Latest Research

  • Article |

    The cryo-electron microscopy structure of the human adenosine A1 receptor in complex with adenosine and heterotrimeric Gi2 protein provides molecular insights into receptor and G-protein selectivity.

    • Christopher J. Draper-Joyce
    • , Maryam Khoshouei
    • , David M. Thal
    • , Yi-Lynn Liang
    • , Anh T. N. Nguyen
    • , Sebastian G. B. Furness
    • , Hariprasad Venugopal
    • , Jo-Anne Baltos
    • , Jürgen M. Plitzko
    • , Radostin Danev
    • , Wolfgang Baumeister
    • , Lauren T. May
    • , Denise Wootten
    • , Patrick M. Sexton
    • , Alisa Glukhova
    •  & Arthur Christopoulos
  • Letter |

    Enzymes that catalyse modifications of wobble uridine 34 tRNA are essential for the survival of melanoma cells that rely on HIF1α-dependent metabolism through codon-dependent regulation of the translation of HIF1A mRNA.

    • Francesca Rapino
    • , Sylvain Delaunay
    • , Florian Rambow
    • , Zhaoli Zhou
    • , Lars Tharun
    • , Pascal De Tullio
    • , Olga Sin
    • , Kateryna Shostak
    • , Sebastian Schmitz
    • , Jolanda Piepers
    • , Bart Ghesquière
    • , Latifa Karim
    • , Benoit Charloteaux
    • , Diane Jamart
    • , Alexandra Florin
    • , Charles Lambert
    • , Andrée Rorive
    • , Guy Jerusalem
    • , Eleonora Leucci
    • , Michael Dewaele
    • , Marc Vooijs
    • , Sebastian A. Leidel
    • , Michel Georges
    • , Marianne Voz
    • , Bernard Peers
    • , Reinhard Büttner
    • , Jean-Christophe Marine
    • , Alain Chariot
    •  & Pierre Close
  • Letter |

    The electrointercalation of lithium into van der Waals heterostructures of graphene, hexagonal boron nitride and molybdenum dichalcogenides is studied at the level of individual atomic interfaces.

    • D. Kwabena Bediako
    • , Mehdi Rezaee
    • , Hyobin Yoo
    • , Daniel T. Larson
    • , S. Y. Frank Zhao
    • , Takashi Taniguchi
    • , Kenji Watanabe
    • , Tina L. Brower-Thomas
    • , Efthimios Kaxiras
    •  & Philip Kim
  • Letter |

    The high-resolution structure of the serotonin 5-HT1B receptor in complex with the agonist donitriptan and a Go heterotrimer highlights features that may underly the specificity of receptor–G-protein coupling and kinetics of signalling.

    • Javier García-Nafría
    • , Rony Nehmé
    • , Patricia C. Edwards
    •  & Christopher G. Tate
  • Article |

    Polymerization of actin in the cell nucleus, promoted by the ARP2/3 complex, drives the clustering of double-strand DNA breaks into nuclear compartments where they can undergo homology-directed repair.

    • Benjamin R. Schrank
    • , Tomas Aparicio
    • , Yinyin Li
    • , Wakam Chang
    • , Brian T. Chait
    • , Gregg G. Gundersen
    • , Max E. Gottesman
    •  & Jean Gautier
  • Letter |

    An analysis based on functional metagenomics reveals a previously unknown group of microbial light-sensory rhodopsins that are widespread among a diverse range of microorganisms.

    • Alina Pushkarev
    • , Keiichi Inoue
    • , Shirley Larom
    • , José Flores-Uribe
    • , Manish Singh
    • , Masae Konno
    • , Sahoko Tomida
    • , Shota Ito
    • , Ryoko Nakamura
    • , Satoshi P. Tsunoda
    • , Alon Philosof
    • , Itai Sharon
    • , Natalya Yutin
    • , Eugene V. Koonin
    • , Hideki Kandori
    •  & Oded Béjà

Latest Reviews & Analysis

  • News & Views |

    The location of nearly half of the ordinary matter in the Universe is unknown. X-ray observations suggest that this elusive ‘baryonic’ matter is hidden in the filamentary structure of the cosmic web.

    • Taotao Fang
  • News & Views |

    The assembly of polymerized actin with motor proteins at DNA breaks in the nucleus supports the mobility and repair of DNA. This finding reveals a layer of regulation that helps to preserve genome integrity.

    • Vassilis Roukos
  • News & Views |

    Weight loss and tissue wasting often occur in pancreatic cancer. Analyses of human and mouse data reveal a mechanism behind these events, and raise the question of whether tissue wasting affects cancer survival rates.

    • J. Matthias Löhr
  • News & Views |

    Single-cell transcriptional profiling of stem and progenitor cells in fat tissue identifies distinct cell subpopulations, one of which inhibits fat growth by signalling to neighbouring cells.

    • David A. Guertin
  • News & Views |

    The idea that everyone in the world is connected to everyone else by just six degrees of separation was explained by the ‘small-world’ network model 20 years ago. What seemed to be a niche finding turned out to have huge consequences.

    • Alessandro Vespignani

News & Comment

Nature Outlook

Huntington’s disease

Neil Webb

Huntington’s disease

There is fresh hope for treating Huntington’s disease, an inherited neurodegenerative condition that causes uncontrollable movements, emotional disturbance and the loss of mental abilities. But biological mysteries remain.

Nature events Directory