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Strategies that utilize the oxidation of unactivated C–H bonds are becoming increasingly popular in natural product total synthesis. This Review classifies and highlights the different strategic use-cases of oxidation reactions as they were applied in recent total syntheses.
The supramolecular self-assembly of lipopeptides is highly dependent on the nature of the hydrophobic tail, the sequence of amino acids and external stimuli, defining their applications in the areas of nanotechnology, medicinal chemistry, biotechnology, biomaterials or catalysis.
The structure of pheromone, produced by microalgae in vanishingly small quantities as part of a signalling cascade that controls sexual reproduction, has been determined.
NMR spectroscopic data can now be fed to algorithms capable of deconvoluting the peaks in the search for its structure. Feeding the software with experimental and modelled data means that accurate fits can be produced in little time.
A general method to depolymerize plastic waste from resin codes 2–7 — including multilayered packaging and oil-contaminated packaging — and produce platform chemicals has been described.
Organozirconium compounds are known for their non-radical C–C bond-formation reactions with electrophiles. Now, such a compound has been used as a radical precursor in an enantioselective radical cross-coupling under visible-light irradiation without the need for an extra photocatalyst.
Pyramidanes are curious molecules. The tetrahedranes and the [4]–[6]pyramidanes exhibit molecular structures derived from trigonal to hexagonal pyramids. Examples of these pyramidanes are presented and their structural, spectroscopic and chemical features are described.
Autocatalytic lipids and their assemblies may have had a special and underappreciated role in the origin of life. This Review discusses how simple lipids can collectively generate fascinating systems-level phenomena and enable functions beyond reproduction, such as selection and soft materials applications.
The volatility of certain ionic liquids can be controlled electrochemically by applying a voltage to break their aromatic components. Cathodic reduction creates combustible species, but once the power is switched off and aromaticity restored, the liquid is thermally stable again.
Seventy years ago, Stanley L. Miller described the synthesis of amino acids from a simple mixture of gases, spurring investigations into the chemical origins of life. Here we discuss the rise, fall and renaissance of endogenous amino acid production.
Drawing inspiration from helical structures in nature, researchers have developed a cobalt-based complex able to twist and untwist, converting between nanohelix and nanowire structures.
Restructuring the way you run and manage your lab can be a daunting task, but doing so is imperative for creating a research environment in which d/Deaf students and other diverse learners can work and thrive.
Quantum Monte Carlo methods using neutral-network ansatzes can provide virtually exact solutions to the electronic Schrödinger equations for small systems and are comparable to conventional quantum chemistry methods when investigating systems with dozens of electrons.
Polymer backbones and their editing are at the root of polymer function and sustainability. This Review defines the concept of polymer backbone editing, categorizes a century’s worth of research in this area and outlines future directions for this field.
To combat worsening environmental crises, chemistry needs a redesign. We see the need for a triple focus on efficiency, safety and circularity as a prerequisite for chemistry to serve sustainability and ensure that essential chemical products and processes are waste-free, functional and safe for both humans and the environment.
The synthesis of a new family of self-assembled Ca2+-seamed capsules is reported. The interior volumes are the largest currently reported voids in molecular capsules, and they are completely isolated from the exterior environments.
A living catalyst transfer polymerization enables access to low dispersity polyphenylenes and ultimately to length-selective synthesis of graphene nanoribbons.
