Ella Marushchenko

Large-scale production of therapeutic extracellular vesicles

The January issue highlights cellular nanoporation as a method for the large-scale generation of extracellular vesicles encapsulating therapeutic mRNAs.

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    The editing of single DNA bases in the genome is being optimized for higher editing precision and versatility.

  • News & Views |

    Negatively charged nanoparticles of about 50 nm in size permit the oral delivery of insulin and other peptide drugs by temporally enhancing the permeability of the intestinal wall.

    • Per Artursson
    •  & Patrik Lundquist
  • News & Views |

    In an adult mouse model of tyrosinaemia, a base editor correcting an A-to-G splice-site mutation in the Fah gene restores the translation of the functional enzyme, promoting the repopulation of the liver with the corrected cells.

    • Kiran Musunuru
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    An injectable biomaterial vaccine encapsulating antigens associated with acute myeloid leukaemia, dendritic-cell-targeting pro-inflammatory cytokines and an adjuvant protects mice from the disease.

    • Guojun Chen
    •  & Zhen Gu
  • News & Views |

    The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.

    • Monique A. J. van Eijndhoven
    • , S. Rubina Baglio
    •  & D. Michiel Pegtel
  • News & Views |

    Large quantities of extracellular vesicles produced via cellular nanoporation, and loaded with endogenously transcribed therapeutic mRNAs and targeting peptides, boost therapeutic outcomes in vivo.

    • Antje M. Zickler
    •  & Samir EL Andaloussi

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