Initial submission

If you intend to submit a manuscript, please check our brief guidelines for preparing initial submissionsFor information about the journal, please refer to our Frequently Asked Questions.

On this page: Brief guide to submission | Cover letter | Initial format requirements | Presubmission enquiries | Submission policies

Brief guide to submission

Please see our brief guidelines for preparing initial submissions for an overview of key information on submitting primary research for publication in Nature Biomedical Engineering.

Cover letter

Authors should provide a cover letter that briefly discusses the significance and broad relevance of the work, and explains its scientific context. The cover letter should help the editors determine whether the work is appropriate for Nature Biomedical Engineering. Any prior discussions with an editor of the journal about the work should also be mentioned. The cover letter can also be used to suggest names, affiliations, e-mail address and expertise of potential referees, as well as any request to exclude particular scientists or laboratories as referees.

Initial format requirements

The Nature journals are flexible with regard to the format of initial submissions. Within reason, style and length will not influence consideration of a manuscript. However, to facilitate the editorial and review processes we strongly encourage you to incorporate the manuscript text and figures into a single PDF file with all lines numbered or a Microsoft Word file (the manuscript tracking system will automatically number lines). Please insert suitably high-resolution figures within the text at appropriate positions. Each figure legend should appear on the same page as its figure. The reference list should include article titles.

Although not required at the initial submission stage, authors are encouraged to review the article format requirements for final submission so that they can familiarize themselves with what will be required if the editor invites submission of a revised version of the manuscript.


Papers submitted to Nature Biomedical Engineering should be accessible to non-specialists; you should ensure that your findings are communicated clearly. Although a shared basic knowledge of biomedical engineering may be assumed, please bear in mind that the language and concepts that are standard in one subfield may be unfamiliar to colleagues working in another area. Thus, technical jargon should be avoided as far as possible and clearly explained where its use is unavoidable. Abbreviations should be kept to a minimum and should be defined at their first occurrence. The background, rationale and main conclusions of the study should be clearly explained. Titles and abstracts in particular should be written in language that will be readily intelligible to any scientists.

No paper will be rejected for poor language. However, if you would like assistance with writing your manuscript, you can consider asking colleagues for their input and/or use a professional editing service such as those provided by our affiliates Nature Research Editing Service or American Journal Experts. The use of a language editing service has no bearing on editorial decisions and is not a requirement for publication.

Presubmission enquiries

Researchers may request feedback from the editors on whether a potential manuscript may be appropriate for the journal. Presubmission enquiries are optional and should not be used to submit a full manuscript. If your manuscript has already been written, please proceed with a full submission.

Submission policies

Submission to Nature Biomedical Engineering is taken to imply that there is no significant overlap between the submitted manuscript and any other papers from the same authors under consideration or in press elsewhere (abstracts or unrefereed preprints do not compromise novelty). The authors must include copies of all related manuscripts with any overlap in authorship that are under consideration or in press elsewhere. If a related manuscript is submitted elsewhere while the manuscript is under consideration at Nature Biomedical Engineering, a copy of the related manuscript should be sent to the editor.

The primary affiliation for each author should be the institution where the majority of their work was done. If an author has subsequently moved, their current address may also be stated.

If the manuscript includes personal communications, please provide a written statement of permission from any person who is quoted. E-mail permission messages are acceptable.

For life sciences manuscripts reporting original research results, please be aware that an editorial policy checklist (to ensure compliance with Nature Research editorial policies) and a completed reporting summary (to promote consistency and transparency in reporting) will be required before the manuscript is sent for external peer review. The reporting summary will be made available to reviewers and will be published with all accepted manuscripts.

Please note: because of advanced features used in these forms, you must use Adobe Reader to open the documents and fill them out.

Additional editorial policies can be found on the Nature journals policies page.