Long-lasting implanted biomaterials
Katie Aguado

Long-lasting implanted biomaterials

The June issue highlights strategies for increasing the functional durability of implanted biomaterials.

Latest Research

  • Article |

    A comparison of the in vivo engraftment of scaffolds containing either an unassembled suspension of human vascular cells or an assembled network of them shows that non-inflammatory host neutrophils are indispensable mediators of vascularization.

    • Ruei-Zeng Lin
    • , Chin Nien Lee
    • , Rafael Moreno-Luna
    • , Joseph Neumeyer
    • , Breanna Piekarski
    • , Pingzhu Zhou
    • , Marsha A. Moses
    • , Monisha Sachdev
    • , William T. Pu
    • , Sitaram Emani
    •  & Juan M. Melero-Martin
  • Review Article |

    This Review discusses advances in implantable biomaterials that mimic the pre-metastatic niche and regulate the behaviour of tumour cells at the implant site, and their prospects for the detection of metastasis and for therapeutic interventions.

    • Brian A. Aguado
    • , Grace G. Bushnell
    • , Shreyas S. Rao
    • , Jacqueline S. Jeruss
    •  & Lonnie D. Shea
  • Article |

    In a rabbit model of prosthetic joint infection, optimization of the shape and loading of antibiotic clusters in a polymer implant augments and prolongs antibiotic elution while maintaining implant strength and wear rate.

    • V. J. Suhardi
    • , D. A. Bichara
    • , S. J. J. Kwok
    • , A. A. Freiberg
    • , H. Rubash
    • , H. Malchau
    • , S. H. Yun
    • , O. K. Muratoglu
    •  & E. Oral
  • Article |

    3D-printed grafts with geometrically designed and endothelialized vasculature rescue the perfusion of distal tissues in rodent models of hind limb ischaemia and myocardial infarction, preventing capillary loss, muscle atrophy and loss of function.

    • T. Mirabella
    • , J. W. MacArthur
    • , D. Cheng
    • , C. K. Ozaki
    • , Y. J. Woo
    • , M. T. Yang
    •  & C. S. Chen
  • Article |

    A simple and versatile assay that relies on the bioconjugation capabilities and ultrafast and localized deposition of polydopamine can be plugged into common laboratory bioassays to improve their detection sensitivity by orders of magnitude.

    • Junwei Li
    • , Madison A. Baird
    • , Michael A. Davis
    • , Wanyi Tai
    • , Larry S. Zweifel
    • , Kristina M. Adams Waldorf
    • , Michael Gale Jr
    • , Lakshmi Rajagopal
    • , Robert H. Pierce
    •  & Xiaohu Gao
  • Article |

    An optimized formulation of glucagon-like peptide-1 recombinantly fused to an elastin-like polypeptide leads to zero-order release kinetics from a subcutaneous depot and to 10 days of glycaemic control in three mouse models of diabetes.

    • Kelli M. Luginbuhl
    • , Jeffrey L. Schaal
    • , Bret Umstead
    • , Eric M. Mastria
    • , Xinghai Li
    • , Samagya Banskota
    • , Susan Arnold
    • , Mark Feinglos
    • , David D’Alessio
    •  & Ashutosh Chilkoti

News & Comment

  • News and Views |

    Implanted scaffolds bearing 3D-printed parallel endothelialized channels restore blood perfusion in ischaemic hind limbs and infarcted hearts in rodents.

    • Shahar Ben-Shaul
    • , Shira Landau
    •  & Shulamit Levenberg
  • Editorial |

    The design of implantable biomaterials with lasting function is rooted in biomolecular and cellular principles.

  • News and Views |

    A universal ‘add-on’ method based on the ultrafast and localized deposition of polydopamine amplifies the sensitivity of a variety of bioassays for clinical diagnostics.

    • Shana O. Kelley
  • News and Views |

    A CRISPR-associated nuclease that can promiscuously cleave RNAs enables a rapid and cheap test for the single-molecule detection and single-base discrimination of nucleic acids.

    • Xiaolei Zuo
    • , Chunhai Fan
    •  & Hong-Yuan Chen
  • News and Views |

    An optimized drug-eluting polymer for the surface of articulating artificial joints may make them infection-free.

    • Noreen J. Hickok

Collections

  • Advances in the isolation of cancer biomarkers in blood and in imaging probes will make a difference in the early detection of cancer.
  • Engineering and materials-science advances drive the miniaturization and long-term and safe operation of bioelectronic devices for diagnostics or therapy.
  • The accelerating power of machine learning in diagnosing disease and in sorting and classifying health data will empower physicians and speed-up decision making in the clinic.
  • Strategies that increase the functional durability of implanted biomaterials suggest that retention of function might be more important than retention of the biomaterial itself.

About the Journal

  • Straddling the life sciences, the physical sciences and engineering, the journal publishes biological, medical and engineering advances — technological, translational, methodological or fundamental — that can directly inspire or lead to improvements in human health.
  • The journal publishes original research in one format: Article. Review Articles provide authoritative and balanced discussions of research developments. Perspectives, Comments, and News & Views include informed opinion.
  • Chief Editor Pep Pàmies has broad editorial expertise in biomaterials and bioengineering. Associate Editors Michelle Korda, Rosy Favicchio and João Duarte have research expertise in advanced therapy clinical trials, molecular imaging and immunoengineering.

For authors & referees

  • Summary of the processes of manuscript submission, peer review and post review, and of editorial and publishing policies.
  • Explanation of the submission, peer-review, decision and revision processes.
  • Information about submitting initial, revised and final submissions.
  • Format requirements for the main text, figures, Methods and Supplementary Information of final submissions.
  • Guidelines for writing reviews, and information about confidentiality, anonymity and other aspects of the peer-review process.

Current Issue

Volume 1 Issue 6

Image by Katie Aguado.

Volume 1 Issue 6

Long-lasting implanted biomaterials

This focus issue highlights strategies for increasing the functional durability of implanted biomaterials.

The cover illustrates a subcutaneously-implanted scaffold for the study and modulation of a pre-metastatic niche (Review Article).

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