Browse Articles

  • Article |

    Macromolecular telmisartan prodrugs optimized for preferential release in fibrotic liver tissue reduce liver fibrosis in mouse models, and are retained and well tolerated in the liver tissue of rats and dogs.

    • Matthew R. Golder
    • , Jenny Liu
    • , Jannik N. Andersen
    • , Michail V. Shipitsin
    • , Farrukh Vohidov
    • , Hung V.-T. Nguyen
    • , Deborah C. Ehrlich
    • , Sung Jin Huh
    • , Bhavatarini Vangamudi
    • , Kyriakos D. Economides
    • , Allison M. Neenan
    • , James C. Ackley
    • , Joelle Baddour
    • , Sattanathan Paramasivan
    • , Samantha W. Brady
    • , Eric J. Held
    • , Lawrence A. Reiter
    • , Jennifer K. Saucier-Sawyer
    • , Paul W. Kopesky
    • , Donald E. Chickering
    • , Peter Blume-Jensen
    •  & Jeremiah A. Johnson
  • Article |

    Transplantation of pancreatic islet cells encapsulated in alginate microspheres into the omental bursa of the peritoneal cavity of NHPs significantly reduces FBRs and extends the longevity of the cells.

    • Matthew A. Bochenek
    • , Omid Veiseh
    • , Arturo J. Vegas
    • , James J. McGarrigle
    • , Meirigeng Qi
    • , Enza Marchese
    • , Mustafa Omami
    • , Joshua C. Doloff
    • , Joshua Mendoza-Elias
    • , Mohammad Nourmohammadzadeh
    • , Arshad Khan
    • , Chun-Chieh Yeh
    • , Yuan Xing
    • , Douglas Isa
    • , Sofia Ghani
    • , Jie Li
    • , Casey Landry
    • , Andrew R. Bader
    • , Karsten Olejnik
    • , Michael Chen
    • , Jennifer Hollister-Lock
    • , Yong Wang
    • , Dale L. Greiner
    • , Gordon C. Weir
    • , Berit Løkensgard Strand
    • , Anne Mari A. Rokstad
    • , Igor Lacik
    • , Robert Langer
    • , Daniel G. Anderson
    •  & Jose Oberholzer
  • News & Views |

    Intratumoral injection of a hydrogel impregnated with radioisotope-labelled catalase and an immunostimulant, along with systemic immune checkpoint blockade, inhibits tumour growth in mouse models of localized cancer and metastatic cancer.

    • Catherine S. Spina
    •  & Charles G. Drake
  • News & Views |

    Ultraflexible coils for magnetic resonance imaging enhance the image quality of body parts that move or that show strong inter-patient variability, as demonstrated by the implementation of the coils on a glove for imaging the moving hand.

    • Elmar Laistler
    •  & Ewald Moser
  • News & Views |

    Two drug-loaded nanoparticle formulations that preferentially accumulate within tumour-associated macrophages induce macrophage repolarization to a tumoricidal state that leads to potent antitumour activity in multiple murine models of cancer.

    • Heather H. Gustafson
    •  & Suzie H. Pun
  • Editorial |

    Cancer therapies that target multiple biological pathways take advantage of synergistic killing, and decrease the risk of relapse.

  • Comment |

    Bringing truly personalized cancer vaccination with tumour neoantigens to the clinic will require overcoming the challenges of optimized vaccine design, manufacturing and affordability, and identification of the most suitable clinical setting.

    • Özlem Türeci
    • , Martin Löwer
    • , Barbara Schrörs
    • , Maren Lang
    • , Arbel Tadmor
    •  & Ugur Sahin
  • Article |

    Coating the sensor in continuous glucose monitors with a zwitterionic polymer significantly reduces signal noise and the need for frequent device recalibration.

    • Xi Xie
    • , Joshua C. Doloff
    • , Volkan Yesilyurt
    • , Atieh Sadraei
    • , James J. McGarrigle
    • , Mustafa Omami
    • , Omid Veiseh
    • , Shady Farah
    • , Douglas Isa
    • , Sofia Ghani
    • , Ira Joshi
    • , Arturo Vegas
    • , Jie Li
    • , Weiheng Wang
    • , Andrew Bader
    • , Hok Hei Tam
    • , Jun Tao
    • , Hui-jiuan Chen
    • , Boru Yang
    • , Katrina Ann Williamson
    • , Jose Oberholzer
    • , Robert Langer
    •  & Daniel G. Anderson
  • Author Correction |

    • Marnix Lameijer
    • , Tina Binderup
    • , Mandy M. T. van Leent
    • , Max L. Senders
    • , Francois Fay
    • , Joost Malkus
    • , Brenda L. Sanchez-Gaytan
    • , Abraham J. P. Teunissen
    • , Nicolas Karakatsanis
    • , Philip Robson
    • , Xianxiao Zhou
    • , Yuxiang Ye
    • , Gregory Wojtkiewicz
    • , Jun Tang
    • , Tom T. P. Seijkens
    • , Jeffrey Kroon
    • , Erik S. G. Stroes
    • , Andreas Kjaer
    • , Jordi Ochando
    • , Thomas Reiner
    • , Carlos Pérez-Medina
    • , Claudia Calcagno
    • , Edward A. Fisher
    • , Bin Zhang
    • , Ryan E. Temel
    • , Filip K. Swirski
    • , Matthias Nahrendorf
    • , Zahi A. Fayad
    • , Esther Lutgens
    • , Willem J. M. Mulder
    •  & Raphaël Duivenvoorden
  • Article |

    Scale models of the human left ventricle made of tissue-engineered nanofibrous scaffolds and primary rat cardiomyocytes or human-stem-cell-derived cardiomyocytes enable the study of contractile function and the modelling of structural arrhythmia.

    • Luke A. MacQueen
    • , Sean P. Sheehy
    • , Christophe O. Chantre
    • , John F. Zimmerman
    • , Francesco S. Pasqualini
    • , Xujie Liu
    • , Josue A. Goss
    • , Patrick H. Campbell
    • , Grant M. Gonzalez
    • , Sung-Jin Park
    • , Andrew K. Capulli
    • , John P. Ferrier
    • , T. Fettah Kosar
    • , L. Mahadevan
    • , William T. Pu
    •  & Kevin Kit Parker
  • Article |

    A low-cost point-of-care device that uses contrast-enhanced microholography and deep learning accurately detects aggressive lymphomas in patients referred for aspiration and biopsy of enlarged lymph nodes.

    • Hyungsoon Im
    • , Divya Pathania
    • , Philip J. McFarland
    • , Aliyah R. Sohani
    • , Ismail Degani
    • , Matthew Allen
    • , Benjamin Coble
    • , Aoife Kilcoyne
    • , Seonki Hong
    • , Lucas Rohrer
    • , Jeremy S. Abramson
    • , Scott Dryden-Peterson
    • , Lioubov Fexon
    • , Misha Pivovarov
    • , Bruce Chabner
    • , Hakho Lee
    • , Cesar M. Castro
    •  & Ralph Weissleder
  • Article |

    The combination of systemic immune checkpoint inhibition with local administration of a hydrogel containing the enzyme catalase, a radioisotope and an immunostimulatory agent promotes effective antitumour immune responses in mice models.

    • Yu Chao
    • , Ligeng Xu
    • , Chao Liang
    • , Liangzhu Feng
    • , Jun Xu
    • , Ziliang Dong
    • , Longlong Tian
    • , Xuan Yi
    • , Kai Yang
    •  & Zhuang Liu
  • Article |

    A magnetic wire for the intravascular recovery of labelled circulating tumour cells improves cell capture in anaesthetized pigs by up to two orders of magnitude with respect to a standard blood draw.

    • Ophir Vermesh
    • , Amin Aalipour
    • , T. Jessie Ge
    • , Yamil Saenz
    • , Yue Guo
    • , Israt S. Alam
    • , Seung-min Park
    • , Charlie N. Adelson
    • , Yoshiaki Mitsutake
    • , Jose Vilches-Moure
    • , Elias Godoy
    • , Michael H. Bachmann
    • , Chin Chun Ooi
    • , Jennifer K. Lyons
    • , Kerstin Mueller
    • , Hamed Arami
    • , Alfredo Green
    • , Edward I. Solomon
    • , Shan X. Wang
    •  & Sanjiv S. Gambhir
  • News & Views |

    A technique combining focused ultrasound for opening the blood–brain barrier and virally encoded engineered G-protein-coupled receptors for promoting the expression of a gene targeting excitatory neurons enables the non-invasive stimulation of specific brain regions and cell types in mice.

    • Caroline Menard
    •  & Scott J. Russo
  • News & Views |

    Polymer-coated gold nanoparticles carrying the CRISPR components for knocking out, in the striatum of adult mice with fragile X syndrome, a gene implied in the syndrome’s pathophysiology rescue the mice from the exaggerated repetitive behaviours characteristic of the syndrome’s phenotype.

    • Yamin Li
    • , Zachary Glass
    •  & Qiaobing Xu
  • Editorial |

    Modelling diseases of the central and peripheral nervous systems and effectively treating neurological disorders via neuronal manipulation requires far better biomaterials and technology than are currently available.

  • Article |

    Hydrogels made from decellularized human brain tissue facilitate the direct conversion of primary mouse embryonic fibroblasts into induced neuronal cells that lead to therapeutic outcomes after transplantation in an animal model of ischaemic stroke.

    • Yoonhee Jin
    • , Jung Seung Lee
    • , Jin Kim
    • , Sungjin Min
    • , Soohyun Wi
    • , Ji Hea Yu
    • , Gyeong-Eon Chang
    • , Ann-Na Cho
    • , Yeeun Choi
    • , Da-Hee Ahn
    • , Sung-Rae Cho
    • , Eunji Cheong
    • , Yun-Gon Kim
    • , Hyong-Pyo Kim
    • , Yonghwan Kim
    • , Dong Seok Kim
    • , Hyun Woo Kim
    • , Zhejiu Quan
    • , Hoon-Chul Kang
    •  & Seung-Woo Cho
  • News & Views |

    Design principles for the development of silicon biointerfaces enable the non-genetic, light-controlled modulation of intracellular Ca2+ dynamics, and of cellular excitability in vitro, in tissue slices and in mouse brains.

    • Seongjun Park
    • , James A. Frank
    •  & Polina Anikeeva
  • News & Views |

    Biopolymer matrices can modulate the transcriptomic profiles of stem-cell-derived neurons in 3D culture to make them resemble cells in specific brain regions, developmental stages and disease conditions.

    • Carsten Werner
  • Article |

    The combination of focused ultrasound and virally encoded receptors engineered to be activated by a designer drug enables, on intravenous administration of the drug, the non-invasive activation or inhibition of brain regions in mice, with cell-type and spatiotemporal specificity.

    • Jerzy O. Szablowski
    • , Audrey Lee-Gosselin
    • , Brian Lue
    • , Dina Malounda
    •  & Mikhail G. Shapiro
  • Article |

    A portable device enables the automated manufacturing of therapeutic-grade biologics in a few hours and under current good-manufacturing-practice conditions.

    • Rajani Adiga
    • , Mustafa Al-adhami
    • , Abhay Andar
    • , Shayan Borhani
    • , Sheniqua Brown
    • , David Burgenson
    • , Merideth A. Cooper
    • , Sevda Deldari
    • , Douglas D. Frey
    • , Xudong Ge
    • , Hui Guo
    • , Chandrasekhar Gurramkonda
    • , Penny Jensen
    • , Yordan Kostov
    • , William LaCourse
    • , Yang Liu
    • , Antonio Moreira
    • , KarunaSri Mupparapu
    • , Chariz Peñalber-Johnstone
    • , Manohar Pilli
    • , Benjamin Punshon-Smith
    • , Aniruddha Rao
    • , Govind Rao
    • , Priyanka Rauniyar
    • , Sergei Snovida
    • , Kanika Taurani
    • , Dagmawi Tilahun
    • , Leah Tolosa
    • , Michael Tolosa
    • , Kevin Tran
    • , Krishna Vattem
    • , Sudha Veeraraghavan
    • , Brandon Wagner
    • , Joshua Wilhide
    • , David W. Wood
    •  & Adil Zuber
  • News & Views |

    Nanoscale metal–organic frameworks carrying an immunotherapy payload and administered into tumours alongside a low dose of radiotherapy enhance local and systemic antitumour immunity in mouse models of breast cancer and colorectal cancer.

    • Wilfred Ngwa