ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
July 15 2008 |
July 8 2008 |
July 1 2008 |
June 24 2008 |
June 17 2008 |
June 10 2008 |
June 3 2008 |
May 6 2008 |
February 12 2008 |
February 5 2008
July 22 2008
Original Article
Histone Deacetylase Inhibitors Augment Antitumor Efficacy of Herpes-based Oncolytic Viruses
Akihiro Otsuki, Ankita Patel, Kazue Kasai, Masataka Suzuki, Kazuhiko Kurozumi, E Antonio Chiocca and Yoshinaga Saeki
Mol Ther advance online publication, July 22, 2008; doi:10.1038/mt.2008.155
July 15 2008
Review
Advances in High-capacity Extrachromosomal Vector Technology: Episomal Maintenance, Vector Delivery, and Transgene Expression
Michele MP Lufino, Pauline AH Edser and Richard Wade-Martins
Mol Ther advance online publication, July 15, 2008; doi:10.1038/mt.2008.156
Original Articles
RNA Interference Screen to Identify Pathways That Enhance or Reduce Nonviral Gene Transfer During Lipofection
Gregory A Barker and Scott L Diamond
Mol Ther advance online publication, July 15, 2008; doi:10.1038/mt.2008.147
The Targeted Oncolytic Poxvirus JX-594 Demonstrates Antitumoral, Antivascular, and Anti-HBV Activities in Patients With Hepatocellular Carcinoma
Ta-Chiang Liu, Taeho Hwang, Byeong-Ho Park, John Bell and David H Kirn
Mol Ther advance online publication, July 15, 2008; doi:10.1038/mt.2008.143
Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian rats
Melissa K McCoy, Kelly A Ruhn, Terina N Martinez, Fiona E McAlpine, Armin Blesch and Malú G Tansey
Mol Ther advance online publication, July 15, 2008; doi:10.1038/mt.2008.146
Acid Sphingomyelinase Overexpression Enhances the Antineoplastic Effects of Irradiation In Vitro and In Vivo
Eric L Smith and Edward H Schuchman
Mol Ther advance online publication, July 15, 2008; doi:10.1038/mt.2008.145
July 8 2008
Original Article
The Immunogenicity of Adenovirus Vectors Limits the Multispecificity of CD8 T-cell Responses to Vector-encoded Transgenic Antigens
Reinhold Schirmbeck, Jörg Reimann, Stefan Kochanek and Florian Kreppel
Mol Ther advance online publication, July 8, 2008; doi:10.1038/mt.2008.141
July 1 2008
Original Article
Viral Vector–mediated Delivery of Estrogen Receptor-
to the Hippocampus Improves Spatial Learning in Estrogen Receptor- Knockout Mice
Thomas C Foster, Asha Rani, Ashok Kumar, Li Cui and Susan L Semple-Rowland
Mol Ther advance online publication, July 1, 2008; doi:10.1038/mt.2008.140
June 24 2008
Original Articles
Double Oxygen–sensing Vector System for Robust Hypoxia/Ischemia-regulated Gene Induction in Cardiac Muscle In Vitro and In Vivo
Ekaterina V Fomicheva, Immanuel I Turner, Terri G Edwards, Janet Hoff, Eric Arden, Louis G D'Alecy and Joseph M Metzger
Mol Ther advance online publication, June 24, 2008; doi:10.1038/mt.2008.136
Targeted Cell Entry of Lentiviral Vectors
Sabrina Funke, Andrea Maisner, Michael D Mühlebach, Ulrike Koehl, Manuel Grez, Roberto Cattaneo, Klaus Cichutek and Christian J Buchholz
Mol Ther advance online publication, June 24, 2008; doi:10.1038/mt.2008.128
Gene Transfer May Be Preventive But Not Curative for a Lysosomal Transport Disorder
Claire Hippert, Grégor Dubois, Carole Morin, Olivier Disson, Sandy Ibanes, Chantal Jacquet, Reto Schwendener, Corinne Antignac, Eric J Kremer and Vasiliki Kalatzis
Mol Ther advance online publication, June 24, 2008; doi:10.1038/mt.2008.126
Reduced Genotoxicity of Avian Sarcoma Leukosis Virus Vectors in Rhesus Long-term Repopulating Cells Compared to Standard Murine Retrovirus Vectors
Jingqiong Hu, Gabriel Renaud, Theotonius Golmes, Andrea Ferris, Paul C Hendrie, Robert E Donahue, Stephen H Hughes, Tyra G Wolfsberg, David W Russell and Cynthia E Dunbar
Mol Ther advance online publication, June 24, 2008; doi:10.1038/mt.2008.135
June 17 2008
Original Articles
Stable and Functional Lymphoid Reconstitution in Artemis-deficient Mice Following Lentiviral Artemis Gene Transfer Into Hematopoietic Stem Cells
Fatine Benjelloun, Alexandrine Garrigue, Corinne Demerens-de Chappedelaine, Pauline Soulas-Sprauel, Michele Malassis-Séris, Daniel Stockholm, Julia Hauer, Johanna Blondeau, Julie Rivière, Annick Lim, Marc Le Lorc'h, Serge Romana, Nicole Brousse, Frederique Pâques, Anne Galy, Pierre Charneau, Alain Fischer, Jean-Pierre de Villartay and Marina Cavazzana-Calvo
Mol Ther advance online publication, June 17, 2008; doi:10.1038/mt.2008.118
A let-7 MicroRNA-sensitive Vesicular Stomatitis Virus Demonstrates Tumor-specific Replication
Robert E Edge, Theresa J Falls, Christopher W Brown, Brian D Lichty, Harold Atkins and John C Bell
Mol Ther advance online publication, June 17, 2008; doi:10.1038/mt.2008.130
Intranasal HGF Administration Ameliorates the Physiologic and Morphologic Changes in Lung Emphysema
Ahmed E Hegab, Hiroshi Kubo, Mutsuo Yamaya, Masanori Asada, Mei He, Naoya Fujino, Shinya Mizuno and Toshikazu Nakamura
Mol Ther advance online publication, June 17, 2008; doi:10.1038/mt.2008.137
Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers
Silvia Muro, Carmen Garnacho, Julie A Champion, John Leferovich, Christine Gajewski, Edward H Schuchman, Samir Mitragotri and Vladimir R Muzykantov
Mol Ther advance online publication, June 17, 2008; doi:10.1038/mt.2008.127
Efficient MHC Class I Presentation by Controlled Intracellular Trafficking of Antigens in Octaarginine-modified Liposomes
Takashi Nakamura, Rumiko Moriguchi, Kentaro Kogure, Nilabh Shastri and Hideyoshi Harashima
Mol Ther advance online publication, June 17, 2008; doi:10.1038/mt.2008.122
AAV8-mediated Gene Transfer of Interleukin-4 to Endogenous 
-Cells Prevents the Onset of Diabetes in NOD Mice
Khaja K Rehman, Massimo Trucco, Zhong Wang, Xiao Xiao and Paul D Robbins
Mol Ther advance online publication, June 17, 2008; doi:10.1038/mt.2008.116
Site-specific Modification of AAV Vector Particles With Biophysical Probes and Targeting Ligands Using Biotin Ligase
Matthew D Stachler, Irwin Chen, Alice Y Ting and Jeffrey S Bartlett
Mol Ther advance online publication, June 17, 2008; doi:10.1038/mt.2008.129
Correction of Multiple Striated Muscles in Murine Pompe Disease Through Adeno-associated Virus–mediated Gene Therapy
Baodong Sun, Sarah P Young, Ping Li, Chunhui Di, Talmage Brown, Maja Z Salva, Songtao Li, Andrew Bird, Zhen Yan, Richard Auten, Stephen D Hauschka and Dwight D Koeberl
Mol Ther advance online publication, June 17, 2008; doi:10.1038/mt.2008.133
Substitution of Hexon Hypervariable Region 5 of Adenovirus Serotype 5 Abrogates Blood Factor Binding and Limits Gene Transfer to Liver
Frédéric Vigant, Delphyne Descamps, Betsy Jullienne, Stéphanie Esselin, Elisabeth Connault, Paule Opolon, Thierry Tordjmann, Emmanuelle Vigne, Michel Perricaudet and Karim Benihoud
Mol Ther advance online publication, June 17, 2008; doi:10.1038/mt.2008.132
June 10 2008
Original Articles
Enhancement of Cytotoxic T-lymphocyte Response in Aged Mice by a Novel Treatment with Recombinant AdIL-12 and Wild-type Adenovirus in Rapid Succession
Jian Chen, John Wang, Jun Li, Qi Wu, Fei Chu Lim, PingAr Yang, Hui-Chen Hsu, David T Curiel and John D Mountz
Mol Ther advance online publication, June 10, 2008; doi:10.1038/mt.2008.121
Systemic Insulin-like Growth Factor-1 Reverses Hypoalgesia and Improves Mobility in a Mouse Model of Diabetic Peripheral Neuropathy
Qiuming Chu, Rod Moreland, Nelson S Yew, Joseph Foley, Robin Ziegler and Ronald K Scheule
Mol Ther advance online publication, June 10, 2008; doi:10.1038/mt.2008.115
Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice
Natee Jearawiriyapaisarn, Hong M Moulton, Brian Buckley, Jennifer Roberts, Peter Sazani, Suthat Fucharoen, Patrick L Iversen and Ryszard Kole
Mol Ther advance online publication, June 10, 2008; doi:10.1038/mt.2008.120
Human Interleukin-10 Gene Transfer Is Protective in a Rat Model of Parkinson's Disease
Louisa C Johnston, Xiaomin Su, Kathleen Maguire-Zeiss, Karen Horovitz, Irina Ankoudinova, Dmitry Guschin, Piotr Hadaczek, Howard J Federoff, Krystof Bankiewicz and John Forsayeth
Mol Ther advance online publication, June 10, 2008; doi:10.1038/mt.2008.113
Oncolytic HSV-1 Infection of Tumors Induces Angiogenesis and Upregulates CYR61
Kazuhiko Kurozumi, Jayson Hardcastle, Roopa Thakur, Joshua Shroll, Michal Nowicki, Akihiro Otsuki, E Antonio Chiocca and Balveen Kaur
Mol Ther advance online publication, June 10, 2008; doi:10.1038/mt.2008.112
Repeat Administration of Proteins to the Eye With a Single Intraocular Injection of an Adenovirus Vector
Duncan McVey, Melissa M Hamilton, Chi Hsu, C Richter King, Douglas E Brough and Lisa L Wei
Mol Ther advance online publication, June 10, 2008; doi:10.1038/mt.2008.124
June 3 2008
Original Articles
Phenotypic Correction of Hemophilia A by Ectopic Expression of Activated Factor VII in Platelets
Tsukasa Ohmori, Akira Ishiwata, Yuji Kashiwakura, Seiji Madoiwa, Katsuyuki Mitomo, Hidenori Suzuki, Mamoru Hasegawa, Jun Mimuro and Yoichi Sakata
Mol Ther advance online publication, June 3, 2008; doi:10.1038/mt.2008.117
Targeting of the CNS in MPS-IH Using a Nonviral Transferrin--L-iduronidase Fusion Gene Product
Mark J Osborn, Ron T McElmurry, Brandon Peacock, Jakub Tolar and Bruce R Blazar
Mol Ther advance online publication, June 3, 2008; doi:10.1038/mt.2008.119
May 6 2008
Original Article
Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy
Jiehua Zhou, Haitang Li, Shirley Li, John Zaia and John J Rossi
Mol Ther advance online publication, May 6, 2008; doi:10.1038/mt.2008.92
February 12 2008
Original Articles
Intraventricular Enzyme Replacement Improves Disease Phenotypes in a Mouse Model of Late Infantile Neuronal Ceroid Lipofuscinosis
Michael Chang, Jonathan D Cooper, David E Sleat, Seng H Cheng, James C Dodge, Marco A Passini, Peter Lobel and Beverly L Davidson
Mol Ther advance online publication, February 12, 2008; doi:10.1038/sj.mt.6300415
Gene Therapy of 
c-Deficient Pulmonary Alveolar Proteinosis (c-PAP): Studies in a Murine in vivo Model
Veronika Kleff, Ursula R Sorg, Carsten Bury, Takuji Suzuki, Ina Rattmann, Moran Jerabek-Willemsen, Christopher Poremba, Michael Flasshove, Bertram Opalka, Bruce Trapnell, Uta Dirksen and Thomas Moritz
Mol Ther advance online publication, February 12, 2008; doi:10.1038/mt.2008.7
Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of -Tocopherol
Kazutaka Nishina, Toshinori Unno, Yoshitaka Uno, Takayuki Kubodera, Tadashi Kanouchi, Hidehiro Mizusawa and Takanori Yokota
Mol Ther advance online publication, February 12, 2008; doi:10.1038/sj.mt.6300420
Bovine Adenoviral Vector–based H5N1 Influenza Vaccine Overcomes Exceptionally High Levels of Pre-existing Immunity Against Human Adenovirus
Neetu Singh, Aseem Pandey, Lakshmi Jayashankar and Suresh K Mittal
Mol Ther advance online publication, February 12, 2008; doi:10.1038/mt.2008.11
February 5 2008
Ranibizumab for Macular Edema Due to Retinal Vein Occlusions; Implication of VEGF as a Critical Stimulator
Peter A Campochiaro, Gulnar Hafiz, Syed Mahmood Shah, Quan Dong Nguyen, Howard Ying, Diana V Do, Edward Quinlan, Ingrid Zimmer-Galler, Julia A Haller, Sharon D Solomon, Jennifer U Sung, Yasmin Hadi, Kashif A Janjua, Nida Jawed, David F Choy and Joseph R Arron
Mol Ther advance online publication, February 5, 2008; doi:10.1038/sj.mt.6300416
A Tumor-selective Biotherapy With Prolonged Impact on Established Metastases Based on Cytokine Gene-engineered MSCs
Xiancheng Chen, Xiaojuan Lin, Jianlei Zhao, Wei Shi, Heng Zhang, Yongsheng Wang, Bing Kan, Licheng Du, Baiding Wang, Yuquan Wei, Yi Liu and Xia Zhao
Mol Ther advance online publication, February 5, 2008; doi:10.1038/sj.mt.6300409
Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer
Shengming Dai, Dong Wei, Zhen Wu, Xiangyang Zhou, Xiaomou Wei, Haixin Huang and Guisheng Li
Mol Ther advance online publication, February 5, 2008; doi:10.1038/sj.mt.6300407
TAT-mediated Delivery of LAD Restores Pyruvate Dehydrogenase Complex Activity in the Mitochondria of Patients with LAD Deficiency
Matan Rapoport, Ann Saada, Orly Elpeleg and Haya Lorberboum-Galski
Mol Ther advance online publication, February 5, 2008; doi:10.1038/sj.mt.6300410
