David McCarthy (cancer cells), Steve Gschmeissner (needle); Science Photo Library.

The promise of cell therapies

The June issue includes a Focus on cell therapies, with an emphasis on cardiac regenerative medicine and immunotherapy.

Latest Research

  • Article |

    A first-in-man study of robotic-assisted intraocular surgery shows the feasibility and safety of the robotic device for the peeling of retinal membranes and for the injection of a therapeutic under the retina.

    • T. L. Edwards
    • , K. Xue
    • , H. C. M. Meenink
    • , M. J. Beelen
    • , G. J. L. Naus
    • , M. P. Simunovic
    • , M. Latasiewicz
    • , A. D. Farmery
    • , M. D. de Smet
    •  & R. E. MacLaren
  • Review Article |

    This Review discusses the manufacturing of cell products for clinically advanced cell therapies, and highlights potential manufacturing bottlenecks and solutions towards the cost-effective commercialization of the therapies.

    • Ayesha Aijaz
    • , Matthew Li
    • , David Smith
    • , Danika Khong
    • , Courtney LeBlon
    • , Owen S. Fenton
    • , Ronke M. Olabisi
    • , Steven Libutti
    • , Jay Tischfield
    • , Marcela V. Maus
    • , Robert Deans
    • , Rita N. Barcia
    • , Daniel G. Anderson
    • , Jerome Ritz
    • , Robert Preti
    •  & Biju Parekkadan
  • Article |

    An epicardial device that enables sustained and repeated administration of small molecules, macromolecules and cells directly to the epicardium provides therapeutic benefits in a rat model of myocardial infarction.

    • William Whyte
    • , Ellen T. Roche
    • , Claudia E. Varela
    • , Keegan Mendez
    • , Shahrin Islam
    • , Hugh O’Neill
    • , Fiona Weafer
    • , Reyhaneh Neghabat Shirazi
    • , James C. Weaver
    • , Nikolay V. Vasilyev
    • , Peter E. McHugh
    • , Bruce Murphy
    • , Garry P. Duffy
    • , Conor J. Walsh
    •  & David J. Mooney

News & Comment

  • News & Views |

    Heart tissue with an adult-like phenotype can be obtained by electromechanically conditioning, with increasing intensity, early-stage human induced pluripotent stem cells derived from cardiomyocytes.

    • Wahiba Dhahri
    • , Rocco Romagnuolo
    •  & Michael A. Laflamme
  • News & Views |

    A tissue-decellularization method enables the culture of organ-specific metastases on a dish.

    • Jelena Urosevic
    •  & Roger R. Gomis
  • Editorial |

    For cell therapies to transition from promises to products, increased efforts need to be put into the identification of the factors and biological mechanisms that affect safety and efficacy, and into the design of cost-effective methods for the harvesting, expansion, manipulation and purification of the cells.

  • News & Views |

    A physiologically relevant microvasculature-on-a-chip device enables the study of microvascular pathology associated with inflammation and haematological diseases.

    • Jessica Motherwell
    •  & Walter Lee Murfee
  • News & Views |

    The sustained delivery of extracellular vesicles, secreted by induced-pluripotent-stem-cell-derived cardiomyocytes, through a hydrogel patch promotes cardiac recovery after myocardial infarction in rats.

    • Todd R. Heallen
    •  & James F. Martin

About the Journal

  • Straddling the life sciences, the physical sciences and engineering, the journal publishes biological, medical and engineering advances — technological, translational, methodological or fundamental — that can directly inspire or lead to improvements in human health.
  • We publish original research in one format: Article. Review Articles provide authoritative and balanced discussions of research developments. Perspectives, Comments, and News & Views include informed opinion.
  • Chief Editor Pep Pàmies has broad editorial expertise in biomaterials and bioengineering. Associate Editors Michelle Korda, Rosy Favicchio and João Duarte have research expertise in advanced therapy clinical trials, molecular imaging and immunoengineering.
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