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Read primary research, opinion and comment highlighting the complexities of cancer. 

Latest Research

  • Article |

    Stewart et al. use circulating tumor cell-derived xenografts from patients with small-cell lung cancer to study tumor heterogeneity following the onset of therapeutic resistance.

    • C. Allison Stewart
    • , Carl M. Gay
    • , Yuanxin Xi
    • , Santhosh Sivajothi
    • , V. Sivakamasundari
    • , Junya Fujimoto
    • , Mohan Bolisetty
    • , Patrice M. Hartsfield
    • , Veerakumar Balasubramaniyan
    • , Milind D. Chalishazar
    • , Cesar Moran
    • , Neda Kalhor
    • , John Stewart
    • , Hai Tran
    • , Stephen G. Swisher
    • , Jack A. Roth
    • , Jianjun Zhang
    • , John de Groot
    • , Bonnie Glisson
    • , Trudy G. Oliver
    • , John V. Heymach
    • , Ignacio Wistuba
    • , Paul Robson
    • , Jing Wang
    •  & Lauren Averett Byers
  • Analysis |

    Degasperi et al. introduce a practical framework and Signal, an online tool, to analyze mutational signatures. They find evidence of tissue-specific variability in mutational signatures, which may impact tumor classification and clinical application.

    • Andrea Degasperi
    • , Tauanne Dias Amarante
    • , Jan Czarnecki
    • , Scott Shooter
    • , Xueqing Zou
    • , Dominik Glodzik
    • , Sandro Morganella
    • , Arjun S. Nanda
    • , Cherif Badja
    • , Gene Koh
    • , Sophie E. Momen
    • , Ilias Georgakopoulos-Soares
    • , João M. L. Dias
    • , Jamie Young
    • , Yasin Memari
    • , Helen Davies
    •  & Serena Nik-Zainal
  • Article |

    Bodenmiller and colleagues pair imaging mass cytometry with data from the METABRIC cohort to define single-cell phenotypic and genomic features of breast cancer with spatial context, finding associations with breast cancer subtypes and prognosis.

    • H. Raza Ali
    • , Hartland W. Jackson
    • , Vito R. T. Zanotelli
    • , Esther Danenberg
    • , Jana R. Fischer
    • , Helen Bardwell
    • , Elena Provenzano
    • , H. Raza Ali
    • , M. Al Sa’d
    • , S. Alon
    • , Samuel Aparicio
    • , G. Battistoni
    • , S. Balasubramanian
    • , R. Becker
    • , Bernd Bodenmiller
    • , E. S. Boyden
    • , D. Bressan
    • , A. Bruna
    • , B. Marcel
    • , Carlos Caldas
    • , M. Callari
    • , I. G. Cannell
    • , H. Casbolt
    • , N. Chornay
    • , Y. Cui
    • , A. Dariush
    • , K. Dinh
    • , A. Emenari
    • , Y. Eyal-Lubling
    • , J. Fan
    • , E. Fisher
    • , E. A. González-Solares
    • , C. González-Fernández
    • , D. Goodwin
    • , W. Greenwood
    • , F. Grimaldi
    • , G. J. Hannon
    • , O. Harris
    • , S. Harris
    • , C. Jauset
    • , J. A. Joyce
    • , E. D. Karagiannis
    • , T. Kovačević
    • , L. Kuett
    • , R. Kunes
    • , A. Küpcü Yoldaş
    • , D. Lai
    • , E. Laks
    • , H. Lee
    • , M. Lee
    • , G. Lerda
    • , Y. Li
    • , A. McPherson
    • , N. Millar
    • , C. M. Mulvey
    • , F. Nugent
    • , C. H. O’Flanagan
    • , M. Paez-Ribes
    • , I. Pearsall
    • , F. Qosaj
    • , A. J. Roth
    • , Oscar M. Rueda
    • , T. Ruiz
    • , K. Sawicka
    • , L. A. Sepúlveda
    • , S. P. Shah
    • , A. Shea
    • , A. Sinha
    • , A. Smith
    • , S. Tavaré
    • , S. Tietscher
    • , I. Vázquez-García
    • , S. L. Vogl
    • , N. A. Walton
    • , A. T. Wassie
    • , S. S. Watson
    • , S. A. Wild
    • , E. Williams
    • , J. Windhager
    • , C. Xia
    • , P. Zheng
    • , X. Zhuang
    • , Oscar M. Rueda
    • , Suet-Feung Chin
    • , Samuel Aparicio
    • , Carlos Caldas
    •  & Bernd Bodenmiller
  • Article |

    Marais and colleagues report that checkpoint inhibitor treatment of patients with melanoma leads to dynamic changes in peripheral T cells and expansion of immune effector cells. This awakening of the immune system occurs early after treatment and could be exploited in the clinic.

    • Sara Valpione
    • , Elena Galvani
    • , Joshua Tweedy
    • , Piyushkumar A. Mundra
    • , Antonia Banyard
    • , Philippa Middlehurst
    • , Jeff Barry
    • , Sarah Mills
    • , Zena Salih
    • , John Weightman
    • , Avinash Gupta
    • , Gabriela Gremel
    • , Franziska Baenke
    • , Nathalie Dhomen
    • , Paul C. Lorigan
    •  & Richard Marais
  • Article |

    Diehn and colleagues report that assaying circulating DNA in patients receiving chemoradiation therapy for non-small-cell lung cancer could identify the patients most likely to benefit from consolidation immunotherapy.

    • Everett J. Moding
    • , Yufei Liu
    • , Barzin Y. Nabet
    • , Jacob J. Chabon
    • , Aadel A. Chaudhuri
    • , Angela B. Hui
    • , Rene F. Bonilla
    • , Ryan B. Ko
    • , Christopher H. Yoo
    • , Linda Gojenola
    • , Carol D. Jones
    • , Jianzhong He
    • , Yawei Qiao
    • , Ting Xu
    • , John V. Heymach
    • , Anne Tsao
    • , Zhongxing Liao
    • , Daniel R. Gomez
    • , Millie Das
    • , Sukhmani K. Padda
    • , Kavitha J. Ramchandran
    • , Joel W. Neal
    • , Heather A. Wakelee
    • , Billy W. Loo Jr
    • , Steven H. Lin
    • , Ash A. Alizadeh
    •  & Maximilian Diehn
  • Article |

    Cong et al. show that MTSS1 suppresses breast cancer initiation by promoting ubiquitin-mediated suppression of the NF-κB pathway. Loss of this regulatory mechanism promotes the activation and expansion of tumor-initiating cells.

    • Min Cong
    • , Yuan Wang
    • , Yang Yang
    • , Cheng Lian
    • , Xueqian Zhuang
    • , Xiaoxun Li
    • , Peiyuan Zhang
    • , Yingjie Liu
    • , Jun Tang
    • , Qifeng Yang
    • , Xue Zhang
    • , Hua Xiong
    • , Ronggui Hu
    •  & Guohong Hu

News & Comment

  • Q&A |

    Zena Werb is Professor and Vice Chair of the Department of Anatomy at the University of California at San Francisco and Associate Director for Basic Science of the UCSF Helen Diller Family Comprehensive Cancer Center. Nature Cancer caught up with her at the 6th International Conference on Tumor Microenvironment and Cellular Stress organized by Aegean Conferences and held in Greece in the fall of 2019, to talk about her career and work in the tumor microenvironment field.

    • Alexia-Ileana Zaromytidou
  • News & Views |

    Tumor heterogeneity remains an obstacle to effective clinical management of breast cancer. Two new studies use high-dimensional imaging of single-cell protein expression in situ in clinical samples to link genomic alterations to multi-cellular features of the tumor microenvironment and reveal breast-cancer phenotypes associated with clinical outcome.

    • Leeat Keren
    •  & Michael Angelo
  • Comment |

    Low- and middle-income countries share the greatest burden of cancer mortality globally but lag behind high-income countries in terms of clinical trials. Here we discuss the challenges facing low- and middle-income countries and the opportunities for conducting trials of affordable, accessible and effective interventions relevant to the local population.

    • Bishal Gyawali
    • , Gauthier Bouche
    • , Nigel Crisp
    •  & Nicolas André
  • News & Views |

    Discerning and analyzing the mutational patterns that arise in the cancer genome can provide essential information on the process of tumorigenesis. An analytical framework and web-based tool now aim to aid in mutational signature assignment for improved tumor stratification.

    • Giovanni Ciriello
  • News & Views |

    Identifying indicators of response to immunotherapy is key for treatment decisions. Two studies now report that early changes in T cell repertoires and CD8+ memory effector cytotoxic T cells in peripheral blood correlate with response to immune-checkpoint inhibitors in metastatic melanoma and may serve as actionable biomarkers of immune activation.

    • Genevieve M. Boland
    •  & Keith T. Flaherty
  • News & Views |

    Drug repurposing is an attractive strategy for extending the arsenal of oncology therapies. Screening of a large collection of existing non-oncology compounds against a panel of cancer cell lines now identifies several drugs capable of selectively inhibiting the growth of cancer cells.

    • Roderick L. Beijersbergen