrey R. Koseff
    • , Stephen G. Monismith
    •  & John O. Dabiri
  • Letter |

    A way of integrating photonics with silicon nanoelectronics is described, using polycrystalline silicon on glass islands alongside transistors on bulk silicon complementary metal–oxide–semiconductor chips.

    • Amir H. Atabaki
    • , Sajjad Moazeni
    • , Fabio Pavanello
    • , Hayk Gevorgyan
    • , Jelena Notaros
    • , Luca Alloatti
    • , Mark T. Wade
    • , Chen Sun
    • , Seth A. Kruger
    • , Huaiyu Meng
    • , Kenaish Al Qubaisi
    • , Imbert Wang
    • , Bohan Zhang
    • , Anatol Khilo
    • , Christopher V. Baiocco
    • , Miloš A. Popović
    • , Vladimir M. Stojanović
    •  & Rajeev J. Ram
  • Article |

    Laser spectroscopy is used to investigate the hyperfine structure and determine the fundamental nuclear properties of the isomer 229mTh, the strongest candidate for the realization of a nuclear clock.

    • Johannes Thielking
    • , Maxim V. Okhapkin
    • , Przemysław Głowacki
    • , David M. Meier
    • , Lars von der Wense
    • , Benedict Seiferle
    • , Christoph E. Düllmann
    • , Peter G. Thirolf
    •  & Ekkehard Peik
  • Letter |

    Binding of an ES cell-specific transcription factor pre-marks cell-type-restricted enhancers in ES cells, and this premarking is required for the robustness of enhancer activation in differentiated cells.

    • Hong Sook Kim
    • , Yuliang Tan
    • , Wubin Ma
    • , Daria Merkurjev
    • , Eugin Destici
    • , Qi Ma
    • , Tom Suter
    • , Kenneth Ohgi
    • , Meyer Friedman
    • , Dorota Skowronska-Krawczyk
    •  & Michael G. Rosenfeld
  • Letter |

    Observations of NGC 6240 show two differently driven outflows of different gases with a combined outflow rate comparable to the star formation rate, suggesting possible negative feedback on star formation.

    • F. Müller-Sánchez
    • , R. Nevin
    • , J. M. Comerford
    • , R. I. Davies
    • , G. C. Privon
    •  & E. Treister
  • Letter |

    A high-resolution X-ray structure and molecular dynamics simulations of the N-methyl-d-aspartate receptor in complexes with channel-blocking ligands reveals the molecular basis of the ligand binding and channel block.

    • Xianqiang Song
    • , Morten Ø. Jensen
    • , Vishwanath Jogini
    • , Richard A. Stein
    • , Chia-Hsueh Lee
    • , Hassane S. Mchaourab
    • , David E. Shaw
    •  & Eric Gouaux
  • Article |

    Epithelial-to-mesenchymal transition in tumour cells occurs through distinct intermediate states, associated with different metastatic potential, cellular properties, gene expression, and chromatin landscape

    • Ievgenia Pastushenko
    • , Audrey Brisebarre
    • , Alejandro Sifrim
    • , Marco Fioramonti
    • , Tatiana Revenco
    • , Soufiane Boumahdi
    • , Alexandra Van Keymeulen
    • , Daniel Brown
    • , Virginie Moers
    • , Sophie Lemaire
    • , Sarah De Clercq
    • , Esmeralda Minguijón
    • , Cédric Balsat
    • , Youri Sokolow
    • , Christine Dubois
    • , Florian De Cock
    • , Samuel Scozzaro
    • , Federico Sopena
    • , Angel Lanas
    • , Nicky D’Haene
    • , Isabelle Salmon
    • , Jean-Christophe Marine
    • , Thierry Voet
    • , Panagiota A. Sotiropoulou
    •  & Cédric Blanpain
  • Letter |

    The immunoregulatory metabolite itaconate and its dimethyl derivative induce electrophilic stress and react with glutathione to induce both Nrf2-dependent and Nrf2-independent responses, resulting in AF3-mediated inhibition of the inflammation-related protein IκBζ.

    • Monika Bambouskova
    • , Laurent Gorvel
    • , Vicky Lampropoulou
    • , Alexey Sergushichev
    • , Ekaterina Loginicheva
    • , Kendall Johnson
    • , Daniel Korenfeld
    • , Mary Elizabeth Mathyer
    • , Hyeryun Kim
    • , Li-Hao Huang
    • , Dustin Duncan
    • , Howard Bregman
    • , Abdurrahman Keskin
    • , Andrea Santeford
    • , Rajendra S. Apte
    • , Raghav Sehgal
    • , Britney Johnson
    • , Gaya K. Amarasinghe
    • , Miguel P. Soares
    • , Takashi Satoh
    • , Shizuo Akira
    • , Tsonwin Hai
    • , Cristina de Guzman Strong
    • , Karine Auclair
    • , Thomas P. Roddy
    • , Scott A. Biller
    • , Marko Jovanovic
    • , Eynav Klechevsky
    • , Kelly M. Stewart
    • , Gwendalyn J. Randolph
    •  & Maxim N. Artyomov
  • Article |

    A new version of the phylogenetic bootstrap method enables assessment of the robustness of phylogenies that are based on large datasets of hundreds or thousands of taxa.

    • F. Lemoine
    • , J.-B. Domelevo Entfellner
    • , E. Wilkinson
    • , D. Correia
    • , M. Dávila Felipe
    • , T. De Oliveira
    •  & O. Gascuel

Latest Reviews & Analysis

  • News & Views |

    Migration of brine shrimp causes substantial mixing of the water column.

    • Henry Gee
  • News & Views |

    The growth of gold nanoparticles has been manipulated using amino acids and peptides to produce twisted structures that alter the rotation of light. The method could simplify the development of optical devices.

    • Guillermo González-Rubio
    •  & Luis M. Liz-Marzán
  • News & Views |

    Inappropriate cellular inflammation can cause disease. It emerges that the protein SAMHD1 prevents the release of newly replicated DNA from the nucleus, blocking an undesirable pro-inflammatory response.

    • Madzia P. Crossley
    •  & Karlene A. Cimprich
  • News & Views |

    A method for integrating photonic devices with state-of-the-art nanoelectronics overcomes previous limitations. The approach shows promise for realizing high-speed, low-power optoelectronic technology.

    • Goran Z. Mashanovich
  • News & Views |

    Cancers of epithelial-cell origin often contain some tumour cells that have acquired traits of mesenchymal cells. How this leads to cancer spread has now been illuminated in mouse models.

    • Erik W. Thompson
    •  & Shivashankar H. Nagaraj
  • News & Views |

    People waiting for a liver transplant can die before an organ is found, or, if one is available but of poor quality, there is a risk of transplant failure. A machine that preserves livers might offer a way forward.

    • Stefan Schneeberger

News & Comment

Nature Outlook

The future of medicine

Modern medicine is affording people longer and healthier lives. But researchers want to take improvements in health even further. With advances in gene editing, technology to overcome paralysis and efforts to address high drug costs, the future of medicine is bright.

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