ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
June 16 2009 |
June 9 2009 |
June 2 2009 |
May 26 2009 |
May 12 2009 |
May 5 2009 |
April 28 2009 |
April 21 2009 |
April 7 2009 |
March 17 2009
June 30 2009
Original Articles
Sexually Dimorphic Patterns of Episomal rAAV Genome Persistence in the Adult Mouse Liver and Correlation With Hepatocellular Proliferation
Allison P Dane, Sharon C Cunningham, Nicole S Graf and Ian E Alexander
Mol Ther advance online publication, June 30, 2009; doi:10.1038/mt.2009.139
Amelioration of Psoriasis by Anti-TNF-
RNAi in the Xenograft Transplantation Model
Maria Jakobsen, Karin Stenderup, Cecilia Rosada, Brian Moldt, Søren Kamp, Tomas N Dam, Thomas G Jensen and Jacob Giehm Mikkelsen
Mol Ther advance online publication, June 30, 2009; doi:10.1038/mt.2009.141
Mechanisms of Fibroblast Cell Therapy for Dystrophic Epidermolysis Bullosa: High Stability of Collagen VII Favors Long-term Skin Integrity
Johannes S Kern, Stefan Loeckermann, Anja Fritsch, Ingrid Hausser, Wera Roth, Thomas M Magin, Claudia Mack, Marcel L Müller, Oliver Paul, Patrick Ruther and Leena Bruckner-Tuderman
Mol Ther advance online publication, June 30, 2009; doi:10.1038/mt.2009.144
Biosafety in Ex Vivo Gene Therapy and Conditional Ablation of Lentivirally Transduced Hepatocytes in Nonhuman Primates
Olivier Menzel, Jacques Birraux, Barbara E Wildhaber, Caty Jond, Françoise Lasne, Walid Habre, Didier Trono, Tuan H Nguyen and Christophe Chardot
Mol Ther advance online publication, June 30, 2009; doi:10.1038/mt.2009.143
June 16 2009
Original Articles
Immunotherapy for Osteosarcoma: Genetic Modification of T cells Overcomes Low Levels of Tumor Antigen Expression
Nabil Ahmed, Vita S Salsman, Eric Yvon, Chrystal U Louis, Laszlo Perlaky, Winfried S Wels, Meghan K Dishop, Eugenie E Kleinerman, Martin Pule, Cliona M Rooney, Helen E Heslop and Stephen Gottschalk
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.133
Phase I/II and Phase II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Chemotherapy-resistant Sarcoma and Osteosarcoma MTOpen
Sant P Chawla, Victoria S Chua, Lita Fernandez, Doris Quon, Andreh Saralou, William C Blackwelder, Frederick L Hall and Erlinda M Gordon
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.126
Fluid Phase Endocytosis Contributes to Transfection of DNA by PEI-25
Hansjörg Hufnagel, Parvez Hakim, Aline Lima and Florian Hollfelder
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.121
Cell-intrinsic and Vector-related Properties Cooperate to Determine the Incidence and Consequences of Insertional Mutagenesis
Olga S Kustikova, Bernhard Schiedlmeier, Martijn H Brugman, Maike Stahlhut, Stefan Bartels, Zhixiong Li and Christopher Baum
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.134
Attraction and Activation of Dendritic Cells at the Site of Tumor Elicits Potent Antitumor Immunity
Natalia Lapteva, Melissa Aldrich, Lisa Rollins, Wenhong Ren, Tatiana Goltsova, Si-Yi Chen and Xue F Huang
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.111
Identification of Protein Cofactors Necessary for Sequence-specific Plasmid DNA Nuclear Import
Aaron M Miller, Felix M Munkonge, Eric WFW Alton and David A Dean
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.127
Allele-specific RNAi Mitigates Phenotypic Progression in a Transgenic Model of Alzheimer's Disease
Edgardo Rodríguez-Lebrón, Cynthia M Gouvion, Steven A Moore, Beverly L Davidson and Henry L Paulson
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.123
Optimization of Skin Electroporation in Mice to Increase Tolerability of DNA Vaccine Delivery to Patients
Anna-Karin Roos, Fredrik Eriksson, Derin C Walters, Pavel Pisa and Alan D King
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.120
A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells
Richard H Smith, Justin R Levy and Robert M Kotin
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.128
High-efficiency Transient Transduction of Human Embryonic Stem Cell–derived Neurons With Baculoviral Vectors
Jieming Zeng, Juan Du, Jiakai Lin, Xiao Ying Bak, Chunxiao Wu and Shu Wang
Mol Ther advance online publication, June 16, 2009; doi:10.1038/mt.2009.124
June 9 2009
Review
New Insights on Adenovirus as Vaccine Vectors
Marcio O Lasaro and Hildegund CJ Ertl
Mol Ther advance online publication, June 9, 2009; doi:10.1038/mt.2009.130
June 2 2009
Review
Integration-deficient Lentiviral Vectors: A Slow Coming of Age
Klaus Wanisch and Rafael J Yáñez-Muñoz
Mol Ther advance online publication, June 2, 2009; doi:10.1038/mt.2009.122
May 26 2009
Original Articles
Treatment With Cyclooxygenase-2 Inhibitors Enables Repeated Administration of Vaccinia Virus for Control of Ovarian Cancer
Chih-Long Chang, Barbara Ma, Xiaowu Pang, T-C Wu and Chien-Fu Hung
Mol Ther advance online publication, May 26, 2009; doi:10.1038/mt.2009.118
Abrogation of Microsatellite-instable Tumors Using a Highly Selective Suicide Gene/Prodrug Combination
Cristina Ferrás, Joachim AF Oude Vrielink, Johan WA Verspuy, Hein te Riele, Anastasia Tsaalbi-Shtylik and Niels de Wind
Mol Ther advance online publication, May 26, 2009; doi:10.1038/mt.2009.114
Evaluation of Vascular Delivery Methodologies to Enhance rAAV6-mediated Gene Transfer to Canine Striated Musculature
Paul Gregorevic, Brian R Schultz, James M Allen, Jeffrey B Halldorson, Michael J Blankinship, Norman A Meznarich, Christian S Kuhr, Caitlin Doremus, Eric Finn, Denny Liggitt and Jeffrey S Chamberlain
Mol Ther advance online publication, May 26, 2009; doi:10.1038/mt.2009.116
Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles
Muri Han, Makoto Oba, Nobuhiro Nishiyama, Mitsunobu R Kano, Shinae Kizaka-Kondoh and Kazunori Kataoka
Mol Ther advance online publication, May 26, 2009; doi:10.1038/mt.2009.119
Converting Tumor-specific Markers Into Reporters of Oncolytic Virus Infection
Ianko D Iankov, Matthew L Hillestad, Allan B Dietz, Stephen J Russell and Evanthia Galanis
Mol Ther advance online publication, May 26, 2009; doi:10.1038/mt.2009.92
Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease
Yinxing Liu, Christa Studzinski, Tina Beckett, Hanjun Guan, Matthew A Hersh, M Paul Murphy, Ronald Klein and Louis B Hersh
Mol Ther advance online publication, May 26, 2009; doi:10.1038/mt.2009.115
May 12 2009
Original Articles
AAV-mediated Tyrosinase Gene Transfer Restores Melanogenesis and Retinal Function in a Model of Oculo-cutaneous Albinism Type I (OCA1)
Annagiusi Gargiulo, Ciro Bonetti, Sandro Montefusco, Simona Neglia, Umberto Di Vicino, Elena Marrocco, Michele Della Corte, Luciano Domenici, Alberto Auricchio and Enrico M Surace
Mol Ther advance online publication, May 12, 2009; doi:10.1038/mt.2009.112
Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma
Elie Hadchity, Marie-Thérèse Aloy, Christian Paulin, Emma Armandy, Emmanuel Watkin, Robert Rousson, Martin Gleave, Olivier Chapet and Claire Rodriguez-Lafrasse
Mol Ther advance online publication, May 12, 2009; doi:10.1038/mt.2009.90
Sonic Hedgehog Expands Diaphyseal Trabecular Bone Altering Bone Marrow Niche and Lymphocyte Compartment
Maija Kiuru, Chisa Hidaka, Ralf-Harto Hubner, Jason Solomon, Anja Krause, Philip L Leopold and Ronald G Crystal
Mol Ther advance online publication, May 12, 2009; doi:10.1038/mt.2009.102
Suppression of Cancer Growth by Nonviral Gene Therapy Based on a Novel Reactive Oxygen Species-responsive Promoter
Lucía L Policastro, Irene L Ibañez, Hebe A Durán, Gastón Soria, Vanesa Gottifredi and Osvaldo L Podhajcer
Mol Ther advance online publication, May 12, 2009; doi:10.1038/mt.2009.103
May 5 2009
Original Article
DNA/Amphiphilic Block Copolymer Nanospheres Promote Low-dose DNA Vaccination
Dorian McIlroy, Benoît Barteau, Jeannette Cany, Peggy Richard, Clothilde Gourden, Sophie Conchon and Bruno Pitard
Mol Ther advance online publication, May 5, 2009; doi:10.1038/mt.2009.84
April 28 2009
Original Article
Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive Antitumor Immunity
Jeanette E Boudreau, Byram W Bridle, Kyle B Stephenson, Kristina M Jenkins, Jérôme Brunellière, Jonathan L Bramson, Brian D Lichty and Yonghong Wan
Mol Ther advance online publication, April 28, 2009; doi:10.1038/mt.2009.95
April 21 2009
Original Articles
AAV2/8-mediated Correction of OTC Deficiency Is Robust in Adult but Not Neonatal Spf ash Mice
Sharon C Cunningham, Afroditi Spinoulas, Kevin H Carpenter, Bridget Wilcken, Philip W Kuchel and Ian E Alexander
Mol Ther advance online publication, April 21, 2009; doi:10.1038/mt.2009.88
Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo
Michael C. Milone, Jonathan D. Fish, Carmine Carpenito, Richard G. Carroll, Gwendolyn K. Binder, David Teachey, Minu Samanta, Mehdi Lakhal, Brian Gloss, Gwenn Danet-Desnoyers, Dario Campana, James L. Riley, Stephan A. Grupp and Carl H. June
Mol Ther advance online publication, April 21, 2009; doi:10.1038/mt.2009.83
Mechanism of Reduction in Titers From Lentivirus Vectors Carrying Large Inserts in the 3'LTR
Fabrizia Urbinati, Paritha Arumugam, Tomoyasu Higashimoto, Anil Perumbeti, Kyle Mitts, Ping Xia and Punam Malik
Mol Ther advance online publication, April 21, 2009; doi:10.1038/mt.2009.89
April 7 2009
Original Articles
The Sea Urchin sns5 Insulator Protects Retroviral Vectors From Chromosomal Position Effects by Maintaining Active Chromatin Structure
Danilo D'Apolito, Elena Baiamonte, Mariella Bagliesi, Rosalba Di Marzo, Roberta Calzolari, Leda Ferro, Vito Franco, Giovanni Spinelli, Aurelio Maggio and Santina Acuto
Mol Ther advance online publication, April 7, 2009; doi:10.1038/mt.2009.74
BH3-based Fusion Artificial Peptide Induces Apoptosis and Targets Human Colon Cancer
Yongjun Liu, Yunfeng Li, Haijuan Wang, Jing Yu, Hongwei Lin, Dongkui Xu, Yang Wang, Ailing Liang, Xiao Liang, Xueyan Zhang, Ming Fu, Haili Qian and Chen Lin
Mol Ther advance online publication, April 7, 2009; doi:10.1038/mt.2009.43
Physiological Transgene Regulation and Functional Complementation of a Neurological Disease Gene Deficiency in Neurons
Pier Paolo Peruzzi, Sean E Lawler, Steve L Senior, Nina Dmitrieva, Pauline AH Edser, Davide Gianni, E Antonio Chiocca and Richard Wade-Martins
Mol Ther advance online publication, April 7, 2009; doi:10.1038/mt.2009.64
March 17 2009
Original Article
Rational Design of Antisense Oligomers to Induce Dystrophin Exon Skipping
Chalermchai Mitrpant, Abbie M Adams, Penny L Meloni, Francesco Muntoni, Sue Fletcher and Steve D Wilton
Mol Ther advance online publication, March 17, 2009; doi:10.1038/mt.2009.49
