Latest Research

  • Article |

    Analyses of current coral reef growth rates in the tropical western Atlantic and Indian Ocean show that few reefs will have the capacity to track sea-level rise projections under Representative Concentration Pathway scenarios without sustained ecological recovery.

    • Chris T. Perry
    • , Lorenzo Alvarez-Filip
    • , Nicholas A. J. Graham
    • , Peter J. Mumby
    • , Shaun K. Wilson
    • , Paul S. Kench
    • , Derek P. Manzello
    • , Kyle M. Morgan
    • , Aimee B. A. Slangen
    • , Damian P. Thomson
    • , Fraser Januchowski-Hartley
    • , Scott G. Smithers
    • , Robert S. Steneck
    • , Renee Carlton
    • , Evan N. Edinger
    • , Ian C. Enochs
    • , Nuria Estrada-Saldívar
    • , Michael D. E. Haywood
    • , Graham Kolodziej
    • , Gary N. Murphy
    • , Esmeralda Pérez-Cervantes
    • , Adam Suchley
    • , Lauren Valentino
    • , Robert Boenish
    • , Margaret Wilson
    •  & Chancey Macdonald
  • Article |

    Cryo-electron microscopy is used to resolve the structure of human dynamin-related protein 1 co-assembled with its receptor mitochondrial dynamics protein of 49 kDa, along with an analysis of structure- and disease-based mutations.

    • Raghav Kalia
    • , Ray Yu-Ruei Wang
    • , Ali Yusuf
    • , Paul V. Thomas
    • , David A. Agard
    • , Janet M. Shaw
    •  & Adam Frost
  • Article |

    A PI3KCA inhibitor reverses symptoms in a mouse model of PROS/CLOVES syndrome, which results from gain-of-function mutations in PI3KCA, and produces improvements in patients with PROS/CLOVES syndrome.

    • Quitterie Venot
    • , Thomas Blanc
    • , Smail Hadj Rabia
    • , Laureline Berteloot
    • , Sophia Ladraa
    • , Jean-Paul Duong
    • , Estelle Blanc
    • , Simon C. Johnson
    • , Clément Hoguin
    • , Olivia Boccara
    • , Sabine Sarnacki
    • , Nathalie Boddaert
    • , Stephanie Pannier
    • , Frank Martinez
    • , Sato Magassa
    • , Junna Yamaguchi
    • , Bertrand Knebelmann
    • , Pierre Merville
    • , Nicolas Grenier
    • , Dominique Joly
    • , Valérie Cormier-Daire
    • , Caroline Michot
    • , Christine Bole-Feysot
    • , Arnaud Picard
    • , Véronique Soupre
    • , Stanislas Lyonnet
    • , Jeremy Sadoine
    • , Lotfi Slimani
    • , Catherine Chaussain
    • , Cécile Laroche-Raynaud
    • , Laurent Guibaud
    • , Christine Broissand
    • , Jeanne Amiel
    • , Christophe Legendre
    • , Fabiola Terzi
    •  & Guillaume Canaud
  • Letter |

    Metagenomic and soil microcosm analyses identify abundant biosynthetic gene clusters in genomes of microorganisms from a northern Californian grassland ecosystem that provide a potential source for the future development of bacterial natural products.

    • Alexander Crits-Christoph
    • , Spencer Diamond
    • , Cristina N. Butterfield
    • , Brian C. Thomas
    •  & Jillian F. Banfield
  • Letter |

    A subset of synaptic proteins are cumulatively phosphorylated during wakefulness and dephosphorylated during sleep, in accordance with sleep need; this may represent a common mechanism underlying regulation of both synaptic homeostasis and sleep–wake homeostasis.

    • Zhiqiang Wang
    • , Jing Ma
    • , Chika Miyoshi
    • , Yuxin Li
    • , Makito Sato
    • , Yukino Ogawa
    • , Tingting Lou
    • , Chengyuan Ma
    • , Xue Gao
    • , Chiyu Lee
    • , Tomoyuki Fujiyama
    • , Xiaojie Yang
    • , Shuang Zhou
    • , Noriko Hotta-Hirashima
    • , Daniela Klewe-Nebenius
    • , Aya Ikkyu
    • , Miyo Kakizaki
    • , Satomi Kanno
    • , Liqin Cao
    • , Satoru Takahashi
    • , Junmin Peng
    • , Yonghao Yu
    • , Hiromasa Funato
    • , Masashi Yanagisawa
    •  & Qinghua Liu

Latest Reviews & Analysis

  • News & Views |

    Extended social isolation causes debilitating effects in social mammals such as humans. A study in mice shows that the gene Tac2 is upregulated throughout the brains of socially isolated animals, driving massive behavioural changes.

    • Noga Zilkha
    •  & Tali Kimchi
  • Perspective |

    The future of Antarctica and the Southern Ocean by 2070 is described under two scenarios, one in which action is taken to limit greenhouse gas emissions, and one in which no action is taken.

    • S. R. Rintoul
    • , S. L. Chown
    • , R. M. DeConto
    • , M. H. England
    • , H. A. Fricker
    • , V. Masson-Delmotte
    • , T. R. Naish
    • , M. J. Siegert
    •  & J. C. Xavier
  • News & Views |

    An assessment of the capacity of coral reefs to grow fast enough to keep up with projected rises in sea level finds that most reefs will fall behind if nothing is done to restore them.

    • Ilsa B. Kuffner

News & Comment

Nature Outlook

Huntington’s disease

Neil Webb

Huntington’s disease

There is fresh hope for treating Huntington’s disease, an inherited neurodegenerative condition that causes uncontrollable movements, emotional disturbance and the loss of mental abilities. But biological mysteries remain.