News & Comment

  • Comment |

    As an intermediary between cells and scaffolding biomaterials, the extracellular matrix secreted by the cells offers challenges and opportunities for the design and fabrication of engineered tissues.

    • Ulrich Blache
    • , Molly M. Stevens
    •  & Eileen Gentleman
  • Editorial |

    The editing of single DNA bases in the genome is being optimized for higher editing precision and versatility.

  • News & Views |

    Negatively charged nanoparticles of about 50 nm in size permit the oral delivery of insulin and other peptide drugs by temporally enhancing the permeability of the intestinal wall.

    • Per Artursson
    •  & Patrik Lundquist
  • News & Views |

    In an adult mouse model of tyrosinaemia, a base editor correcting an A-to-G splice-site mutation in the Fah gene restores the translation of the functional enzyme, promoting the repopulation of the liver with the corrected cells.

    • Kiran Musunuru
  • News & Views |

    An injectable biomaterial vaccine encapsulating antigens associated with acute myeloid leukaemia, dendritic-cell-targeting pro-inflammatory cytokines and an adjuvant protects mice from the disease.

    • Guojun Chen
    •  & Zhen Gu
  • News & Views |

    The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.

    • Monique A. J. van Eijndhoven
    • , S. Rubina Baglio
    •  & D. Michiel Pegtel
  • News & Views |

    Large quantities of extracellular vesicles produced via cellular nanoporation, and loaded with endogenously transcribed therapeutic mRNAs and targeting peptides, boost therapeutic outcomes in vivo.

    • Antje M. Zickler
    •  & Samir EL Andaloussi
  • News & Views |

    The overexpression of the transcription factor c-Jun improves chimeric-antigen-receptor T-cell functionality and enhances the killing of low-antigen-expressing liquid and solid cancers in mice.

    • Martin W. LaFleur
    • , Brian C. Miller
    •  & Arlene H. Sharpe
  • News & Views |

    A deep-learning algorithm trained with retinal images and subject metadata from the UK Biobank predicts blood-haemoglobin levels.

    • Yih-Chung Tham
    • , Ching Yu Cheng
    •  & Tien Yin Wong
  • News & Views |

    Functional changes in leukocytes isolated from 50-μL samples of peripheral blood from sepsis patients correlate with the patients’ clinical status.

    • Daniel Irimia
  • News & Views |

    A non-invasive biomarker of the degree of collective order of monolayers of corneal endothelial cells cultured for transplantation predicts the long-term prognosis of corneal restoration in patients.

    • Jodhbir S. Mehta
    • , Viridiana Kocaba
    •  & Gary S. Peh
  • News & Views |

    The simultaneous removal of endogenous T-cell receptor α-chains and β-chains, and the orthotopic placement of an exogenous receptor in human T cells via CRISPR gene-editing, prevents the mispairing between endogenous and transgenic receptors while preserving the cells’ function.

    • Dian Kortleve
    • , Dora Hammerl
    •  & Reno Debets
  • News & Views |

    In injured intervertebral discs, disruptions in fibre organization and in cellular contractility result in a fibrotic phenotype and progressive tissue degeneration.

    • Tyler J. DiStefano
    • , Svenja Illien-Jünger
    •  & James C. Iatridis
  • Editorial |

    The physical properties of living tissues are a compelling source of biomarkers of health and disease.

  • News & Views |

    A data-clustering method that incorporates prior knowledge of biological context reveals prognostic signatures of proteomic expression in patients with acute myeloid leukaemia.

    • Matthew A. Clarke
    •  & Jasmin Fisher
  • News & Views |

    Personalized computational modelling of optimal ablation targets on heart tissue guides the treatment of patients with persistent atrial fibrillation.

    • Hui-Nam Pak
    •  & Byounghyun Lim
  • News & Views |

    Computationally designed antibody–drug conjugates easily self-assemble via affinity ligands that non-covalently link a therapeutic drug to conserved sites on native IgG antibodies.

    • Christine S. Nervig
    •  & Shawn C. Owen
  • News & Views |

    Applying motion correction to standard foetal magnetic resonance imaging via image-registration techniques improves the diagnostic evaluation of cardiovascular structures in foetuses.

    • Ali Gholipour
    •  & Simon K. Warfield
  • Editorial |

    The discoveries of this year’s Nobel laureates in Physiology and Medicine have improved diagnostic and therapeutic strategies relying on oxygen sensing.

  • News & Views |

    A deep-learning model for cancer detection trained on a large number of scanned pathology slides and associated diagnosis labels enables model development without the need for pixel-level annotations.

    • Jeroen van der Laak
    • , Francesco Ciompi
    •  & Geert Litjens
  • News & Views |

    Haematopoietic stem and progenitor cells, edited via CRISPR to mimic mutations ameliorating sickle-cell disease, engraft when transplanted in macaques and maintain foetal haemoglobin in circulation.

    • Daniel E. Bauer
  • News & Views |

    In the manufacturing of cell-based therapeutics, isolating cells via DNA aptamers is an attractive alternative to magnetic-activated cell sorting.

    • Yvonne Y. Chen
  • Editorial |

    Broadening access to personalized medicines will require scalable and efficient manufacturing processes that help decrease production costs.

  • News & Views |

    Orthologues of CRISPR-associated proteins and of viral vectors evade immune recognition in mice, enabling repeated gene therapy.

    • Eric A. Wilson
    •  & Karen S. Anderson
  • News & Views |

    For genome-wide screens and other applications that require the processing of a large number of cells, the immunomagnetic sorting of cells on a microfluidic chip is a scalable, rapid and cost-efficient alternative to fluorescence-activated cell sorting.

    • Mateusz Legut
    •  & Neville E. Sanjana
  • Editorial |

    Translational cancer nanomedicine needs to increasingly exploit newly discovered tumour-targeting strategies as well as the further optimization of proven means to selectively increase the concentration of cytotoxic drugs in solid tumours.

  • News & Views |

    Encapsulation of the therapeutic monoclonal antibody rituximab, and its molecular targeting to brain metastases of B-cell lymphoma, significantly boosts the antibody’s therapeutic effectiveness in mice.

    • Reina Bendayan
  • News & Views |

    A suite of microelectrodes integrated into glass pipettes, for the simultaneous recording of intracellular and extracellular data in the brains of living mice and rats, yields ground-truth data for the validation of the performance of spike-sorting algorithms.

    • Takashi D. Y. Kozai
    •  & Erin K. Purcell
  • News & Views |

    Drug-loaded nanoparticles that specifically bind to phages infecting cancer-promoting bacteria found in colonic tumours augment the effects of chemotherapy against colorectal cancer in mice.

    • Nikhil Aggarwal
    • , In Young Hwang
    •  & Matthew Wook Chang
  • News & Views |

    A viscoelastic adhesive cardiac patch with optimal mechanical behaviour, determined using a computational model, restores heart function and slows down pathological remodelling following myocardial infarction in rodents.

    • Dawn Bannerman
    • , Simon Pascual-Gil
    •  & Milica Radisic
  • Editorial |

    Soft biomaterials for implantation in the body are increasingly designed to be functional for a finite time and to then disappear via degradation or resorption.

  • News & Views |

    Needle-sized photonic devices that slowly dissolve in the body can spectroscopically characterize cerebral temperature, blood oxygenation and neural activity for weeks in unconstrained mice.

    • Sarah Forward
    • , Sheldon J. J. Kwok
    •  & Seok-Hyun Yun
  • News & Views |

    A rapidly gelling, biocompatible co-polymer, tested in rabbit and non-human-primate models of retinal detachment, makes for an effective replacement of the damaged vitreous.

    • Stanley Chang
  • News & Views |

    Smartphone-controlled optofluidic neural implants with replaceable and replenishable plug-like drug cartridges enable the selective wireless manipulation of brain circuits in rodents via chronic pharmacology and photostimulation.

    • John F. Zimmerman
    •  & Bozhi Tian
  • News & Views |

    In mouse models of cancer, the inhibition of a set of regulatory proteins improves checkpoint-blockade therapy by causing regulatory T cells to produce the cytokine interferon-γ.

    • Tomasz Maj
    •  & Weiping Zou
  • News & Views |

    Targeting antigens to the liver by glycosylation promotes antigen-specific immune tolerance via the expansion of regulatory T cells and prevents autoimmunity in a mouse model of type-1 diabetes.

    • Derek G. Doherty
  • News & Views |

    The localization of target proteins, at subcellular resolution, in fixed patient-derived tissues can now be achieved via antibodies conjugated with tetrahedral DNA nanostructures self-assembled in situ.

    • Yizhe Zhang
    • , Alden Moss
    • , Kristine Tan
    •  & Amy E. Herr
  • News & Views |

    A microfluidic chip incorporating oxygen gradients, a diverse human microbiota and patient-derived cells, mimics interactions between microorganisms and host tissue in the human gut.

    • Roberta Poceviciute
    •  & Rustem F. Ismagilov
  • Editorial |

    Modelling human tissues in microphysiologically relevant ‘chips’ will increasingly help to unravel mechanistic knowledge underlying disease, and might eventually accelerate the productivity of drug development and predict how individual patients will respond to specific drugs.

  • Comment |

    The safety and security of medical devices driven by software, the software-development processes, and the need for data collection and privacy, all offer challenges and opportunities for device regulation and clinical care.

    • William J. Gordon
    •  & Ariel D. Stern
  • News & Views |

    Retinoic acid induces the rapid osteogenic differentiation of patient-derived induced pluripotent stem cells, enabling the in vitro recapitulation of an osteogenesis imperfecta phenotype.

    • Christina Jacobsen
    •  & April M. Craft
  • News & Views |

    An osteoarthritis model in a cartilage-on-a-chip, enabled by hyperphysiological compression, recapitulates the progression of the disease and its response to drugs.

    • Riccardo Gottardi
  • News & Views |

    Plasmids coding for a toxin gene that is only expressed in the presence of a virulence-associated transcription factor lead to the killing of only the virulent form of the bacterium Vibrio cholerae in a mixed bacterial population.

    • Richard Novick
  • News & Views |

    An electrical biosensor that relies on the binding of target nucleic acid sequences to Cas9 immobilized on a graphene field-effect transistor enables the rapid detection of mutations in purified samples without the need for nucleic acid amplification.

    • Richard Bruch
    • , Gerald A. Urban
    •  & Can Dincer
  • News & Views |

    Histologically stained slides can be generated from unlabelled autofluorescence images of tissue samples via deep learning.

    • Spyridon Bakas
    •  & Michael D. Feldman
  • News & Views |

    A microfluidic assay that quantifies the abundance and degree of proliferation of migratory cells predicts the metastatic potential of breast-cancer cell lines and patient-derived cells.

    • Zhengpeng Wan
    •  & Roger D. Kamm
  • News & Views |

    Early-stage ovarian cancer can be detected in few-microlitre plasma samples via a microfluidic chip, patterned with nanoporous herringbone structures so as to enhance the capture of extracellular vesicles from the samples.

    • Yuan Wan
    •  & Si-Yang Zheng
  • Comment |

    The development of implantable electrode arrays that broadly and seamlessly integrate with brain tissue will require innovation that responsibly considers clinically relevant neuroethical concerns.

    • Laura Cabrera
    • , Charles Sadle
    •  & Erin Purcell