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Barcoded DNA structures for the subcellular profiling of proteins
This issue highlights tumour-cell-derived microparticles as efficient drug-delivery carriers, the boosting of chemotherapy in colonic tumours via the phage-guided modulation of gut microbiota, the delivery of a therapeutic monoclonal antibody to metastases in the central nervous system, the augmentation of canonical Wnt signalling to produce cell factories of therapeutically potent exosomes, integrated glass microelectrodes for in vivo brain electrophysiology, and barcoded DNA nanostructures for the profiling of subcellular protein distribution.
The cover illustrates tetrahedral DNA nanostructures that act as barcodes for the high-throughput multiplexed profiling of the subcellular expression and distribution of proteins in cells.
Translational cancer nanomedicine needs to increasingly exploit newly discovered tumour-targeting strategies as well as the further optimization of proven means to selectively increase the concentration of cytotoxic drugs in solid tumours.
The localization of target proteins, at subcellular resolution, in fixed patient-derived tissues can now be achieved via antibodies conjugated with tetrahedral DNA nanostructures self-assembled in situ.
Encapsulation of the therapeutic monoclonal antibody rituximab, and its molecular targeting to brain metastases of B-cell lymphoma, significantly boosts the antibody’s therapeutic effectiveness in mice.
A suite of microelectrodes integrated into glass pipettes, for the simultaneous recording of intracellular and extracellular data in the brains of living mice and rats, yields ground-truth data for the validation of the performance of spike-sorting algorithms.
The overexpression of β-catenin and the transcription factor Gata4 in skin fibroblasts induces these cells to secrete reparative exosomes, as shown in mice models of myocardial infarction and Duchenne muscular dystrophy.
The polymer encapsulation of the monoclonal antibody rituximab and the ligand-mediated targeting of metastases in the central nervous system significantly improve antitumour efficacy in mouse models of metastatic non-Hodgkin lymphoma.
Dextran nanoparticles loaded with a chemotherapeutic agent and bound to phages that eliminate a pro-tumoural gut bacterium and promote the growth of anticancer-compound-producing bacteria boost chemotherapy responses in mouse models of colorectal cancer.
A suite of glass pipettes with integrated microelectrodes that simultaneously acquire intracellular and extracellular data in living mice and rats yield ground-truth data for validation of the performance of spike-sorting algorithms.