Latest Research

  • Article |

    Expression of α6 integrin enables acute lymphoblastic leukaemia cells to use neural migratory pathways to invade the central nervous system and metastasize to the brain.

    • Hisayuki Yao
    • , Trevor T. Price
    • , Gaia Cantelli
    • , Brandon Ngo
    • , Matthew J. Warner
    • , Lindsey Olivere
    • , Sarah M. Ridge
    • , Elizabeth M. Jablonski
    • , Joseph Therrien
    • , Stacey Tannheimer
    • , Chad M. McCall
    • , Anjen Chenn
    •  & Dorothy A. Sipkins
  • Letter |

    A comprehensive analysis of the thymic medulla identifies a tuft-cell-like thymic epithelial cell population that is necessary for shaping thymic function.

    • Corey N. Miller
    • , Irina Proekt
    • , Jakob von Moltke
    • , Kristen L. Wells
    • , Aparna R. Rajpurkar
    • , Haiguang Wang
    • , Kristin Rattay
    • , Imran S. Khan
    • , Todd C. Metzger
    • , Joshua L. Pollack
    • , Adam C. Fries
    • , Wint W. Lwin
    • , Eric J. Wigton
    • , Audrey V. Parent
    • , Bruno Kyewski
    • , David J. Erle
    • , Kristin A. Hogquist
    • , Lars M. Steinmetz
    • , Richard M. Locksley
    •  & Mark S. Anderson
  • Letter |

    The 53BP1 effector complex shieldin is involved in non-homologous end-joining and immunoglobulin class switching, and acts to protect DNA ends to facilitate the repair of DNA by 53BP1.

    • Sylvie M. Noordermeer
    • , Salomé Adam
    • , Dheva Setiaputra
    • , Marco Barazas
    • , Stephen J. Pettitt
    • , Alexanda K. Ling
    • , Michele Olivieri
    • , Alejandro Álvarez-Quilón
    • , Nathalie Moatti
    • , Michal Zimmermann
    • , Stefano Annunziato
    • , Dragomir B. Krastev
    • , Feifei Song
    • , Inger Brandsma
    • , Jessica Frankum
    • , Rachel Brough
    • , Alana Sherker
    • , Sébastien Landry
    • , Rachel K. Szilard
    • , Meagan M. Munro
    • , Andrea McEwan
    • , Théo Goullet de Rugy
    • , Zhen-Yuan Lin
    • , Traver Hart
    • , Jason Moffat
    • , Anne-Claude Gingras
    • , Alberto Martin
    • , Haico van Attikum
    • , Jos Jonkers
    • , Christopher J. Lord
    • , Sven Rottenberg
    •  & Daniel Durocher
  • Letter |

    Modulation of DNA 5-hydroxymethylcytosine by glucose reveals an AMPK–TET2–5hmC axis that links diabetes to cancer.

    • Di Wu
    • , Di Hu
    • , Hao Chen
    • , Guoming Shi
    • , Irfete S. Fetahu
    • , Feizhen Wu
    • , Kimberlie Rabidou
    • , Rui Fang
    • , Li Tan
    • , Shuyun Xu
    • , Hang Liu
    • , Christian Argueta
    • , Lei Zhang
    • , Fei Mao
    • , Guoquan Yan
    • , Jiajia Chen
    • , Zhaoru Dong
    • , Ruitu Lv
    • , Yufei Xu
    • , Mei Wang
    • , Yong Ye
    • , Shike Zhang
    • , Danielle Duquette
    • , Songmei Geng
    • , Clark Yin
    • , Christine Guo Lian
    • , George F. Murphy
    • , Gail K. Adler
    • , Rajesh Garg
    • , Lydia Lynch
    • , Pengyuan Yang
    • , Yiming Li
    • , Fei Lan
    • , Jia Fan
    • , Yang Shi
    •  & Yujiang Geno Shi
  • Letter |

    A comprehensive characterization of the thymic stroma identifies a tuft-cell-like thymic epithelial cell population that is critical for shaping the immune niche in the thymus.

    • Chamutal Bornstein
    • , Shir Nevo
    • , Amir Giladi
    • , Noam Kadouri
    • , Marie Pouzolles
    • , François Gerbe
    • , Eyal David
    • , Alice Machado
    • , Anna Chuprin
    • , Beáta Tóth
    • , Ori Goldberg
    • , Shalev Itzkovitz
    • , Naomi Taylor
    • , Philippe Jay
    • , Valérie S. Zimmermann
    • , Jakub Abramson
    •  & Ido Amit

Latest Reviews & Analysis

  • News & Views |

    It emerges that viruses called phages, which infect bacteria, can suppress the bacterial immune system during an initial wave of unsuccessful infection, enabling subsequent viral infection to succeed.

    • Aude Bernheim
    •  & Rotem Sorek
  • News & Views |

    How genetic and environmental factors contribute to the generation of various subtypes of inhibitory neurons called interneurons in the brain is unclear. A study in mice provides new insight into this process.

    • Christian Mayer
    •  & Gord Fishell
  • News & Views |

    An autoimmune attack on cells that make the hormone insulin causes type 1 diabetes. A mouse study reveals that pancreatic-cell release of insulin peptide fragments into the bloodstream triggers this harmful process.

    • Jiajie Wei
    •  & Jonathan W. Yewdell
  • News & Views |

    The molecule succinate, which is a product of metabolism, promotes heat production and therefore calorie burning in brown fat in mice. This discovery could have implications for combating obesity in humans.

    • Sheng Hui
    •  & Joshua D. Rabinowitz
  • News & Views |

    An electron microscope has been developed that produces images at higher resolution than conventional approaches can achieve, and is suitable for studying fragile materials that can be damaged by electron beams.

    • John Rodenburg

News & Comment

Nature Outlook

Huntington’s disease

Neil Webb

Huntington’s disease

There is fresh hope for treating Huntington’s disease, an inherited neurodegenerative condition that causes uncontrollable movements, emotional disturbance and the loss of mental abilities. But biological mysteries remain.