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NCOR1/2 and glucocorticoid receptor orchestrate hepatic function
In this issue of Nature Metabolism, the research team of Mitchell Lazar reveals unexpected consequences of double loss of the coregulators NCOR1 and NCOR2 (NCOR1/2) in hepatocytes of adult mice, which affects chromatin functioning and glucocorticoid receptor (GR)-mediated gene transcription.
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Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization
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A call for accessible tools to unlock single-cell immunometabolism research
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Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis
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Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis