Web Focus
Stem Cell Therapy
- The striking advances in the area of embryonic and adult stem cell biology and the enormous potential of using cells or tissues derived from such cells to treat a host of diseases have caught the imagination of the scientific community as well as the lay public. Even more exciting is the recent genetic reprogramming of terminally-differentiated adult cells into induced pluripotent stem (iPS) cells, which exhibit many characteristics that imply they may be an excellent alternative for cell-based therapies and regenerative medicine. In this web focus, we gather together studies representative of the enormous potential of stem cells for the treatment of disease.
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: 2009
Can Mesenchymal Stem Cells Induce Tolerance to Cotransplanted Human Embryonic Stem Cells?
Etienne Puymirat, Raghed Geha, André Tomescot, Valérie Bellamy, Jérôme Larghero, Ludovic Trinquart, Patrick Bruneval, Michel Desnos, Albert Hagége, Michel Pucéat and Philippe Menasché
Mol Ther 17: 176-182; doi:10.1038/mt.2008.208
Cancer Stem Cell-Directed Therapies: Recent Data From the Laboratory and Clinic
Christopher Y Park, Diane Tseng and Irving L Weissman
Mol Ther 17, 219-230; doi:10.1038/mt.2008.254
Mesenchymal Stromal Cells Engineered to Express Erythropoietin Induce Anti-erythropoietin Antibodies and Anemia in Allorecipients
Philippe M Campeau, Moutih Rafei, Moïra François, Elena Birman, Kathy-Ann Forner and Jacques Galipeau
Mol Ther 17, 369-372; doi:10.1038/mt.2008.270
Upping the Ante: Recent Advances in Direct Reprogramming
Lars UW Müller, George Q Daley and David A Williams
Mol Ther advance online publication, March 31, 2009; doi:10.1038/mt.2009.72
Repair of Tissues by Adult Stem/Progenitor Cells (MSCs): Controversies, Myths, and Changing Paradigms
Darwin J Prockop
Mol Ther advance online publication, March 31, 2009; doi:10.1038/mt.2009.62
: 2008
Top of pageGenetic Modification of Neural Stem Cells
Rahul Jandial, Ilyas Singec, Christopher P Ames and Evan Y Snyder
Mol Ther 16: 450-457; doi:10.1038/sj.mt.6300402
Adult Bone Marrow-derived Cells Do Not Acquire Functional Attributes of Cardiomyocytes When Transplanted into Peri-infarct Myocardium
John A Scherschel, Mark H Soonpaa, Edward F Srour, Loren J Field and Michael Rubart
Mol Ther 16: 1129-1137; doi:10.1038/mt.2008.64
Does Retroviral Insertional Mutagenesis Play a Role in the Generation of Induced Pluripotent Stem Cells?
Robert G Hawley
Mol Ther 16: 1354-1355; doi:10.1038/mt.2008.142
Mash1 and Neurogenin 2 Enhance Survival and Differentiation of Neural Precursor Cells After Transplantation to Rat Brains via Distinct Modes of Action
Sang-Hoon Yi, A-Young Jo, Chang-Hwan Park, Hyun-Chul Koh, Rae-Hee Park, Haeyoung Suh-Kim, Incheol Shin, Yong-Sung Lee, Jaesang Kim and Sang-Hun Lee
Mol Ther 16: 1873-1882; doi:10.1038/mt.2008.189
Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS
Masatoshi Suzuki, Jacalyn McHugh, Craig Tork, Brandon Shelley, Antonio Hayes, Ilaria Bellantuono, Patrick Aebischer and Clive N Svendsen
Mol Ther 16: 2002-2010; doi:10.1038/mt.2008.197
: 2007
Top of pageStem and Progenitor Cells in Skeletal Muscle Development, Maintenance, and Therapy
Bruno Péault, Michael Rudnicki, Yvan Torrente, Giulio Cossu, Jacques P Tremblay, Terry Partridge, Emanuela Gussoni, Louis M Kunkel and Johnny Huard
Mol Ther 15: 867-877; doi:10.1038/mt.sj.6300145
Transgenic Enrichment of Cardiomyocytes From Human Embryonic Stem Cells
David Anderson, Tim Self, Ian R Mellor, Gareth Goh, Stephen J Hill and Chris Denning
Mol Ther 15: 2027-2036; doi:10.1038/sj.mt.6300303
: Bone Marrow Transplantation
Top of pageAdoptive cellular immunotherapy for childhood malignancies
L J N Cooper
Bone Marrow Transplant 41: 183-192; doi:10.1038/sj.bmt.1705930
: Clinical Pharmacology & Therapeutics
Top of pageLazarus's Gate: Challenges and Potential of Epigenetic Reprogramming of Somatic Cells
JT Henderson
Clin Pharmacol Ther 83: 889-893; doi:10.1038/clpt.2008.51
Stem Cells: Biologics for Regeneration
TJ Nelson, A Behfar and A Terzic
Clin Pharmacol Ther 84: 620-623; doi:10.1038/clpt.2008.146
: Nature Medicine
Top of pageA method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability
Peter Eirew, John Stingl, Afshin Raouf, Gulisa Turashvili, Samuel Aparicio, Joanne T Emerman and Connie J Eaves
Nature Medicine 14: 1384-1389; doi:10.1038/nm.1791
: Nature Reviews Molecular Cell Biology
Top of pageThe promise of human induced pluripotent stem cells for research and therapy
Shin-ichi Nishikawa, Robert A. Goldstein and Concepcion R. Nierras
Nature Reviews Molecular Cell Biology 9: 725-729; doi:10.1038/nrm2466
: Oncogene
Top of pageGlioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria
H S Günther, N O Schmidt, H S Phillips, D Kemming, S Kharbanda, R Soriano, Z Modrusan, H Meissner, M Westphal and K Lamszus
Oncogene 27: 2897-2909; doi:10.1038/sj.onc.1210949
: Spinal Cord
Top of pageCan cell therapy heal a spinal cord injury?
M W Ronsyn, Z N Berneman, V F I Van Tendeloo, P G Jorens and P Ponsaerts
Spinal Cord 46: 532-539; doi:10.1038/sc.2008.13
The cell culture expansion of bone marrow stromal cells from humans with spinal cord injury: implications for future cell transplantation therapy
K T Wright, W El Masri, A Osman, S Roberts, J Trivedi, B A Ashton and W E B Johnson
Spinal Cord 46: 811-817; doi:10.1038/sc.2008.77
