Image design by Karen Moore.

Nanoparticle delivery of CRISPR tools

The November issue highlights the delivery of CRISPR components via nanoparticles.

Latest Research

  • Review Article |

    This Review discusses the role of glia as an effector of the performance and integration of devices implanted in the brain, and the implications of this for device development.

    • Joseph W. Salatino
    • , Kip A. Ludwig
    • , Takashi D. Y. Kozai
    •  & Erin K. Purcell
  • Article |

    A model accounting for the properties of the local chromatin environment predicts the modulation of patterns in gene expression and helps screen for chemotherapeutic adjuvants that lead to an enhanced therapeutic response in cancer cells.

    • Luay M. Almassalha
    • , Greta M. Bauer
    • , Wenli Wu
    • , Lusik Cherkezyan
    • , Di Zhang
    • , Alexis Kendra
    • , Scott Gladstein
    • , John E. Chandler
    • , David VanDerway
    • , Brandon-Luke L. Seagle
    • , Andrey Ugolkov
    • , Daniel D. Billadeau
    • , Thomas V. O’Halloran
    • , Andrew P. Mazar
    • , Hemant K. Roy
    • , Igal Szleifer
    • , Shohreh Shahabi
    •  & Vadim Backman
  • Article |

    An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.

    • Canan Dagdeviren
    • , Farhad Javid
    • , Pauline Joe
    • , Thomas von Erlach
    • , Taylor Bensel
    • , Zijun Wei
    • , Sarah Saxton
    • , Cody Cleveland
    • , Lucas Booth
    • , Shane McDonnell
    • , Joy Collins
    • , Alison Hayward
    • , Robert Langer
    •  & Giovanni Traverso
  • Perspective |

    This Perspective discusses recent technological developments in flow cytometry and DNA sequencing that enable the interrogation of T-cell specificities in infection, cancer and autoimmunity to inform disease development and treatment.

    • Sine Reker Hadrup
    •  & Evan W. Newell
  • Article |

    A fluorescence-based assay is used to screen cyclic peptides for their activity in preventing protein misfolding, an event that can generate pathogenic aggregates that lead to diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.

    • Ilias Matis
    • , Dafni Chrysanthi Delivoria
    • , Barbara Mavroidi
    • , Nikoletta Papaevgeniou
    • , Stefania Panoutsou
    • , Stamatia Bellou
    • , Konstantinos D. Papavasileiou
    • , Zacharoula I. Linardaki
    • , Alexandra V. Stavropoulou
    • , Kostas Vekrellis
    • , Nikos Boukos
    • , Fragiskos N. Kolisis
    • , Efstathios S. Gonos
    • , Marigoula Margarity
    • , Manthos G. Papadopoulos
    • , Spiros Efthimiopoulos
    • , Maria Pelecanou
    • , Niki Chondrogianni
    •  & Georgios Skretas

News & Comment

  • News and Views |

    The expression of two DNA repair factors improves the recombination of single-stranded oligodeoxynucleotides with Cas9-induced double-strand breaks, facilitating precise and efficient gene editing.

    • Sanum Bashir
    •  & Ralf Kühn
  • News and Views |

    The DNA mutation that causes Duchenne muscular dystrophy in mice can be corrected, with minimal off-target effects, by gold nanoparticles carrying the CRISPR components.

    • Zachary Glass
    • , Yamin Li
    •  & Qiaobing Xu
  • News and Views |

    The early stages of the formation of calcific nodules in the aortic valve can be detected by two-photon excited fluorescence microscopy.

    • Jack P. M. Andrews
    •  & Marc R. Dweck
  • News and Views |

    A theoretical model of chromatin packing heterogeneity predicts patterns in gene expression and can be used to screen for effective chemotherapeutic adjuvants.

    • Alexandra Zidovska
  • News and Views |

    The genetic, epigenetic and transcriptomic profiles of human-induced pluripotent stem cells are shaped by the reprogramming route.

    • Thomas F. Allison
    •  & William E. Lowry

About the Journal

  • Straddling the life sciences, the physical sciences and engineering, the journal publishes biological, medical and engineering advances — technological, translational, methodological or fundamental — that can directly inspire or lead to improvements in human health.
  • The journal publishes original research in one format: Article. Review Articles provide authoritative and balanced discussions of research developments. Perspectives, Comments, and News & Views include informed opinion.
  • Chief Editor Pep Pàmies has broad editorial expertise in biomaterials and bioengineering. Associate Editors Michelle Korda, Rosy Favicchio and João Duarte have research expertise in advanced therapy clinical trials, molecular imaging and immunoengineering.

For authors & referees

  • Summary of the processes of manuscript submission, peer review and post review, and of editorial and publishing policies.
  • Explanation of the submission, peer-review, decision and revision processes.
  • Information about submitting initial, revised and final submissions.
  • Format requirements for the main text, figures, Methods and Supplementary Information of final submissions.
  • Guidelines for writing reviews, and information about confidentiality, anonymity and other aspects of the peer-review process.

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