FIGURE 3
FROM:
Quantitative Assessment of Human Endometriotic Tissue Maintenance and Regression in a Noninvasive Mouse Model of Endometriosis
Marylène Fortin, Manon Lépine, Yannick Merlen, Isabelle Thibeault, Claudine Rancourt, Diane Gosselin, Patrice Hugo and Ann-Muriel Steff
BACK TO ARTICLEFigure 3.
Kaplan–Meier analysis of endometriotic-like lesion regression in mice lacking estradiol supplementation. Ovariectomized nude mice having received or not an E2 pellet (N = 8 for each group) were periodically imaged in triplicate, and endometriotic-like lesion size (number of pixels) was quantified with image analysis software. The time at which each mouse had a lesion with (A) a 75% or (B) a 50% reduction in its initial size was used to generate survival curves (Kaplan–Meier analysis). A significant difference was observed between E2-supplemented and nonsupplemented groups (log rank test, P = 0.0001 and P = 0.0002 for A and B, respectively).
