Latest Research

  • Letter |

    In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.

    • Sanjeev Mariathasan
    • , Shannon J. Turley
    • , Dorothee Nickles
    • , Alessandra Castiglioni
    • , Kobe Yuen
    • , Yulei Wang
    • , Edward E. Kadel III
    • , Hartmut Koeppen
    • , Jillian L. Astarita
    • , Rafael Cubas
    • , Suchit Jhunjhunwala
    • , Romain Banchereau
    • , Yagai Yang
    • , Yinghui Guan
    • , Cecile Chalouni
    • , James Ziai
    • , Yasin Şenbabaoğlu
    • , Stephen Santoro
    • , Daniel Sheinson
    • , Jeffrey Hung
    • , Jennifer M. Giltnane
    • , Andrew A. Pierce
    • , Kathryn Mesh
    • , Steve Lianoglou
    • , Johannes Riegler
    • , Richard A. D. Carano
    • , Pontus Eriksson
    • , Mattias Höglund
    • , Loan Somarriba
    • , Daniel L. Halligan
    • , Michiel S. van der Heijden
    • , Yohann Loriot
    • , Jonathan E. Rosenberg
    • , Lawrence Fong
    • , Ira Mellman
    • , Daniel S. Chen
    • , Marjorie Green
    • , Christina Derleth
    • , Gregg D. Fine
    • , Priti S. Hegde
    • , Richard Bourgon
    •  & Thomas Powles
  • Article |

    Increased expression of the potassium channel Kir4.1 on astrocytes in the lateral habenula drives neuronal bursting in rodent models of depression.

    • Yihui Cui
    • , Yan Yang
    • , Zheyi Ni
    • , Yiyan Dong
    • , Guohong Cai
    • , Alexandre Foncelle
    • , Shuangshuang Ma
    • , Kangning Sang
    • , Siyang Tang
    • , Yuezhou Li
    • , Ying Shen
    • , Hugues Berry
    • , Shengxi Wu
    •  & Hailan Hu
  • Letter |

    High-angular-resolution measurements allow the direct observation of the scattering of energetic electrons by chorus waves in the magnetosphere, which causes quasiperiodic electron precipitation that gives rise to pulsating aurorae.

    • S. Kasahara
    • , Y. Miyoshi
    • , S. Yokota
    • , T. Mitani
    • , Y. Kasahara
    • , S. Matsuda
    • , A. Kumamoto
    • , A. Matsuoka
    • , Y. Kazama
    • , H. U. Frey
    • , V. Angelopoulos
    • , S. Kurita
    • , K. Keika
    • , K. Seki
    •  & I. Shinohara
  • Letter |

    A two-qubit quantum processor in a silicon device is demonstrated, which can perform the Deutsch–Josza algorithm and the Grover search algorithm.

    • T. F. Watson
    • , S. G. J. Philips
    • , E. Kawakami
    • , D. R. Ward
    • , P. Scarlino
    • , M. Veldhorst
    • , D. E. Savage
    • , M. G. Lagally
    • , Mark Friesen
    • , S. N. Coppersmith
    • , M. A. Eriksson
    •  & L. M. K. Vandersypen
  • Article |

    Single-cell transcriptomic analysis of the murine blood–brain barrier provides molecular definitions of the main vascular cell types, classifies perivascular cell types and sheds light on the organization of the arteriovenous axis.

    • Michael Vanlandewijck
    • , Liqun He
    • , Maarja Andaloussi Mäe
    • , Johanna Andrae
    • , Koji Ando
    • , Francesca Del Gaudio
    • , Khayrun Nahar
    • , Thibaud Lebouvier
    • , Bàrbara Laviña
    • , Leonor Gouveia
    • , Ying Sun
    • , Elisabeth Raschperger
    • , Markus Räsänen
    • , Yvette Zarb
    • , Naoki Mochizuki
    • , Annika Keller
    • , Urban Lendahl
    •  & Christer Betsholtz
  • Letter |

    In mouse pancreas cells with only one copy of the Nr5a2 gene, the orphan nuclear receptor NR5A2 undergoes a marked transcriptional shift from differentiation-specific to inflammatory genes, which results in an epithelial-cell-autonomous basal pre-inflammatory state.

    • Isidoro Cobo
    • , Paola Martinelli
    • , Marta Flández
    • , Latifa Bakiri
    • , Mingfeng Zhang
    • , Enrique Carrillo-de-Santa-Pau
    • , Jinping Jia
    • , Víctor J. Sánchez-Arévalo Lobo
    • , Diego Megías
    • , Irene Felipe
    • , Natalia del Pozo
    • , Irene Millán
    • , Liv Thommesen
    • , Torunn Bruland
    • , Sara H. Olson
    • , Jill Smith
    • , Kristina Schoonjans
    • , William R. Bamlet
    • , Gloria M. Petersen
    • , Núria Malats
    • , Laufey T. Amundadottir
    • , Erwin F. Wagner
    •  & Francisco X. Real
  • Letter |

    Freezing on a spherical surface is shown to proceed by the sequestration of defects into 12 icosahedrally coordinated ‘seas’ that enable the formation of a crystalline ‘continent’ with long-range orientational order.

    • Rodrigo E. Guerra
    • , Colm P. Kelleher
    • , Andrew D. Hollingsworth
    •  & Paul M. Chaikin
  • Letter |

    Single-cell fluorescence microscopy reveals that cytokinesis occurs in two stages in Staphylococcus aureus, an initial slow phase followed by a faster phase after MurJ protein recruitment to the midcell triggers peptidoglycan synthesis.

    • João M. Monteiro
    • , Ana R. Pereira
    • , Nathalie T. Reichmann
    • , Bruno M. Saraiva
    • , Pedro B. Fernandes
    • , Helena Veiga
    • , Andreia C. Tavares
    • , Margarida Santos
    • , Maria T. Ferreira
    • , Vânia Macário
    • , Michael S. VanNieuwenhze
    • , Sérgio R. Filipe
    •  & Mariana G. Pinho

Latest Reviews & Analysis

  • News & Views |

    Quantum spin liquids are long-sought exotic states of matter that could transform quantum computing. Signatures of such a state have now been observed in a compound comprising iridium ions on a honeycomb lattice.

    • Martin Mourigal
  • News & Views |

    The mouse pancreas adopts a pre-inflammatory state in response to a chemical injury or the loss of one copy of the gene Nr5a2. This state might predispose mice, and possibly humans, to pancreatitis and pancreatic cancer.

    • L. Charles Murtaugh
    •  & Raymond J. MacDonald
  • News & Views |

    Salvos of neuronal activity in the brain’s lateral habenula, regulated by astrocyte cells, drive depression-like behaviours in rodents. The finding might help us to understand one antidepressant and to develop more.

    • William M. Howe
    •  & Paul J. Kenny
  • News & Views |

    Spectacular light shows in Earth’s atmosphere called pulsating auroras are directly linked to processes in space. After decades of research, the full chain of events that creates such auroras has been observed.

    • Allison N. Jaynes
  • News & Views |

    Piezo proteins allow cells to sense forces by letting ions pass through the cell membrane in response to mechanical stimuli. Three structures of a Piezo protein shed light on how this crucial process works.

    • Yuh Nung Jan
    •  & Lily Yeh Jan
  • News & Views |

    During breast-cancer progression, tumour cells that arise in the milk duct spread elsewhere in the breast. The origin of these invasive tumour cells is now revealed by an analysis of spatially defined single cells.

    • Douglas S. Micalizzi
    •  & Shyamala Maheswaran

News & Comment

Outlook

Cancer immunotherapy

Elin Svensson

Cancer immunotherapy

Drugs that mobilize our immune systems against cancer are dramatically improving care for many people, and research is rapidly moving ahead in the lab and the clinic.

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