Latest Research

  • Article |

    Physiological modelling of first-pass metabolism using data from a robotic instrument that fluidically links relevant organ chips predicts human pharmacokinetic parameters for orally administered nicotine and for intravenously injected cisplatin.

    • Anna Herland
    • , Ben M. Maoz
    • , Debarun Das
    • , Mahadevabharath R. Somayaji
    • , Rachelle Prantil-Baun
    • , Richard Novak
    • , Michael Cronce
    • , Tessa Huffstater
    • , Sauveur S. F. Jeanty
    • , Miles Ingram
    • , Angeliki Chalkiadaki
    • , David Benson Chou
    • , Susan Marquez
    • , Aaron Delahanty
    • , Sasan Jalili-Firoozinezhad
    • , Yuka Milton
    • , Alexandra Sontheimer-Phelps
    • , Ben Swenor
    • , Oren Levy
    • , Kevin K. Parker
    • , Andrzej Przekwas
    •  & Donald E. Ingber
  • Article |

    A system employing liquid-handling robotics and an integrated mobile microscope enables the automated culture, sample collection and in situ microscopy imaging of up to ten fluidically coupled organ chips within a standard tissue-culture incubator.

    • Richard Novak
    • , Miles Ingram
    • , Susan Marquez
    • , Debarun Das
    • , Aaron Delahanty
    • , Anna Herland
    • , Ben M. Maoz
    • , Sauveur S. F. Jeanty
    • , Mahadevabharath R. Somayaji
    • , Morgan Burt
    • , Elizabeth Calamari
    • , Angeliki Chalkiadaki
    • , Alexander Cho
    • , Youngjae Choe
    • , David Benson Chou
    • , Michael Cronce
    • , Stephanie Dauth
    • , Toni Divic
    • , Jose Fernandez-Alcon
    • , Thomas Ferrante
    • , John Ferrier
    • , Edward A. FitzGerald
    • , Rachel Fleming
    • , Sasan Jalili-Firoozinezhad
    • , Thomas Grevesse
    • , Josue A. Goss
    • , Tiama Hamkins-Indik
    • , Olivier Henry
    • , Chris Hinojosa
    • , Tessa Huffstater
    • , Kyung-Jin Jang
    • , Ville Kujala
    • , Lian Leng
    • , Robert Mannix
    • , Yuka Milton
    • , Janna Nawroth
    • , Bret A. Nestor
    • , Carlos F. Ng
    • , Blakely O’Connor
    • , Tae-Eun Park
    • , Henry Sanchez
    • , Josiah Sliz
    • , Alexandra Sontheimer-Phelps
    • , Ben Swenor
    • , Guy Thompson II
    • , George J. Touloumes
    • , Zachary Tranchemontagne
    • , Norman Wen
    • , Moran Yadid
    • , Anthony Bahinski
    • , Geraldine A. Hamilton
    • , Daniel Levner
    • , Oren Levy
    • , Andrzej Przekwas
    • , Rachelle Prantil-Baun
    • , Kevin K. Parker
    •  & Donald E. Ingber
  • Article |

    A vascularized human bone-marrow-on-a-chip improves the maintenance of patient-derived CD34+ cells, and recapitulates clinically relevant aspects of bone marrow injury as well as key haematopoietic defects of patients with a rare genetic disorder.

    • David B. Chou
    • , Viktoras Frismantas
    • , Yuka Milton
    • , Rhiannon David
    • , Petar Pop-Damkov
    • , Douglas Ferguson
    • , Alexander MacDonald
    • , Özge Vargel Bölükbaşı
    • , Cailin E. Joyce
    • , Liliana S. Moreira Teixeira
    • , Arianna Rech
    • , Amanda Jiang
    • , Elizabeth Calamari
    • , Sasan Jalili-Firoozinezhad
    • , Brooke A. Furlong
    • , Lucy R. O’Sullivan
    • , Carlos F. Ng
    • , Youngjae Choe
    • , Susan Marquez
    • , Kasiani C. Myers
    • , Olga K. Weinberg
    • , Robert P. Hasserjian
    • , Richard Novak
    • , Oren Levy
    • , Rachelle Prantil-Baun
    • , Carl D. Novina
    • , Akiko Shimamura
    • , Lorna Ewart
    •  & Donald E. Ingber
  • Article |

    A method that quantifies signal reductions in proton magnetic resonance spectroscopy resulting from the replacement of 1H with 2H after the administration of a deuterated substrate can be used to monitor the turnover of cellular metabolites in vivo.

    • Laurie J. Rich
    • , Puneet Bagga
    • , Neil E. Wilson
    • , Mitchell D. Schnall
    • , John A. Detre
    • , Mohammad Haris
    •  & Ravinder Reddy
  • Article |

    Optimized adeno-associated viruses delivering split cytosine base editors and adenine base editors with trans-splicing inteins can edit brain, liver, retina, heart and skeletal-muscle tissues at therapeutically relevant efficiencies.

    • Jonathan M. Levy
    • , Wei-Hsi Yeh
    • , Nachiket Pendse
    • , Jessie R. Davis
    • , Erin Hennessey
    • , Rossano Butcher
    • , Luke W. Koblan
    • , Jason Comander
    • , Qin Liu
    •  & David R. Liu
  • Article |

    A comparison of compatibilities in protospacer adjacent motifs and of on-target and off-target activities of Streptococcus pyogenes Cas9 variants at endogenous sites in human cells enables the editing of new genomic sites associated with genetic diseases.

    • Hui Kwon Kim
    • , Sungtae Lee
    • , Younggwang Kim
    • , Jinman Park
    • , Seonwoo Min
    • , Jae Woo Choi
    • , Tony P. Huang
    • , Sungroh Yoon
    • , David R. Liu
    •  & Hyongbum Henry Kim
  • Article |

    Structural and functional analyses of the remodelling of intact lymphatic vasculature after the ligation of a hind-limb lymphatic vessel in sheep reveal the adaptations to the changes in fluid load that occur after lymphatic injury.

    • Tyler S. Nelson
    • , Zhanna Nepiyushchikh
    • , Joshua S. T. Hooks
    • , Mohammad S. Razavi
    • , Tristan Lewis
    • , Cristina C. Clement
    • , Merrilee Thoresen
    • , Matthew T. Cribb
    • , Mindy K. Ross
    • , Rudolph L. Gleason Jr
    • , Laura Santambrogio
    • , John F. Peroni
    •  & J. Brandon Dixon
  • Article |

    An optical-imaging instrument that integrates a visible multispectral imaging system with the detection of near-infrared fluorescence in the first and second windows aids the fluorescence-guided surgical resection of liver tumours in patients.

    • Zhenhua Hu
    • , Cheng Fang
    • , Bo Li
    • , Zeyu Zhang
    • , Caiguang Cao
    • , Meishan Cai
    • , Song Su
    • , Xingwang Sun
    • , Xiaojing Shi
    • , Cong Li
    • , Tiejun Zhou
    • , Yuanxue Zhang
    • , Chongwei Chi
    • , Pan He
    • , Xianming Xia
    • , Yue Chen
    • , Sanjiv Sam Gambhir
    • , Zhen Cheng
    •  & Jie Tian
  • Article |

    Machine-learning algorithms trained with retinal fundus images, with subject metadata or with both data types, predict haemoglobin concentration with mean absolute errors lower than 0.75 g dl–1 and anaemia with areas under the curve in the range of 0.74–0.89.

    • Akinori Mitani
    • , Abigail Huang
    • , Subhashini Venugopalan
    • , Greg S. Corrado
    • , Lily Peng
    • , Dale R. Webster
    • , Naama Hammel
    • , Yun Liu
    •  & Avinash V. Varadarajan
  • Article |

    A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppressor function in mice with orthotopically implanted phosphatase and tensin homologue (PTEN)-deficient brain gliomas.

    • Zhaogang Yang
    • , Junfeng Shi
    • , Jing Xie
    • , Yifan Wang
    • , Jingyao Sun
    • , Tongzheng Liu
    • , Yarong Zhao
    • , Xiuting Zhao
    • , Xinmei Wang
    • , Yifan Ma
    • , Veysi Malkoc
    • , Chiling Chiang
    • , Weiye Deng
    • , Yuanxin Chen
    • , Yuan Fu
    • , Kwang J. Kwak
    • , Yamin Fan
    • , Chen Kang
    • , Changcheng Yin
    • , June Rhee
    • , Paul Bertani
    • , Jose Otero
    • , Wu Lu
    • , Kyuson Yun
    • , Andrew S. Lee
    • , Wen Jiang
    • , Lesheng Teng
    • , Betty Y. S. Kim
    •  & L. James Lee
  • Article |

    A near-infrared-light-sensitive photovoltaic subretinal prosthesis triggers behavioural responses in awake macaques, even two years after device implantation.

    • Paul-Henri Prévot
    • , Kevin Gehere
    • , Fabrice Arcizet
    • , Himanshu Akolkar
    • , Mina A. Khoei
    • , Kévin Blaize
    • , Omar Oubari
    • , Pierre Daye
    • , Marion Lanoë
    • , Manon Valet
    • , Sami Dalouz
    • , Paul Langlois
    • , Elric Esposito
    • , Valérie Forster
    • , Elisabeth Dubus
    • , Nicolas Wattiez
    • , Elena Brazhnikova
    • , Céline Nouvel-Jaillard
    • , Yannick LeMer
    • , Joanna Demilly
    • , Claire-Maëlle Fovet
    • , Philippe Hantraye
    • , Morgane Weissenburger
    • , Henri Lorach
    • , Elodie Bouillet
    • , Martin Deterre
    • , Ralf Hornig
    • , Guillaume Buc
    • , José-Alain Sahel
    • , Guillaume Chenegros
    • , Pierre Pouget
    • , Ryad Benosman
    •  & Serge Picaud
  • Article |

    The local delivery of a calcium channel blocker and a Rho-kinase inhibitor, determined by screening for small molecules that cause ureteral relaxation, significantly reduce ureteral contraction in pigs.

    • Christopher X. Lee
    • , Jaime H. Cheah
    • , Christian K. Soule
    • , Huiming Ding
    • , Charles A. Whittaker
    • , Kyle Karhohs
    • , Aurora A. Burds
    • , Kriti S. Subramanyam
    • , Anne E. Carpenter
    • , Brian H. Eisner
    •  & Michael J. Cima
  • Article |

    A wireless device designed to be conformally placed on the suprasternal notch can continuously provide real-time information of essential vital signs as well as talking time, swallow counts and sleep patterns.

    • KunHyuck Lee
    • , Xiaoyue Ni
    • , Jong Yoon Lee
    • , Hany Arafa
    • , David J. Pe
    • , Shuai Xu
    • , Raudel Avila
    • , Masahiro Irie
    • , Joo Hee Lee
    • , Ryder L. Easterlin
    • , Dong Hyun Kim
    • , Ha Uk Chung
    • , Omolara O. Olabisi
    • , Selam Getaneh
    • , Esther Chung
    • , Marc Hill
    • , Jeremy Bell
    • , Hokyung Jang
    • , Claire Liu
    • , Jun Bin Park
    • , Jungwoo Kim
    • , Sung Bong Kim
    • , Sunita Mehta
    • , Matt Pharr
    • , Andreas Tzavelis
    • , Jonathan T. Reeder
    • , Ivy Huang
    • , Yujun Deng
    • , Zhaoqian Xie
    • , Charles R. Davies
    • , Yonggang Huang
    •  & John A. Rogers
  • Article |

    The serial assessment of the functional parameters of leukocytes isolated via an inertial microfluidic system from 50 μl of peripheral blood from sepsis patients provides significantly more prognostic information than leukocyte counting.

    • Bakr Jundi
    • , Hyunryul Ryu
    • , Do-Hyun Lee
    • , Raja-Elie E. Abdulnour
    • , Braden D. Engstrom
    • , Melody G. Duvall
    • , Angelica Higuera
    • , Mayra Pinilla-Vera
    • , Maura E. Benson
    • , Jaemyon Lee
    • , Nandini Krishnamoorthy
    • , Rebecca M. Baron
    • , Jongyoon Han
    • , Joel Voldman
    •  & Bruce D. Levy
  • Perspective |

    This Perspective summarizes the most recent developments in the bioprinting of cartilage, bone and skin for clinical applications, and discusses translational challenges and opportunities in the fabrication of complex 3D-printed tissues and organs.

    • Sean V. Murphy
    • , Paolo De Coppi
    •  & Anthony Atala
  • Author Correction |

    • Mohammed F. Shaheen
    • , Dong Jin Joo
    • , Jeffrey J. Ross
    • , Brett D. Anderson
    • , Harvey S. Chen
    • , Robert C. Huebert
    • , Yi Li
    • , Bruce Amiot
    • , Anne Young
    • , Viviana Zlochiver
    • , Erek Nelson
    • , Taofic Mounajjed
    • , Allan B. Dietz
    • , Gregory Michalak
    • , Benjamin G. Steiner
    • , Dominique Seetapun Davidow
    • , Christopher R. Paradise
    • , Andre J. van Wijnen
    • , Vijay H. Shah
    • , Mengfei Liu
    •  & Scott L. Nyberg
  • Article |

    Attaching a syndecan-binding domain to vascular endothelial and platelet-derived growth factor variants enhances their binding to syndecans and triggers tonic signalling for enhanced bone regeneration and wound repair in mice.

    • Mayumi Mochizuki
    • , Esra Güç
    • , Anthony J. Park
    • , Ziad Julier
    • , Priscilla S. Briquez
    • , Gisela A. Kuhn
    • , Ralph Müller
    • , Melody A. Swartz
    • , Jeffrey A. Hubbell
    •  & Mikaël M. Martino
  • Article |

    A computational approach for the design of self-assembling antibody–drug conjugates via affinity ligands for specific conserved amino acid residues in antibodies yields homogenous and stable antibody–drug conjugates that form in less than 8 min.

    • Nimish Gupta
    • , Aasif Ansari
    • , Gaurao V. Dhoke
    • , Maheshwerreddy Chilamari
    • , Jwala Sivaccumar
    • , Smita Kumari
    • , Snigdha Chatterjee
    • , Ravinder Goyal
    • , Pradip Kumar Dutta
    • , Mallik Samarla
    • , Madhumita Mukherjee
    • , Arindam Sarkar
    • , Swadhin K. Mandal
    • , Vishal Rai
    • , Goutam Biswas
    • , Aniruddha Sengupta
    • , Sudip Roy
    • , Monideepa Roy
    •  & Shiladitya Sengupta
  • Article |

    Functionalized multi-walled carbon nanotubes twisted into helical fibre bundles that mimic the hierarchical structure of muscle can be used for the long-term monitoring of multiple disease biomarkers in vivo.

    • Liyuan Wang
    • , Songlin Xie
    • , Zhiyuan Wang
    • , Fei Liu
    • , Yifan Yang
    • , Chengqiang Tang
    • , Xiaoying Wu
    • , Peng Liu
    • , Yongjing Li
    • , Hexige Saiyin
    • , Shuang Zheng
    • , Xuemei Sun
    • , Fan Xu
    • , Hongbo Yu
    •  & Huisheng Peng
  • Article |

    The analysis of behavioural patterns from standardized video recordings of infants with varying degrees of visual impairment enables, via deep learning, classification of the infants by visual-impairment severity and by ophthalmological condition.

    • Erping Long
    • , Zhenzhen Liu
    • , Yifan Xiang
    • , Andi Xu
    • , Jialing Huang
    • , Xiucheng Huang
    • , Xiaoyan Li
    • , Zhuoling Lin
    • , Jing Li
    • , Jingjing Chen
    • , Yan Zhang
    • , Yi Zhu
    • , Chuan Chen
    • , Ziheng Zhou
    • , Xiaowei Ding
    • , Xiaohang Wu
    • , Wangting Li
    • , Hui Chen
    • , Ruiyang Li
    • , Yahan Yang
    • , Weishi Zheng
    • , Weirong Chen
    • , Haotian Lin
    •  & Yizhi Liu
  • Article |

    Downregulation of the transcription factor KLF4 in keratinocyte precursors improves the proliferation and maintenance of immature keratinocytes in vitro and the generation of epidermis in vivo.

    • Nicolas O. Fortunel
    • , Loubna Chadli
    • , Julien Coutier
    • , Gilles Lemaître
    • , Frédéric Auvré
    • , Sophie Domingues
    • , Emmanuelle Bouissou-Cadio
    • , Pierre Vaigot
    • , Sophie Cavallero
    • , Jean-François Deleuze
    • , Paul-Henri Roméo
    •  & Michèle T. Martin
  • Article |

    Decellularized whole porcine livers revascularized with human endothelial cells and implanted heterotopically into immunosuppressed pigs whose spleens had been removed can sustain perfusion for up to 15 days.

    • Mohammed F. Shaheen
    • , Dong Jin Joo
    • , Jeffrey J. Ross
    • , Brett D. Anderson
    • , Harvey S. Chen
    • , Robert C. Huebert
    • , Yi Li
    • , Bruce Amiot
    • , Anne Young
    • , Viviana Zlochiver
    • , Erek Nelson
    • , Taofic Mounajjed
    • , Allan B. Dietz
    • , Gregory Michalak
    • , Benjamin G. Steiner
    • , Dominique Seetapun Davidow
    • , Christopher R. Paradise
    • , Andre J. van Wijnen
    • , Vijay H. Shah
    • , Mengfei Liu
    •  & Scott L. Nyberg
  • Article |

    The loss of residual strains in the intervertebral disc alters the microenvironment and instigates aberrant tissue remodelling and the adoption of atypical cellular phenotypes, promoting disease progression.

    • Edward D. Bonnevie
    • , Sarah E. Gullbrand
    • , Beth G. Ashinsky
    • , Tonia K. Tsinman
    • , Dawn M. Elliott
    • , Pen-hsiu Grace Chao
    • , Harvey E. Smith
    •  & Robert L. Mauck
  • Article |

    Immunomagnetic cell sorting implemented in a microfluidic chip can perform loss-of-function CRISPR–Cas9-mediated phenotypic screening at higher throughput than fluorescence-activated cell sorting.

    • Barbara Mair
    • , Peter M. Aldridge
    • , Randy S. Atwal
    • , David Philpott
    • , Meng Zhang
    • , Sanna N. Masud
    • , Mahmoud Labib
    • , Amy H. Y. Tong
    • , Edward H. Sargent
    • , Stéphane Angers
    • , Jason Moffat
    •  & Shana O. Kelley
  • Article |

    The overexpression of β-catenin and the transcription factor Gata4 in skin fibroblasts induces these cells to secrete reparative exosomes, as shown in mice models of myocardial infarction and Duchenne muscular dystrophy.

    • Ahmed G. E. Ibrahim
    • , Chang Li
    • , Russel Rogers
    • , Mario Fournier
    • , Liang Li
    • , Sharon D. Vaturi
    • , Travis Antes
    • , Lizbeth Sanchez
    • , Akbarshakh Akhmerov
    • , Jennifer Johnson Moseley
    • , Brooke Tobin
    • , Luis Rodriguez-Borlado
    • , Rachel R. Smith
    • , Linda Marbán
    •  & Eduardo Marbán
  • Article |

    A reconfigurable microfluidic cell-culture system that facilitates the assembly of 3D tissue models by stacking layers containing preconditioned microenvironments enables the modelling of the spatiotemporal dynamics of paracrine signalling.

    • Jiaquan Yu
    • , Erwin Berthier
    • , Alexandria Craig
    • , Theodorus E. de Groot
    • , Sidney Sparks
    • , Patrick N. Ingram
    • , David F. Jarrard
    • , Wei Huang
    • , David J. Beebe
    •  & Ashleigh B. Theberge
  • Article |

    Personalized computational modelling can reliably predetermine ablation targets in patients with persistent atrial fibrillation and atrial fibrosis.

    • Patrick M. Boyle
    • , Tarek Zghaib
    • , Sohail Zahid
    • , Rheeda L. Ali
    • , Dongdong Deng
    • , William H. Franceschi
    • , Joe B. Hakim
    • , Michael J. Murphy
    • , Adityo Prakosa
    • , Stefan L. Zimmerman
    • , Hiroshi Ashikaga
    • , Joseph E. Marine
    • , Aravindan Kolandaivelu
    • , Saman Nazarian
    • , David D. Spragg
    • , Hugh Calkins
    •  & Natalia A. Trayanova
  • Perspective |

    This Perspective overviews immunotherapies leveraging engineering approaches, including the design of biomaterials, delivery strategies and nanotechnology solutions, for the realization of individualized cancer treatments.

    • Lindsay Scheetz
    • , Kyung Soo Park
    • , Qiao Li
    • , Pedro R. Lowenstein
    • , Maria G. Castro
    • , Anna Schwendeman
    •  & James J. Moon
  • Article |

    Bioresorbable photonic devices for the spectroscopic characterization of tissues and biofluids can continuously monitor cerebral temperature, oxygenation and neural activity in the brains of freely moving mice before they are fully resorbed.

    • Wubin Bai
    • , Jiho Shin
    • , Ruxing Fu
    • , Irawati Kandela
    • , Di Lu
    • , Xiaoyue Ni
    • , Yoonseok Park
    • , Zhonghe Liu
    • , Tao Hang
    • , Di Wu
    • , Yonghao Liu
    • , Chad R. Haney
    • , Iwona Stepien
    • , Quansan Yang
    • , Jie Zhao
    • , Khizar Rehan Nandoliya
    • , Hao Zhang
    • , Xing Sheng
    • , Lan Yin
    • , Keith MacRenaris
    • , Anlil Brikha
    • , Fraser Aird
    • , Maryam Pezhouh
    • , Jessica Hornick
    • , Weidong Zhou
    •  & John A. Rogers
  • Article |

    A sprayable dynamically crosslinked supramolecular polymer–nanoparticle hydrogel that robustly adheres to tissue reduces the severity of cardiac adhesions in rats and sheep.

    • Lyndsay M. Stapleton
    • , Amanda N. Steele
    • , Hanjay Wang
    • , Hector Lopez Hernandez
    • , Anthony C. Yu
    • , Michael J. Paulsen
    • , Anton A. A. Smith
    • , Gillie A. Roth
    • , Akshara D. Thakore
    • , Haley J. Lucian
    • , Kailey P. Totherow
    • , Sam W. Baker
    • , Yuko Tada
    • , Justin M. Farry
    • , Anahita Eskandari
    • , Camille E. Hironaka
    • , Kevin J. Jaatinen
    • , Kiah M. Williams
    • , Hunter Bergamasco
    • , Clifton Marschel
    • , Blaine Chadwick
    • , Frederick Grady
    • , Michael Ma
    • , Eric A. Appel
    •  & Y. Joseph Woo
  • Article |

    Smartphone-controlled soft optofluidic probes with replaceable plug-like drug cartridges enable chronic in vivo pharmacology and optogenetics for the selective wireless manipulation of brain circuits in rodents.

    • Raza Qazi
    • , Adrian M. Gomez
    • , Daniel C. Castro
    • , Zhanan Zou
    • , Joo Yong Sim
    • , Yanyu Xiong
    • , Jonas Abdo
    • , Choong Yeon Kim
    • , Avery Anderson
    • , Frederik Lohner
    • , Sang-Hyuk Byun
    • , Byung Chul Lee
    • , Kyung-In Jang
    • , Jianliang Xiao
    • , Michael R. Bruchas
    •  & Jae-Woong Jeong
  • Article |

    The polymer encapsulation of the monoclonal antibody rituximab and the ligand-mediated targeting of metastases in the central nervous system significantly improve antitumour efficacy in mouse models of metastatic non-Hodgkin lymphoma.

    • Jing Wen
    • , Di Wu
    • , Meng Qin
    • , Chaoyong Liu
    • , Lan Wang
    • , Duo Xu
    • , Harry V. Vinters
    • , Yang Liu
    • , Emiko Kranz
    • , Xin Guan
    • , Guibo Sun
    • , Xiaobo Sun
    • , YooJin Lee
    • , Otoniel Martinez-Maza
    • , Daniel Widney
    • , Yunfeng Lu
    • , Irvin S. Y. Chen
    •  & Masakazu Kamata
  • Article |

    A parameter derived from the collective order of monolayers of corneal endothelial cells makes for a non-invasive quantitative biomarker of the quality of the cells in culture and of the long-term prognosis of corneal restoration in patients.

    • Akihisa Yamamoto
    • , Hiroshi Tanaka
    • , Munetoyo Toda
    • , Chie Sotozono
    • , Junji Hamuro
    • , Shigeru Kinoshita
    • , Morio Ueno
    •  & Motomu Tanaka
  • Article |

    Orthologous therapeutic proteins can elude the adaptive immune system and allow for effective repeated dosing, as shown for CRISPR gene editing with orthologues of adeno-associated viral capsids and of the Cas9 protein.

    • Ana M. Moreno
    • , Nathan Palmer
    • , Fernando Alemán
    • , Genghao Chen
    • , Andrew Pla
    • , Ning Jiang
    • , Wei Leong Chew
    • , Mansun Law
    •  & Prashant Mali
  • Article |

    In a 3D model of breast cancer, a stiff extracellular matrix promotes a tumorigenic phenotype through broad changes in chromatin accessibility and in the activity of histone deacetylases and the transcription factor Sp1.

    • Ryan S. Stowers
    • , Anna Shcherbina
    • , Johnny Israeli
    • , Joshua J. Gruber
    • , Julie Chang
    • , Sungmin Nam
    • , Atefeh Rabiee
    • , Mary N. Teruel
    • , Michael P. Snyder
    • , Anshul Kundaje
    •  & Ovijit Chaudhuri
  • Article |

    The detection of small tumours with PET is significantly enhanced by temporal integration of the imaging signals, triggered by the acidic milieu of cancers, from pH-sensitive positron-emitting polycationic polymers.

    • Gang Huang
    • , Tian Zhao
    • , Chensu Wang
    • , Kien Nham
    • , Yahong Xiong
    • , Xiaofei Gao
    • , Yihui Wang
    • , Guiyang Hao
    • , Woo-Ping Ge
    • , Xiankai Sun
    • , Baran D. Sumer
    •  & Jinming Gao