Scott Finnance

Ultrasound-triggered anaesthesia

The August issue highlights an approach for on-demand nerve block.

Latest Research

  • Article |

    Ultrasound pulses controlling the release of an anaesthetic encapsulated in liposomes allow for the timing, intensity and duration of sciatic-nerve blocks in rats.

    • Alina Y. Rwei
    • , Juan L. Paris
    • , Bruce Wang
    • , Weiping Wang
    • , Christopher D. Axon
    • , María Vallet-Regí
    • , Robert Langer
    •  & Daniel S. Kohane
  • Article |

    A system consisting of a glass microelectrode and a boron-doped diamond microsensor can simultaneously track, in rat brains and in the guinea pig cochlea, the local real-time kinetics of injected drugs and the resulting electrophysiological activity.

    • Genki Ogata
    • , Yuya Ishii
    • , Kai Asai
    • , Yamato Sano
    • , Fumiaki Nin
    • , Takamasa Yoshida
    • , Taiga Higuchi
    • , Seishiro Sawamura
    • , Takeru Ota
    • , Karin Hori
    • , Kazuya Maeda
    • , Shizuo Komune
    • , Katsumi Doi
    • , Madoka Takai
    • , Ian Findlay
    • , Hiroyuki Kusuhara
    • , Yasuaki Einaga
    •  & Hiroshi Hibino
  • Article |

    Uniform iron oxide nanoparticle clusters are highly biocompatible and can be used as contrast agents for high-resolution magnetic resonance angiography of large animals.

    • Yang Lu
    • , Yun-Jun Xu
    • , Guo-bing Zhang
    • , Daishun Ling
    • , Ming-quan Wang
    • , Yong Zhou
    • , Ya-Dong Wu
    • , Tao Wu
    • , Michael J. Hackett
    • , Byung Hyo Kim
    • , Hogeun Chang
    • , Jonghoon Kim
    • , Xin-Tian Hu
    • , Liang Dong
    • , Nohyun Lee
    • , Fangyuan Li
    • , Jia-Cai He
    • , Li Zhang
    • , Hui-Qin Wen
    • , Bo Yang
    • , Seung Hong Choi
    • , Taeghwan Hyeon
    •  & Duo-Hong Zou
  • Article |

    Polymer–lipid–peptide nanoparticles carrying an antiplatelet antibody and a chemotherapy drug deplete tumour-associated platelets to increase vascular permeability and augment the accumulation of the drug in tumours.

    • Suping Li
    • , Yinlong Zhang
    • , Jing Wang
    • , Ying Zhao
    • , Tianjiao Ji
    • , Xiao Zhao
    • , Yanping Ding
    • , Xiaozheng Zhao
    • , Ruifang Zhao
    • , Feng Li
    • , Xiao Yang
    • , Shaoli Liu
    • , Zhaofei Liu
    • , Jianhao Lai
    • , Andrew K. Whittaker
    • , Gregory J. Anderson
    • , Jingyan Wei
    •  & Guangjun Nie
  • Article |

    An array-based method can identify synthetic hydrogels that outperform Matrigel in screening for vascular-disruptor compounds and in supporting the expansion and pluripotency of human embryonic stem cells.

    • Eric H. Nguyen
    • , William T. Daly
    • , Ngoc Nhi T. Le
    • , Mitra Farnoodian
    • , David G. Belair
    • , Michael P. Schwartz
    • , Connie S. Lebakken
    • , Gene E. Ananiev
    • , Mohammad Ali Saghiri
    • , Thomas B. Knudsen
    • , Nader Sheibani
    •  & William L. Murphy

News & Comment

  • News and Views |

    Exosomes expressing CD47 and loaded with interfering RNA dodge phagocytosis and accumulate in pancreatic tumours to silence the expression of the oncogene Kras in mice, with remarkable therapeutic efficacy.

    • Sander A. A. Kooijmans
    • , Pieter Vader
    •  & Raymond M. Schiffelers
  • News and Views |

    High-frequency transcranial electric-field oscillations stimulate neural circuits in the deep brain.

    • Alexander Opitz
    •  & William J. Tyler
  • News and Views |

    Uniform iron oxide nanoparticles with a hydrodynamic diameter of about 12 nm offer high biocompatibility and diagnostic yield as contrast agents for the magnetic resonance imaging of large animals.

    • Ali Yilmaz
  • News and Views |

    A new microsensor can simultaneously track drug pharmacokinetics and pharmacodynamics and the resulting electrophysiological activity in live animals.

    • Chunyan Li
    •  & Raj K. Narayan
  • News and Views |

    The ability to release an anaesthetic from liposomes by applying ultrasound opens up the possibility of managing localized pain on-demand.

    • Patrick Couvreur
  • News and Views |

    Depletion of tumour-associated platelets improves the delivery of anticancer drugs.

    • Abdullah Muhammad Syed
    • , Shrey Sindhwani
    •  & Warren C. W. Chan

Collections

  • Advances in the isolation of cancer biomarkers in blood and in imaging probes will make a difference in the early detection of cancer.
  • Engineering and materials-science advances drive the miniaturization and long-term and safe operation of bioelectronic devices for diagnostics or therapy.
  • The accelerating power of machine learning in diagnosing disease and in sorting and classifying health data will empower physicians and speed-up decision making in the clinic.
  • Strategies that increase the functional durability of implanted biomaterials suggest that retention of function might be more important than retention of the biomaterial itself.

About the Journal

  • Straddling the life sciences, the physical sciences and engineering, the journal publishes biological, medical and engineering advances — technological, translational, methodological or fundamental — that can directly inspire or lead to improvements in human health.
  • The journal publishes original research in one format: Article. Review Articles provide authoritative and balanced discussions of research developments. Perspectives, Comments, and News & Views include informed opinion.
  • Chief Editor Pep Pàmies has broad editorial expertise in biomaterials and bioengineering. Associate Editors Michelle Korda, Rosy Favicchio and João Duarte have research expertise in advanced therapy clinical trials, molecular imaging and immunoengineering.

For authors & referees

  • Summary of the processes of manuscript submission, peer review and post review, and of editorial and publishing policies.
  • Explanation of the submission, peer-review, decision and revision processes.
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  • Format requirements for the main text, figures, Methods and Supplementary Information of final submissions.
  • Guidelines for writing reviews, and information about confidentiality, anonymity and other aspects of the peer-review process.

Current Issue

Volume 1 Issue 8

Image by Scott Finnance

Volume 1 Issue 8

Ultrasound-triggered anaesthesia

This issue highlights the use of ultrasound for the on-demand delivery of an anaesthetic, and also includes advances in nanoparticle delivery to tumours, the biocompatibility of iron oxide nanoparticles, and technology for measuring local drug kinetics in small animals.

The cover illustrates the concept of on-demand nerve block via ultrasound-triggered drug delivery of an anaesthetic (Article).

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