Browse Articles

  • Article |

    A hydrogel patch for the sustained delivery of extracellular vesicles from cardiomyocytes derived from induced pluripotent stem cells improves tissue regeneration in infarcted rat hearts.

    • Bohao Liu
    • , Benjamin W. Lee
    • , Koki Nakanishi
    • , Aranzazu Villasante
    • , Rebecca Williamson
    • , Jordan Metz
    • , Jinho Kim
    • , Mariko Kanai
    • , Lynn Bi
    • , Kristy Brown
    • , Gilbert Di Paolo
    • , Shunichi Homma
    • , Peter A. Sims
    • , Veli K. Topkara
    •  & Gordana Vunjak-Novakovic
  • Article |

    A cell-culture method involving decellularized tissue scaffolds enables the spontaneous formation of cell colonies that phenotypically recapitulate in vivo organ-specific cancer metastases.

    • Xi Tian
    • , Michael E. Werner
    • , Kyle C. Roche
    • , Ariel D. Hanson
    • , Henry P. Foote
    • , Stephanie K. Yu
    • , Samuel B. Warner
    • , Jonathan A. Copp
    • , Haydee Lara
    • , Eliane L. Wauthier
    • , Joseph M. Caster
    • , Laura E. Herring
    • , Longzhen Zhang
    • , Joel E. Tepper
    • , David S. Hsu
    • , Tian Zhang
    • , Lola M. Reid
    •  & Andrew Z. Wang
  • Article |

    An endothelialized microfluidic system that recapitulates physiological properties of the microvasculature enables the real-time visualization of vascular-pathology features associated with sickle-cell disease and malaria, with high spatiotemporal resolution.

    • Yongzhi Qiu
    • , Byungwook Ahn
    • , Yumiko Sakurai
    • , Caroline E. Hansen
    • , Reginald Tran
    • , Patrice N. Mimche
    • , Robert G. Mannino
    • , Jordan C. Ciciliano
    • , Tracey J. Lamb
    • , Clinton H. Joiner
    • , Solomon F. Ofori-Acquah
    •  & Wilbur A. Lam
  • Article |

    A nanoparticle-based immunotherapy targeted to a protein responsible for signalling between monocytes and macrophages reduces plaque inflammation in atherosclerotic mice and appears to be safe in non-human primates.

    • Marnix Lameijer
    • , Tina Binderup
    • , Mandy M. T. van Leent
    • , Max L. Senders
    • , Francois Fay
    • , Joost Malkus
    • , Brenda L. Sanchez-Gaytan
    • , Abraham J. P. Teunissen
    • , Nicolas Karakatsanis
    • , Philip Robson
    • , Xianxiao Zhou
    • , Yuxiang Ye
    • , Gregory Wojtkiewicz
    • , Jun Tang
    • , Tom T. P. Seijkens
    • , Jeffrey Kroon
    • , Erik S. G. Stroes
    • , Andreas Kjaer
    • , Jordi Ochando
    • , Thomas Reiner
    • , Carlos Pérez-Medina
    • , Claudia Calcagno
    • , Edward A. Fischer
    • , Bin Zhang
    • , Ryan E. Temel
    • , Filip K. Swirski
    • , Matthias Nahrendorf
    • , Zahi A. Fayad
    • , Esther Lutgens
    • , Willem J. M. Mulder
    •  & Raphaël Duivenvoorden
  • Editorial |

    Accurate diagnostics need technology — from imaging hardware and image reconstruction to machine learning — to detect markers associated with the cause of disease.

  • News & Views |

    A microfluidic device for assaying neutrophil motility in blood samples from sepsis patients and a machine-learning algorithm trained with the motility data enable a faster and accurate sepsis diagnosis.

    • Umer Hassan
    • , Enrique Valera
    •  & Rashid Bashir
  • News & Views |

    Topically applied spherical nucleic acids targeting an intracellular mRNA biomarker associated with abnormal scarring enable the fluorescent detection of abnormal scars during wound healing.

    • Ronnie H. Fang
    •  & Liangfang Zhang
  • Article |

    Topically applied imaging nanoprobes for the detection of intracellular mRNA expression from connective tissue growth factor enable the detection of hypertrophic scars and keloids in the skin of small live animals and in ex vivo human skin.

    • David C. Yeo
    • , Christian Wiraja
    • , Amy S. Paller
    • , Chad A. Mirkin
    •  & Chenjie Xu
  • Article |

    A method that uses thin sheets of X-ray radiation to generate emissions of Cherenkov luminescence can image an oxygen-sensitive molecular probe to map oxygenation in tumours in vivo at submillimetre resolution and nanomolar sensitivity.

    • Brian W. Pogue
    • , Jinchao Feng
    • , Ethan P. LaRochelle
    • , Petr Bruža
    • , Huiyun Lin
    • , Rongxiao Zhang
    • , Jennifer R. Shell
    • , Hamid Dehghani
    • , Scott C. Davis
    • , Sergei A. Vinogradov
    • , David J. Gladstone
    •  & Lesley A. Jarvis
  • News & Views |

    Shaping an X-ray beam as a thin sheet generates Cherenkov emissions that enable molecular sensing at submillimetre resolution and deep into tissue in small animals.

    • Jan Grimm
  • Article |

    A continuous-acquisition method for reducing artefacts caused by the beating heart and other body motions in cardiovascular magnetic resonance imaging reduces the reliance on electrocardiography triggering and breath holds.

    • Anthony G. Christodoulou
    • , Jaime L. Shaw
    • , Christopher Nguyen
    • , Qi Yang
    • , Yibin Xie
    • , Nan Wang
    •  & Debiao Li
  • News & Views |

    A method that separates overlapping cardiovascular dynamics arising from the beating of the heart, respiration and signal relaxation simplifies and quantifies cardiovascular magnetic resonance imaging.

    • Ricardo Otazo
  • Article |

    Culturing conditions affect the transcriptomic profiles of induced neuronal cells, and 3D co-cultures of induced neuronal cells and astrocytic cells can be rapidly generated from the same pool of human embryonic stem cells.

    • Halil Tekin
    • , Sean Simmons
    • , Beryl Cummings
    • , Linyi Gao
    • , Xian Adiconis
    • , Cynthia C. Hession
    • , Ayan Ghoshal
    • , Danielle Dionne
    • , Sourav R. Choudhury
    • , Volkan Yesilyurt
    • , Neville E. Sanjana
    • , Xi Shi
    • , Congyi Lu
    • , Matthias Heidenreich
    • , Jen Q. Pan
    • , Joshua Z. Levin
    •  & Feng Zhang
  • Article |

    Self-assembled ribonucleoprotein octamers bearing an endosomolytic peptide and a siRNA–targeting-ligand conjugate facilitate endosomal destabilization and targeted delivery, achieving efficient gene silencing in mouse models of prostate cancer.

    • Wanyi Tai
    • , Junwei Li
    • , Eva Corey
    •  & Xiaohu Gao
  • News & Views |

    A scalable and fast method for profiling single-molecule protein–protein interactions predicts the sensitivity of cells to inhibitors of the epidermal growth factor receptor, which is typically overexpressed in cancer.

    • Punit Saraon
    • , Ingrid Grozavu
    •  & Igor Stagljar
  • Article |

    The characterization of protein–protein interactions by combined single-molecule pull-down and single-molecule co-immunoprecipitation assays uncovers, for specific cancers, their dependence on signalling complexes of the human epidermal growth-factor receptor.

    • Hong-Won Lee
    • , Byoungsan Choi
    • , Han Na Kang
    • , Hyunwoo Kim
    • , Ahrum Min
    • , Minkwon Cha
    • , Ji Young Ryu
    • , Sangwoo Park
    • , Jinyoung Sohn
    • , Kihyuk Shin
    • , Mi Ran Yun
    • , Joo Yeun Han
    • , Min Ju Shon
    • , Cherlhyun Jeong
    • , Junho Chung
    • , Seung-Hyo Lee
    • , Seock-Ah Im
    • , Byoung Chul Cho
    •  & Tae-Young Yoon
  • Article |

    Combining immune checkpoint inhibition with radiotherapy–radiodynamic therapy, enabled by intratumorally injected nanoscale metal–organic frameworks, promotes systemic antitumour immunity and tumour rejection in mouse models of breast and colorectal cancer.

    • Kuangda Lu
    • , Chunbai He
    • , Nining Guo
    • , Christina Chan
    • , Kaiyuan Ni
    • , Guangxu Lan
    • , Haidong Tang
    • , Charles Pelizzari
    • , Yang-Xin Fu
    • , Michael T. Spiotto
    • , Ralph R. Weichselbaum
    •  & Wenbin Lin
  • Article |

    A microfluidics-based sequencing method that profiles genome-wide DNA methylation using only sub-nanogram quantities of DNA finds distinct DNA methylome patterns in glial and neuronal cell nuclei from mouse brains treated with an antipsychotic drug.

    • Sai Ma
    • , Mario de la Fuente Revenga
    • , Zhixiong Sun
    • , Chen Sun
    • , Travis W. Murphy
    • , Hehuang Xie
    • , Javier González-Maeso
    •  & Chang Lu
  • News & Views |

    A stiffness-sensing piezoelectric microsystem that can be mounted onto conventional biopsy needles distinguishes abnormal tissue from healthy tissue.

    • Pengfei Song
    •  & James F. Greenleaf
  • News & Views |

    Smoking status, blood pressure, age and other cardiovascular risk factors can be predicted from retinal images by using deep learning.

    • Daniel Shu Wei Ting
    •  & Tien Yin Wong
  • News & Views |

    T cells can be efficiently and controllably expanded for adoptive cell therapy in a culture system consisting of lipid bilayers bearing membrane-bound cues for the stimulation of T-cell receptors and of supporting silica microrods that release a T-cell proliferation factor.

    • Michael C. Milone
    •  & Bruce L. Levine
  • Editorial |

    Artificial intelligence may eventually help diagnose eye conditions and the risk of cardiovascular disease, solely from retinal images.