May issue now live!
Image & Design: Rachael Tremlett

May issue now live!

Read issue 5 of Nature Reviews Chemistry

Latest Reviews

  • Perspective |

    Quadruplex DNA structures were first observed more than 50 years ago, but have only relatively recently attracted interest for their role in the development of cancer. This Perspective considers attempts to selectively bind and stabilize these structures using small molecules, with the aim of developing anticancer therapeutics.

    • Stephen Neidle
  • Review Article |

    Homogenous transition metal electrocatalysts are topical owing to their role in processing electrical energy and mediating the synthesis of chemical fuels. Mechanisms can be uncovered using electrochemical techniques and data analyses, along with complementary spectroscopic techniques. This Review presents case studies highlighting the utility of these methods in the context of electrocatalysis for chemical fuel production.

    • Katherine J. Lee
    • , Noémie Elgrishi
    • , Banu Kandemir
    •  & Jillian L. Dempsey
  • Review Article |

    The disconnection of C–H and C–C bonds is an efficient approach to functionalize organic molecules. Particularly useful are transformations in which these two cleavage reactions operate in tandem. This Review describes this tandem strategy and provides examples of its application in synthetic chemistry.

    • Zackaria Nairoukh
    • , Morgan Cormier
    •  & Ilan Marek
  • Review Article |

    The counterfeiting of goods has economic implications and is a threat to health and security. One promising solution for product authentication is the incorporation of physical unclonable functions. This Review delineates how stochastic chemical processes can afford unique anti-counterfeiting tags that cannot be reproduced.

    • Riikka Arppe
    •  & Thomas Just Sørensen
  • Perspective |

    The technological progress made since the industrial revolution has brought with it one of our greatest challenges: how to power our world while also minimizing environmental harm. This Perspective highlights the important role that quantum chemistry has in sustainable energy research.

    • Johannes M. Dieterich
    •  & Emily A. Carter

News & Comment

Current Issue

Volume 1 Issue 5

Image and design: Rachael Tremlett

Volume 1 Issue 5

Quadruplex structures are known to form from guanine rich DNA sequences such as those found in the telomere. Formation of these structures is known to decrease the activity of telomerase, an enzyme whose activity has been implicated in the development of several types of cancer. Small molecules which bind to and stabilize quadruplex DNA are thus being investigated as potential cancer therapeutics.

See  Neidle, S. Nat. Rev. Chem. 1, 0041 (2017).