Nobuyuki Tanaka and Per Uhlén

Phenotyping intratumoural heterogeneity

The October issue highlights the analysis of tumour heterogeneity for the stratification of patient prognosis.

Latest Research

  • Article |

    An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.

    • Canan Dagdeviren
    • , Farhad Javid
    • , Pauline Joe
    • , Thomas von Erlach
    • , Taylor Bensel
    • , Zijun Wei
    • , Sarah Saxton
    • , Cody Cleveland
    • , Lucas Booth
    • , Shane McDonnell
    • , Joy Collins
    • , Alison Hayward
    • , Robert Langer
    •  & Giovanni Traverso
  • Perspective |

    This Perspective discusses recent technological developments in flow cytometry and DNA sequencing that enable the interrogation of T-cell specificities in infection, cancer and autoimmunity to inform disease development and treatment.

    • Sine Reker Hadrup
    •  & Evan W. Newell
  • Article |

    A fluorescence-based assay is used to screen cyclic peptides for their activity in preventing protein misfolding, an event that can generate pathogenic aggregates that lead to diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.

    • Ilias Matis
    • , Dafni Chrysanthi Delivoria
    • , Barbara Mavroidi
    • , Nikoletta Papaevgeniou
    • , Stefania Panoutsou
    • , Stamatia Bellou
    • , Konstantinos D. Papavasileiou
    • , Zacharoula I. Linardaki
    • , Alexandra V. Stavropoulou
    • , Kostas Vekrellis
    • , Nikos Boukos
    • , Fragiskos N. Kolisis
    • , Efstathios S. Gonos
    • , Marigoula Margarity
    • , Manthos G. Papadopoulos
    • , Spiros Efthimiopoulos
    • , Maria Pelecanou
    • , Niki Chondrogianni
    •  & Georgios Skretas
  • Article |

    An implantable device consisting of a biodegradable core and a tubular braided sleeve autonomously elongates to accommodate tissue growth, as shown with prototypes implanted on a rat tibial bone and a piglet heart valve.

    • Eric N. Feins
    • , Yuhan Lee
    • , Eoin D. O’Cearbhaill
    • , Nikolay V. Vasilyev
    • , Shogo Shimada
    • , Ingeborg Friehs
    • , Douglas Perrin
    • , Peter E. Hammer
    • , Haruo Yamauchi
    • , Gerald Marx
    • , Andrew Gosline
    • , Veaceslav Arabagi
    • , Jeffrey M. Karp
    •  & Pedro J. del Nido
  • Article |

    The expression of two specific DNA-repair factors promotes homology-directed repair and enhances the precision of CRISPR–Cas9 gene editing at multiple loci in human cells, including patient-derived induced pluripotent stem cells.

    • Bruna S. Paulsen
    • , Pankaj K. Mandal
    • , Richard L. Frock
    • , Baris Boyraz
    • , Rachita Yadav
    • , Srigokul Upadhyayula
    • , Paula Gutierrez-Martinez
    • , Wataru Ebina
    • , Anders Fasth
    • , Tomas Kirchhausen
    • , Michael E. Talkowski
    • , Suneet Agarwal
    • , Frederick W. Alt
    •  & Derrick J. Rossi
  • Article |

    Epigenetic and transcriptomic differences in human induced pluripotent stem cells generated from the same fibroblast population reveals that the reprogramming method affects the cells’ gene-expression levels but not their differentiation potential.

    • Jared M. Churko
    • , Jaecheol Lee
    • , Mohamed Ameen
    • , Mingxia Gu
    • , Meenakshi Venkatasubramanian
    • , Sebastian Diecke
    • , Karim Sallam
    • , Hogune Im
    • , Gavin Wang
    • , Joseph D. Gold
    • , Nathan Salomonis
    • , Michael P. Snyder
    •  & Joseph C. Wu

News & Comment

  • News and Views |

    The genetic, epigenetic and transcriptomic profiles of human-induced pluripotent stem cells are shaped by the reprogramming route.

    • Thomas F. Allison
    •  & William E. Lowry
  • News and Views |

    Light-sheet microscopy reveals 3D tumour heterogeneity in optically cleared paraffin-embedded tumour samples.

    • Boyan K. Garvalov
    •  & Ali Ertürk
  • News and Views |

    Flexible piezoelectric sensors can detect mechanical deformations in the gastrointestinal tract of ambulating pigs and simultaneously harvest energy from it.

    • Ghazaleh Haghiashtiani
    •  & Michael C. McAlpine
  • News and Views |

    High-throughput screening of large libraries of cyclic peptides expressed in bacteria yields rescuers of the pathogenic misfolding of proteins associated with neurodegenerative diseases.

    • Tobias Langenberg
    • , Joost Schymkowitz
    •  & Frederic Rousseau
  • Editorial |

    When reading or writing about biomedical findings, be mindful of factual accuracy and wary of unapparent caveats.

  • News and Views |

    Devices made with resorbable polymers and braided materials can accommodate tissue growth in long-bone and heart-valve animal models.

    • Scott J. Hollister

Collections

  • Advances in the isolation of cancer biomarkers in blood and in imaging probes will make a difference in the early detection of cancer.
  • Engineering and materials-science advances drive the miniaturization and long-term and safe operation of bioelectronic devices for diagnostics or therapy.
  • The accelerating power of machine learning in diagnosing disease and in sorting and classifying health data will empower physicians and speed-up decision making in the clinic.
  • Strategies that increase the functional durability of implanted biomaterials suggest that retention of function might be more important than retention of the biomaterial itself.

About the Journal

  • Straddling the life sciences, the physical sciences and engineering, the journal publishes biological, medical and engineering advances — technological, translational, methodological or fundamental — that can directly inspire or lead to improvements in human health.
  • The journal publishes original research in one format: Article. Review Articles provide authoritative and balanced discussions of research developments. Perspectives, Comments, and News & Views include informed opinion.
  • Chief Editor Pep Pàmies has broad editorial expertise in biomaterials and bioengineering. Associate Editors Michelle Korda, Rosy Favicchio and João Duarte have research expertise in advanced therapy clinical trials, molecular imaging and immunoengineering.

For authors & referees

  • Summary of the processes of manuscript submission, peer review and post review, and of editorial and publishing policies.
  • Explanation of the submission, peer-review, decision and revision processes.
  • Information about submitting initial, revised and final submissions.
  • Format requirements for the main text, figures, Methods and Supplementary Information of final submissions.
  • Guidelines for writing reviews, and information about confidentiality, anonymity and other aspects of the peer-review process.

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