Latest Research

  • Article |

    BRCA1, but not BRCA2, suppresses the formation of tandem duplications at stalled replication forks in primary mammalian cells.

    • Nicholas A. Willis
    • , Richard L. Frock
    • , Francesca Menghi
    • , Erin E. Duffey
    • , Arvind Panday
    • , Virginia Camacho
    • , E. Paul Hasty
    • , Edison T. Liu
    • , Frederick W. Alt
    •  & Ralph Scully
  • Letter |

    Cryo-electron microscopy analysis of yeast Rad26 bound to RNA polymerase II provides insight into the initiation of the transcription-coupled DNA repair mechanism in eukaryotes.

    • Jun Xu
    • , Indrajit Lahiri
    • , Wei Wang
    • , Adam Wier
    • , Michael A. Cianfrocco
    • , Jenny Chong
    • , Alissa A. Hare
    • , Peter B. Dervan
    • , Frank DiMaio
    • , Andres E. Leschziner
    •  & Dong Wang
  • Letter |

    Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage.

    • Samantha W. Alvarez
    • , Vladislav O. Sviderskiy
    • , Erdem M. Terzi
    • , Thales Papagiannakopoulos
    • , Andre L. Moreira
    • , Sylvia Adams
    • , David M. Sabatini
    • , Kıvanç Birsoy
    •  & Richard Possemato
  • Letter |

    In a step towards hybrid quantum networks, a quantum state can be transferred between two fundamentally different systems—a cold atomic ensemble and a solid-state crystal—by a single photon.

    • Nicolas Maring
    • , Pau Farrera
    • , Kutlu Kutluer
    • , Margherita Mazzera
    • , Georg Heinze
    •  & Hugues de Riedmatten
  • Letter |

    A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and systemic immunity.

    • Dylan Dodd
    • , Matthew H. Spitzer
    • , William Van Treuren
    • , Bryan D. Merrill
    • , Andrew J. Hryckowian
    • , Steven K. Higginbottom
    • , Anthony Le
    • , Tina M. Cowan
    • , Garry P. Nolan
    • , Michael A. Fischbach
    •  & Justin L. Sonnenburg
  • Letter |

    Ground-based observations during a thunderstorm provide conclusive evidence of positrons being produced after lightning, confirming that lightning can trigger photonuclear reactions.

    • Teruaki Enoto
    • , Yuuki Wada
    • , Yoshihiro Furuta
    • , Kazuhiro Nakazawa
    • , Takayuki Yuasa
    • , Kazufumi Okuda
    • , Kazuo Makishima
    • , Mitsuteru Sato
    • , Yousuke Sato
    • , Toshio Nakano
    • , Daigo Umemoto
    •  & Harufumi Tsuchiya
  • Letter |

    Using a ligand as a promoter enhances the reactivity of the palladium catalyst in non-directed C–H functionalization of arenes, enabling the arene to be used as the limiting reagent.

    • Peng Wang
    • , Pritha Verma
    • , Guoqin Xia
    • , Jun Shi
    • , Jennifer X. Qiao
    • , Shiwei Tao
    • , Peter T. W. Cheng
    • , Michael A. Poss
    • , Marcus E. Farmer
    • , Kap-Sun Yeung
    •  & Jin-Quan Yu

Latest Reviews & Analysis

  • News and Views |

    Modification of messenger RNAs through a process called m6A methylation facilitates dynamic temporal regulation of RNA levels in neural precursor cells, enabling fine-tuning of developing neuronal circuits in the brain. 

    • J. David Sweatt
  • News and Views |

    Immunotherapy can reawaken T cells to destroy tumour cells. Modelling of tumour and T-cell interactions suggests why certain tumour cells are targeted and improves predictions of immunotherapy outcome.

    • Siranush Sarkizova
    •  & Nir Hacohen
  • News and Views |

    Materials that consist of just one or a few layers of atoms could have a range of useful applications. Computer simulations now show that the element tellurium might form three such phases, and that they have potentially useful properties.

    • Evan J. Reed
  • News and Views |

    Carbon–hydrogen bonds in organic molecules can be cut to install other chemical groups on the carbon atom, but these reactions have been limited. A catalytic palladium complex opens up fresh opportunities.

    • Joanna Wencel-Delord
    •  & Françoise Colobert
  • News and Views |

    The peptide-loading complex is key to the initiation of an immune response that raises killer T cells in vertebrates. Its structure has now been determined, and might provide information that improves immune protection.

    • Hidde Ploegh
  • News and Views |

    The discovery that thunderstorms can trigger nuclear reactions provides insight into the physics of atmospheric electricity and unveils a previously unknown natural source of radioactive isotopes on Earth.

    • Leonid Babich

News & Comment

Outlook

Fatty liver disease

Neil Webb

Fatty liver disease

The worldwide increase in obesity and diabetes has led to a spike in non-alcoholic fatty liver disease. Inside this Outlook: the innovative technologies enabling earlier diagnosis; how a surge in drug development is poised to deliver new treatments; and the disturbing rise of fatty liver disease in children.

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