Abstract
MANY of the biochemical actions of catecholamines and other hormones are mediated by alterations in intracellular levels of adenosine 3′,5′-monophosphate (cyclic AMP)1. For example, adrenaline stimulates glycogenolysis in heart muscle by increasing intracellular cyclic AMP levels. It is not clear, however, whether any of the effects of adrenaline on the electrophysiology of the heart are similarly mediated by this cyclic nucleotide2, although recent experiments indicate that exogenous cyclic AMP can accelerate the rhythmic beating of heart cells in culture3. We have studied the currents which underlie the action potential plateau in cardiac Purkinje fibres4–6 as a means of exploring the possible role of the cyclic nucleotide in modifying individual ionic current components. Our results strongly suggest that cyclic AMP does mediate the action of adrenaline on the plateau.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Robison, G. A., Burcher, R. W., and Sutherland, E. W., Cyclic AMP (Academic Press, New York, 1971).
Langslet, A., and Øye, I., Europ. J. Pharmacol., 12, 137 (1970).
Krause, E. G., Halle, W., Kallabi, E., and Wollenberger, A., J. Mol. Cell. Cardiol., 1, 1 (1970).
Reuter, H., J. Physiol., 192, 479 (1967).
Noble, D., and Tsien, R. W., J. Physiol., 200, 205 (1969).
Vitek, M., and Trautwein, W., Pflügers Archiv., 323, 204 (1971).
Otsuka, M., Pflügers Archiv., 266, 512 (1958).
Deck, K. A., Kern, R., and Trautwein, W., Pflügers Archiv., 280, 50 (1964).
Hauswirth, O., Noble, D., and Tsien, R. W., Science, 162, 916 (1968).
Giotti, A., Ledda, F., and Mannaioni, P. F., Brit. J. Pharmacol., 34, 695 (1968).
Vassalle, M., Amer. J. Physiol., 210, 1335 (1966).
Carmeliet, E., and Vereecke, Pflügers Archiv., 313, 300 (1969).
Sheppard, H., and Wiggan, G., Mol. Pharmacol., 7, 111 (1970).
Hoffman, B. F., and Singer, D. H., Ann. NY Acad. Sci., 139, 914 (1967).
Borasio, P. G., and Vassalle, M., Fed. Proc., Abs., 2641 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TSIEN, R., GILES, W. & GREENGARD, P. Cyclic AMP Mediates the Effects of Adrenaline on Cardiac Purkinje Fibres. Nature New Biology 240, 181–183 (1972). https://doi.org/10.1038/newbio240181a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio240181a0
This article is cited by
-
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics
Nature (2020)
-
Suspect that modulates the heartbeat is ensnared
Nature (2020)
-
Muscarinic regulation of cardiac ion channels
British Journal of Pharmacology (2003)
-
Histamine H1‐receptor‐mediated modulation of the delayed rectifier K+ current in guinea‐pig atrial cells: opposite effects on IKs and IKr
British Journal of Pharmacology (1999)
