TABLE OF CONTENTS

Volume 9, Issue S1 (May 2004)

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Abstracts

1. Molecular Long-Term Follow Up in Non-Human Primates That Received Retrovirally Transduced Stem Cells: Despite Proto-Oncogene Insertion No Leukemia or Hematopoietic Abnormalities

Brian C. Beard, Kirsten A. Keyser, Julie Morris, Bobbie Thomasson and Hans-Peter Kiem

Mol Ther 9: S1-S1; doi:10.1016/j.ymthe.2004.05.042

2. Promoter Trapping Reveals Significant Differences in Integration Site Selection Between MLV and HIV Vectors

Michele De Palma, Eugenio Montini, Francesca R. Santoni de Sio, Alessandra Gentile, Enzo Medico and Luigi Naldini

Mol Ther 9: S1-S1; doi:10.1016/j.ymthe.2004.05.043

3. Effect of Retroviral and Lentiviral Vector Integrations on Transcription of Flanking Genes

Eugenio Montini, Daniela Cesana and Luigi Naldini

Mol Ther 9: S1-S2; doi:10.1016/j.ymthe.2004.05.084

4. In Vitro and In Vivo Analysis of Feline Immunodeficiency Virus-Based Lentiviral Vector Integration

Yubin Kang, Todd E. Scheetz, Christopher J. Moressi, Diane Thi Tran, Litao Xie, Beverly L. Davidson, Thomas L. Casavant and Paul B. McCray Jr

Mol Ther 9: S2-S2; doi:10.1016/j.ymthe.2004.05.086

5. Evaluation of the Genotoxic Potential of a Self-Inactivating |[gamma]|-Globin Lentiviral Vector

Phillip W. Hargrove, Hideki Hanawa, Steven Kepes, Cheng Cheng, Geoffrey Neale, Arthur W. Nienhuis and Derek A. Persons

Mol Ther 9: S2-S3; doi:10.1016/j.ymthe.2004.05.087

6. Investigations into the Relative Safety of Lentiviral Vectors to Oncoretroviral Vectors

Xiaobin Lu, Ziping Chen, Rene Molina, Poorna Ramamurthy, Gwendolyn K. Binder and Boro Dropulic

Mol Ther 9: S3-S3; doi:10.1016/j.ymthe.2004.05.085

7. The Risk of Integration: Cell Lines for Determining the Frequency and Character of Vector-Mediated Insertional Gene Activation

Andrea D. Converse, Nikunj V. Somia and R. Scott McIvor

Mol Ther 9: S3-S3; doi:10.1016/j.ymthe.2004.05.088

8. Integrated Self-Inactivating Lentiviral Vectors Produce Full-Length Genomic Transcripts Competent for Encapsidation and Integration

Aaron C. Logan, Dennis L. Haas, Tal Kafri and Donald B. Kohn

Mol Ther 9: S4-S4; doi:10.1016/j.ymthe.2004.05.089

9. Mobilization of Sendai Virus Vectors (SeVV) by Phylogenetic Related Human Pathogens: Implications for Future Vector Generations

Christian Bernloehr, Sascha Bossow, Sorin Armeanu, Guy Ungerechts, Michael Gregor, Wolfgang J. Neubert, Ulrich M. Lauer and Michael Bitzer

Mol Ther 9: S4-S4; doi:10.1016/j.ymthe.2004.05.090

10. Cell Cycle-Dependent Transcription from Unintegrated Lentiviral Vector DNA Internal Promoters: Analyses with Class I Integrase Mutants

Dyana Saenz, Nils Loewen, David Leske, Kyle Howell, Jonathan Holmes, Margaret Good and Eric Poeschla

Mol Ther 9: S4-S5; doi:10.1016/j.ymthe.2004.05.091

11. Reporter Gene-Based Analysis of rAAV Genome Circularization and Recombination

Douglas M. McCarty, Vivian Choi and Richard J. Samulski

Mol Ther 9: S5-S5; doi:10.1016/j.ymthe.2004.05.092

12. A New Class of Hybrid Adeno-Associated Viral Vectors with Non-Homologous ITRs Improves Directional Recombination and Dual-Vector Reconstitution of Large Transgenes

Ziying Yan, Roman Zak, Yulong Zhang and John F. Engelhardt

Mol Ther 9: S5-S6; doi:10.1016/j.ymthe.2004.05.093

13. Hot Spots for rAAV2 Vector Integration in Mice

Hiroyuki Nakai, Xiaolin Wu, Sally Fuess, Theresa Storm, Shawn Burgess, Markus Grompe and Mark A. Kay

Mol Ther 9: S6-S6; doi:10.1016/j.ymthe.2004.05.094

14. Absence of T-Shaped Structure and Deletions of B and C Hairpins Have Minimal Effects on Essential Functions of AAV Inverted Terminal Repeats

Xiaodong Zhu, Juan Li and Xiao Xiao

Mol Ther 9: S6-S6; doi:10.1016/j.ymthe.2004.05.095

15. Trans-Splicing Adeno-Associated Viral Vector-Mediated Gene Therapy Is Limited by Transcription across the ITR Junction but Not by Dual Vector Co-Infection Efficiency

Zhuping Xu, Yongping Yue, Chaoyang Ye, Jianming Qiu, David J. Pintel and Dongsheng Duan

Mol Ther 9: S6-S7; doi:10.1016/j.ymthe.2004.05.096

16. Visualization of the Foci of Recombinant AAV Replication and Their Relationship with Cellular Proteins Involved in the Recognition and Repair of Double-Stranded DNA Breaks

Tiziana Cervelli, Lorena Zentilin, Alessandro Marcello and Mauro Giacca

Mol Ther 9: S7-S7; doi:10.1016/j.ymthe.2004.05.097

17. Role of Vp2 in AAV Packaging

Joshua C. Grieger, Joseph E. Rabinowitz, Dawn E. Bowles and Richard J. Samulski

Mol Ther 9: S7-S7; doi:10.1016/j.ymthe.2004.05.098

18. Incorporation of the Green Fluorescent Protein into the Adeno-Associated Virus Type 2 Capsid

Kerstin Lux, Nico Goerlitz, Kristin Leike, Daniela Goldnau, Stefan Finke, Michael Hallek and Hildegard Buening

Mol Ther 9: S8-S8; doi:10.1016/j.ymthe.2004.05.099

19. The Transcapsidation of AAV Serotypes

Joseph E. Rabinowitz, Dawn E. Bowles, Susan M. Faust, Julie G. Ledford, Scott E. Cunningham and R. Jude Samulski

Mol Ther 9: S8-S8; doi:10.1016/j.ymthe.2004.05.100

20. Directed Evolution of AAV2 Yields Novel Capsid Variants

Narendra Maheshri, Brian Kaspar and David V. Schaffer

Mol Ther 9: S8-S8; doi:10.1016/j.ymthe.2004.05.101

21. Induction of CEA in Pulmonary Vasculature to Study Targeting Strategies for Cancer

Maaike Everts, Sang Ae Kim-Park, Long P. Le, Paul N. Reynolds, William E. Grizzle and David T. Curiel

Mol Ther 9: S9-S9; doi:10.1016/j.ymthe.2004.05.044

22. Tumor Homing of Genetically Modified Bone Marrow Cells

Zong-Yi Li, Shaoheng Ni, Tobias Neff, Dmitry Shayakhmetovvv and Andre Lieber

Mol Ther 9: S9-S9; doi:10.1016/j.ymthe.2004.05.045

23. T Cell Carriers for Gene Delivery to Tumors

Caroline Cole, Rosa M. Diaz, Michael Forshaw, Timothy Kottke, Jill Thompson, Michael Gough, Xandra Breakefield, Miguel Sena-Esteves, Jian Qiao and Richard G. Vile

Mol Ther 9: S9-S10; doi:10.1016/j.ymthe.2004.05.046

24. Antibody-Targeted Fusion Provides a Versatile Platform for Novel Targeted Therapies

Takafumi Nakamura, Kah-Whye Peng, Sompong Vongpunsawad, Mary Harvey, Hiroyuki Mizuguchi, Takao Hayakawa, Roberto Cattaneo and Stephen J. Russell

Mol Ther 9: S10-S10; doi:10.1016/j.ymthe.2004.05.047

25. Molecular Imaging-Guided Gene Therapy of Experimental Gliomas

Maria A. Rueger, Alexandra Winkeler, Lisa Li, Benedikt Rueckriem, Stefan Vollmar, Wolf D. Heiss and Andreas H. Jacobs

Mol Ther 9: S10-S11; doi:10.1016/j.ymthe.2004.05.048

26. Tropism Illustrated: How a Morbillivirus Takes Over the Immune System

von Messling Veronika, Milosevic Dragana and Cattaneo Roberto

Mol Ther 9: S11-S11; doi:10.1016/j.ymthe.2004.05.049

27. Differential Phage Display for Discovery of Nuclear Localization Peptides: Application to Mammary Adenocarcinoma

Ashley A. Weiner and Todd D. Giorgio

Mol Ther 9: S11-S12; doi:10.1016/j.ymthe.2004.05.050

28. A clinically relevant ex vivo toxicity assay using human liver slices to determine specificity of oncolytic viruses

Marianne G. Rots, Marieke GL Elferink, Dorenda Oosterhuis, Peter Olinga, David T. Curiel, Hidde J. Haisma and Geny M. M. Groothuis

Mol Ther 9: S12-S12; doi:10.1016/j.ymthe.2004.05.051

29. In Vivo Imaging and Therapy of Breast Cancer Xenografts Following MUC1 Promoter-Driven Expression of the Sodium Iodide Symporter (NIS)

Roisin M. Dwyer, Elizabeth R. Bergert, Michael K. O'Connor, Sandra J. Gendler and John C. Morris

Mol Ther 9: S12-S12; doi:10.1016/j.ymthe.2004.05.052

30. Patient Oriented DNA Based Therapy from the Bench to the Patient

Patricia Ohana, Ofer Gofrit, Basem Ayesh, Imad Matouk, Tatiana Birman, Suhail Ayesh, Aya Mizrahi, Ami Sidi, Tamar Schneider, Nathan de Groot and Abraham Hochberg

Mol Ther 9: S13-S13; doi:10.1016/j.ymthe.2004.05.053

31. Creation of a Hemophilia B Mouse Expressing Defective Human Factor IX

Paul E. Monahan, Tai-Ping Zhang, Da-Yun Jin, Tong Gui and Darrel W. Stafford

Mol Ther 9: S13-S13; doi:10.1016/j.ymthe.2004.05.054

32. Efficacy and Safety of Mouse Coagulation Factor VIIa Gene Transfer in Hemophilia B Mice

Majed N. Aljamali, Paris Margaritis, Valder R. Arruda, Alexander Schlachterman, Rodney M. Camire and Katherine A. High

Mol Ther 9: S14-S14; doi:10.1016/j.ymthe.2004.05.055

33. Induction of Antigen-Specific T Cell Anergy and Deletion by Hepatic AAV Gene Transfer

Eric Dobrzynski, Lixin Wang, Ou Cao, Federico Mingozzi and Roland W. Herzog

Mol Ther 9: S14-S14; doi:10.1016/j.ymthe.2004.05.056

34. Retroviral Vector-Mediated Neonatal Gene Therapy Results in Long-Term and Therapeutic Levels of Canine Factor VIII Expression in Hemophilia A Mice and Dogs

Lingfei Xu, Timothy C. Nichols, Rita Sarkar, Stephanie McCorquodale, Dwight Bellinger and Katherine P. Ponder

Mol Ther 9: S14-S15; doi:10.1016/j.ymthe.2004.05.057

35. Downregulation of Immune Responses Induced by Oral DNA Administration

Andrew Gomez Vargas and Gonzalo Hortelano

Mol Ther 9: S15-S15; doi:10.1016/j.ymthe.2004.05.058

36. Permanent Phenotypic Correction of Haemophilia B in Immunocompetent Mice by Prenatal Gene Therapy

Simon N. Waddington, Megha S. Nivsarkar, Ajay R. Mistry, Suzanne M. K. Buckley, Geoffrey Kemball-Cook, Karen L. Mosley, Kyriacos Mitrophanous, Pippa Radcliffe, Maxine V. Holder, Mairi Brittan, Tassos Georgiadis, Faisal Al-Allaf, Brian W. Bigger, Lisa G. Gregory, Terence H. Cook, Robin R. Ali, Adrian Thrasher, Edward G. D. Tuddenham, Mike Themis and Charles Coutelle

Mol Ther 9: S15-S15; doi:10.1016/j.ymthe.2004.05.059

37. Duration of Immunologically Detectable AAV-2 Capsid in an Animal Model

Denise E. Sabatino, Federico Mingozzi, David C. Brooks, Alex Schlachterman, Shyrie Edmonson, Linda Couto, Peter Colosi, Haifeng Chen, Hildegund C. J. Ertl and Katherine A. High

Mol Ther 9: S16-S16; doi:10.1016/j.ymthe.2004.05.060

38. AAV-mediated gene therapy for systemic lupus erythematosus (SLE)

Xiaojing Ye, Tong Zhu, Juan Li and Xiao Xiao

Mol Ther 9: S16-S16; doi:10.1016/j.ymthe.2004.05.061

39. Reversal of Diabetes by Inducing Islet Neogenesis Using Helper Dependent Adenovirus Mediated Gene Therapy

Vijay Yechoor, Hideto Kojima, Mineko Fujimiya, Bonne Thompson, Benny Chang, Laura Nelly, Philip Ng and Lawrence Chan

Mol Ther 9: S16-S17; doi:10.1016/j.ymthe.2004.05.062

40. Correction of Dyslipidemia in Murine and Feline Models of Lipoprotein Lipase Deficiency by Intramuscular Administration of AAV1-LPLS447X

Colin J. D. Ross, Jaap Twisk, Jan Albert Kuivenhoven, Guoqing Liu, Fudan Miao, Karen van den Oever, Maarten Beetz, Dennis Verbart, Andrew Bakker, Paul P. A. Oranje, Wim T. Hermens, Paul Dijkhuizen, John J. P. Kastelein, Janneke J. M. Meulenberg and Michael R. Hayden

Mol Ther 9: S17-S17; doi:10.1016/j.ymthe.2004.05.063

41. Ex Vivo Gene Therapy Provides a Unique Therapeutic Benefit and Corrects Metachromatic (MLD) and Globoid (GLD) Leukodystrophy in the Mouse Models

Alessandra Biffi, Ilaria Visigalli, Angelo Quattrini, Ilaria Bertani, Michele De Palma, Ubaldo Del Carro, Riccardo Brambilla, Sergio Marchesini, Claudio Bordignon and Luigi Naldini

Mol Ther 9: S17-S18; doi:10.1016/j.ymthe.2004.05.064

42. AAV-mediated gene therapy causes functional improvements in a murine model of infantile neuronal ceroid lipofuscinosis (INCL, Batten Disease)

M. Griffey, D. Wozniak, M. Wong, S. Rothman, E. Bible, J. Cooper, C. Vogler and M. Sands

Mol Ther 9: S18-S18; doi:10.1016/j.ymthe.2004.05.065

43. Immunological Response Characterization in an Alzheimer's Disease Mouse Model Following HSV Amplicon-Based A|[beta]| Vaccination

William J. Bowers, Michael A. Mastrangelo, Hilary A. Stanley, Ya-Hui Chiu and Howard J. Federoff

Mol Ther 9: S18-S18; doi:10.1016/j.ymthe.2004.05.068

44. AAV Retrograde Transport Potential and Therapeutic Approaches for ALS

Brian K. Kaspar, Jeronia Vich, Lindsey Christian, Jeffrey D. Rothsten and Fred H. Gage

Mol Ther 9: S18-S19; doi:10.1016/j.ymthe.2004.05.066

45. Adenoviral tetanus toxin light chain gene expression in the brainstem induces specific motor inhibition

Ajit A. Krishnaney, Zuowei Zhao, Qingshang Teng, James Liu, Diana Tenase, Mary Garrity-Moses, Michael Davis and Nicholas M. Boulis

Mol Ther 9: S19-S19; doi:10.1016/j.ymthe.2004.05.067

46. Clinical and Functional Recovery from Experimental Autoimmune Encephalomyelitis by Intracisternal Delivery of IL4 from a Helper-Dependent Adenoviral Vector. A Pre-Clinical Model of Gene Therapy of Multiple Sclerosis

Erica Butti, Alessandra Recchia, Alessandra Bergami, Anna Stornaiuolo, Elena Brambilla, Roberto Furlan, Gianvito Martino and Fulvio Mavilio

Mol Ther 9: S19-S20; doi:10.1016/j.ymthe.2004.05.069

47. Cytokine gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model

Kazuhiko Kurozumi, Kiminori Nakamura, Tomotsugu Ichikawa, Yasuhiro Ono, Takashi Tamiya, Yoshinori Ito, Osamu Honmou, Kiyohiro Houkin, Hirofumi Hamada and Isao Date

Mol Ther 9: S20-S20; doi:10.1016/j.ymthe.2004.05.070

48. In vivo and in situ delivery of huntingtin-specific single-chain Fv intrabody genes as therapeutic agents for Huntington's disease

Todd W. Miller, William J. Wolfgang, Kevin Manley, Yangsheng Zhou, Chun Zhou, Jack M. Webster, Nicholas D. Mazarakis and Anne Messer

Mol Ther 9: S20-S21; doi:10.1016/j.ymthe.2004.05.071

49. AAV Vector-Mediated Gene Delivery of Aromatic L-Amino Acid Decarboxylase Restored L-DOPA Efficacy in a Primate Bilateral Model of Parkinson's Disease

Shin-ichi Muramatsu, Fumiko Ono, Yuko Nara, Mika Kodera, Naomi Takino, Junko Tsuchida, Katsuyoshi Kawasaki, Kunihiko Ikeguchi, Kenichi Fujimoto, Hideo Tsukada, Keiji Terao, Imaharu Nakano and Keiya Ozawa

Mol Ther 9: S21-S21; doi:10.1016/j.ymthe.2004.05.072

50. AAV-Mediated Expression and Secretion of ADNF-9 Protects Substantia Nigra Neurons from 6-OHDA Damage

Sophia Papadeas, George R. Breese and Thomas J. McCown

Mol Ther 9: S21-S21; doi:10.1016/j.ymthe.2004.05.073

51. A Novel Approach to Stem Cell Gene Therapy: Controlling Stem Cell ifferentiation with Engineered Zinc-Finger Protein Transcription Factors

Victor V. Bartsevich, Jeffrey C. Miller, Casey C. Case and Carl O. Pabo

Mol Ther 9: S21-S22; doi:10.1016/j.ymthe.2004.05.074

52. Gut Enriched Kruppel-Like Factor (GKLF) Inhibits Differentiation and Induces Self-Renewal of Murine Embryonic Stem Cells

Rebecca J. Chan, Yanjun Li, Li Zhong and Mervin C. Yoder

Mol Ther 9: S22-S22; doi:10.1016/j.ymthe.2004.05.075

53. Inducable FGFr-1 stimulates self renewal of hematopoietic cells

Michael A. Weinreich and C. Anthony Blau

Mol Ther 9: S22-S22; doi:10.1016/j.ymthe.2004.05.078

54. Restriction of Transgene Expression to the B-Lymphoid Progeny of Human Lentivirally Transduced CD34+ Cells

Thomas Moreau, Florence Bardin, Jean Imbert, Christian Chabannon and Cecile Tonnelle

Mol Ther 9: S23-S23; doi:10.1016/j.ymthe.2004.05.076

55. Alteration of Primitive Hematopoietic Cell Fate and Growth by the GATA-2 Transcription Factor

Stacy L. Throm and Derek A. Persons

Mol Ther 9: S23-S23; doi:10.1016/j.ymthe.2004.05.077

56. Intraplacental Gene Transfer of IGF-1 Corrects Intrauterine rowth Restriction in the Rabbit Model

Sundeep G. Keswani, Anna B. Katz, Elliot B. Kozin, Phillip W. Zoltic and Timothy M. Cromblehome

Mol Ther 9: S24-S24; doi:10.1016/j.ymthe.2004.05.037

57. Persistent PEDF Expression Following Intravitreal Administration of High-Capacity Adenovectors

Joseph T. Bruder, Ping Chen, Kurt Kroeger, Melissa Hamilton, Miguel Carrion, Douglas E. Brough, Lisa L. Wei, C. Richter King, Peter A. Campochiaro and Peter Gehlbach

Mol Ther 9: S24-S24; doi:10.1016/j.ymthe.2004.05.038

58. Toward Adenoviral Mediated RNA Interference for the Treatment of Hepatitis B Virus Infection

Anton P. McCaffrey, Kusum Pandey, Anja Ehrhardt, Zan Huang and Mark A. Kay

Mol Ther 9: S24-S25; doi:10.1016/j.ymthe.2004.05.039

59. Development of Conditionally Replicative Adenoviruses as Platforms for the Expression of shRNAs or Therapeutic Genes

Jan E. Carette, Frederik H. E. Schagen, Ren|[eacute]|e M. Overmeer, Jeroen D.C. Mastenbroek, Winald R. Gerritsen and Victor W. van Beusechem

Mol Ther 9: S25-S25; doi:10.1016/j.ymthe.2004.05.040

60. Site-specific integration in human somatic cell DNA by adeno/AAV hybrid vectors

Alessandra Recchia, Laura Perani, Daniela Sartori, Clelia Olgiati and Fulvio Mavilio

Mol Ther 9: S25-S26; doi:10.1016/j.ymthe.2004.05.041

61. Prevention of liver cirrhosis development in rats with recombinant SV40 vectors expressing IGF-I

Maria Vera, Laura Martinez, Mikel Zaratiegui, Carlos M. Rodriguez, Jesus Prieto and Puri Fortes

Mol Ther 9: S26-S26; doi:10.1016/j.ymthe.2004.05.080

62. Ras Signaling as a Marker for Application of Oncolytic Herpes Mutant Against Lymphoma

Faris Farassati, Natasha Atanaskova, Corey Raffel, Patrick Johnston and Patrick Lee

Mol Ther 9: S26-S26; doi:10.1016/j.ymthe.2004.05.079

63. Re-directed herpes simplex virus infection by a soluble, bi-specific adapter protein for gD in combination with nectin-1 blocking agents

Kenji Nakano, Ryutaro Asano, Kohei Tsumoto, William F. Goin, Izumi Kumagai, Justus B. Cohen and Joseph C. Glorioso

Mol Ther 9: S26-S26; doi:10.1016/j.ymthe.2004.05.081

64. Bioluminescence Imaging of Regulated Gene Expression Using HSV-1 Amplicon Vectors in Rodent Brain

Sam Wang, Jeremy Petravicz and Xandra O. Breakefield

Mol Ther 9: S27-S27; doi:10.1016/j.ymthe.2004.05.082

65. Systemic Cancer Therapy with an Enhanced Tumor-Selective Vaccinia Virus Lacking Anti-Apoptosis Viral Genes Spi-2 and Spi-1

Zongsheng Guo, Arpana Naik, Yun Hu, Richard DeMarco, Mark O'Malley, Richard Alexander, Bernard Moss, Mike Lotze and David L. Bartlett

Mol Ther 9: S27-S27; doi:10.1016/j.ymthe.2004.05.083

66. A safe and efficient lentiviral vector system: optimisation of virus production and purification

Donald S. Anson

Mol Ther 9: S27-S27; doi:10.1016/j.ymthe.2004.06.001

67. Bovine Immunodeficiency Virus Based Lentiviral Vector with Improved Safety Features

Rene P. Molina, Hongqing Q. Ye, James Brady, Jingli Zhang, Heather Zimmerman, Michael Kaleko and Tianci Luo

Mol Ther 9: S28-S28; doi:10.1016/j.ymthe.2004.06.002

68. Improved lentiviral vector system with enhanced safety features

Jill Oldenburg, Aaron C. Logan, Maria Barcova, Celina Ngiam and Paula M. Cannon

Mol Ther 9: S28-S28; doi:10.1016/j.ymthe.2004.06.003

69. Closing-in on the titer gap between transient transfection and packaging cell lines

Adam S. Cockrell, Kailing Fu, Hong Ma, Thomas McCown and Tal Kafri

Mol Ther 9: S28-S28; doi:10.1016/j.ymthe.2004.06.004

70. Stable packaging cell lines development for the production of lentiviral vectors

Sophie Broussau, Nadine Jabbour, Guillaume Lachapelle, Yan Xu, Alaka Mullick, Renald Gilbert and Bernard Massie

Mol Ther 9: S29-S29; doi:10.1016/j.ymthe.2004.06.005

71. Chimeric lentiviral vectors derived from HIV-1 and HIV-2

Suresh K. Arya, Jenice D'Costa, Geetanjali Sachdeva, Jean Cho and Kritika Kachapati

Mol Ther 9: S29-S29; doi:10.1016/j.ymthe.2004.06.006

72. Position and Copy Number Dependence of the Central Polypurine Tract (cPPT) Function in Simple and Complex Lentiviral Vectors

Alex H. Chang, Leszek Lisowski, Matthias Stephan, Isabelle Rivi|[egrave]|re and Michel Sadelain

Mol Ther 9: S29-S30; doi:10.1016/j.ymthe.2004.06.007

73. An inhibitory effect of a sequence just upstream of the central polypurine tract of HIV-1 on RNA production of an HIV-1-based vector

Ryuta Sakuma, Aikichi Iwamoto and Yoshihiro Kitamura

Mol Ther 9: S30-S30; doi:10.1016/j.ymthe.2004.06.008

74. Factors affecting long terminal repeat (LTR)-driven gene expression using VL30 retro-vectors and DNA plasmid vectors

Jim Williams, Jeremy Luke and Clague Hodgson

Mol Ther 9: S30-S30; doi:10.1016/j.ymthe.2004.06.009

75. The Optimization of a Single-LTR HIV-1 Vectors for Functional Genomic Applications

Hong Ma and Tal Kafri

Mol Ther 9: S30-S31; doi:10.1016/j.ymthe.2004.06.010

76. Development of multigene lentiviral vectors containing the encephalomyocarditis virus IRES and foot-and-mouth disease virus 2A cleavage factor

Dhanalakshmi Chinnasamy, Michael Milsom, James Neuenfeldt, Geoffrey P. Margison, Leslie J. Fairbairn and Nachimuthu Chinnasamy

Mol Ther 9: S31-S31; doi:10.1016/j.ymthe.2004.06.011

77. Production and Purification of Measles Virus for Oncolytic Virotherapy Clinical Trials

Kirsten K. Langfield, Troy R. Wegman, Henry J. Walker, Guy E. Griesmann, Julie A. Sauer, Sharon A. Stephan and Mark J. Federspiel

Mol Ther 9: S31-S31; doi:10.1016/j.ymthe.2004.06.012

78. Enhancement of Retroviral-Mediated Gene Transfer by Purification of Virus Stocks from Inhibitors of Transduction

Natalia Landazuri and Joseph M. Le Doux

Mol Ther 9: S32-S32; doi:10.1016/j.ymthe.2004.06.013

79. Validation of viable producer cell removal/inactivation from clinical-grade oncoretroviral vector supernatant produced in cell factories

Mark Przybylowski, Amir Hakakha, Yong Fan and Isabelle Riviere

Mol Ther 9: S32-S32; doi:10.1016/j.ymthe.2004.06.014

80. A Rapid and Effective Lentivirus Purification Procedure

Christine R. Rowley, Patrick L. Sinn, Linda Bullinga, Paul B. McCray Jr. and Beverly L. Davidson

Mol Ther 9: S32-S32; doi:10.1016/j.ymthe.2004.06.015

81. Modification of HEK 293 cell integrin expression profile allows convenient large-scale roller bottle production of lentiviral vectors

Manij Patel, David A. Wilcox, Angela M. Giddings, Tristan R. McKay and John C. Olsen

Mol Ther 9: S33-S33; doi:10.1016/j.ymthe.2004.06.016

82. Adaptation of a lentiviral vector producer cell line to reduced-serum, suspension culture for large scale production

Kay Townsend, Yong Chen, Jonathan Dayao, Deborah Farson, William M. Miller and Andy Lin

Mol Ther 9: S33-S33; doi:10.1016/j.ymthe.2004.06.017

83. Development of an RCL assay for EIAV based products

James E. Miskin, Holger Roehl, Denise Westfall, Jonathan Rohll, Daniel Chipchase, Douglas Jolly, Susan M. Kingsman and Kyriacos A. Mitrophanous

Mol Ther 9: S33-S33; doi:10.1016/j.ymthe.2004.06.018

84. Enhanced detection method for retrovirus in vaccine

Ji Young Yoo, Beom-Seok Suh, Sue Nie Park, Joo-Hang Kim and Chae-Ok Yun

Mol Ther 9: S34-S34; doi:10.1016/j.ymthe.2004.06.037

85. High-Level Expression of Wild-Type p53 from the Novel p53-Responsive pCLPG Retrovirus Halts the Proliferation of Tumor Cells Regardless of Their p53 Status

Bryan E. Strauss, Marcio C. Bajgelman and Eugenia Costanzi-Strauss

Mol Ther 9: S34-S34; doi:10.1016/j.ymthe.2004.06.019

86. Mutation Frequency of the p53 cDNA Introduced by the Retroviral Vector

Su Su, Atushi Watanabe and Takashi Shimada

Mol Ther 9: S34-S35; doi:10.1016/j.ymthe.2004.06.020

87. APOBEC3G and Immunity to retroviruses

Reuben S. Harris

Mol Ther 9: S35-S35; doi:10.1016/j.ymthe.2004.06.021

88. AAV clades: Their Ability To Recombine and Cross Species-Barriers

Luk H. Vandenberghe, Guangping Gao, Mauricio R. Alvira, Roberto Calcedo and James M. Wilson

Mol Ther 9: S35-S35; doi:10.1016/j.ymthe.2004.06.024

89. Isolation of a Close AAV5 Relative from Goat Tissues: Evidence of Host Promiscuity

Alejandra E. Arbetman, Michael A. Lochrie, Britta Randlev, Richard T. Surosky, Shangzhen Zhou, Jennifer Wellman, Cheryl Pater, Howard Lehmkuhl, Lea Ann Hobbs, Glenn Pierce and Peter Colosi

Mol Ther 9: S35-S36; doi:10.1016/j.ymthe.2004.06.038

90. Evaluation of Novel Gene Transfer Vectors Derived from Infectious Molecular Clones of Primate AAVs

Xiaoyang Zhou, Guangping Gao, Roland A. Owens, Roberto Calcedo and James M. Wilson

Mol Ther 9: S36-S36; doi:10.1016/j.ymthe.2004.06.025

91. Universal purification of AAV serotypes 1|[ndash]|5 modified to contain a heparin binding epitope

Susan M. Faust, Dawn E. Bowles, Scott E. Cunningham, Joseph E. Rabinowitz and R. Jude Samulski

Mol Ther 9: S36-S36; doi:10.1016/j.ymthe.2004.06.026

92. Metabolically Biotinylated Adeno-Associated Virus (AAV) Types 1, 2, 3, 4 and 5 for Scalable Purification and Vector Retargeting

A. Kate Sasser, Gregory S. Arnold and Jeffrey S. Bartlett

Mol Ther 9: S37-S37; doi:10.1016/j.ymthe.2004.06.027

93. Targeting AAV to Brain Vascular Endothelium

Yong Hong Chen and Beverly L. Davidson

Mol Ther 9: S37-S37; doi:10.1016/j.ymthe.2004.06.028

94. Targeting Endothelial Cells in Mice with Adeno-Associated Virus Serotype 1 Vector

Haiyan Fu, Joseph Muenzer, Richard J. Samulski, Kang Lu, Jerillyn S. Jennings and Douglas M. McCarty

Mol Ther 9: S37-S38; doi:10.1016/j.ymthe.2004.06.029

95. Retargeting AAV-2 to Angiogenic Endothelial Cells with Tumor Vasculature Specific Capsid Variants

Andreas Riederer, Bernard Kaess, Luca Perabo, Hildegard Buening and Michael Hallek

Mol Ther 9: S38-S38; doi:10.1016/j.ymthe.2004.06.030

96. Transgene Expression from Recombinant AAV-8 Vectors in the Liver Occurs Independently of the Serotype Origin of the Viral Inverted Terminal Repeats

Dirk Grimm, Hiroyuki Nakai, Theresa A. Storm, Efren P. Riu and Mark A. Kay

Mol Ther 9: S38-S38; doi:10.1016/j.ymthe.2004.06.031

97. Selection of Potent AAV Pseudotypes To Transduce Rat Pancreatic Islets

Brigitte Le Mauff, Fran|[ccedil]|oise Boeffard, Nasro Benrezzak and Ignacio Anegon

Mol Ther 9: S38-S39; doi:10.1016/j.ymthe.2004.06.032

98. Adeno-Associated Virus SerOtype 8 as a Vector for HEPATIC Delivery of alpha-1 Anti-Trypsin (AAT)

Thomas J. Conlon, Travis L. Cossette and Terence R. Flotte

Mol Ther 9: S39-S39; doi:10.1016/j.ymthe.2004.06.033

99. Long-term Expression of Soluble TNFR:Fc Protein Following Multiple Administrations of AAV-TNFR:Fc Vector Pseudotyped with Capsids of Alternate Serotypes

Ziv Sandalon, Kurt Lustig and Haim Burstein

Mol Ther 9: S39-S39; doi:10.1016/j.ymthe.2004.06.034

100. An Evaluation of the Use of Adeno-Associated Virus Serotypes AAV1 and AAV8 To Obtain Stable Therapeutic Levels of Apolipoprotein A-I in Mouse Plasma

Karen F. Kozarsky, Deborah A. Welham and Mary H. Donahee

Mol Ther 9: S39-S40; doi:10.1016/j.ymthe.2004.06.035

101. Toxicology and Biodistribution Studies of a Recombinant Adeno-Associated Virus 2 (rAAV2) Alpha-1 Antitrypsin (AAT) Vector

Amy E. Poirier, Lynn A. Combee, Ashley T. Martino and Terence R. Flotte

Mol Ther 9: S40-S40; doi:10.1016/j.ymthe.2004.06.036

102. Catheter-Based Intrahepatic rAAV Gene Delivery: Influence of Infusion Flow Rate and Volume on Uptake

Lin He, Dea Nagy, Joe Vargas, Tongyao Liu, Ciaran Scallan, Shangzhen Zhou, Sharmila Vijay, Jurg Sommer, Kirk W. Johnson, Linda B. Couto, Pierce F. Glenn and Bin Yang

Mol Ther 9: S40-S40; doi:10.1016/j.ymthe.2004.06.039

103. Comparison of the Efficacy on Gene Transfer by AAV Vectors Delivered by Distinct Routes of Administration to the Liver of Hemophilia B Dogs

Valder Arruda, Ciaran Scallan, Haiyan Jiang, Linda Couto, Roland W. Herzog, Timothy Nichols, Glenn Pierce and Katherine A. High

Mol Ther 9: S40-S41; doi:10.1016/j.ymthe.2004.06.040

104. A novel Deletion in the FVIII B-Domain That Reduces Transgene Size While Preserving FVIII Activity

Yi-Lin Liu, Hua Zhu, Alexander Schlachterman, Heesoon Chang, Rodney M. Carime and Katherine A. High

Mol Ther 9: S41-S41; doi:10.1016/j.ymthe.2004.06.041

105. Optimization of Short-Hairpin RNAs for the Treatment of the Hepatitis C Virus Using AAV Vectors with Multiple Expression Cassettes

Peter W. Roelvink, David A. Suhy, Alexander A. Kolykhalov, Sara M. Cunningham, Taka Mizutani and Mark A. Kay

Mol Ther 9: S41-S41; doi:10.1016/j.ymthe.2004.06.042

106. Functional Human alpha 1 Antitrypsin Secreted from Muscle Transduced by Adeno-Associated Virus (rAAV1) Vector

Yuanqing Lu, Martha Compbell-Yhompason, Chengwen Li, Terence R. Flotte and Sihong Song

Mol Ther 9: S41-S42; doi:10.1016/j.ymthe.2004.06.043

107. Use of Adeno-Associated Viral Vectors for Effective Delivery of Engineered Zinc Finger Protein Transcription Factors

Yuxin Liang, Linda Hinh, Steve Zhang, Lei Zhang, Deng-Feng Xia, Kristine Venstrom, S. Kaye Spratt, Edward Rebar and Casey Case

Mol Ther 9: S42-S42; doi:10.1016/j.ymthe.2004.06.044

108. In Vitro Down-Regulation of Transgene Expression with Cre/loxP Mediated Recombination

J. Lawrence Merritt II, Jan Daniels and David B. Schowalter

Mol Ther 9: S42-S42; doi:10.1016/j.ymthe.2004.06.045

109. Cyclical Mechanical Stretch and AAV2 Mediated Gene Transfer to Cultured Human Vascular Cells

Sabyasachi Sen, Jeff S. Bartlett, Yvonne Birney, Paul Cahill and Timothy O'Brien

Mol Ther 9: S42-S42; doi:10.1016/j.ymthe.2004.06.046

110. Helper-Dependent Adenovirus with the Cytokeratin-18 Promoter Produces Greater Transepithelial Chloride Current and More Persistent Transgene Expression Than the CMV Promoter in Differentiated Human Airway Epithelia

Sara L. Farmen, Philip H. Karp, Philip Ng, David R. Koehler, Jim Hu, Joseph Zabner and Michael J. Welsh

Mol Ther 9: S42-S43; doi:10.1016/j.ymthe.2004.06.047

111. A chimeric Adenovirus Vector Encoding Reovirus Attachment Protein sigma 1 Targets Cells Expressing Junctional Adhesion Molecule 1 and Sialic acid

George T. Mercier, Jacquelyn A. Campbell, James D. Chappell, Terence S. Dermody, Thilo Stehle and Michael A. Barry

Mol Ther 9: S43-S43; doi:10.1016/j.ymthe.2004.06.048

112. Gene Transfer into a Hematopoietic Cell Line Using a Helper-Dependent Adenoviral Vector with the Chimeric Ad5/35 Fiber

Michael A. Balamotis, Katie Huang and Ko Mitani

Mol Ther 9: S43-S43; doi:10.1016/j.ymthe.2004.06.049

113. Role of CD46 on Ad35 Vector-Mediated Transduction

Fuminori Sakurai, Hiroyuki Mizuguchi, Kenji Kawabata, Naokazu Inoue, Masaru Okabe, Teruhide Yamaguchi and Takao Hayakawa

Mol Ther 9: S44-S44; doi:10.1016/j.ymthe.2004.06.050

114. Adenoviral Vectors for Gene Therapy with Improved Entry of Malignant Glioma

Eric Brouwer, Olga J. Ophorst, Menzo J. E. Havenga, Bertie H. C. G. M. de Leeuw, Rob C. Hoeben and Peter A. E. Sillevis Smitt

Mol Ther 9: S44-S44; doi:10.1016/j.ymthe.2004.06.051

115. Genetic Fiber Mosaic Adenovirus Confers New Properties to Adenoviral Particles

Larisa Pereboeva, Svetlana Komarova and David T. Curiel

Mol Ther 9: S44-S45; doi:10.1016/j.ymthe.2004.06.052

116. Members of Adenovirus Subgroup B Utilize CD80 (B7.1) and CD86 (B7.2) as Primary Cellular Attachment Receptors

Joshua J. Short, Alexander V. Pereboev, Yosuke Kawakami, Chenthamarakshan Vasu, Mark J. Holterman and David T. Curiel

Mol Ther 9: S45-S45; doi:10.1016/j.ymthe.2004.06.082

117. Antitumor Immunity Induced by Adenovirus Vector-Mediated Transduction of OX40 Ligand

Toshiaki Kikuchi, Sita Andarini and Toshihiro Nukiwa

Mol Ther 9: S45-S45; doi:10.1016/j.ymthe.2004.06.055

118. Efficient Infection of Head and Neck Cancer Cells by Ad5/35 Hybrid Virus

Elina Suominen, Reidar Grenman and Mikko Savontaus

Mol Ther 9: S46-S46; doi:10.1016/j.ymthe.2004.06.056

119. Studies on the Targeting of Adenoviral Vectors Carrying a Tumor-Cell Specific Peptide

Karola Rittner, Valerie Schreiber, Klaus Schughart, Nicolas Futin, Catherine Ledoux and Monika Lusky

Mol Ther 9: S46-S46; doi:10.1016/j.ymthe.2004.06.059

120. Transient Saturation of the Reticuloendothelial System by Non-Cytotoxic Liposomes Increases Hepatocyte Transduction After Adenoviral Gene Transfer

Jan Snoeys, Geertrui Mertens, Joke Lievens, D|[eacute]|sir|[eacute]| Collen, Eric Biessen and Bart De Geest

Mol Ther 9: S47-S47; doi:10.1016/j.ymthe.2004.06.061

121. Specific Targeting of Adenoviral Vectors Using the Reovirus Attachment Protein

Frederik H. E. Schagen, Jan E. Carette, Terence S. Dermody, Winald R. Gerritsen and Victor W. van Beusechem

Mol Ther 9: S47-S47; doi:10.1016/j.ymthe.2004.06.062

122. Expression of hCD40 in the Pulmonary Endothelium Targeted Via a Fiber-Modified Adenovirus Improves Gene Delivery to the Lung

Miiru Izumi, Yosuke Kawakami, Joel N. Glasgow, Natalya Belousova and David T. Curiel

Mol Ther 9: S47-S48; doi:10.1016/j.ymthe.2004.06.063

123. Adenovirus Type 11 Based Vectors as a Platform for Treatment of Metastatic and Hematopoietic Disease

Daniel Stone and Andre Lieber

Mol Ther 9: S48-S48; doi:10.1016/j.ymthe.2004.06.064

124. Efficient Transduction and Activation of Dendritic Cells by Adenoviral Vectors Targeted to DC-SIGN

Nikolay Korokhov, Wayne A. Aldrich, Alex Krendelchtchikov, Angela Granelli-Piperno, Papia T. Banerjee, Stephen D. Gillies, Pierre L. Triozzi, Abner M. Mhashilkar and David T. Curiel

Mol Ther 9: S48-S49; doi:10.1016/j.ymthe.2004.06.065

125. Formulation and In Vitro Properties of Adenovirus-Polylactide Nanoparticle Affinity-based and Magnetic Composites

Michael Chorny, Ilia Fishbein, Ivan S. Alferiev, Origene Nyanguile and Robert J. Levy

Mol Ther 9: S49-S49; doi:10.1016/j.ymthe.2004.06.066

126. Zc-Ad Vector: A Novel Immunotargeting Vector with a Modified Fc-binding Domain

Sam C. Noureddini, Nikolay Korokhov, Abner Mhashilkar, Joanne T. Douglas and David T. Curiel

Mol Ther 9: S49-S49; doi:10.1016/j.ymthe.2004.06.067

127. Adenovirus type 5 vectors pseudotyped with fibers from subgroup D (19p and 37) show detargeting from hepatocytes in vitro and in vivo

Laura Denby, Delyth Graham, Dan J. Von Seggern, Stuart A. Nicklin and Andrew H. Baker

Mol Ther 9: S50-S50; doi:10.1016/j.ymthe.2004.06.083

128. Use of chimeric adenoviral vectors to assess capsid neutralization determinants

Soumitra Roy, David Clawson, Corinna Lebherz, Roberto Calcedo, Julio Sanmiguel, Di Wu and James M. Wilson

Mol Ther 9: S50-S50; doi:10.1016/j.ymthe.2004.06.084

129. Infectivity enhancement of an adenovirus vector via genetic incorporation of the reovirus spike protein sigma 1

Yuko Tsuruta, Larisa Pereboeva, Joel N. Glasgow, Cindy L. Luongo, Svetlana Komarova, Yosuke Kawakami and David T. Curiel

Mol Ther 9: S50-S51; doi:10.1016/j.ymthe.2004.06.085

130. Targeting of adenovirus vectors to mesothelin via a bispecific antibody reveals enhanced gene transfer to human pancreatic cancer cells

Michael A. van Geer, Ira Pastan, Victor W. van Beusechem, Hidde J. Haisma, Piter J. Bosma, Dirk J. Gouma and John G. Wesseling

Mol Ther 9: S51-S51; doi:10.1016/j.ymthe.2004.06.086

131. Cell-targeting ligand discovery using context-specific phage-presenting peptide libraries

Debadyuti Ghosh and Michael A. Barry

Mol Ther 9: S51-S51; doi:10.1016/j.ymthe.2004.06.087

132. Lentivirus-mediated expression of adenovirus fibers for the complementation or packaging of fiber gene-mutated or -deleted adenovirus vectors

Taco G. Uil, Jort Vellinga, On Ying Chan, Stephanie van der Heijdt and Rob Hoeben

Mol Ther 9: S51-S52; doi:10.1016/j.ymthe.2004.06.088

133. Enhanced expression of ABCA4 stargardt protein mediated by adenoviral vectors in a simulated ocular environment

Joshua N. Mallam, Mary Y. Hurwitz, Donna Palmer, Philip Ng and Richard L. Hurwitz

Mol Ther 9: S52-S52; doi:10.1016/j.ymthe.2004.06.089

134. Structural requirements of adenovirus targeting via by modification of minor capsid protein IX

Rob C. Hoeben, Steve J. Cramer, Leif Lindholm, Martijn J. Rabelink, Diana J. Van den Wollenberg, Stephanie Van der Heijdt and Jort Vellinga

Mol Ther 9: S52-S52; doi:10.1016/j.ymthe.2004.06.090

135. A new ligand-pseudoreceptor system for the generation of adenoviral vectors with altered tropism

Yue Zeng, Jairo Jaime, Lucie Bourget, Dreg D. Crescenzo, Maureen O'Connor and Bernard Massie

Mol Ther 9: S52-S53; doi:10.1016/j.ymthe.2004.06.091

136. Vector host interactions of group B adenoviruses in CD46 transgenic mice

Anuj Gaggar, Dmitry M. Shayakhmetov, Sonia Marwah, Shaoheng Ni and Andre M. Lieber

Mol Ther 9: S53-S53; doi:10.1016/j.ymthe.2004.06.092

137. pFex: a novel fiber exchange system for the creation of modified-fiber gene therapy vectors

Shawn E. Lupold, Wasim H. Chowdhury and Ronald Rodriguez

Mol Ther 9: S53-S53; doi:10.1016/j.ymthe.2004.06.093

138. Purification of plasmid DNA on an anion exchange column without the use of RNase to process scale

Tina M. Pitarresi, Sibylle U. Herzer, Bob Kennedy and Peter Moore

Mol Ther 9: S53-S54; doi:10.1016/j.ymthe.2004.06.493

139. Optimization of electroporation parameters for the intramuscular delivery of plasmids in pigs

Amir S. Khan, Louis C. Smith, Ronald V. Abruzzese, Kathleen K. Cummings, Melissa A. Pope, Patricia A. Brown and Ruxandra Draghia-Akli

Mol Ther 9: S54-S54; doi:10.1016/j.ymthe.2004.06.053

140. Hydrodynamics-based transfection of the liver: entrance into hepatocytes of DNA that causes expression, takes place very early after injection

Fanjam Andrianaivo, Mich|[egrave]|le Lecocq, Simone Wattiaux-De Coninck, Robert Wattiaux and Michel Jadot

Mol Ther 9: S54-S54; doi:10.1016/j.ymthe.2004.06.054

141. Development of a one-step column purification of minicircle vector DNA devoid of bacterial sequences that results in high level persistent transgene expression in vivo

Zhi-Ying Chen, Cheng-Yi He and Mark A. Kay

Mol Ther 9: S54-S55; doi:10.1016/j.ymthe.2004.06.057

142. Innovations in process technology for plasmid DNA manufacturing |[ndash]| modular variations of a generic process, regulatory relevance, and economic impact

Wayne A. Tvrdik, John Vu, Astrid Breul, Markus Mueller and Joachim Schorr

Mol Ther 9: S55-S55; doi:10.1016/j.ymthe.2004.06.058

143. Use of ciliated cell specific promoter FoxJ1 in gene transfer vectors for the airway epithelium

Anna E. Lawton, Stephanie G. Sumner-Jones, Anusha Varathalingam, Lee A. Davies, Stephen C. Hyde and Deborah R. Gill

Mol Ther 9: S55-S55; doi:10.1016/j.ymthe.2004.06.060

144. Duration of reporter gene expression from naled pDNA in the mouse lung following direct electroporation and development or wire electrodes for sheep lung electroporation studies

Ian A. Pringle, Lee L. A. Davies, Gerry McLachlan, David D. Collie, Deborah R. Gill and Stephen C. Hyde

Mol Ther 9: S56-S56; doi:10.1016/j.ymthe.2004.06.069

145. Electroporation-mediated IFN-|[beta]| gene transfer

Claire F. Evans, Maida M. de las Alas, Edward M. Nolan, Alain Luxembourg, Drew W. Hannaman, Gerald K. Nakamura, Barry L. Ellefsen and Robert M. Bernard

Mol Ther 9: S56-S56; doi:10.1016/j.ymthe.2004.06.070

146. Golden cells: gold conjugate labeling as a potential enhancer of electro-gene transfer

Feng Liu, C. E. Polley, L. B. Stiger, S. Majetich and Leaf Huang

Mol Ther 9: S56-S57; doi:10.1016/j.ymthe.2004.06.071

147. Chemical enhancers of non-viral salivary gland gene transfer

Beth M. McMahon, Yen-Ju Chen, Edmund J. Niedzinski and Michael J. Bennett

Mol Ther 9: S57-S57; doi:10.1016/j.ymthe.2004.06.068

148. The altered binding properties of sleeping beauty transposase hyperactive mutants may explain their enhanced efficacy

Julie Park, Stephen R. Yant and Mark A. Kay

Mol Ther 9: S57-S57; doi:10.1016/j.ymthe.2004.06.072

149. Anti-idiotypic CDR3 vaccination against chronic b-cell lymphoma: DNA vaccine strategy

Monica Rinaldi, Sandra Iurescia, Daniela Fioretti, Emanuela Signori, Simona Cali, Gisella Volpe, Claudia Casnici, Ornella Marelli, Giuseppe Saglio, Giancarlo Tonon and Vito Michele Fazio

Mol Ther 9: S57-S58; doi:10.1016/j.ymthe.2004.06.073

150. Cooperative strand invasion of super-coiled plasmid DNA by mixed linear PNA and PNA-peptide chimeras

Karin E. Lundin, Rongbin Ge, Mathias G. Svahn, Elisabeth Tornquist, Lars J. Branden and C. I. Edvard Smith

Mol Ther 9: S58-S58; doi:10.1016/j.ymthe.2004.06.074

151. Gene delivery in larger animals

Torunn Elisabeth Tjelle, Rune Kjeken, Ragnar Salte and Iacob Mathiesen

Mol Ther 9: S58-S58; doi:10.1016/j.ymthe.2004.06.081

152. Nucleofection and phage phiC31 integrase mediate stable introduction of a dystrophin fusion gene into muscle derived stem cell and human myoblasts

Simon P. Quenneville, Pierre Chapdelaine, Joel Rousseau, Nicolas J. Caron, Daniel Skuk, Eric C. Olivares, Michele P. Calos and Jacques P. Tremblay

Mol Ther 9: S58-S58; doi:10.1016/j.ymthe.2004.06.075

153. VEGF associated with TP to refine angiogenesis in gene therapy

Anna Rita Bellu, Marianne G. Rotz, Diane Bou|[iuml]|s, Nanno H. Mulder, Wendy Dam, Vincent van Weel, Pieter Koolwijk, Paul H. A. Quax, Hidde J. Haisma and Geke A. P. Hosper

Mol Ther 9: S58-S59; doi:10.1016/j.ymthe.2004.06.076

154. Small inhibitory RNA expressed from sleeping beauty transposons can reduce alpha1-antitrypsin expression

Kirk J. Wangensteen, Zongyu J. Chen, Clifford J. Steer and Stephen C. Ekker

Mol Ther 9: S59-S59; doi:10.1016/j.ymthe.2004.06.077

155. Non-viral gene therapy for type 1 diabetes by electrotransfer of insulin and glucokinase genes to skeletal muscle

Joel Montane, Alexandre Mas, Miquel Chillon, Xavier M. Anguela, Sergio Mu|[ntilde]|oz, Efren Riu, Pedro J. Otaegui and Fatima Bosch

Mol Ther 9: S59-S59; doi:10.1016/j.ymthe.2004.06.078

156. Delivery of plasmid DNA to the nucleus using non-viral gene transfection in tumor cell lines and primary tumors

Jill A. Gershan, James J. Weber and Rimas J. Orentas

Mol Ther 9: S59-S60; doi:10.1016/j.ymthe.2004.06.080

157. Clinical evaluation of pain and muscle damage induced by electroporation of skeletal muscle in humans

Rune Kjeken, Torunn Elisabeth Tjelle, Dag Kvale and Iacob Mathiesen

Mol Ther 9: S60-S60; doi:10.1016/j.ymthe.2004.06.079

158. Transient Immunosuppresion by CTLA4Ig and Anti-CD40L Promotes Long-Term Tolerance Specifically Against HFVIII in Hemophilia A Mice Following Naked DNA Transfer

Peiqing Ye, Ling Zhou, Zhenping Shen, Arthur R. Thompson, David J. Rawlings, Hans D. Ochs and Carol H. Miao

Mol Ther 9: S60-S60; doi:10.1016/j.ymthe.2004.06.094

159. Vector genome loss does not account for decline of plasma cFVIII protein in hemophilic dogs that demonstrate long term clinical correction following helper-dependent adenoviral gene therapy

W. Michael McCormack Jr., Terry K. Bertin, Kiran Ubhayakar, Margaretha Guenther, Viraj P. Mane, Philip Ng, Timothy C. Nichols, Milton J. Finegold, Donna Palmer, Arthur Beaudet and Brendan H. Lee

Mol Ther 9: S61-S61; doi:10.1016/j.ymthe.2004.06.119

160. Overcoming the size limitations of gene transfer vectors: using segmental trans-splicing to deliver the coding sequence of Von Willebrand factor

Robert G. Pergolizzi, Rachel Dragos, Katsutoshi Nakayama, Denisa Wagner and Ronald G. Crystal

Mol Ther 9: S61-S61; doi:10.1016/j.ymthe.2004.06.120

161. Novel pseudotyped AAV vectors for hemophilia B gene therapy

Lili Wang, Jean-Pierre Louboutin, Timothy C. Nichols and James M. Wilson

Mol Ther 9: S61-S62; doi:10.1016/j.ymthe.2004.06.121

162. Neonatal gene therapy induces tolerance in dogs but not cats

Lingfei Xu, Patty O'Donnell, Tom O'Malley, Mark E. Haskins, Wan-Ching Chan, Yuli Liu and Katherine P. Ponder

Mol Ther 9: S62-S62; doi:10.1016/j.ymthe.2004.06.122

163. Phenotypic correction of a hemophilia B dog following systemic administration of a helper-dependent ad vector encoding canine coagulation factor IX

Nicola Brunetti-Pierri, Donna Palmer, Timothy C. Nichols, Arthur L. Beaudet and Philip Ng

Mol Ther 9: S62-S63; doi:10.1016/j.ymthe.2004.06.123

164. Secretion of human recombinant factor IX from cells of adipose, myogenic and hepatic origin transduced with replication-defective HSV-1 genomic vectors

Julie Fradette, Ryan Flanigan, David M. Krisky, William F. Goins and Joseph C. Glorioso

Mol Ther 9: S63-S63; doi:10.1016/j.ymthe.2004.06.124

165. Long-term factor VIII expression and phenotypic correction in a murine model of hemophilia A achieved by immunosuppression and non-viral gene transfer using the sleeping beauty transposon

John R. Ohlfest, Scott Perkinson, Paul Lobitz, Joel Frandsen, R. Scott McIvor, Perry Hackett, Karl Clark, Jeff Essner, Nigel Key and David A. Largaespada

Mol Ther 9: S63-S63; doi:10.1016/j.ymthe.2004.06.125

166. Induction of immune tolerance and phenotypic rescue of hemophilic mice by stem cell mediated gene transfer

Brian W. Bigger, Elena K. Siapati, Ajay Mistry, Simon N. Waddington, Megha S. Nivsarkar, Maxine V. Holder, Chris Ridler, Geoff Kemball-Cook, Robyn R. Ali, Stuart Forbes, Charles Coutelle, Nick Wright, Malcolm Alison, Adrian Thrasher, Dominique Bonnet and Michael Themis

Mol Ther 9: S64-S64; doi:10.1016/j.ymthe.2004.06.126

167. Partial correction of the hemophilic phenotype in mice implanted with encapsulated human primary myoblasts secreting FIX

Jianping Wen, Frederick A. Ofosu and Gonzalo Hortelano

Mol Ther 9: S64-S64; doi:10.1016/j.ymthe.2004.06.127

168. EIAV-based vectors for the treatment of haemophilia A

Pippa A. Radcliffe, Fraser J. Wilkes, Georgina L. Beard, Susan M. Kingsman and Kyriacos A. Mitrophanous

Mol Ther 9: S64-S64; doi:10.1016/j.ymthe.2004.06.128

169. Intrapancreatic injections of adeno-associated virus vectors for local gene expression

Scott A. Loiler, Qiushi Tang, Marcel Perret-Gentil, Martha L. Campbell-Thompson, Mark A. Atkinson and Terence R. Flotte

Mol Ther 9: S64-S65; doi:10.1016/j.ymthe.2004.06.129

170. Ex vivo gene therapy of metabolic liver disorders using uncultured and lentivirally transduced hepatocytes

Tuan Huy Nguyen, Jacques Birraux, Barbara Wildhaber, Catherine Fux-Cametti, Claude Le Coultre and Didier Trono

Mol Ther 9: S65-S65; doi:10.1016/j.ymthe.2004.06.130

171. Enhancing hepatocyte gene transfer with baculovirus GP64 Glycoprotein

Yubin Kang, Litao Xie, Diane Thi Tran, Melissa Hickey, Colleen S. Stein, Beverly L. Davidson and Paul B. McCray Jr

Mol Ther 9: S65-S65; doi:10.1016/j.ymthe.2004.06.131

172. Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo

Alfred Y. Wang, Peter D. Peng, Anja Ehrhardt, Theresa A. Storm and Mark A. Kay

Mol Ther 9: S66-S66; doi:10.1016/j.ymthe.2004.06.132

173. Adenovirus-mediated gene transfer to mouse and dog pancreas in vivo

Eduard Ayuso, Miguel Chillon, Felix Garcia, Judith Agudo, Anna Andaluz, Virginia Haurigot, Assumpcio Bosch, Pedro J. Otaegui and Fatima Bosch

Mol Ther 9: S66-S66; doi:10.1016/j.ymthe.2004.06.133

174. High efficiency HDAd-mediated hepatic transduction can be achieved by delivery into the surgically isolated liver of nonhuman primates

Nicola Brunetti-Pierri, William Cioffi, David Iannitti, Thomas Ng, Donna Palmer, Arthur Beaudet, Milton Finegold, Karen Rice, Dee Carey and Philip Ng

Mol Ther 9: S66-S66; doi:10.1016/j.ymthe.2004.06.134

175. A clinical trial in Japan of retroviral-mediated gene transfer to bone marrow CD34+ cells as a treatment of adenosine deaminase (ADA)-deficiency

Makoto Otsu, Tadashi Ariga, Yoshihiro Maeyama, Jukei Yoshida, Satoru Nakajima, Miyuki Kida, Nariaki Toita, Norikazu Hatano, Nobuaki Kawamura, Motohiko Okano, Ryouji Kobayashi, Osamu Tatsuzawa, Masafumi Onodera, Fabio Candotti, Kunihiko Kobayashi and Yukio Sakiyama

Mol Ther 9: S67-S67; doi:10.1016/j.ymthe.2004.06.135

176. In vivo selective enhancement of correction of human X-linked chronic granulomatous disease neutrophils in NOD/SCID mice transplanted with CD34+ stem cells transduced with a bicistronic gp91phox/benzyl guanine resistant methylguanine methyltransferase vector

Uimook Choi, Kouhei Yamashita, Lanise Caldwell and Harry L. Malech

Mol Ther 9: S67-S67; doi:10.1016/j.ymthe.2004.06.136

177. Lentiviral Vector Mediated ADA Gene Transfer in ADA-Deficient SCID Mice

Denise A. Carbonaro, Xiangyang Jin, Dinithi Senadherra, Karen Pepper, Denise Petersen, Xiao-Jin Yu, Dianne Skelton and Donald B. Kohn

Mol Ther 9: S68-S68; doi:10.1016/j.ymthe.2004.06.137

178. Site-Specific Base Alteration in the Promoter Region of the Human Gamma Globin Gene by Single-Stranded Oligonucleotides for Gene Therapy of Sickle Cell Disease

W. Yin, B. T. Kren and C. J. Steer

Mol Ther 9: S68-S68; doi:10.1016/j.ymthe.2004.06.138

179. Oncoretroviral Vector-Mediated Gene Therapy for Murine WAS Fails to Correct Most of the Deficient Biological Responses to S. pneumonia or M. bovis

Ted S. Strom, Jon McCullers, Robert Rutschman, Peter Murray, Marguerite Evans-Galea, John M. Cunningham and Arthur W. Nienhuis

Mol Ther 9: S68-S69; doi:10.1016/j.ymthe.2004.06.139

180. Use of Skeletal Muscle for Regulated Expression of Parathyroid Hormone to Treat Hypoparathyroidism

Maja Z. Salva, Jeffrey Bonadio and Stephen D. Hauschka

Mol Ther 9: S69-S69; doi:10.1016/j.ymthe.2004.06.140

181. Human CBS (Cystathionine |[beta]|-Synthase) Gene Transfer Mediated by Recombinant Adeno-Associated Virus Vector

Hyun-Jeong Oh, Eun-Sook Park, Warren Kruger, Sung-Chul Jung and Jin-Sung Lee

Mol Ther 9: S69-S70; doi:10.1016/j.ymthe.2004.06.141

182. Towards the Correction of the Genetic Defect in Corneal Keratinocytes from Patients with Macular Corneal Dystrophy Type II

Stefano Ferrari, Giuliana Ferrari, Claudia Rossi, Annarita Miccio, Nicola Volpi, Fulvio Mavilio, Graziella Pellegrini and Michele De Luca

Mol Ther 9: S70-S70; doi:10.1016/j.ymthe.2004.06.142

183. Hemochromatosis: AAV Coding an Antisense Gene Against DMT-1 Iron Transporter in Intestinal Epithelial Cells Acts as RNAi. And Inhibits Iron Transport

Fernando E. Ezquer, Marco T. Nunez and Yedy Israel

Mol Ther 9: S70-S70; doi:10.1016/j.ymthe.2004.06.143

184. Evaluation of Cystine Transport in Cultured Human Kidney Cells: Primer to Gene Therapy of Cystinuria

Sreedhar Sagi, Thomas Knoll, Axel Schaaf, Peter Alken and Maurice Stephan Michel

Mol Ther 9: S70-S71; doi:10.1016/j.ymthe.2004.06.144

185. Systemic Protein Delivery by Muscle-Directed Gene Transfer Is Limited by a Local Immune Response

Lixin Wang, Eric Dobrzynski, Ou Cao and Roland Herzog

Mol Ther 9: S71-S71; doi:10.1016/j.ymthe.2004.06.147

186. Phenotypic Correction of Hemophilic Mice Using Hematopoietic Stem Cells Transduced with an MSCV-Based Oncoretroviral Vector

Morvarid Moayeri, Ali Ramezani, Richard A. Morgan, Teresa S. Hawley and Robert G. Hawley

Mol Ther 9: S71-S72; doi:10.1016/j.ymthe.2004.06.145

187. Adeno-Associated Virus Vector-Mediated Soluble Flt-1 Gene Transfer Prevents Diabetic Retinopathy in Spontaneously Diabetic Rat Model

Junichi Ideno, Hiroaki Mizukami, Akihiro Kakehashi, Yuka Saito, Takashi Okada, Akihiro Kume, Masatoshi Kuroki, Masanobu Kawakami, Shun Ishibashi and Keiya Ozawa

Mol Ther 9: S72-S72; doi:10.1016/j.ymthe.2004.06.095

188. Effects of Long-Term Expression of VEGF-A and Sema3A after Gene Delivery In Vivo Using AAV Vectors

Serena Zacchigna, Pattarini Lucia, Arsic Nikola, Zentilin Lorena, Tomasi Sara, Dapas Marina and Giacca Mauro

Mol Ther 9: S72-S73; doi:10.1016/j.ymthe.2004.06.096

189. Sendai Virus Mediated Angiopoietin-1 Gene Therapy for Cardiovascular Diseases

Yoshinori Ito, Jinghua Huang, Takeshi Uzuka, Yukiko Honma, Hironari Dehari, Masayoshi Kobune, Kiminori Nakamura, Makoto Inoue, Mamoru Hasegawa and Hirofumi Hamada

Mol Ther 9: S73-S73; doi:10.1016/j.ymthe.2004.06.097

190. Myocardial Gene Therapy by Naked Angiopoietin-1 Plasmid Injection Efficiently Induces Angiogenesis and Prevents the Remodeling Following Acute Myocardial Infarction

Takeshi Uzuka, Yoshinori Ito, Masayuki Morikawa, Jinghua Huang, Masayoshi Kobune, Kiminori Nakamura, Yukiko Honma, Keiji Ishii, Tomio Abe and Hirofumi Hamada

Mol Ther 9: S73-S73; doi:10.1016/j.ymthe.2004.06.098

191. Improvement of Myocardial Dysfunction by Therapeutic Angiogenesis Induced by Transfection of HGF Gene Using Left Ventricular Electromechanical Mapping in Porcine Chronic Myocardial Infarction Model

Junya Azuma, Yosiaki Taniyama, Motokuni Aoki, Yasuhumi Kaneda, Toshio Ogihara and Ryuichi Morisita

Mol Ther 9: S74-S74; doi:10.1016/j.ymthe.2004.06.099

192. Cardiac-Specific and Hypoxia-Responsive Vascular Endothelial Growth Factor Expression in Ischemic Hearts

Hua Su, Yu Huang, Alicia Barcena, Janice Arakawa-Hoyt, Shuji Joho, Richard Sievers, William Grossman and Yuet Wai Kan

Mol Ther 9: S74-S74; doi:10.1016/j.ymthe.2004.06.100

193. Hypoxia-Inducible VEGF Gene Therapy Using the RTP801 Promoter

Donghoon Choi, Minhyung Lee, David A. Bull, Russel Reiss, Chien-Wen Chang, Lane Christensen and Sung Wan Kim

Mol Ther 9: S74-S75; doi:10.1016/j.ymthe.2004.06.101

194. Deltavasc|[trade]| - Phase I Study of Intramuscular Administration of Plasmid Del-1 (Developmentally Regulated Endothelial Cell Locus |[ndash]|1) in Humans with Peripheral Arterial Disease (PAD)

Sanjay Rajagopalan, Jeffrey Snell, Stuart W. Young and Gary L. Schaer

Mol Ther 9: S75-S75; doi:10.1016/j.ymthe.2004.06.102

195. Therapeutic Angiogenesis in Mouse Ischemic Heart after Intramyocardial Injection of a Novel Two Gene Plasmid Vector Co-Expressing High Levels of Human VEGF and bFGF Genes

Phoebe Luo, Kengo Kusano, Tom Tsang, David Harris and Douglas Losordo

Mol Ther 9: S75-S75; doi:10.1016/j.ymthe.2004.06.103

196. Regional Angiogenesis Mediated by Platelet-Derived VEGF in Response to Thrombopoietin Gene Transfer

Hideki Amano, Neil R. Hackett, Koji Shido, Rafael Tejada, Scott Avegilla, Shahin Rafii and Ronald G. Crystal

Mol Ther 9: S75-S76; doi:10.1016/j.ymthe.2004.06.104

197. Do Bone Marrow-Derived Progenitor Cells Contribute to VEGF-Induced Post-Natal Neovascularization?

Lorena Zentilin, Sabrina Tafuro, Nikola Arsic, Serena Zacchigna, Milena Sinigaglia, Sara Tomasi, Lucia Pattarini, Marina Dapas and Mauro Giacca

Mol Ther 9: S76-S76; doi:10.1016/j.ymthe.2004.06.105

198. Cell-Based Gene Therapy for Primary Pulmonary Hypertension Using a Non-Viral Gene Delivery System

Linda N. Liu, Linhong Li, Yidan Zhao, Qiuwang Zhang, Rama Shivakumar, Cornell Allen, Joseph C. Fratantoni, Duncan J. Stewart and David W. Courtman

Mol Ther 9: S76-S77; doi:10.1016/j.ymthe.2004.06.106

199. Circulating Endothelial Progenitor Cells Restore Endothelial Function of Balloon Injured Rabbit Carotid Artery

Tongrong He, Leslie A. Smith, Noel M. Caplice and Zvonimir S. Katusic

Mol Ther 9: S77-S77; doi:10.1016/j.ymthe.2004.06.107

200. Cholesterol Modified Polyurethane as a Matrix for Cell Based Cardiovascular Therapy Using Blood Outgrowth Endothelial Cells (BOEC): Potential for Lentivirus Mediated Gene Therapy

Stanley J. Stachelek, Ivan S. Alferiev, Phillip W. Zoltick, Jeanne M. Connolly, Richard W. Bianco, Robert P. Hebbel and Robert J. Levy

Mol Ther 9: S77-S77; doi:10.1016/j.ymthe.2004.06.108

201. Angiogenic Gene Therapy of Coronary Artery Disease - from Bench to the Clinic

Maciej Malecki, Piotr Kolsut, Zbigniew Religa and Przemyslaw Janik

Mol Ther 9: S77-S78; doi:10.1016/j.ymthe.2004.06.111

202. Using RNA to Inhibit Intimal Hperplasia by Blocking E2F Function

Alice K. Tanner, Joseph Nevins and Bruce Sullenger

Mol Ther 9: S78-S78; doi:10.1016/j.ymthe.2004.06.112

203. Electroporation-Mediated Gene Delivery to Mouse Femoral Arteries in a Model of Vascular Injury

Jennifer L. Young, Daniel Eefting, Paul H.A. Quax and David A. Dean

Mol Ther 9: S78-S78; doi:10.1016/j.ymthe.2004.06.113

204. Angiographic Luminal Loss in Porcine Coronary Arteries is Reduced by Stent-Based Adenovirus-Mediated Antagonism of TGF-|[beta]|1

Clare E. Appleby, Paul A. Kingston, Michel Verhoeven, Anita Driessen and Anthony M. Heagerty

Mol Ther 9: S79-S79; doi:10.1016/j.ymthe.2004.06.114

205. Histopathlogical and Physiological Impact on Monkey Intracranial Aneurysms Transfecting Transforming Growth Factor-Beta-1 Mediated by Adenovirus

Shigeki Ono, Tomoyuki Ogawa, Tomohito Hishikawa, Tomotsugu Ichikawa and Isao Date

Mol Ther 9: S79-S79; doi:10.1016/j.ymthe.2004.06.116

206. Adenovirus-Mediated GTP Cyclohydrolase I Gene Delivery Augments Tetrahydrobiopterin and Restores Nitric Oxide Synthase Function in Hyperglycaemic Human Aortic Endothelial Cells

Shijie Cai and Keith M. Channon

Mol Ther 9: S79-S80; doi:10.1016/j.ymthe.2004.06.117

207. Micro RNAs as Novel siRNA Shuttles

Ryan Boudreau, Haibin Xia and Beverly L. Davidson

Mol Ther 9: S80-S80; doi:10.1016/j.ymthe.2004.06.148

208. Regenerative Properties of Retinoic Acid Receptor |[beta]|2 in Rat Model of Dorsal Rhizotomy

Liang-Fong Wong, Ping K. Yip, Anna Battaglia, John Grist, Lucy E. Walmsley, Malcolm Maden, Susan M. Kingsman, Alan J. Kingsman, Stephen B. McMahon and Nicholas D. Mazarakis

Mol Ther 9: S80-S80; doi:10.1016/j.ymthe.2004.06.149

209. Gene Silencing of Human Huntingtin Using Lentivirus-Delivered shRNA

Scott Q. Harper, Patrick D. Staber, Christine R. Rowley, Xiaohua He, Ines H. Martins, Qinwen Mao, Henry L. Paulson and Beverly L. Davidson

Mol Ther 9: S80-S81; doi:10.1016/j.ymthe.2004.06.150

210. AAV Vector-Mediated Enzyme Replacement Therapy Is Efficacious in Reversing Storage Pathology and Preventing Purkinje Cell Death in a Mouse Model of Niemann-Pick A Disease

Marco A. Passini, Jie Bu, James C. Dodge, Qi Zhao, Tatyana V. Taksir, Holly A. Collins, Catherine R. O'Riordan and Gregory R. Stewart

Mol Ther 9: S81-S81; doi:10.1016/j.ymthe.2004.06.151

211. Creation of a HSV VP22-Sleeping Beauty Fusion Protein To Facilitate Integration of HSV-1 Amplicon Vectors

Hilary A. Stanley, William J. Bowers, Michael A. Mastrangelo and Howard J. Federoff

Mol Ther 9: S81-S81; doi:10.1016/j.ymthe.2004.06.152

212. AAV-Mediated Gene Transfer Protects Against Mitochondrial Optic Neuropathy in Mice

Xiaoping Qi, Liang Sun, John Guy, William W. Hauswirth and Alfred S. Lewin

Mol Ther 9: S82-S82; doi:10.1016/j.ymthe.2004.06.153

213. Peripherally Delivered Glutamic Acid Decarboxylase (GAD) Gene Therapy for Below-Level Spinal Cord Injury Neuropathic Pain

Darren Wolfe, Liu Jun, Hao Shuanglin, Huang Shuahua, Marina Mata, Joseph Glorioso and David Fink

Mol Ther 9: S82-S82; doi:10.1016/j.ymthe.2004.06.154

214. Additive Effects of HSV Vectors Expressing Proenkephalin, Interleukin-4, and Tumor Necrosis Factor Alpha Soluble Receptor To Treat Bone Cancer Pain

James R. Goss, Christine Fetterolf, William Goins, Darren Wolfe, Shaohua Huang, David Krisky, Joseph C. Glorioso, Marina Mata and David J. Fink

Mol Ther 9: S82-S82; doi:10.1016/j.ymthe.2004.06.155

215. Dimerizer-Regulated AADC Expression with Two AAV Vectors in 6-OHDA Lesioned Rats

Laura M. Sanftner, Victor M. Rivera, Lan Feng, Lori Berk, John R. Forsayeth, Tim Clackson and Janet Cunningham

Mol Ther 9: S83-S83; doi:10.1016/j.ymthe.2004.06.156

216. Gene Therapy of Huntington Disease Using RNA Interference and Sleeping Beauty Transposon

Zongyu J. Chen, Xiaoming Ma, Philip Wong, Mikel Roe, Chang-won Park, Betsy T. Kren, Walter C. Low and Clifford J. Steer

Mol Ther 9: S83-S83; doi:10.1016/j.ymthe.2004.06.157

217. Widespread Distribution of Beta-Glucuronidase in the Mouse Brain Is Achieved after a Single Inoculation with a Neuroattenuated HSV Vector: Distribution Differs with Inoculation Site

Bradford K. Berges, John H. Wolfe and Nigel W. Fraser

Mol Ther 9: S84-S84; doi:10.1016/j.ymthe.2004.06.159

218. Nonhuman Primate Models for Retinal and Choroidal Neovascularization Using AAV2-Mediated Overexpression of Vascular Endothelial Growth Factor

Corinna Lebherz, Albert M. Maguire, Alberto Auricchio, Waixing Tang, Tomas S. Aleman, Zhangyong Wei, Rebecca L. Grant, Artur V. Cideciyan, Samuel G. Jacobson, James M. Wilson and Jean Bennett

Mol Ther 9: S84-S84; doi:10.1016/j.ymthe.2004.06.160

219. Prolonged Bioactive Transgene Expression Driven by the HSV Latency Active Promoter 2 (LAP2) in the Peripheral Nervous System

Munmun Chattopadhyay, Darren P. Wolfe, William C. Goins, Shaohua Huang, Joseph C. Glorioso, Marina Mata and David J. FINK

Mol Ther 9: S85-S85; doi:10.1016/j.ymthe.2004.06.161

220. Prolonged Biologically Active Transgene Expression Driven by HSV Latency Active Promoter 2 (LAP2) in Brain In Vivo

Veljko Puskovic, Darren Wolfe, James R. Goss, Shaohua Hang, Joseph C. Glorioso, Marina Mata and David J. Finnk

Mol Ther 9: S85-S85; doi:10.1016/j.ymthe.2004.06.162

221. Developing HSV-Mediated Gene Therapy Vectors To Adjust the Metabolic Imbalance of A|[beta]| in Alzheimer's Disease

Chang-Sook Hong, James R. Goss, William F. Goins, David J. Fink and Joseph C. Glorioso

Mol Ther 9: S85-S86; doi:10.1016/j.ymthe.2004.06.163

222. HSV Amplicon Expression of Single Chain Antibodies Directed Against |[alpha]|-Synuclein Conformers

Kathleen A. Maguire-Zeiss, Eric Yehling, Rita Giuliano, Mark Sullivan and Howard J. Federoff

Mol Ther 9: S86-S86; doi:10.1016/j.ymthe.2004.06.165

223. Delivery of HSV Based Vectors for Correction of CNS Pathology in Mucopolysaccharodosis Type vii (MPS vii)

Srikanth Yellayi, Bradford Berges, John Wolfe, Charles Vite and Nigel Fraser

Mol Ther 9: S86-S86; doi:10.1016/j.ymthe.2004.06.166

224. Adenoviral Co-Delivery of BDNF and Noggin Induces Striatal Neuronal Replacement and Delays Motor Impairment in a Transgenic Model of Huntington's Disease

Sung-Rae Cho, Eva Chmielnicki and Steven A. Goldman

Mol Ther 9: S86-S87; doi:10.1016/j.ymthe.2004.06.168

225. Phenotypic Correction of ALD Mouse after Hematopoietic Cell Transplantation and Evaluation of Hematopoietic Stem Cell Gene Therapy with a Lentivirus Vector

Sonia Benhamida, Fran|[ccedil]|oise Fouquet, Ann Moser, Patrick Aubourg and Nathalie Cartier

Mol Ther 9: S87-S87; doi:10.1016/j.ymthe.2004.06.169

226. Developing a CNS-Specific Inflammatory Model To Investigate Gene Therapy/Inflammation Interactions in the Context of Neurodegeneration

Michelle C. Janelsins, Michael A. Mastrangelo, Howard J. Federoff and William J. Bowers

Mol Ther 9: S87-S87; doi:10.1016/j.ymthe.2004.06.170

227. Anatomical and Behavioral Effects of AAV2-Mediated Delivery of Neurturin to the Rat Striatum Prior to 6-Hydroxydopamine Induced Nigrostriatal Degeneration

Christopher D. Herzog, Mehdi Gasmi, Justine J. Cunningham, Eugene P. Brandon, Anthony Ramirez, Alistair Wilson, Eva K. Hofer, Jennifer Hwang, Leo Manlapaz, Jeffrey H. Kordower, Jeffrey M. Ostrove and Raymond T. Bartus

Mol Ther 9: S88-S88; doi:10.1016/j.ymthe.2004.06.172

228. A Novel Therapeutic Strategy To Treat Brain Ischemia: Over-Expression of Hepatocyte Growth Factor Gene Reduced Ischemic Injury without Cerebral Edema in Rat Model

Munehisa Shimamura, Naoyuki Sato, Toshio Ogihara, Yasufumi Kaneda and Ryuichi Morishita

Mol Ther 9: S88-S88; doi:10.1016/j.ymthe.2004.06.174

229. AAV4 Mediated Gene Transfer in Mucopolysaccharidosis Type VII Mice

Gumei Liu, John A. Chiorini and Beverly L. Davidson

Mol Ther 9: S89-S89; doi:10.1016/j.ymthe.2004.06.175

230. Neural Progenitor Cell Transduction with AAV Serotypes 1 and 4

Gumei Liu, Robert M. Kotin, John A. Chiorini and Beverly L. Davidson

Mol Ther 9: S89-S89; doi:10.1016/j.ymthe.2004.06.178

231. Supplementation of Peripherin/rds Rescues Mutation-Associated Rod and Cone Photoreceptor Defects in Transgenic Mice

May Nour, Muna I. Naash and Steven J. Fliesler

Mol Ther 9: S89-S89; doi:10.1016/j.ymthe.2004.06.179

232. Transplantation of Human Embryonic Stem Cell Derived Oligodendroglial Progenitors for the Treatment of Spinal Cord Injury

Jane Lebkowski, Gabriel Nistor, Giovanna Bernal, Minodora Totoiu, Catherine Priest, Scott Thies, Jerrod Denham and Hans Keirstead

Mol Ther 9: S89-S90; doi:10.1016/j.ymthe.2004.06.181

233. Gene Control as a Therapeutic Intervention: Zinc-Finger Protein Transcription Factors as Regulators of the Molecular Determinants of Neuropathic Pain

Yann Jouvenot, John R. Forsayeth, Siyuan Tan, Andrew McNamara, Raymond A. Chavez and Philip Gregory

Mol Ther 9: S90-S90; doi:10.1016/j.ymthe.2004.06.183

234. Correction of Pathology in Galactosialidosis Mice Crossed into Transgenic Mice Expressing PPCA in Neural Cells

Huimin Hu, Linda Mann, Erik Bonton, Taylor Walker and Alessanrdra d'Azzo

Mol Ther 9: S90-S90; doi:10.1016/j.ymthe.2004.06.185

235. The Fetal Approach: A Novel Therapy for the Treatment of Musculo-Skeletal Disease

Michael Themis, Lisa G. Gregory, Simon N. Waddington, Maxine V. Holder, Kyriacos A. Mitrophanous, Suzanne M. K. Buckley, Brian W. Bigger, Fiona E. Ellard, Lucy E. Walmsley, Pippa Radcliffe, Nick Mazarakis, Mimoun Azzouz, Lorraine Lawrence, Terrence Cook, Faisal A. Allaf, Susan Kingsman and Charles Coutelle

Mol Ther 9: S91-S91; doi:10.1016/j.ymthe.2004.06.164

236. Delivery of VEGF Using AAV Vectors Stimulates Skeletal Muscle Regeneration In Vivo

Nikola Arsic, Serena Zacchigna, Lorena Zentilin, Genaro Ramirez-Correa, Alessandro Salvi, Gianfranco Sinagra and Mauro Giacca

Mol Ther 9: S91-S91; doi:10.1016/j.ymthe.2004.06.167

237. Transgenic Expression of Dp116 in Muscle Does Not Ameliorate Dystrophy in mdx 4cv Mice

Luke M. Judge and Jeffrey S. Chamberlain

Mol Ther 9: S91-S91; doi:10.1016/j.ymthe.2004.06.171

238. A Comparison of Gene Delivery and Vector Systems to Achieve High Levels of Sustained Skeletal Muscle Gene Expression

Hu Sheng Qian, Perry Liu, Paul Szymanski, Peter Kretschmer, Alan Brooks, Maxine Bauzon, Fang Jin, Richard N. Harkins, Richard J. Samulski, Gabor M. Rubanyi and Terry W. Hermiston

Mol Ther 9: S91-S92; doi:10.1016/j.ymthe.2004.06.173

239. Human Myoblast Deimmortalization Using Tat-Mediated Cre Recombinase Delivery

Nicolas J. Caron, Marie-Eve Ducharme, Philippe Mills, Simon P. Quenneville and Jacques P. Tremblay

Mol Ther 9: S92-S92; doi:10.1016/j.ymthe.2004.06.211

240. Immunogenicity of Dystrophins Delivered to Mice by Gutted Adenoviral Vectors

Jie Mi, Leonard Leuse, Jeannine Scott, Shannon Barker, Shanna Sawatzki, Dennis Hartigan-O'Connor and Jeffrey S. Chamberlain

Mol Ther 9: S92-S92; doi:10.1016/j.ymthe.2004.06.176

241. Lentivirus Mediated Dystrophin Expression in mdx Muscles

En Kimura, Sheng Li, Brent Fall, Sanna Sawatzki, Leonard Meuse and Jeffery S. Chamberlain

Mol Ther 9: S92-S93; doi:10.1016/j.ymthe.2004.06.177

242. A Novel MiniDys-eGFP Fusion Gene for Developing Cell-Based Therapies of Duchenne Muscular Dystrophy

Sheng Li, En Kimura, Leonard Meuse, Xin Ye, Brent Fall, Steven D. Hauschka, John Faulkner and Jeffrey S. Chamberlain

Mol Ther 9: S93-S93; doi:10.1016/j.ymthe.2004.06.180

243. Delivery of Igf-I and Dystrophin to Dystrophic mdx muscle

Simone Abmayr, Paul Gregorevic, James M. Allen, Shanna M. Sawatzki and Jeffrey S. Chamberlain

Mol Ther 9: S93-S93; doi:10.1016/j.ymthe.2004.06.182

244. Successful AAV Vector-Mediated Gene Transfer into Canine Skeletal Muscle Required Suppression of Excess Immune Responses

Katsutoshi Yuasa, Madoka Yoshimura, Nobuyuki Urasawa, Katsujiro Sato, Yuko Miyagoe-Suzuki, John McC Howell and Shin'ichi Takeda

Mol Ther 9: S94-S94; doi:10.1016/j.ymthe.2004.06.184

245. Muscle-Derived Stem Cells Display an Extended, but Not Unlimited, Expansion Capability: Implication for Muscle Regeneration

Bridget M. Deasy, Burhan M. Gharaibeh, Michele Jones, Michael A. Lucas and Johnny Huard

Mol Ther 9: S94-S94; doi:10.1016/j.ymthe.2004.06.186

246. Gender Differences in Transplantation Efficiency Using Muscle-Derived Stem Cells for Muscular Dystrophy

Bridget M. Deasy, Aiping Lu, Burhan M. Gharaibeh, Michele Jones, Jessica Tebbets and Johhny Huard

Mol Ther 9: S94-S95; doi:10.1016/j.ymthe.2004.06.187

247. Expressing Full-Length Dystrophin in 50% Cardiomyocytes Corrects Cardiomyopathy in the Mdx Mouse Model for Duchenne Muscular Dystrophy

Yongping Yue, Jeffrey W. Skimming, Mingju Liu, Yujiang Fang, Tammy Strawn and Dongsheng Duan

Mol Ther 9: S95-S95; doi:10.1016/j.ymthe.2004.06.188

248. cFLIP or IKBSR Inhibition of NF-|[kappa]|B Activation in Mouse Myoblast Cells: Potential Application of Gene Therapy for Cancer Cachexia

Zhilong Jiang and Paula R. Clemens

Mol Ther 9: S95-S95; doi:10.1016/j.ymthe.2004.06.189

249. New Canine Models of Duchenne Muscular Dystrophy: Identification and Molecular Characterization

Bruce F. Smith, Lucia Alvarez and Kerriann Sparks

Mol Ther 9: S96-S96; doi:10.1016/j.ymthe.2004.06.190

250. Cross-Correction in Pompe Mice after Immunomodulation and Hepatic Delivery of Recombinant AAA5 and AAV8 Vectors

Kerry O. Cresawn, Clive Wasserfall, Mark A. Atkinson, Cathryn Mah, Thomas J. Fraites Jr., Irene Zolotukhin and Barry J. Byrne

Mol Ther 9: S96-S96; doi:10.1016/j.ymthe.2004.06.191

251. rAAV-Mediated Gene Therapy To Treat Limb Girdle Muscular Dystrophy Type 2D (LGMD-2D)

Christina A. Pacak, Denise Cloutier, Irene Zolotukhin, Gabriel S. Gaidosh, Kevin Campbell, Glenn A. Walter and Barry J. Byrne

Mol Ther 9: S96-S97; doi:10.1016/j.ymthe.2004.06.192

252. Phase II Study of MVA Expressing E6 and E7 of HPV16 in Patients with CIN2/3

Patrick Squiban, Patrice Mathevet, Bernard Huynh, Jean-Pai; Bory and Jean-Marc Balloul

Mol Ther 9: S97-S97; doi:10.1016/j.ymthe.2004.06.193

253. Regression of Large Solid Tumors Using Engineered Drug Resistant Immunocompetent Cells and Selective Chemotherapy

Douglas W. McMillin, Becker Hewes, Bagirath Gangadharan and H. Trent Spencer

Mol Ther 9: S97-S98; doi:10.1016/j.ymthe.2004.06.194

254. Vaccination of Recurrent Glioma Patients with Tumour Lysate-Pulsed Dendritic Cells Elicits Immune Responses: Results of a Clinical Phase I/II Trial

Ryuya Yamanaka, Junpei Homma, Naoki Yajima, Naoto Tsuchiya and Ryuichi Tanaka

Mol Ther 9: S98-S98; doi:10.1016/j.ymthe.2004.06.195

255. Potent Cancer Immunotherapy with Dendritic Cells Generated from Genetically Modified Hematopoietic Stem Cells

Tsukasa Nabekura, Hiromitsu Nakauchi, Toshirou Nagasawa and Masafumi Onodera

Mol Ther 9: S98-S98; doi:10.1016/j.ymthe.2004.06.196

256. Importance of Temporal Control of HSVtk Gene Therapy in Combination with T Cell Based Therapies for Cancer

Luis A. Sanchez-Perez, Michael Gough, Jill Thompson and Richard G. Vile

Mol Ther 9: S98-S98; doi:10.1016/j.ymthe.2004.06.197

257. AAV Vector-Loading DC with an Autoimmune Domain-Depleted HCV Core Gene Stimulates High Anti-Core and Low Anti-Self CTL

Maurizio Chiriva-Internati, Yong Liu, Rongcheng Luo, Changxuan You and Paul L. Hermonar

Mol Ther 9: S98-S99; doi:10.1016/j.ymthe.2004.06.198

258. Multi-Modality Non-Invasive Imaging of NK-92 Cells Trafficking and Tumor Targeting in Mice

Vilia Tourkova, Michael Doubrovin, Malgorzata Dabrowska, Jelena Vider, Shangive Cai, Ronald Finn, Juri Gelovani Tjuvajev and Vladimir Ponomarev

Mol Ther 9: S99-S99; doi:10.1016/j.ymthe.2004.06.199

259. In Vivo Suicide Gene Therapy of Human T Lymphocytes in a Murine Xenograft Model

Bruno Nervi, Michael Rettig, Julie Ritchey, John Walker, Gerhard Bauer, Philip Herrbrich, Jan A. Nolta and John F. DiPersio

Mol Ther 9: S99-S100; doi:10.1016/j.ymthe.2004.06.200

260. Anti-Tumor Response by Adenovirus-Mediated, Tumor Specific Expression of a Pro-Apoptotic Protein (TRAIL) and a Heat Shock Protein (GRP94)

Nelson C. Di Paolo, Shaoheng Ni and Andre Lieber

Mol Ther 9: S100-S100; doi:10.1016/j.ymthe.2004.06.210

261. Immune Evasion in Gene Therapy

Rob C. Hoeben, Martine Ossevoort, Birgit M. Visser, Arnaud Zaldumbide, Ellen I. Van der Voort, Diana J. Van den Wollenberg and Rene E. Toes

Mol Ther 9: S100-S100; doi:10.1016/j.ymthe.2004.06.201

262. Dendritic Cell (DC) Vaccine Loaded with Apoptotic Tumor Fragments Effectively Suppress Preestablished Malignant Melanoma in Mice

Hidetsugu Asada, Tsunao Kishida, Hideyo Hirai, Jiro Imanishi and Osam Mazda

Mol Ther 9: S100-S101; doi:10.1016/j.ymthe.2004.06.202

263. Antigen Epitope-Expressing Cytokines for DNA Immunization

Xianghui He, Tom C. Tsang, Tong Zhang, Phoebe Luo and David T. Harris

Mol Ther 9: S101-S101; doi:10.1016/j.ymthe.2004.06.203

264. Non-Invasive Monitoring of the Response of Orthotopic Bladder Tumors to GM-CSF Gene Therapy Using the Prostate Specific Antigen Gene as a Reporter

Qinghui Wu, Ratha Mahendran and Kesavan Esuvaranathan

Mol Ther 9: S101-S101; doi:10.1016/j.ymthe.2004.06.204

265. ImmunoVexEx Vivo: A Herpes Simplex Virus-Based, Dendritic Cell-Mediated Anti-Cancer Vaccine Platform

Philip Reay, Mei Yi-Sun, Binlei Liu, Yvonne McGrath, Madeleine Wakeling, Justin John, Emma Turnbull, Suzanne Thomas and Rob Coffin

Mol Ther 9: S102-S102; doi:10.1016/j.ymthe.2004.06.205

266. OncoVEX: A Family of Oncolytic Herpes Simplex Viruses Optimised for Therapeutic Use

Binlei Liu, Ziquin Han, Guy Simpson and Rob Coffin

Mol Ther 9: S102-S102; doi:10.1016/j.ymthe.2004.06.206

267. Enhancement of T-Cell Immunity by CEA Delivery to Dendritic Cells with Adenovirus Retargeted Via sCAR-Fibritin-CD40L

Papia T. Banerjee, Stephan G. Klinz, Alexander V. Pereboev, Douglas R. Nelson, James S. Huston, David T. Curiel and Stephen D. Gillies

Mol Ther 9: S102-S103; doi:10.1016/j.ymthe.2004.06.207

268. Enhancement of DNA Vaccine Potency by Coadministration of a Tumor Antigen Gene and DNA Encoding Serine Protease Inhibitor-6

Chien-fu Hung, Taewoo Kim and T. C. Wu

Mol Ther 9: S103-S103; doi:10.1016/j.ymthe.2004.06.208

269. Targeting Self Antigens through Allogeneic TCR Gene Transfer

Moniek de Witte, Miriam Coccoris, Monika C. Wolkers, Marly van den Boom, Helmut W. Kessels and Ton N. Schumacher

Mol Ther 9: S103-S103; doi:10.1016/j.ymthe.2004.06.209

270. Treatment of CT26 Tumors with Dendritic Cells Transduced with a Recombinant SV40 Vector Expressing Interleukine 15

Maria Vera, Gloria G. Aseguinolaza, Nerea Razquin, Ignacio Melero, Jesus Prieto and Puri Fortes

Mol Ther 9: S103-S103; doi:10.1016/j.ymthe.2004.06.225

271. Helper-Dependent, Capsid-Modified Adenoviral Vectors for Immunotherapy of Breast Cancer

Nelson C. Di Paolo, Daniel Stone, Dmitry Shayakhmetov and Andre Lieber

Mol Ther 9: S104-S104; doi:10.1016/j.ymthe.2004.06.226

272. Development of |[ldquo]|Full|[rdquo]|-Closed Sterile and Automatic Retroviral Gene Transfer System for Clinical Gene Therapy

Shin Kaneko, Makoto Otsu, Yuichi Hasegawa, Hiroshi Kojima, Takashi Shimizu, Takashi Fukushima, Ryo Sumazaki, Masafumi Onodera and Toshiro Nagasawa

Mol Ther 9: S104-S104; doi:10.1016/j.ymthe.2004.06.228

273. Long-Term Effects of Plasmid-Mediated Growth Hormone Releasing Hormone in Dogs

Catherine M. Tone, Dawn M. Cardoza, Robert H. Carpenter and Ruxandra Draghia-Akli

Mol Ther 9: S105-S105; doi:10.1016/j.ymthe.2004.06.230

274. Combination of a Second Generation Genetically Modified Herpes Simplex Virus 1 (HSV 1) with Paclitaxel in the Treatment of Breast Cancer In Vitro

Jennifer Hu, G. Hallden, Claire Shorrock, Guy Simpson, Rob Coffin, T. Kamalati and R. Coombes

Mol Ther 9: S105-S105; doi:10.1016/j.ymthe.2004.06.231

275. Prostate Targeting Peptides Via the Prostate Specific Membrane Antigen

Shawn E. Lupold and Ronald Rodriguez

Mol Ther 9: S105-S106; doi:10.1016/j.ymthe.2004.06.212

276. Evaluation of an Oncolytic Adenovirus: Efficacy Studies on Primary Human Tumor Cell Cultures and Safety Studies in Non-Human Primates

Shaoheng Ni, Anuj Gaggar, Pavel Sova, Robert Strauss, Nelson C. DiPaolo and Andre Lieber

Mol Ther 9: S106-S106; doi:10.1016/j.ymthe.2004.06.213

277. Variability in Infectivity of Primary Cell Cultures of Human Brain Tumors with HSV-1 Amplicon Vectors

Maria A. Rueger, Alexandra Winkeler, Hrvoje Miletic, Christine Kaestle, Raphaela Richter, Gabriele Schneider, Juergen A. Hampl, Cornel Fraefel and Andreas H. Jacobs

Mol Ther 9: S106-S106; doi:10.1016/j.ymthe.2004.06.214

278. Hypoxia Reduces Adenoviral Replication in Cancer Cells by Down-Regulation of Viral Protein Expression

Teona Pipiya, Harald Sauthoff, Yao Qi Huang, Benjamin Chang, William N. Rom and John G. Hay

Mol Ther 9: S106-S107; doi:10.1016/j.ymthe.2004.06.216

279. Methotrexate Chemotherapy of L1210 Leukemia in Mice Transplanted with Transgenic Marrow Expressing Drug-Resistant Dihydrofolate Reductase

Joel L. Frandsen, Debra Swanson and R. Scott McIvor

Mol Ther 9: S107-S107; doi:10.1016/j.ymthe.2004.06.217

280. The Use of the Regulatory Sequences of H19 and IGF2 Genes in DNA Based Therapy of Colorectal Rat Liver Metastases

Patricia Ohana, Pinhas Schacter, Basem Ayesh, Aya Mizrahi, Suhail Ayesh, Tatiana Birman, Tamar Schneider, Imad Maatouk, Peter J. K. Kuppen, Nathan de Groot, Abraham Czerniak and Abraham Hochberg

Mol Ther 9: S107-S108; doi:10.1016/j.ymthe.2004.06.218

281. Modulating the Immune Response to Oncolytic Measles Viruses

Rae M. Myers, Mary E. Harvey, Diane C. Soeffker, Suzanne M. Greiner, Kah-Whye Peng and Stephen J. Russell

Mol Ther 9: S108-S108; doi:10.1016/j.ymthe.2004.06.219

282. Transient Adenoviral Methylpurine DNA Glycosylase Overexpression Imparts Chemotherapeutic Sensitivity to Human Breast Cancer Cells

Mikael Rinne, David Caldwell, Ying He and Mark R. Kelley

Mol Ther 9: S108-S108; doi:10.1016/j.ymthe.2004.06.220

283. Adeno-Associated Viral Vector Expression Angiostatin and IL-15 for Brain Cancer Gene Therapy

Horng Jyh Harn, Kuang Wen Liao and Shinn Zong Lin

Mol Ther 9: S108-S108; doi:10.1016/j.ymthe.2004.06.221

284. Oncolytic Adenovirus E1B-19kD Deletion and E3B Retention Results in Both Enhanced Potency and Tumor Necrosis Factor - Mediated Selectivity

Ta-Chiang Liu, Yaohe Wang, Gunnel Hallden, Jennelle Francis, Gabriel Brooks, Nick Lemoine and David Kirn

Mol Ther 9: S109-S109; doi:10.1016/j.ymthe.2004.06.222

285. Evidence of Antiangiogenic and Antimetastatic Activities of the Recombinant Disintegrin Domain of Metargidin

Veronique Trochon-Joseph, Dominique Renoir, Lluis M. Mir, Annick Thomaidis, Paule Opolon, Elisabeth Connault, Hong Li, Christophe Grenet, Francoise Fauvel-Lafeve, Jeannette Soria, Chantal Legrand, Claudine Soria, Michel Perricaudet and He Lu

Mol Ther 9: S109-S109; doi:10.1016/j.ymthe.2004.06.223

286. Conditionally Replicating Adenoviral Vectors for Glioblastoma Treatment

Bertie H. C. G. M. de Leeuw, Maarten ter Horst, Mark Rodijk, Michael Brenner, Rob C. Hoeben and Peter A. E. Sillevis Smitt

Mol Ther 9: S109-S109; doi:10.1016/j.ymthe.2004.06.224

287. Enhancement of Therapeutic Efficacy of G207 for the Treatment of Malignant Glioma Through Musashi1 Promotor Retargeting of ICP 34.5 Gene-Mediated Virulence

Takahito Yazaki, Ryuichi Kanai, Hideyuki Tomita, Atsuo Shinoda, Hideyuki Okano and Takeshi Kawase

Mol Ther 9: S110-S110; doi:10.1016/j.ymthe.2004.06.830

288. Synergism Between a Conditionally Replicating Adenovirus Expressing p53 and Oxaliplatin in the Antiproliferative Effects on Human Colon Cancer Cell Lines

Dinja Oosterhoff, Victor W. van Beusechem, Epie Boven, Herbert M. Pinedo and Winald R. Gerritsen

Mol Ther 9: S110-S110; doi:10.1016/j.ymthe.2004.06.227

289. Cisplatin and Doxorubicin Enhance the Activity of the CRAd Ad5-|[Delta]|24RGD Against Osteosarcoma Cell Lines but Not Primary Osteosarcoma Cells

Harm C. A. Graat, M. Adhiambo Witlox, Frederik H. E. Schagen, Gertjan J. L. Kaspers, David T. Curiel, Marco N. Helder, Johannes Bras, Gerard R. Schaap, Winald R. Gerritsen, Paul I. J. M. Wuisman and Victor W. van Beusechem

Mol Ther 9: S110-S110; doi:10.1016/j.ymthe.2004.06.229

290. Demonstration of Antitumor Efficacy with an Oncolytic Adenovirus CG8840 for the Treatment of Bladder Cancer in an Orthotopic Tumor Model in Mice

Nagarajan Ramesh, Ying Ge, Jun Liu, Deborah Farson, Melinda Van Roey, Virginia Rojas, Peter Working and DeChao Yu

Mol Ther 9: S111-S111; doi:10.1016/j.ymthe.2004.06.232

291. Enhanced Therapeutic Effect of Adenoviral Vector-Mediated RTVP-1 Gene Therapy in Combination with Irradiation for Prostate Cancer

Tetsuo Fujita, Koji Naruishi, Nobuyuki Kusaka, Takefumi Satoh, Xiaorong Ji, Jianxiang Wang, Xiaohong Zhu, Guang Yang, Alexei A. Goltsov, Terry L. Timme, Maria T. Vlachaki, Bin S. Teh, E. Brian Butler and Timothy C. Thompson

Mol Ther 9: S111-S111; doi:10.1016/j.ymthe.2004.06.233

292. Modification of the p53 Transgene of a Replication-Competent Adenovirus Improves p53 Stability and Cancer Cell Killing

Harald Sauthoff, Teona Pipiya, Shu Chen, Sheila Heitner, Yao Qi Huang, William N. Rom and John G. Hay

Mol Ther 9: S112-S112; doi:10.1016/j.ymthe.2004.06.234

293. The Epithelial Glycoprotein-2 Promoter Controls Selective and Efficient Killing of Epithelium Derived Cancer Cells

Willemijn M. Gommans, Marianne G. Rots, Pamela M. J. McLaughlin, Simone J. van Eert, Martin C. Harmsen, Masato Yamamoto, David T. Curiel and Hidde J. Haisma

Mol Ther 9: S112-S112; doi:10.1016/j.ymthe.2004.06.235

294. Herpes Simplex Virus Mediated Oncolysis is an Effective Intratumoral Therapy in High-Risk Neuroblastoma Tumor Models

Nehal S. Parikh, Mark A. Currier, Lisa C. Adams, Margaret H. Collins and Timothy P. Cripe

Mol Ther 9: S112-S113; doi:10.1016/j.ymthe.2004.06.236

295. Selective Breast Tumor Growth Suppression Mediated by the Enhanced Breast Cancer-Specific Promoter

Chi-Ping Day, Kun-Ming Rau and Mien-Chie Hung

Mol Ther 9: S113-S113; doi:10.1016/j.ymthe.2004.06.237

296. Combination Therapy with Adenovirus (Ad5) and Cytotoxic Drugs Can Act Synergistically To Induce Cell Death in Carcinoma Cell Lines in Culture

Gunnel K. Hallden, Jiang Hui Meng, Richard Hill, Yaohe Wang, Jennelle Francis, Nicholas N. Lemoine and David H. Kirn

Mol Ther 9: S113-S113; doi:10.1016/j.ymthe.2004.06.238

297. Development of HVJ-E High Throughput Gene Function Screening System: Screening of Endothelial Cell Growth Factors

Tomoyuki Nishikawa, Hironobu Nakagami, Chiah Yian Yo and Yasufumi Kaneda

Mol Ther 9: S113-S114; doi:10.1016/j.ymthe.2004.06.239

298. RNA Mediated Transcriptional Gene Silencing in Human Cells

Kevin V. Morris, Chris Chung and David J. Looney

Mol Ther 9: S114-S114; doi:10.1016/j.ymthe.2004.06.240

299. Insertion Site Analysis and In Vivo Selection

Michael A. Harkey, Michael Weinreich, Yasuo Nagasawa, Patrick A. Navas and C. Anthony Blau

Mol Ther 9: S114-S115; doi:10.1016/j.ymthe.2004.06.241

300. Targeted Gene Correction in Mouse Embryonic Stem Cells Using Helper-Dependent Adenoviral Vectors

Fumi Ohbayashi, Michael A. Balamotis and Ko Mitani

Mol Ther 9: S115-S115; doi:10.1016/j.ymthe.2004.06.242

301. CID-Mediated In Vivo Selection: Heterogeneity Among Large Animal Models

Robert E. Richard, R. Angelo De Claro, Sylvia Chien, Hans-Peter Kiem, Tim Clackson, Robert Andrews and C. Anthony Blau

Mol Ther 9: S115-S115; doi:10.1016/j.ymthe.2004.06.243

302. Engineered Zinc Finger Transcription Factors: A Platform for Therapeutic Gene Regulation with Exquisite Specificity

Dmitry Guschin, Steve Zhang, Lei Zhang, Siyuan Tan, Victor Bartsevich, Casey Case, Edward Rebar and Philip Gregory

Mol Ther 9: S116-S116; doi:10.1016/j.ymthe.2004.06.244

303. Impaired Nuclear Transport and Virus Uncoating Limit Recombinant Adeno-Associated Virus 2 Vector-Mediated Transduction of Primary Murine Hematopoietic Cells

Li Zhong, Weiming Li, Zuocheng Yang, Njeri Maina, Keyun Qing, Yanjun Li, Linyuann Chen, Mengqun Tan, Rebecca J. Chan, Weihong Zhao, Steven H. Larsen, Mervin C. Yoder, Weinian Shou and Arun Srivastava

Mol Ther 9: S116-S116; doi:10.1016/j.ymthe.2004.06.245

304. Atelocollagen-Based Cell Transfection Array Allows High-Throughput Screening of Gene Functions

Kimi Honma, Hiroshi Ito, Syunji Nagahara, Teruo Miyata and Takahiro Ochiya

Mol Ther 9: S116-S117; doi:10.1016/j.ymthe.2004.06.246

305. Regulation of Targeted Gene Repair by DNA Replication and by DNA Replication Arrest

Eric B. Kmiec, Jennifer Sonntag and Erin Brachman

Mol Ther 9: S117-S117; doi:10.1016/j.ymthe.2004.06.247

306. Noninvasive Monitoring of Transgene Expression Using Surrogate Marker Peptides

Linh D. Pham, Suzanne Greiner, Takafumi Nakamura, Kah-Whye Peng, Gabriela A. Rosales, Kent R. Bailey, Pai C. Kao and Stephen J. Russell

Mol Ther 9: S117-S117; doi:10.1016/j.ymthe.2004.06.248

307. A Mechanism for AZT Mediated Enhancement of Transgene Expression

Fayaz R. Khazi, Andrew C. Edmondson and Katherine A. High

Mol Ther 9: S117-S118; doi:10.1016/j.ymthe.2004.06.249

308. A New Model to Functionally Measure Fusion Events in the Liver After Bone-Marrow Transplantation Over Time

Konrad L. Streetz, Denison D. Jenkins, Michael T. Longaker, Karl G. Sylvester and Mark A. Kay

Mol Ther 9: S118-S118; doi:10.1016/j.ymthe.2004.06.250

309. Controlling Embryogenesis Using Engineered Zinc Fingers in Drosophila

Andrew C. Jamieson, Thomas J. Cradick, Bo Guan, Hong Xiao and Pamela M. Carroll

Mol Ther 9: S118-S118; doi:10.1016/j.ymthe.2004.06.251

310. Feasibility and Limitations of Target Gene Repair in Mammalian Cells

Eric B. Kmiec, Li Liu and Hetal Parekh-Olmedo

Mol Ther 9: S118-S119; doi:10.1016/j.ymthe.2004.06.252

311. Targeted Gene Delivery to Selected Liver Segments by Isolated Hepatic Perfusion with Clamping of the Portal Vein

Hiroyasu Kinoshita, Sanae Hisayasu, Atsushi Watanabe, Satoru Suzuki and Takashi Shimada

Mol Ther 9: S119-S119; doi:10.1016/j.ymthe.2004.06.253

312. Developing Qualified Activity and Potency Assays for Gene Therapy and DNA Vaccine Products

Rick Hancock and Christopher Duffy

Mol Ther 9: S119-S119; doi:10.1016/j.ymthe.2004.06.254

313. Ligand-Specific Multiplex Gene Switch Expression in a Mouse Model

David W. Potter, Mohan B. Kumar, Martha A. DiPietro and Subba R. Palli

Mol Ther 9: S119-S119; doi:10.1016/j.ymthe.2004.06.255

314. mRNA Production is the Major Factor Limiting Autogene-Based Cytoplasmic Expression

Jonathan D. Finn, Ian MacLachlan and Pieter R. Cullis

Mol Ther 9: S119-S120; doi:10.1016/j.ymthe.2004.06.256

315. Targeted Gene Repair Exhibits a Polar Bias in the Directionality of Correction

Eric B. Kmiec and Miya Drury

Mol Ther 9: S120-S120; doi:10.1016/j.ymthe.2004.06.257

316. Cystic Fibrosis Airway Epithelial Cells Transfection

Rosalie Maurisse, Yann Fichou, Judy Chen, Claude Ferec, Jian-Sheng Sun and Dieter C. Gruenert

Mol Ther 9: S120-S120; doi:10.1016/j.ymthe.2004.06.258

317. DNA Damage and Homologous Recombination Regulate the Frequency and Process of Targeted Gene Repair

Eric B. Kmiec, Luciana Ferrara, Katie Maguire, Hetal Parekh-Olmedo and Tim Schwartz

Mol Ther 9: S120-S121; doi:10.1016/j.ymthe.2004.06.259

318. Cationic Lipids/Ligands Induce DNA Helix Denaturation and Alter Transcriptional Activity

K. T. Prasad, Madhusudhana N. Rao and Vijaya Gopal

Mol Ther 9: S121-S121; doi:10.1016/j.ymthe.2004.06.260

319. Improvement of Transgene Expression Through the Direct Intrahepatic Injection of Adenoviral Vectors

Julien Swen Crettaz, Pedro Berraondo, Gloria Gonzalez-Aseguinolaza, Veijay Shankar and Laura Ochoa

Mol Ther 9: S121-S121; doi:10.1016/j.ymthe.2004.06.261

320. Effect of Sexual Steroid Hormones on Human egr-1 Promoter

Francisco Martinez-F., Hilda Villegas-C., Alejandro Jimenez-O., Roberto Razo and David T. Curiel

Mol Ther 9: S121-S122; doi:10.1016/j.ymthe.2004.06.262

321. siFECT|[trade]|: Optimised Formulation for the Delivery of siRNA at Minimum Doses and Maximum Specificity

Sebastien Spagnou, Michael Jorgensen, Andrew D. Miller and Michael Keller

Mol Ther 9: S122-S122; doi:10.1016/j.ymthe.2004.06.263

322. Characterization of IFN|[gamma]| Gene Expressions in Rat Tissues with Real Time Quantitative RT-PCR

Baohong Tian, Sarah S. Rentz, Gregory S. Gorman, Rogers Tina and John G. Page

Mol Ther 9: S122-S123; doi:10.1016/j.ymthe.2004.06.264

323. Adenovirus Mediated Transfer of LacZ Gene in the Murine Melanoma Cell B16

Hui Li and Jiansheng Li

Mol Ther 9: S123-S123; doi:10.1016/j.ymthe.2004.06.265

324. The Degron Motif: A Protein Destruction Module with Potent Transcriptional Activation Properties for ZFP-Targeted Gene Regulation

Siyuan Tan, Dmitry Guschin, Carolyn Dent, Andreas Reik, Pei-Qi Liu and Philip D. Gregory

Mol Ther 9: S123-S123; doi:10.1016/j.ymthe.2004.06.266

325. Identification of Mechanistically Distinct Repression Domains at Endogenous Genes Using Engineered Zinc Finger Proteins

Siyuan Tan, Lei Zhang, H. Steven Zhang, Xaohong Zhong, Yann Jouvenot, Andrew W. Snowden, Andrew R. McNamara, Casey C. Case, Carl O. Pabo and Philip D. Gregory

Mol Ther 9: S123-S123; doi:10.1016/j.ymthe.2004.06.267

326. Zinc Finger Protein Targeted Epigenetic Gene Regulation: Toward Directed Long-Term Gene Control

Andrew R. McNamara, Andrew W. Snowden and Philip D. Gregory

Mol Ther 9: S123-S124; doi:10.1016/j.ymthe.2004.06.268

327. Retargetable Oncolytic Measles Viruses for Cancer Virotherapy

Takafumi Nakamura, Kah-Whye Peng, Mary Harvey and Stephen J. Russell

Mol Ther 9: S124-S124; doi:10.1016/j.ymthe.2004.06.269

328. Paramyxovirus Fusion Protein Trimers: Partial Membrane-Proximal Ectodomain Cleavage Enhances Function

Veronika von Messling, Dragana Milosevic, Patricia Devaux and Roberto Cattaneo

Mol Ther 9: S124-S124; doi:10.1016/j.ymthe.2004.06.270

329. Long-Term Transgene Expression by Hepatocytes Transduced with Retroviral Vectors Requires Induction of Immune Tolerance to the Transgene

Juliana Pupi, Carole Guillonneau, Virginie Picard, Maria C. Cuturi, Nicolas Ferry and Ignacio Anegon

Mol Ther 9: S124-S125; doi:10.1016/j.ymthe.2004.06.271

330. Genetic Modification of Murine Embryonic Stem Cells by the Gene Silencing Resistance Retroviral Vector GCDsap

Sanae Hamanaka, Joichi Usui, Satoru Takahashi, Hisahiro Yoshida, Michio Nagata, Makoto Otsu, Shin Kaneko, Toshiro Nagasawa, Hiromitsu Nakauchi and Masafumi Onodera

Mol Ther 9: S125-S125; doi:10.1016/j.ymthe.2004.06.272

331. Human T Cells Efficiently Abort RCR-Infection Through a CEM15/APOBEC3G-Mediated Mechanism

Saskia B. Ebeling, Elles Simonetti, Stephanie Laufs, Frank Giordano, Stefan Fruehauf and Anton Hagenbeek

Mol Ther 9: S125-S126; doi:10.1016/j.ymthe.2004.06.273

332. Dual Gene Transfer and Transgenesis by Novel Lentiviral Vectors Carrying Synthetic Bi-Directional Promoters

Mario Amendola, Mary Anna Venneri, Elisa Vigna and Luigi Naldini

Mol Ther 9: S126-S126; doi:10.1016/j.ymthe.2004.06.274

333. Vector Development by Molecular Evolution: A Selection Procedure for Envelope Proteins Pseudotyping Lentiviral Particles

Christoph A. Merten, Joern Stitz, Klaus Cichutek and Christian J. Buchholz

Mol Ther 9: S126-S126; doi:10.1016/j.ymthe.2004.06.275

334. Micro-Environmental Effects on Gene Transfer by Pseudotyped Lentiviral Vectors

James R. Gilbert and Frank Park

Mol Ther 9: S127-S127; doi:10.1016/j.ymthe.2004.06.276

335. Long-Term Genetic Modification of the Ocular Outflow Tract Coupled with Non-Invasive Real-Time Imaging of Gene Expression

Nils A. Loewen, Michael P. Fautsch, Wu-Lin Teo, Cindy K. Bahler, Douglas H. Johnson and Eric M. Poeschla

Mol Ther 9: S127-S127; doi:10.1016/j.ymthe.2004.06.277

336. Foamy Virus |[mdash]| Adenovirus Hybrid Vectors

Axel Rethwilm, Marcus Picard-Maureau, Florian Kreppel, Dirk Lindemann, Thomas Juretzek, Ottmar Herchenroeder, Martin Heinkelein and Stefan Kochanek

Mol Ther 9: S127-S127; doi:10.1016/j.ymthe.2004.06.278

337. Unrestricted Liver Transduction with AAV Serotype 8 Vector in Mice

Hiroyuki Nakai, Theresa Storm, Sally Fuess and Mark A. Kay

Mol Ther 9: S128-S128; doi:10.1016/j.ymthe.2004.06.279

338. Therapeutic Levels for |[alpha]|1-Antitrypsin Following Intrapleural Administration of a Non-Human Primate Serotype rh10 AAV Vector Expressing |[alpha]|1-Antitrypsin

Bishnu P. De, Nabil Wasif, Neil R. Hackett, Guangping Gao, James M. Wilson and Ronald G. Crystal

Mol Ther 9: S128-S128; doi:10.1016/j.ymthe.2004.06.280

339. Sustained, High-Level Expression of Human Acid Alpha-Glucosidase and Correction of Glycogen Storage Disease Type II (GSD II) with an Adeno-Associated Virus 8 (AAV2/8) Vector Containing a Liver-Specific Promoter

Luis M. Franco, Baodong Sun, Andrew Bird, Haoyue Zhang, Andrea Amalfitano, Y.-T. Chen and Dwight D. Koeberl

Mol Ther 9: S129-S129; doi:10.1016/j.ymthe.2004.06.652

340. Assessment of the Transduction Patterns of Alternative AAV Vector Serotypes in the CNS of Rhesus Macaques

Bruce A. Bunnell, Jason DuFour, Gretchen Belenchia, Xavier Alvarez, Kate Baker, Pete Didier, Andrew Lackner and John H. Wolfe

Mol Ther 9: S129-S129; doi:10.1016/j.ymthe.2004.06.282

341. Autoimmune Anemia in Macaques Following Erythropoietin Gene Therapy

Guangping Gao, Corinna Lebherz, Daniel J. Weiner, Rebecca L. Grant, Roberto Calcedo, Adam Bagg, Yi Zhang and James M. Wilson

Mol Ther 9: S130-S130; doi:10.1016/j.ymthe.2004.06.995

342. Self-Complementary Adeno-Associated Virus 2 (AAV)-T Cell Protein Tyrosine Phosphatase Vector as a Helper-Virus to Improve Transduction Efficiency of Conventional AAV Vectors in vitro and in vivo

Li Zhong, Linyuan Chen, Yanjun Li, Keyun Qing, Rebecca J. Chan, Mervin C. Yoder, Koppal S. Rao and Arun Srivastava

Mol Ther 9: S130-S130; doi:10.1016/j.ymthe.2004.06.287

343. Characterization of Delivery Routes of AAV Vectors for Neonatal Gene Transfer

Tsuyoshi Ogura, HIroaki Mizukami, Jun Mimuro, Takashi Okada, Hiromi Hamada, Akihiro Kume, Hiroyuki Yoshikawa, Yoichi Sakata and Keiya Ozawa

Mol Ther 9: S130-S131; doi:10.1016/j.ymthe.2004.06.290

344. Recombinant Adeno-Associated Virus 2 Suicide Vectors for the Treatment of Human Sarcomas and Mesotheliomas

Marlon R. Veldwijk, Simone Berlinghoff, Stephanie Laufs, Frederik Wenz, Stefan Fruehauf and W. Jens Zeller

Mol Ther 9: S131-S131; doi:10.1016/j.ymthe.2004.06.292

345. Sensitive Molecular Detection of Various Stable Episomal Concatemeric and Integrated Forms of rAAV2 after Long-Term Expression In Vivo

Karim Zaoui, Manfred Schmidt, Denise E. Sabatino, Fayaz R. Khazi, Hanno Glimm, Junwei Sun, Katherine A. High and Christof von Kalle

Mol Ther 9: S131-S132; doi:10.1016/j.ymthe.2004.06.295

346. Characterization of Adeno-Associated Virus Sequences in Human Tissues

Chun-Liang Chen, Ryan L. Jensen, Bruce C. Schnepp, K. Reed Clark and Philip R. Johnson

Mol Ther 9: S132-S132; doi:10.1016/j.ymthe.2004.06.299

347. Pharmacological Regulation of Dendritic Cell Activation: Enhancing Cancer Vaccine Efficacy

Brent A. Hanks, Jianghong Jiang and David M. Spencer

Mol Ther 9: S132-S133; doi:10.1016/j.ymthe.2004.06.283

348. IL-21 and IL-15 Gene Therapy Induces Powerful Antitumor Effect Against Head and Neck Squamous Cell Carcinoma

Hiroshi Nakano, Tsunao Kishida, Hidetsugu Asada, Takashi Shinomiya, Jiro Imanishi, Yasuo Hisa and Osamu Mazda

Mol Ther 9: S133-S133; doi:10.1016/j.ymthe.2004.06.289

349. GM-CSF / IL-2 Fusion Transgene is More Potent than GM-CSF and IL-2 in Combination and is Dependent upon CD8 and NK Cells for Antitumor Effect

John Stagg, Nathaniel Bouganim and Jacques Galipeau

Mol Ther 9: S133-S133; doi:10.1016/j.ymthe.2004.06.296

350. Gene Transfer of Modified Idiotype into Dendritic Cells for Immunotherapy of Non-Hodgkin Lymphomas

Sara Muraro, Attilio Bondanza, Matteo Bellone, Philip Greenberg and Chiara Bonini

Mol Ther 9: S134-S134; doi:10.1016/j.ymthe.2004.06.301

351. Enhanced Therapeutic Efficacy of a Cytokine Expressing Oncolytic Herpes Simplex Virus Against Prostate Cancer

Susan Varghese, Samuel D. Rabkin, Wenzheng Wang and Robert L. Martuza

Mol Ther 9: S134-S134; doi:10.1016/j.ymthe.2004.06.303

352. Intentional Killing of Normal Melanocytes by Gene Transfer Generates Curative Anti Melanoma Immunity without Obligate Autoimmunity

Gregory Daniels, Luis Sanchez-Perez, Timothy Kottke, Rosa M. Diaz, Jill Thompson, Mayoi Lai, Michael Gough, Mahzuz Karim, Andrew Bushell, Heung Chong, Alan Melcher, Kevin Harrington and Richard G. Vile

Mol Ther 9: S134-S135; doi:10.1016/j.ymthe.2004.06.306

353. In a Model of Tumor Dormancy, Long-Term Persistent Leukemic Cells Have Increased B7-H1 and B7.1 Expression and Resist CTL-Mediated Lysis

Aurore Saudemont and Bruno Quesnel

Mol Ther 9: S135-S135; doi:10.1016/j.ymthe.2004.06.309

354. CD8 Immunomagnetic Selection and Interleukin-15 (IL-15) Facilitate the Isolation of Human CD8+ Cytotoxic T-Lymphocytes (CTL) Genetically Engineered To Express an Anti-CD20 Chimeric T-Cell Receptor (cTCR)

Eric Y. Chen, Oliver W. Press and Michael C. Jensen

Mol Ther 9: S135-S135; doi:10.1016/j.ymthe.2004.06.313

355. Specific Lysis of Multiple Myeloma Cells by T-Cells Engineered to Express a Chimeric Immune Receptor Targeting WUE-Antigen

Max S. Topp, Horst D. Hummel, Gabriele Kuntz, Christina Neff and Hermann Einsele

Mol Ther 9: S136-S136; doi:10.1016/j.ymthe.2004.06.318

356. IL-12 Transduced Bone Marrow Cells Home to Bone and Generate Anti-Metastatic Activities in a Mouse Prostate Cancer Model

Hongyu Wang, Guang Yang, Terry L. Timme, Tetsuo Fujita, Koji Naruishi, Xiaorong Ji, Malcolm K. Brenner, Dov Kadmon and Timothy C. Thompson

Mol Ther 9: S136-S136; doi:10.1016/j.ymthe.2004.06.324

357. Selective Depletion of Kupffer Cells Leads to Enhanced Transgene Expression in Rat Liver Following Intraductal Infusion of Naked DNA and DNA Nanoparticles

Hui Dai, Xuan Jiang, Weiseng Lim, Xuesong Jiang, Yong Chen, Hai-Quan Mao and Kam W. Leong

Mol Ther 9: S136-S137; doi:10.1016/j.ymthe.2004.06.284

358. Route of Administration of sec-R Targeted Compacted DNA Influences Both the Site of Expression and Host Immune Response to the Vector

Assem G. Ziady, John Kim, Joseph Colla and Pamela B. Davis

Mol Ther 9: S137-S137; doi:10.1016/j.ymthe.2004.06.286

359. Enhanced Gene Delivery by a Novel Tumor-Specific Vector Containing Peptide and Nucleic Acid Based Nuclear Translocation Signals

Stanley Saamoah-Moffatt, Sandra Wiehle and Richard J. Cristiana

Mol Ther 9: S137-S138; doi:10.1016/j.ymthe.2004.06.288

360. Long-Term Gene Transfer and Expression in Xenografted Human Glioblastoma by Non-Viral Gene Transfer with the Sleeping Beauty Transposon

John R. Ohlfest, Scott Perkinson, Paul Lobitz, Diane Hasz and David A. Largaespada

Mol Ther 9: S138-S138; doi:10.1016/j.ymthe.2004.06.291

361. Reduction of Polyethylenimine Buffering Capacity Enhances In-Vitro Gene Delivery Activity

M. Laird Forrest, Nathan Gabrielson and Daniel W. Pack

Mol Ther 9: S138-S138; doi:10.1016/j.ymthe.2004.06.293

362. Novel Synthetic Poly(hydroxylamidoamine)s Facilitate Efficient and Nontoxic Gene Delivery with Mammalian Cells

Theresa M. Reineke, Yemin Liu and Laura Wenning

Mol Ther 9: S139-S139; doi:10.1016/j.ymthe.2004.06.294

363. Uptake and Intracellular Trafficking of Stabilized and Unstabilized Gene Delivery Particles

Swaroop Mishra, Paul Webster and Mark E. Davis

Mol Ther 9: S139-S139; doi:10.1016/j.ymthe.2004.06.297

364. The Proteasome Metabolizes Non-Viral Gene Delivery Systems

Ji-seon Kim and Kevin G. Rice

Mol Ther 9: S139-S139; doi:10.1016/j.ymthe.2004.06.298

365. Cell Membrane Lipid Rafts Mediate Caveolar Endocytosis of HIV-1 Tat Fusion Proteins

Antonio Fittipaldi, Silvia Agostini, Aldo Ferrari, Caterina Arcangeli, Vittorio Pellegrini, Fabio Beltram and Mauro Giacca

Mol Ther 9: S139-S140; doi:10.1016/j.ymthe.2004.06.300

366. Negative Feedback Inhibition of HIV-1: A Novel HIV-1 LTR-hsp70 Fusion Promoter Directs HIV-1 Inducible siRNA Expression

Hoshang J. Unwalla, James D. Kim, Haitang Li and John J. Rossi

Mol Ther 9: S140-S140; doi:10.1016/j.ymthe.2004.06.302

367. Development of Lentiviral Vectors Carrying shRNA, Ribozyme and RNA Decoy for the Inhibition of HIV-1 Infection

Ming-Jie Li, James Kim, Shirley Li, John Zaia, Jiing-Kuan Yee and John J. Rossi

Mol Ther 9: S140-S140; doi:10.1016/j.ymthe.2004.06.304

368. Pseudotyping HIV Vector with the Spike Envelope Protein of SARS-CoV for Studying Viral Tropism, Immunology and Gene Therapy Applications

Gary P. Kobinger, Heinz Feldmann, Gregory P. Schumer and James M. Wilson

Mol Ther 9: S140-S140; doi:10.1016/j.ymthe.2004.06.305

369. Selective Expansion of Human T Lymphocytes Transduced by HIV Vectors Containing IMPDH2 and Anti-HIV siRNA Genes

Priscilla Yam, Ying Yu, Jerry Wu, Michael C. Jensen, John A. Zaia and Jiing-Kuan Yee

Mol Ther 9: S141-S141; doi:10.1016/j.ymthe.2004.06.307

370. Potent In Vivo Inhibition of HIV-1 Infection in Thy/Liv-SCID-Hu Mice after In Vivo Treatment with a Combination of SV40-Derived Vectors Targeting CCR5 Expression

Mahesh Patel, Pierre Cordelier, David S. Strayer and Harris Goldstein

Mol Ther 9: S141-S141; doi:10.1016/j.ymthe.2004.06.310

371. Complete Inhibition of Hepatitis B Virus Gene Expression In Vivo with Short Hairpin RNA Expressed from a Novel Double-Stranded, Bi-Cistronic Adeno-Associated Virus Pseudotype 8 Vector

Dirk Grimm, Konrad L. Streetz, Theresa A. Storm, Hiroyuki Nakai, Anton P. McCaffrey, Zan Huang, Felix H. Salazar, Patricia L. Marion and Mark A. Kay

Mol Ther 9: S141-S142; doi:10.1016/j.ymthe.2004.06.918

372. Passive Immunotherapy for Anthrax Mediated by an Adenovirus Expressing Anti-Protective Antigen Single Chain Antibody

Kazuhiko Kasuya, Julie L. Boyer, Yadi Tan, D. Olivier Alipui, Neil R. Hackett and Ronald G. Crystal

Mol Ther 9: S142-S142; doi:10.1016/j.ymthe.2004.06.315

373. Simian Adenoviral Vector Based-Vaccine Fully Protect Against Ebola Virus Even in the Presence of Pre-Existing Immunity to Human Adenovirus

Gary P. Kobinger, Heinz Feldmann, Yan Zhi, Gregory P. Schumer, Guangping Gao, Frederik Feldmann, Steven Jones and James M. Wilson

Mol Ther 9: S142-S142; doi:10.1016/j.ymthe.2004.06.317

374. Development of a Genetic Vaccine Conferring Protective Immunity Against |[alpha]|-Cobratoxin Following a Single Administration of an Adenovirus Vector Encoding a Modified, Non-Toxic Cobratoxin Variant

Robert G. Pergolizzi, Rachel Dragos, Alexander Ropper, Andre Menez and Ronald G. Crystal

Mol Ther 9: S143-S143; doi:10.1016/j.ymthe.2004.06.319

375. The Function of F12-Vif Mutant in the Context of APOBEC3G/Vif Model

Giuliana Vallanti, Rossella Lupo, Maurizio Federico, Fulvio Mavilio and Chiara Bovolenta

Mol Ther 9: S143-S143; doi:10.1016/j.ymthe.2004.06.320

376. A Metabolically Responsive Insulin Transgene Delivered by AAV2/8 Pseudotyped, Self-Complementary AAV (SC-AAV2/8) Controls Glycemia in STZ-Diabetic Mice

Mirek Kozlowski, Dorota Lyszcowizc, Adam G. Campbell, Darin E. Olson, Janet E. Rubin and Peter M. Thule

Mol Ther 9: S143-S144; doi:10.1016/j.ymthe.2004.06.308

377. Expression of Acid |[alpha]|-Glucosidase in Nonhuman Primate Diaphragm and Peritoneum after Direct In Utero Delivery of Recombinant Adeno-Associated Virus Type 1

Mary B. Rucker, Alice F. Tarantal, Thomas Conlon, Terence R. Flotte and Barry J. Byrne

Mol Ther 9: S144-S144; doi:10.1016/j.ymthe.2004.06.311

378. An AAV Vector-Mediated Micro-Dystrophin Expression in Relatively Small Percentage of Dystrophin-Deficient mdx Myofibers Still Improved the mdx Phenotype Through Compensatory Hypertrophy

Madoka Ikemoto, Madoka Yoshimura, Miki Sakamoto, Yasushi Mochizuki, Katsutoshi Yuasa, Toshifumi Yokota, Yuko Miyagoe-Suzuki and Shin'ichi Takeda

Mol Ther 9: S144-S145; doi:10.1016/j.ymthe.2004.06.312

379. Myogenic Differentiation of Multipotent Adult Progenitor Cells Derived from Bone Marrow and Muscle Tissue

Morayma Reyes, Sheng Li, En Kimura, Leonard Meuse and Jeffrey Chamberlain

Mol Ther 9: S145-S145; doi:10.1016/j.ymthe.2004.06.314

380. Dedifferentiation of Primary Murine Myoblasts Induced by Ectopic Expression of Msx1

Qiang Liu, Wen Liu, Paul Allen and Yaming Wang

Mol Ther 9: S145-S146; doi:10.1016/j.ymthe.2004.06.316

381. Self-Cleaving Multimeric Hammerhead Ribozymes Abolish Mutant Collagen Transcripts In Cellulo and Exhibit Activity In Vivo

Belinda E. Peace, Jane B. Florer, George Y. Wu, Yoel Smicum, Michael W. Kilpatrick, Petros Tsipouras and Richard J. Wenstrup

Mol Ther 9: S146-S146; doi:10.1016/j.ymthe.2004.06.919

382. In Utero Intramuscular Delivery of a High-Capacity Adenoviral Vector Carrying a Full-Length Murine Dystrophin cDNA Provides Functional Benefit and Reassembly of the Dystrophin-Glycoprotein Complex in Hind Limb Muscles of mdx Mice

Daniel P. Reay, Roberto Bilbao, Eric Wu, Terry L. O'Day, Jon F. Watchko and Paula R. Clemens

Mol Ther 9: S146-S146; doi:10.1016/j.ymthe.2004.06.321

383. Cloning of the Minimal Functional Domain of Human LIM Mineralization Protein-3 Able to Induce Bone Mineralization: In Vitro and In Vivo Study

Enrico Pola, Wanda Lattanzi, Wentao Go, Huijie Sun, Kaori Okada, Andrea Gambotto, Carlo A. Logroscino and Paul D. Robbins

Mol Ther 9: S147-S147; doi:10.1016/j.ymthe.2004.06.322

384. Stem Cells Expressing SMAD 8: A Platform for Tendon Regeneration

Gadi Pelled, Andrea Hoffman, Gadi Turgeman, Peter Eberle, Yoram Zilberman, Hadassah Shinar, Keren Keinan-Adamsky, Andreas Winkel, Gil Navon, Gerhard Gross and Dan Gazit

Mol Ther 9: S147-S147; doi:10.1016/j.ymthe.2004.06.325

385. Noggin Gene-Based Therapy Inhibits Cranial Defect Healing in Mice

Gregory M. Cooper, Hairong Peng, Arvydas Usas, Mark P. Mooney and Johnny Huard

Mol Ther 9: S148-S148; doi:10.1016/j.ymthe.2004.06.327

386. Intra-Arterial Adenoviral Mediated |[beta]|2Adrenergic Receptor (AR) Gene Delivery Induces Neoangiogenesis in Rat Ischemic Hindlimb

Guido Iaccarino, Vincenzo Cerullo, Michele Ciccarelli, Gennaro Galasso, Daniela Sorriento, Walter J. Koch, Federico Piscione, Lucio Pastore, Francesco Salvatore and Bruno Trimarco

Mol Ther 9: S148-S148; doi:10.1016/j.ymthe.2004.06.323

387. The Size of Sinusoidal Fenestrae Is a Critical Determinant of Hepatocyte Transduction after Adenoviral Gene Transfer

Joke Lievens, Jan Snoeys, Katrien Vekemans, Sophie Van Linthout, Ronald de Zanger, D|[eacute]|sir|[eacute]| Collen, Eddie Wisse and Bart De Geest

Mol Ther 9: S149-S149; doi:10.1016/j.ymthe.2004.06.326

388. Protection of End-Organ Damage in Stroke-Prone Spontaneously Hypertensive Rats by Intramuscular Injection of AAV Vector Expressing Interleukin-10

Tatsuya Nomoto, Takashi Okada, Kuniko Shimazaki, Toru Yoshioka, Mutsuko Sarukawa, Koichi Takeuchi, Hiroaki Mizukami, Takashi Matsushita, Ken-ichiro Katsura, Keiji Yamamoto, Akihiro Kume, Uichi Ikeda, Shigeo Ookawara, Yasuo Katayama and Keiya Ozawa

Mol Ther 9: S149-S149; doi:10.1016/j.ymthe.2004.06.328

389. Placental Growth Factor (PIGF) Gene Transfer to the Periadventitial Tissue

Shalini Bhardwaj, Himadri Roy, Kari Alitalo and Seppo Yla-Herttuala

Mol Ther 9: S150-S150; doi:10.1016/j.ymthe.2004.06.329

390. eNOS Gene Transfected Endothelial Cells Inhibit Smooth Muscle Cell Proliferation and Platelet Aggregation In Vitro

Guanhua Xue, Jiwei Zhang, Hao Zhang, baigen Zhang and Minli Sun

Mol Ther 9: S150-S150; doi:10.1016/j.ymthe.2004.06.330

391. Targeted Delivery of Adenovirus Expressing eNOS to the Endothelium In Vivo Lowers Blood Pressure in Hypertensive Rats

William H. Miller, M. Julia Brosnan, Delyth Graham, Arlene J. Frater, Keith M. Channon, Sergei M. Danilov, Paul N. Reynolds, Andrew H. Baker and Anna F. Dominiczak

Mol Ther 9: S150-S151; doi:10.1016/j.ymthe.2004.06.332

392. High Intrinsic Expression of Manganese Superoxide Dismutase is a Critical Protective Mechanism Against Oxidative Stress in Human Endothelial Progenitor Cells

Tongrong He, Timothy E. Peterson, Ekhson L. Holmuhamedov, Andre Terzic, Noel M. Caplice, Larry W. Oberley and Zvonimir S. Katusic

Mol Ther 9: S151-S151; doi:10.1016/j.ymthe.2004.06.334

393. rAAV-Mediated Apo a-1 Milano Gene Transfer Results in Significant Inhibition of Atherogenesis

Sarah Hardy, Prediman K. Shah, Svapna Patel, Juliana Yano, Tripathi B. Rajavashisth, K. K. Wong and Saswati Chatterjee

Mol Ther 9: S151-S151; doi:10.1016/j.ymthe.2004.06.336

394. Effective Focal, Homogeneous Gene Transfer after Coronary Infusion of Adenoviruses

Tetsuo Sasano, Kan Kikuchi, Amy McDonald, Kevin Mills, Leah Peller and Kevin Donahue

Mol Ther 9: S151-S152; doi:10.1016/j.ymthe.2004.06.339

395. Beta-Blockers Restrict Maximum Levels of Transgene Expression Elicited by CMV Promoters in Vascular Smooth Muscle Cells

Husein K. Salem, Paul A. Kingston and Anthony M. Heagerty

Mol Ther 9: S152-S152; doi:10.1016/j.ymthe.2004.06.341

396. Factors Affecting Retroviral Gene Transfer to Human CD34+ Cells

Youngtae Hong, Seungshin Yu, Sujeong Kim, Joonggon Kim and Sunyoung Kim

Mol Ther 9: S152-S152; doi:10.1016/j.ymthe.2004.06.331

397. Transduction of Primary Human CD34+ Cells by Self-Inactivating FIV Vectors

Charlene F. Barroga, Mehdi Gasmi, Olivera Marjanovic, Laura Innis and David J. Looney

Mol Ther 9: S152-S153; doi:10.1016/j.ymthe.2004.06.333

398. Transduction of Human Hematopoietic Stem Cells and T-Lymphocytes with RD114-TR-Pseudotyped Lentiviral Vectors

Francesca Di Nunzio, Bianca Piovani, Sabrina Cazzaniga, Chiara Bonini, Francois-Loic Cosset, Fulvio Mavilio and Anna Stornaiuolo

Mol Ther 9: S153-S153; doi:10.1016/j.ymthe.2004.06.338

399. Transduction of Hematopoietic Stem Cells Using Polymer-Concentrated Ecotropic Retrovirus Coupled with In Vivo Selection of Gene-Modified Cells

Douglas W. McMillin, Natalia Landazuri, Bagirath Gangadharan, David Archer, Joseph Le Doux and H. Trent Spencer

Mol Ther 9: S153-S154; doi:10.1016/j.ymthe.2004.06.342

400. Transduction of Human Embryonic Stem Cells with Lentiviral Vectors: Variable Promoter Activity in Pluripotent Cells

Andrew Hinton, Theodore Friedmann and Alberto Hayek

Mol Ther 9: S154-S154; doi:10.1016/j.ymthe.2004.06.347

401. Engineering Retroviral Vectors for Stem Cell Therapies-Overcoming the Effect of Gene Silencing

Gary K. Lee and David V. Schaffer

Mol Ther 9: S154-S154; doi:10.1016/j.ymthe.2004.06.350

402. Retrovirus and Lentivirus Vectors Are Silenced in ES Cells by Dynamic Interplay of Multiple Epigenetic Modifications

Shuyuan Yao, Tanya Sukonnik, Tara Kean, Rikki Bharadwaj, Peter Pasceri and James Ellis

Mol Ther 9: S154-S155; doi:10.1016/j.ymthe.2004.06.354

403. Selective Engraftment of Genetically Modified Hematopoietic Stem Cells by a Truncated Erythropoietin Receptor

Fabrizia Urbinati, Alexis Grande, Francesco Lotti, Giulia Facchini, Giuliana Ferrari and Fulvio Mavilio

Mol Ther 9: S155-S155; doi:10.1016/j.ymthe.2004.06.360

404. Cloning and Expression of Canine O6-Methylguanine|[ndash]|DNA Methyltransferase Fene in Ex Vivo Cultured Cells

Michail M. Zaboikin, Narasimhachar Srinivasakumar, Tatiana N. Zaboikina and Friedrich G. Schuening

Mol Ther 9: S155-S155; doi:10.1016/j.ymthe.2004.06.366

405. Efficient Lentivirus Vector-Mediated Transduction of Neonatal Porcine Islet Cell Clusters: A Powerful Tool for Xenotransplantation Research

Samantha L. Ginn, Wayne J. Hawthorne, Anita T. Patel, Rebecca Stokes, Stacey N. Walters, Philip J. O'Connell, Peter B. Rowe and Ian E. Alexander

Mol Ther 9: S155-S156; doi:10.1016/j.ymthe.2004.06.371

406. Determination of the Most Efficient Vector System for Gene Transduction into Dendritic Cells (DC)

Eigo Satoh, Hua Yan, Xiao-Kang Li, Wataru Sugiura, Naoki Yamamoto, Kenichi Teramoto, Shigeki Arii and Hiromitsu Kimura

Mol Ther 9: S156-S156; doi:10.1016/j.ymthe.2004.06.377

407. Comparison of Transgene Expression Driven from 4 Different Retroviral Long Terminal Repeats

Sujeong Kim, Mi-Dong Kim, Seock Kang, Chang Wan Joo, Haesook An, Karim Lee, Sunyoung Kim and Seung Shin Yu

Mol Ther 9: S156-S156; doi:10.1016/j.ymthe.2004.06.390

408. Developing Lentiviral Vectors for Specific Gene Expression in CD4+ T Cells

Kit L. Shaw, Karen Pepper, Denise Petersen and Donald B. Kohn

Mol Ther 9: S156-S157; doi:10.1016/j.ymthe.2004.06.396

409. In Vivo Comparison of Liver-Specific Enhancer-Promoter Constructs in the Context of Lentiviral Vectors

Tatiana Khakhoulina, Tuan Huy Nguyen, Catherine Fux-Cametti and Didier Trono

Mol Ther 9: S157-S157; doi:10.1016/j.ymthe.2004.06.402

410. Multivalent siRNAs for Combinatorial HIV Gene Therapy

Joseph S. Anderson, Akhil Banerjea, Ming-Jie Li, John Rossi and Ramesh Akkina

Mol Ther 9: S157-S157; doi:10.1016/j.ymthe.2004.06.407

411. Creation of Novel Lentiviral Vectors That Co-Package Anti-HIV Ribozymes with HIV-1

Shuo Gu, James D. Kim and Gerhard Bauer

Mol Ther 9: S157-S158; doi:10.1016/j.ymthe.2004.06.411

412. Cyclosporine Inhibits the Induction of GFP Specific Immune Responses after Transplantation of Lentivirally Transduced GFP Expressing Hematopoietic Stem Cells in Dogs

Karen Beagles, Laura Peterson, Tobias Neff and Hans-Peter Kiem

Mol Ther 9: S158-S158; doi:10.1016/j.ymthe.2004.06.419

413. Development and Characterization of Lentiviral Vectors for Hemophilia Gene Therapy

Lieven Thorrez, Michael Maris, Carol Miao, Nico Van Rooijen, D|[eacute]|sir|[eacute]| Collen and Marinee Chuah Thierry VandenDriessche

Mol Ther 9: S158-S159; doi:10.1016/j.ymthe.2004.06.424

414. Design of an HIV Vector for Site-Specific Gene Insertion

Gilles Michel, Ying Yu and Jiing-Kuan Yee

Mol Ther 9: S159-S159; doi:10.1016/j.ymthe.2004.06.429

415. Conditional Expression of a Suicide Gene by the Telomere Reverse Transcriptase Promoter for Post-Therapeutic Deletion of Insertional Mutagenesis

Richard G. Painter, Nicholas A. Lanson, Zhengmin Jin, Frank Park and Guoshun Wang

Mol Ther 9: S159-S159; doi:10.1016/j.ymthe.2004.06.432

416. Transient Gene Expression by Non-Integrating Lentiviral (NIL) Vectors

Sarah Nightingale, Roger P. Hollis, Catherine Yang, Ingrid Bahner, Karen A. Pepper and Donald B. Kohn

Mol Ther 9: S159-S160; doi:10.1016/j.ymthe.2004.06.435

417. Simultanous Transfer of the p16INK4a and p21Waf1 Tumor Suppressor Genes Plus GFP Mediated by a Novel Polycistronic Retroviral Vector

Lia K. Muschellack, Bryan E. Strauss and Eugenia Costanzi-Strauss

Mol Ther 9: S160-S160; doi:10.1016/j.ymthe.2004.06.437

418. Adaptation of the Wave Bioreactor to Baculoviral Production of AAV Vectors: Scale-Up Considerations

Haifeng Chen, Shangzhen Zhou, Glenn P. Pierce and Peter Colosi

Mol Ther 9: S160-S160; doi:10.1016/j.ymthe.2004.06.335

419. Production of Recombinant Adeno-Associated Virus Type 5 in Insect Cells

Masashi Urabe, Takayo Nakakura, Keiya Ozawa and Robert M. Kotin

Mol Ther 9: S160-S161; doi:10.1016/j.ymthe.2004.06.337

420. Adaptation of Baculovirus System for Large-Scale Production of rAAV Vector Serotypes

Erik Kohlbrenner, George Aslanidi, David R. Knop, Oleg Gorbatyuk, Kevin Nash, Ronald J. Mandel, Nicholas Muzyczka, Barry J. Burns, Richard O. Snyder and Sergei Zolotukhin

Mol Ther 9: S161-S161; doi:10.1016/j.ymthe.2004.06.340

421. Large-Scale Production of AAV and Adenovirus Vectors Using Active Gassing with Large Culture Vessel

Takashi Okada, Tatsuya Nomoto, Toru Yoshioka, Tsuyoshi Ogura, Takashi Matsushita, Hiroaki Mizukami, Akihiro Kume, Villy Nielsen and Keiya Ozawa

Mol Ther 9: S161-S162; doi:10.1016/j.ymthe.2004.06.343

422. Optimization of AAV Vector Production by Transient Transfection

Xiaofei Wang, Sooah Sohr, Floro Cataniag, Fraser Wright and Guang Qu

Mol Ther 9: S162-S162; doi:10.1016/j.ymthe.2004.06.344

423. Isolation of an Adeno-Associated Virus (AAV)-Specific Camelid-Derived Single Chain Antibody Fragment: A Novel Tool for Purification of AAV Vectors of Different Serotypes

Paul P. A. Oranje, Peter Verheesen, Dennis Verbart, Yvonne Mijnsbergen, Hans J. W. Haard, Pim Hermans, Mark R. ten Haaft, Jaap Twisk, Paul A. Dijkhuizen, Wim T. J. M. C. Hermens and Janneke J. M. Meulenberg

Mol Ther 9: S162-S162; doi:10.1016/j.ymthe.2004.06.345

424. Development of a Scalable Column Chromatography-Based Purification Process to Manufacure Empty Capsid-Free AAV Vectors

Guang Qu, Xiaofei Wang, Jac Luna, Sooah Sohr, Floro Cataniag and Fraser J. Wright

Mol Ther 9: S162-S162; doi:10.1016/j.ymthe.2004.06.346

425. Formulation Development for AAV2 Vectors: Identification of Excipients That Inhibit Vector Aggregation

J. Fraser Wright, Tannie Le, Hoc Nguyen, Jurg M. Sommer, Glenn Pierce and Guang Qu

Mol Ther 9: S163-S163; doi:10.1016/j.ymthe.2004.06.356

426. Novel Chromatographic Process for the Purification of Recombinant Adeno-Associated Virus Pseudotypes

Michael Moxley, Donald Fisher, Anthony P. Green and Timothy D. Kierstead

Mol Ther 9: S163-S163; doi:10.1016/j.ymthe.2004.06.359

427. Adipose Tissue as a Novel Target for In Vivo Gene Transfer Using Adeno-Associate Virus (AAV) Vectors

Hiroaki Mizukami, Jun Mimuro, Tsuyoshi Ogura, Takashi Okada, Akihiro Kume, Yoichi Sakata and Keiya Ozawa

Mol Ther 9: S163-S163; doi:10.1016/j.ymthe.2004.06.363

428. Adrenomedullin Gene Delivery Attenuates Renal Damage and Hypertension in Spontaneous Hypertension Rats

Xin Wei, Chunxia Zhao, Jiangang Jiang, Zhenjun Liu and Daowen Wang

Mol Ther 9: S164-S164; doi:10.1016/j.ymthe.2004.06.367

429. Alpha 1 Antitrypsin Gene Delivery for Preventing Type 1 Diabetes in NOD Mice

Yuanqing Lu, Mei Tang, Clive Wasserfall, Young-Kook Choi, Thomas Gardmann, Martha Campbell-Thompson, Mark A. Atkinson and Sihong Song

Mol Ther 9: S164-S164; doi:10.1016/j.ymthe.2004.06.384

430. AAV-Microbead Conjugates for the Enhanced Delivery of AAV-Based Vectors

Samuel J. Farlow, Mark W. Pandori and Takeshi Sano

Mol Ther 9: S164-S164; doi:10.1016/j.ymthe.2004.06.386

431. Selective Upregulation of TGFb1ACT in the Rat Heart To Induce Cardioprotection from Ischemia-Reperfusion Injury

Kui Chen, Yong Liu, Dayuan Li, Paul L. Hermonat and Jawahar L. Mehta

Mol Ther 9: S164-S165; doi:10.1016/j.ymthe.2004.06.391

432. Safety of Administration of AAV2CUhCLN2, a Candidate Treatment for Late Infantile Neuronal Lipofuscinosis to the Brain of Rats and Non-Human Primates

Neil R. Hackett, D. Eugene Redmond Jr., Dolan Sondhi, E. Lela Giannaris, Elizabeth Vassallo, Stephen M. Kaminsky and Ronald G. Crystal

Mol Ther 9: S165-S165; doi:10.1016/j.ymthe.2004.06.395

433. Micro-Utrophin as a Therapeutic Protein in rAAV Mediated Gene Therapy for Duchenne Muscular Dystrophy

Michael J. Blankinship, Paul Gregorevic and Jeffrey S. Chamberlain

Mol Ther 9: S165-S165; doi:10.1016/j.ymthe.2004.06.398

434. Recombinant Adeno-Associated Virus 2 -Mediated Anti-Angiogenic Gene Therapy in a Mouse Model of Intraperitoneal Ovarian Cancer

Tatyana Isayeva, Changchun Ren and Selvarangan Ponnazhagan

Mol Ther 9: S166-S166; doi:10.1016/j.ymthe.2004.06.400

435. Adeno-Associated Virus Vectors Are Able To Restore FALDH Deficiency in Cells of Sjoegren-Larsson Syndrome

Markus Braun-Falco, Stefanie Haug and Hildegard Buning

Mol Ther 9: S166-S166; doi:10.1016/j.ymthe.2004.06.831

436. Recombinant Adeno-Associated Virus Gene Therapy for Cob(I)Alamin Adenosyltransferase Deficiency

Kirsten Elizabeth Erger, Thomas James Conlon, Dietrich Matern, Thomas A. Bobik and Terence R. Flotte

Mol Ther 9: S166-S167; doi:10.1016/j.ymthe.2004.06.832

437. Developing a Mouse Model of the Mitochondrial NARP Syndrome Using AAV-Ribozymes for ATP6

Jennifer A. Bongorno, John Guy and Alfred S. Lewin

Mol Ther 9: S167-S167; doi:10.1016/j.ymthe.2004.06.410

438. In Vitro Studies Towards the Development of a Recombinant Adeno-Associated Virus for the Treatment of Medium-Chain Acyl-CoA Dehydrogenase Deficiency

J. Lawrence Merritt II, Dietrich Matern, Jerry Vockley, Joeseph Huey and David B. Schowalter

Mol Ther 9: S167-S167; doi:10.1016/j.ymthe.2004.06.414

439. Neuronal Membrane Specific Binding Peptides Isolated Via Phage Display Biopanning Against Trisialogangliosides

James K. Liu, Qingshan Teng, Diana Tanase, Mary Moses, Ajit Krishnaney and Nicholas M. Boulis

Mol Ther 9: S167-S168; doi:10.1016/j.ymthe.2004.06.417

440. The Multidrug Resistant Phenotype in Tumor Cells Facilitates Adenoviral Replication: New Concepts for Oncolytic Vector Development

Alexandra Bernshausen, Gabriel Glockzin, Klaus Mantwill, Hans-Dieter Royer, Karsten Juerchott, Bernd Gaensbacher and Per Sonne Holm

Mol Ther 9: S168-S168; doi:10.1016/j.ymthe.2004.06.348

441. Conditional Replication Competent Adenovirus Ad-mTERT-|[Delta]|19 Driven by Human Telomerase Promoter Replicates and Elicits Cytopathic Effect Specifically in Cancer Cells

Eunhee Kim, Taeyoung Koo, Dong Hyun Ko, Yoon A. Kang, Joo-Hang Kim and Chae-Ok Yun

Mol Ther 9: S168-S168; doi:10.1016/j.ymthe.2004.06.351

442. Novel cox-2 Driven Infectivity Enhanced CRAds for Treatment of Ovarian Cancer

Gerd J. Bauerschmitz, Anna Kanerva, Masato Yamamoto, Dirk Nettelbeck, Tanja Hakkarainen, Peter Dall, David T. Curiel and Akseli Hemminki

Mol Ther 9: S168-S169; doi:10.1016/j.ymthe.2004.06.358

443. Incorporating the Survivin Promoter in an Infectivity Enhanced CRAd-Analysis of Oncolysis in Five Different Cancer Cell Lines

Zeng B. Zhu, Sharmila K. Makhija, Baogen Lu, Minghui Wang, Angel A. Rivera, Gene P. Siegal, Ronald D. Alvarez and David T. Curiel

Mol Ther 9: S169-S169; doi:10.1016/j.ymthe.2004.06.361

444. ADP-Overexpressing Adenovirus Elicits Enhanced Cytopathic Effect by Induction of Apoptosis

Eunhee Kim, Taeyoung Koo, Dae-Bong Kang, Il-Kyu Choi, Joo-Hyuk Sohn, Chae-Ok Yun and Joo-Hang Kim

Mol Ther 9: S169-S169; doi:10.1016/j.ymthe.2004.06.365

445. CG5757, an Oncolytic Adenovirus for the Treatment of Retinoblstoma (Rb) Pathway-Defective and Telomerase-Positive Cancers

Yuanhao Li, Natalie Nguyen, Derek Ko, Melinda VanRoey, Gail Colben, Neeraja Idamakanti, Orlena Tam, Trini Arroyo, P.Seshidhar Reddy, Peter Working and De-Chao Yu

Mol Ther 9: S169-S170; doi:10.1016/j.ymthe.2004.06.375

446. A Rapid, Efficient and Feasible Method for Constructing Conditionally-Replicating Adenoviral Vectors that Specifically Target Cancer Cells with Multiple Factors

Satoshi Nagano, Yohiteru Murofushi, Setsuro Komiya and Ken-ichiro Kosai

Mol Ther 9: S170-S170; doi:10.1016/j.ymthe.2004.06.382

447. Replication-Competent Oncolytic Adenovirus Vectors That Express TRAIL and Over-Express ADP

Baoling Ying, Peter Krajcsi, Ann E. Tollefson, Jacqueline F. Spencer, Konstantin Doronin, Drew L. Lichtenstein and William S. M. Wold

Mol Ther 9: S170-S171; doi:10.1016/j.ymthe.2004.06.385

448. Armed Oncolytic Adenovirus with an Antiangiogenic Gene, sflt-1: A Novel Effective Antitumor Approach

Zilai Zhang, Jinhui Wang, Weiguo Zou, Binghua Li, Zifei Pei, Jinfa Gu, Cheng Qian and Xinyuan Liu

Mol Ther 9: S171-S171; doi:10.1016/j.ymthe.2004.06.388

449. Evaluation of New Generation of Prostate Specific Replication Competent Adenoviruses with E1A-AR Chimera

Ying Li, Chien-lun Chen, Aarup Kubal, Qinghua Xia and Ronald Rodriguez

Mol Ther 9: S171-S171; doi:10.1016/j.ymthe.2004.06.393

450. Anti-CD22 Immunolipoplexes Enhance Transduction of Adenovirus in B Lymphoma Cells Independent on Adenovirus' Receptor but do not Enhance the Cytotoxicity of Oncolytic Adenovirus

 Yaohe, H. Pen,  Jennelle,  Gunnel,  Shao-an, Beverly E. Grriffin and Nick R. Lemoine

Mol Ther 9: S171-S172; doi:10.1016/j.ymthe.2004.06.397

451. A Novel Cell Cycle Dependent Conditionally Replicating Adenovirus Vector for Targeting a Broad-Spectrum of Cancer

Atique Ahmed, Jian Qiao, Jesus Moreno and Richard G. Vile

Mol Ther 9: S172-S172; doi:10.1016/j.ymthe.2004.06.401

452. Adenoviral Gene Therapy Using CRAd Targeted to Cells with Hyperactive Wnt/|[beta]|-Catenin Signaling

Phillip H. Abbosh and Kenneth P. Nephew

Mol Ther 9: S172-S172; doi:10.1016/j.ymthe.2004.06.404

453. Reproductive Safety Evaluation and Quantification of Adenoviral Vectors in the Mouse

Gyu Seek Rhee, Hyun Joo Lee, Soon Sun Kim, Seung Jun Kwack, Rhee Da Lee, Ji Hyun Seok, Soo Yeong Chae, Jae Woo Kim, Young Hyuk Won, Seung Hoon Lee and Kui Lea Park

Mol Ther 9: S172-S173; doi:10.1016/j.ymthe.2004.06.406

454. Evaluation of Polyethylene Glycol (PEG) Modification of Adenoviral Vectors to Reduce Innate Immune Response and Increase Vector Persistence

Hoyin S. Mok and Michael A. Barry

Mol Ther 9: S173-S173; doi:10.1016/j.ymthe.2004.06.409

455. Neutrophils Interact with Adenovirus Vectors Via the |[beta]|2-Integrin CD11b

Daniel A. Muruve and Matthew J. Cotter

Mol Ther 9: S173-S173; doi:10.1016/j.ymthe.2004.06.413

456. A Comparison of Adenoviral-Mediated Gene Transfer in Human and Mouse Dendritic Cells

Brian J. Morrison, Yoshio Sakai, John E. Janik and John C. Morris

Mol Ther 9: S173-S174; doi:10.1016/j.ymthe.2004.06.416

457. Fibronectin Peptide Reduces the Immune Response to Adenovirus and Enhances Transgene Expression

Takako Miyamae, Anthony D. Marinov, Sylvie Fabre, David C. Wilson, Tomoyuki Imagawa, Bruce C. Trapnell, Gregory P. Boivin and Raphael Hirsch

Mol Ther 9: S174-S174; doi:10.1016/j.ymthe.2004.06.418

458. Efficient Transduction of Human and Murine Cells and Circumvention of Preexisting Human Adenoviral Immunity by Porcine Adenoviral Vectors

Dinesh Singh and Suresh K. Mittal

Mol Ther 9: S174-S174; doi:10.1016/j.ymthe.2004.06.421

459. Immune System Regulation of Transgene Expression in the Brain 1: Systemically Activated Immune Responses Silence Adenoviral Vector-Encoded Transgene Expression in the Brain Through Both Non-Cytolytic, and Cytotoxic Mechanisms

Carlos Barcia, Clare Thomas, Jeff Zirger, Weidong Xiong, Olivier Boyer, David Klatzmann, Maria G. Castro and Pedro R. Lowenstein

Mol Ther 9: S174-S175; doi:10.1016/j.ymthe.2004.06.423

460. Immunogenicity of E2b-Deleted Adenoviral Vectors Compared with First Generation Vectors

Jie Mi, Shannon Barker, Leonard Meuse, Shanna Sawatzki, Dennis Hartigan-O'Connor and Jeffrey S. Chamberlain

Mol Ther 9: S175-S175; doi:10.1016/j.ymthe.2004.06.426

461. In Vivo Immunogenicity of Adenoviral Vectors with Improved Dendritic Cell Tropism

Catherine Hsu, Megan M. Boysen, Phyllis D. Frosst and Dan J. Von Seggern

Mol Ther 9: S175-S175; doi:10.1016/j.ymthe.2004.06.428

462. Toxicity Related to Predosing with Adenoviral Vectors Carrying Lac-Z or Dominant Negative IKK2 Transgenes

Viraj P. Mane, Racel Cela, Nicola Brunetti, Phil Ng and Brendan Lee

Mol Ther 9: S175-S176; doi:10.1016/j.ymthe.2004.06.431

463. Conditionally Replicative Adenovirus Expressing Degradation-Resistant p53 for Enhanced Oncolysis of MDM2 Overexpressing Cancers

Victor W. van Beusechem, Petra B. van den Doel and Winald R. Gerritsen

Mol Ther 9: S176-S176; doi:10.1016/j.ymthe.2004.06.433

464. Severe Pulmonary Pathology after Intravenous Administration of Adenovirus Vectors in Cirrhotic Rats

Jeffrey S. Smith, Jie Tian, Jay N. Lozier and Andrew P. Byrnes

Mol Ther 9: S176-S176; doi:10.1016/j.ymthe.2004.06.434

465. Delivery of NF-|[kappa]||[beta]| Decoy Related Oligodeoxynucleotides Reduces Pro-Inflammatory Cytokine Responses Associated with Plasmid DNA/Lipid Mediated Gene Transfer to Murine Lungs

Anusha Varathalingam, Ian A. Pringle, Seng H. Cheng, Deborah R. Gill and Stephen C. Hyde

Mol Ther 9: S177-S177; doi:10.1016/j.ymthe.2004.06.349

466. Downregulation of ATF2 Desensitizes Oral Squamous Cell Carcinoma to Apoptosis

Sleiman N. Razzouk, Svetlana M. Dolgilevich and Dianne C. Duffey

Mol Ther 9: S177-S177; doi:10.1016/j.ymthe.2004.06.352

467. Cationic Liposome-Based Delivery of DNA Modulating Enzymes to Specifically Regulate Gene Expression in Carcinoma Derived Cell Lines

Pamela M. J. McLaughlin, Monika Trzpis, Ieneke T. F. van der Gun, Martin C. Harmsen and Marcel H. J. Ruiters

Mol Ther 9: S177-S178; doi:10.1016/j.ymthe.2004.06.353

468. Tissue Factor as a Link Between Wounding and Tissue Repair

Jiang Chen, Michael Kasper, Katsumi Nakagawa, Lin Bai, Wu Gang, Youming Zhang, Per M. Humpert, Martin Andrassy, Thomas Luther, Stephan Schiekofer, Baosheng Chen, Michael Morcos, Andreas Hamann, David M. Stern, Peter P. Nawroth and Angelika Bierhaus

Mol Ther 9: S178-S178; doi:10.1016/j.ymthe.2004.06.355

469. Improved Transfection with Mixtures of Cationic Lipids: Application to Human Umbilical Artery Endothelial Cells (HUAEC)

Li Wang and Robert C. MacDonald

Mol Ther 9: S178-S178; doi:10.1016/j.ymthe.2004.06.357

470. Enhanced Transposition Activities of Mutant Sleeping Beauty Transposases

Bradley S. Fletcher, James Baus and Arne Heggestad

Mol Ther 9: S178-S179; doi:10.1016/j.ymthe.2004.06.362

471. Efficient Non-Viral Vectorisation of siRNA in the Brains of Newborn Mice

Zahra Hassani, Gregory Lemkine, Patrick Erbacher, Carine Giovannangeli, Jean Paul Behr and Barbara A. Demeneix

Mol Ther 9: S179-S179; doi:10.1016/j.ymthe.2004.06.364

472. In Vitro and In Vivo Gene Expression Mediated by Cationic Sendai F/HN Virosomes

Hong Sung Kim, Keun Sik Kim, Myung Min Choi, Ji Eun Lee and Yong Serk Park

Mol Ther 9: S179-S179; doi:10.1016/j.ymthe.2004.06.368

473. Magnetofection to Enhance Airway Gene Transfer

Stefania Xenariou, Uta Griesenbach, Stefano Ferrari, Phillip Dean, Ron Scheule, Seng Cheng, Duncan Geddes, Christian Plank and Eric Alton

Mol Ther 9: S180-S180; doi:10.1016/j.ymthe.2004.06.369

474. The Barrier to Liposomal Transfection is Enhanced by DNASES Lacking Lysosomal-Targetting Glycosylation

Andrew Wilber, Gary Armour and Michael C. Schneider

Mol Ther 9: S180-S180; doi:10.1016/j.ymthe.2004.06.370

475. Anionic Polyethyleneglycol Lipids Added to Cationic Lipoplexes Increase Their Plasmatic Circulation Time

C|[eacute]|line Nicolazzi, Nathalie Mignet, Nathalia Dela Figuera, Mamonjy Cadet, Raoul Torero Ibad, Johanne Seguin, Daniel Scherman and Michel Bessodes

Mol Ther 9: S180-S181; doi:10.1016/j.ymthe.2004.06.372

476. Human Mesenchymal Stem Cells Genetically Modified To Express High Levels of Erythropoietin Through Transfer of an Artificial Chromosome Engineered Using the ACE System

Sandra Vanderbyl, Neil MacDonald, Tom Stodola, Adele Telenius, Sandra Stewart, Harry C. Ledebur Jr. and Carl F. Perez

Mol Ther 9: S181-S181; doi:10.1016/j.ymthe.2004.06.373

477. New pyridinium cationic lipids for gene delivery synthesized via pyrylium salts

Marc A. Ilies, Betty H. Johnson, William A. Seitz, Edward L. Ezell, Aaron Miller, E. Brad Thompson and Alexandru T. Balaban

Mol Ther 9: S181-S181; doi:10.1016/j.ymthe.2004.06.374

478. Preinjection of free DiC14-amidine liposome and dexamethasone synergistically enhance the intravenous transfection efficiency of cationic lipid/DNA lipoplex

Caroline Lonez, Jean-Marie Ruysschaert and Abdelatif Elouahabi

Mol Ther 9: S181-S181; doi:10.1016/j.ymthe.2004.06.376

479. KLN-47, a safe lipophosphoramide reagent, efficiently transfects (>100 kb) large plasmids into epithelial cells

Tristan Y. Montier, Laura Hyndman, A. Christopher Boyd, Catherine Payne, Ann Doherty, Pascal Delepine, Claude Ferec and David Porteous

Mol Ther 9: S182-S182; doi:10.1016/j.ymthe.2004.06.378

480. Magnetofection to enhance transfection efficiency of large genomic context vectors in vitro

Stefania Xenariou, Uta Griesenbach, Ramsay Bowden, Elizabeth Hillery, Ann Doherty, Duncan Geddes, David Porteous, Christian Plank, Eric Alton and A. Christopher Boyd

Mol Ther 9: S182-S182; doi:10.1016/j.ymthe.2004.06.379

481. Efficient gene transfer into human epithelial cell lines using glycosylated cationic carriers and neutral glycosylated co-lipids

Tristan Montier, Pascal Delepine, Thierry Benvegnu, Daniel Plusquellec and Claude Ferec

Mol Ther 9: S182-S183; doi:10.1016/j.ymthe.2004.06.380

482. Design and production of peptide transfecting agents using recombinant TAT-Mu-NLS sequences

Y. Ramadas, Madhusudhana N. Rao and Vijaya Gopal

Mol Ther 9: S183-S183; doi:10.1016/j.ymthe.2004.06.381

483. Acoustically active liposomes for oligonucleotide/drug encapsulation; delivery agents with capacity for ultrasound-triggered release

Shao-Ling Huang, David D. McPherson and Robert C. MacDanold

Mol Ther 9: S183-S184; doi:10.1016/j.ymthe.2004.06.383

484. Longevity of Expression Following Liposome-Mediated Gene Transfer

Wendy E. Walker and Andy D. Miller

Mol Ther 9: S184-S184; doi:10.1016/j.ymthe.2004.06.387

485. Marked transfection enhancement by the DPL (DNA/peptide/liposomes) trimeric complex

Jong-Gu Park and Ik-Jae Moon

Mol Ther 9: S184-S184; doi:10.1016/j.ymthe.2004.06.389

486. Plasmid DNA constructs expressing SARS-CoV antigens are immunogenic in mice and rabbits

Adrian Vilalta, Michal Margalith, Tom Evans, David C. Kaslow and Peter Hobart

Mol Ther 9: S184-S184; doi:10.1016/j.ymthe.2004.06.392

487. Influence surface modification of lipoplexes on the pharmacokinetics of non-viral vectors for gene delivery

Eric Perouzel, Annabelle Caussin, Kristina Ulrich, Andrew D. Miller, Charles Coutelle, Michael Keller and Michael Jorgensen

Mol Ther 9: S185-S185; doi:10.1016/j.ymthe.2004.06.394

488. Adenovirus-mediated delivery of ADAM10, a novel candidate gene for COPD, results in emphysematous changes in the mouse lung

Hiroki Saitoh, Adriana Heguy, Timothy P. O'Connor, Ben-Gary Harvey, Philip L. Leopold, Neil R. Hackett, Adam Cieciuch and Ronald G. Crystal

Mol Ther 9: S185-S185; doi:10.1016/j.ymthe.2004.06.1017

489. Comparison of AAV2 and AAV2/5 CFTR vectors in the lungs of cynomolgus macaques

Keith L. Munson, Laurie M. Tatalick, Carolina I. Smith, Anne C. Fischer, Pervin Anklesaria, Barrie J. Carter and William B. Guggino

Mol Ther 9: S185-S186; doi:10.1016/j.ymthe.2004.06.399

490. Long Term Expression and Biodistribution of HIV Vector Pseudotyped with Deletion Mutant of the Ebola Envelope Glycoprotein Following Instillation in Airway of Nonhuman Primates

Gregory P. Schumer, Gary P. Kobinger, Maria F. Medina, Daniel J. Weiner and James M. Wilson

Mol Ther 9: S186-S186; doi:10.1016/j.ymthe.2004.06.403

491. Improved Apical Airway Epithelia Targeting Properties of FIV Vector Pseudotyped with Envelopes from LCMV

Douglas E. Dylla, Melissa A. Hickey, Daniel E. Michele, Beverly L. Davidson, Kevin P. Campbell and Paul B. McCray Jr.

Mol Ther 9: S186-S186; doi:10.1016/j.ymthe.2004.06.405

492. Characterization of the Apical Transduction of Well-Differentiated Mouse Tracheal Cultures by an Equine Lentivirus Pseudotyped with Avian Influenza Coat Proteins

Tristan R. McKay, Manij Patel, Angela M. Giddings, Raymond J. Pickles and John C. Olsen

Mol Ther 9: S186-S187; doi:10.1016/j.ymthe.2004.06.408

493. Enhanced Transgene Transfer and Expression by an Endobronchially Delivered Pseudotyped AAV2/5 Vector

Anne C. Fischer, Carolina I. Smith, Terence R. Flotte and William B. Guggino

Mol Ther 9: S187-S187; doi:10.1016/j.ymthe.2004.06.412

494. Topical Delivery of mRNA to the Murine Lung and Nasal Epithelium

Hazel Painter, Stephanie G. Sumner-Jones, Seng H. Cheng, Steve C. Hyde and Deborah R. Gill

Mol Ther 9: S187-S187; doi:10.1016/j.ymthe.2004.06.415

495. Efficient In Vivo Transduction of Mouse Airway Epithelial Cells by the Simian Immunodeficiency Virus Vector Pseudotyped with Sendai Virus F and HN Proteins

Hisao Shirohzu, Katsuhisa Mitomo, Toshiaki Tabata, Uta Griesenbach, Steve C. Hyde, Eric W. Alton, Yasuji Ueda and Mamoru Hasegawa

Mol Ther 9: S188-S188; doi:10.1016/j.ymthe.2004.06.420

496. Recombinant Sendai Virus Vector to Evaluate Vector Distribution in a Large Animal Model of Lung Gene Transfer

Gerry McLachlan, Uta Griesenbach, Toshi Owaki, Liz Hillery, John Williams, Zhu Yafeng, Chris Boyd, Deborah Gill, Mamoru Hasegawa, Eric W. F. W. Alton and David Collie

Mol Ther 9: S188-S188; doi:10.1016/j.ymthe.2004.06.422

497. Ciliated-Cell Specific Expression of a Transgene by a Self-Inactivating Murine Retrovirus in Human Bronchial Epithelial Cells

Lawrence E. Ostrowski, Kerri A. Kendrick, Angela M. Giddings and John C. Olsen

Mol Ther 9: S188-S189; doi:10.1016/j.ymthe.2004.06.425

498. Targeted Gene Transfer to Lung Airway Epithelium Using Plasmid or Adenoviral Vectors Formulated with an Anti-Inflammatory Dexamethasone-Spermine Conjugate

Amber Price, Maria Limberis, Jeffrey Gruneich, James M. Wilson and Scott L. Diamond

Mol Ther 9: S189-S189; doi:10.1016/j.ymthe.2004.06.427

499. Inhibition of Non-Small Cell Lung Cancer by Silencing EGFR with RNAi

Ming Wei, M. Zhang, X. Zhang, J. Chen, L. Gao, J. Hu, Q. Y. Hong, M. West and C. X. Bai

Mol Ther 9: S189-S190; doi:10.1016/j.ymthe.2004.06.430

500. Local and systemic inhibition of lung tumor growth after liposome mediated mda-7/IL-24 gene delivery

Rajagopal Ramesh, Isao Ito, Ryo Miyahara, Yuji Saito, Zheng Wu, Abner M. Mhashilkar, Deborah R. Wilson, Cynthia D. Branch, Sunil Chada and Jack A. Roth

Mol Ther 9: S190-S190; doi:10.1016/j.ymthe.2004.06.436

501. Aerosols of compacted DNA nanoparticles retain structural integrity and biological activity

Sharon M. Oette, Christopher R. Gedeon, Tomasz H. Kowalczyk, Tamara L. Fink, Susannah L. Hyatt, Robert C. Moen and Mark J. Cooper

Mol Ther 9: S190-S190; doi:10.1016/j.ymthe.2004.06.438

502. Formulation of adenoviral vectors with inhibitors of mucociliary clearance enhances gene transfer to airway epithelia in vivo

Patrick L. Sinn, Ankur Shah, Maureen D. Donovan and Paul B. McCray Jr

Mol Ther 9: S190-S191; doi:10.1016/j.ymthe.2004.06.439

503. Gene transfer strategies for pulmonary hypertension

Larry G. Johnson, Manij Patel, Miriam K. Vanhook and John C. Olsen

Mol Ther 9: S191-S191; doi:10.1016/j.ymthe.2004.06.440

504. Gene Transfection into Fetal Sheep Airway Epithelium Using Cationic BGTC/DOPE Liposomes

Noufissa Oudrhiri, Dominique Luton, Pascal De Lagausie, Abderrahim Aissaoui, Michelle Hauchecorne, Michel Peuchmaur, Jean-Pierre Vigneron, Jean-Francois Oury, Yves Aigrain, Jean-Marie Lehn and Pierre Lehn

Mol Ther 9: S191-S191; doi:10.1016/j.ymthe.2004.06.441

505. Effective Transgene Expression in the Murine Lung Using Compacted DNA Nanoparticles Formulated with Plasmid DNAs of 5, 10, and 20 kbp

Tamara L. Fink, Patrick J. Klepcyk, Sharon M. Oette, Christopher R. Gedeon, Susannah L. Hyatt, Tomasz H. Kowalczyk, Robert C. Moen and Mark J. Cooper

Mol Ther 9: S192-S192; doi:10.1016/j.ymthe.2004.06.442

506. LPS-Induced Lung Inflammation and Bronchial Hyperreactivity: Effects of Murine IL-10 When Injected in the Airways or Generated in the Circulation after Muscle Electrotransfer of Murine IL-10 Encoding Plasmid

Virginie Deleuze, Jean Lefort, Michel-Francis Bureau, Daniel Scherman and B. Boris Vargaftig

Mol Ther 9: S192-S192; doi:10.1016/j.ymthe.2004.06.443

507. Down-Regulation of the Epithelial Sodium Channel ENaC through Antisense Oligonucleotides

Uta Griesenbach, Sara Escudero Garcia, Chris Kitson, Raymond Farley, Charanjit Singh, Hazel Painter, Rebecca L. Smith, Ron Scheule, Seng Cheng, Mark Edbrooke, Steve Hyde, Duncan M. Geddes and Eric W. F. W. Alton

Mol Ther 9: S192-S193; doi:10.1016/j.ymthe.2004.06.445

508. AAV2 and AAV6 Serology in Normal and Cystic Fibrosis Populations

Christine L. Halbert, A. Dusty Miller, Ron L. Gibson and Moira L. Aitken

Mol Ther 9: S193-S193; doi:10.1016/j.ymthe.2004.06.446

509. Non-Viral Gene Delivery in the Murine Nasal Epithelium by Hypotonic Shock

Jerome L. Lemoine and Leaf Huang

Mol Ther 9: S193-S193; doi:10.1016/j.ymthe.2004.06.448

510. In Vivo-Gene Expression of Aerosolized PEI Gene Vector Complexes Is Solvent-Dependent

Carsten Rudolph, Aurora Ortiz, Ulrike Schillinger, Christian Plank and Joseph Rosenecker

Mol Ther 9: S193-S194; doi:10.1016/j.ymthe.2004.06.449

511. Improvement of Aerosol Delivery of Polyethylenimine (PEI)-Based Gene Vectors to the Lungs of Mice

Carsten Rudolph, Aurora Ortiz, Ulrike Schillinger, Jurgen Jauernig, Christian Plank and Joseph Rosenecker

Mol Ther 9: S194-S194; doi:10.1016/j.ymthe.2004.06.451

512. Electroporation-Mediated Gene Transfer of Human Hepatocyte Growth Factor Reduces Bleomycin-Induced Pulmonary Fibrosis in Rats

Amiq Gazdhar, Patrick Fachinger, Jaroslaw Pierog, Steven Hyde, Mathias Gugger, Ralph Schmid and Thomas Geiser

Mol Ther 9: S194-S194; doi:10.1016/j.ymthe.2004.06.452

513. Prevention of Irradiation-Induced Organizing Alveolitis by Inhalation Delivery of Manganese Superoxide Dismutase-Plasmid/Liposome (MnSOD-PL) Complexes to Mouse Lung

Matthew Carpenter, Anurag Agarwal, Suhua Nie, Lauren Hricisak, Michael W. Epperly and Joel S. Greenberger

Mol Ther 9: S194-S195; doi:10.1016/j.ymthe.2004.06.453

514. Potential of Bone Marrow Mesenchymal Stem Cells for Cystic Fibrosis Therapy

Guoshun Wang, Bruce A. Bunnell, Richard G. Painter, Susan Tom, Nicholas A. Lanson, Jeffery L. Spees, Donna Bertucci, Daniel J. Weiss, Vincent G. Valentine, Darwin J. Prockop and Jay K. Kolls

Mol Ther 9: S195-S195; doi:10.1016/j.ymthe.2004.06.455

515. Mutation Independent Knockdown of Mutant mRNA by RNA Interference and Replacement by mRNA with Knockdown-Resistant Codons

Rajendra Kumar-Singh, Erin Binkley and Siobhan Cashman

Mol Ther 9: S195-S196; doi:10.1016/j.ymthe.2004.06.444

516. Vestibular Hair Cell Regeneration and Re-Establishment of Balance Function Induced by Math1 Gene Delivery

Hinrich Staecker, Mark Praetorius, Kim Baker and Douglas E. Brough

Mol Ther 9: S196-S196; doi:10.1016/j.ymthe.2004.06.447

517. Prevention of Onset of Parkinson's Disease by In Vivo Gene Transfer of Human Hepatocyte Growth Factor in Primate Model: A Model of Gene Therapy for Parkinson's Disease

Hiromi Koike, Akihiko Ishida, Munehisa Shimamura, Naoyuki Sato, Naruya Tomita, Yasufumi Kaneda and Ryuichi Morishita

Mol Ther 9: S196-S196; doi:10.1016/j.ymthe.2004.06.450

518. Long-term lentiviral vector-mediated transgene expression in neural progenitor cells following implantation into the injured rat spinal cord

Bas Blits, Caroline V. Caperton, Brandon M. Kitay, Gaelle Corrales and Mary Bunge

Mol Ther 9: S196-S196; doi:10.1016/j.ymthe.2004.06.454

519. Minimally invasive strategies for administration of genetically-modified glia to the contused spinal cord

Damien D. Pearse, Bas Blits, Mary B. Bunge, Patrick M. Wood, Andre R. Sanchez, Andres Hurtado, Enrique P. Lopez and Oudega Martin

Mol Ther 9: S197-S197; doi:10.1016/j.ymthe.2004.06.456

520. Canine neural progenitor cells: phenotypic markers in vitro and in situ

Raquel M. Walton, Deborah J. Watson and John H. Wolfe

Mol Ther 9: S197-S197; doi:10.1016/j.ymthe.2004.06.460

521. Helper-dependent adenovirus with gene switch regulation may provide an optimal vector of therapeutic gene delivery for treatment of Parkinson's disease

Q. Chen, Y. He, X. Q. Yuan, P. Ng, P. Yotnda, Y. Long, E. C. Lai and K. Yang

Mol Ther 9: S197-S198; doi:10.1016/j.ymthe.2004.06.462

522. Increased expression of OCT4, SOX2 and FGF4 genes following injection of embryonic stem cell into damaged murine brain

Anand S. Srivastava, Steve Shenouda, Mohamed E. Moustafa and Ewa Carrier

Mol Ther 9: S198-S198; doi:10.1016/j.ymthe.2004.06.464

523. Inhibition of retinal neovascularization by intraocular gene delivery of soluble VEGF receptors

Abraham Scaria, Peter Pechan, Michael Lukason, Hillard Rubin and Samuel Wadsworth

Mol Ther 9: S198-S198; doi:10.1016/j.ymthe.2004.06.465

524. Adenovirus-mediated silencing of Huntingtin expression by hsiRNA

Bin Huang and Stefan Kochanek

Mol Ther 9: S198-S199; doi:10.1016/j.ymthe.2004.06.468

525. Therapy for Alzheimer's disease by neprilysin gene transfer

Robert A. Marr, Edward Rockenstien, Mark S. Kindy, Louis B. Hersh, Fred H. Gage, Eliezer Masliah and Inder M. Verma

Mol Ther 9: S199-S199; doi:10.1016/j.ymthe.2004.06.470

526. A new mouse reporter strain with nuclear-localized lacZ expression allows reliable detection of transplanted and donor-derived cells

Pei-Rong Wang, Daniel G. Miller, George Vassilopoulos and David W. Russell

Mol Ther 9: S199-S199; doi:10.1016/j.ymthe.2004.06.472

527. CERE-110, an AAV2-based vector to deliver NGF, provides trophic activity to basal forebrain cholinergic neurons in rats and cynomolgous monkeys

Kathie M. Bishop, Katrin Hofer, Denise Rius, Arpesh Mehta, Shokry Lawandry, Lamar Brown, Brian Kruegel, Mehdi Gasmi, Mark Tuszynski and Raymond T. Bartus

Mol Ther 9: S199-S200; doi:10.1016/j.ymthe.2004.06.473

528. VEGF gene therapy with retrogradely transported lentivirus prolongs survival in mouse ALS model

Mimoun Azzouz, Thanh Le, Scott G. Ralph, Fraser Wilkes, Arthur H. Burghes, Susan M. Kingsman, Kyriacous A. Mitrophanous and Nicholas D. Mazarakis

Mol Ther 9: S200-S200; doi:10.1016/j.ymthe.2004.06.474

529. rAAV mediated parkin expression confers some protection in the rat 6-OHDA lesion model

Fredric P. Manfredsson, Alfred S. Lewin and Ronald J. Mandel

Mol Ther 9: S200-S200; doi:10.1016/j.ymthe.2004.06.476

530. Spinal interleukin-10 (IL-10) gene therapy using viral and non-viral vectors controls inflammatory- and chronic constriction injury-induced pain states in rats

Erin D. Milligan, Raymond A. Chavez, Stephen J. Langer, Evan M. Sloane, Maru Chacur, Julie L. Wieseler-Frank, Matthew G. Frank, Terrence R. Flotte, Pedro Cruz, Leslie Leinwand, Jennifer A. Shumilla, John R. Forsayeth, Steven F. Maier and Linda R. Watkins

Mol Ther 9: S200-S201; doi:10.1016/j.ymthe.2004.06.477

531. Activation of VEGF by Engineered Zinc Finger Transcriptional Activators: A Novel Therapeutic Approach to Diabetic Neuropathy

Carolyn L. Dent, Gabriel Lau, Edward J. Rebar, Lei Zhang, YaLi Lee, Andrew C. Jamieson, Casey C. Case, Tyler Martin and Philip D. Gregory

Mol Ther 9: S201-S201; doi:10.1016/j.ymthe.2004.06.478

532. Cervical Spinal Cord Delivery of a Lentiviral Vector in SOD-1 Transgenic Mice

Diana Tanase, Qingshan Teng, Ajit A. Krishnaney, James K. Liu, Mary E. Garrity-Moses, Nicholas Mazarakis, Lucy E. Walmsley, Mimoun Azzouz and Nicholas M. Boulis

Mol Ther 9: S201-S201; doi:10.1016/j.ymthe.2004.06.479

533. In Vitro and In Vivo Expression of Modified Mouse Galactosylceramidase in the Twitcher Mouse Model of Krabbe Disease

James Cronin, Xian-Yang Zhang and Jacob Reiser

Mol Ther 9: S201-S201; doi:10.1016/j.ymthe.2004.06.481

534. Recombinant adeno-associated virus serotype 1 vector-mediated transduction within the murine hippocampus

Chuansong Wang and Thomas J. Sferra

Mol Ther 9: S202-S202; doi:10.1016/j.ymthe.2004.06.658

535. Efficient transduction of rat spinal cord cells in vitro and in vivo using neuron-specific and non-specific lentiviral vectors

Tetsuya Nejime, Atsushi Miyanohara, Osamu Kakinohana and Martin Marsala

Mol Ther 9: S202-S202; doi:10.1016/j.ymthe.2004.06.659

536. Design and production of an AAV2 vector encoding a chimeric cDNA allowing efficient secretion of functional human neurturin from human cells

Anthony Ramirez, Junshan Hao, Eli Kethchum, Kevin Kwok, Dominick Vacante, Raymond Bartus and Mehdi Gasmi

Mol Ther 9: S202-S203; doi:10.1016/j.ymthe.2004.06.661

537. Further characterisation of myo-neurospheres

Simon P. Quenneville, Marie-Eve Ducharme, Joel Rousseau, Alain Garnier and Jacques P. Tremblay

Mol Ther 9: S203-S203; doi:10.1016/j.ymthe.2004.06.663

538. Functional correction of A-T cells by ATM gene expression mediated by HSV amplicon vector after the ionizing radiation or under oxidative stress condition

Ryan Manuszak, Rodney Shackelford, Charles J. Link and Suming Wang

Mol Ther 9: S203-S203; doi:10.1016/j.ymthe.2004.06.665

539. Biodistribution and safety profile of CERE-110 (AAV2-NGF) delivered to the rodent brain

Mark Landers, Melissa Austin, Kevin Kwok, Eli Ketchum, Richard Lin, Leo Manlapaz, Arpesh Mehta, Javier Fernandez, Mehdi Gasmi, Dominick Vacante, Raymond T. Bartus, Kathie Bishop and Marie Printz

Mol Ther 9: S203-S204; doi:10.1016/j.ymthe.2004.06.667

540. Retroviral mediated gene transfer of Hexb in Sandhoff Disease

Susan S. Tom and Bruce A. Bunnell

Mol Ther 9: S204-S204; doi:10.1016/j.ymthe.2004.06.670

541. Mechanisms of adenovirus vector gene delivery to the inner ear

Douglas E. Brough, Mark Praetorius, Chi Hsu, Kim Baker and Hinrick Staecker

Mol Ther 9: S204-S204; doi:10.1016/j.ymthe.2004.06.671

542. DNA shuffling generates novel HIV-1 envelope variants that can induce broadly neutralizing antibodies in rabbits

Xiaohan Du, Li Xu, Wenge Zhang, Susan Tang, NayWei Soong, Michael B. Zwick, Dennis R. Burton and Robert G. Whalen

Mol Ther 9: S204-S204; doi:10.1016/j.ymthe.2004.06.457

543. Ad DNA polymerase and preterminal protein (pTP) genes each mediate inhibition of HIV-1 replication in human alveolar macrophages

Robert J. Kaner, Francisco Santiago, Dmitri Igonkin, Jerome Schaack, Andrea Amalfitano and Ronald G. Crystal

Mol Ther 9: S204-S205; doi:10.1016/j.ymthe.2004.06.458

544. Strong, Long-Lasting Immune Responses Against Lentivirus Antigens Using rSV40 Vectors Carrying HIV Tat and Envelope

Hayley J. McKee and David S. Strayer

Mol Ther 9: S205-S205; doi:10.1016/j.ymthe.2004.06.459

545. Lentiviral vector mediated gene transfer of the anti HIV gene revM10 into primitive hematopoietic cells for gene therapy of HIV infection

Ingrid Bahner, Gerald Cho, Barbara Engels, Denise Peterson, Karen Pepper and Donald B. Kohn

Mol Ther 9: S205-S206; doi:10.1016/j.ymthe.2004.06.499

546. Optimization of Expression of the SIV-Specific 9456 Ribozyme by the tRNAval PolIII Promoter within an MLV- or Lentiviral-Vector

S. E. Braun, FE Wong, AL Chesebro, B. Nornen, D. J. Looney, F. Wong-Staal and R. P. Johnson

Mol Ther 9: S206-S206; doi:10.1016/j.ymthe.2004.06.461

547. Antiviral RNA Interference Strategies That Resist HIV Escape

Joshua N. Leonard and David V. Schaffer

Mol Ther 9: S206-S206; doi:10.1016/j.ymthe.2004.06.463

548. Cyclophilin A as a cellular target for gene therapy of HIV-1

Harris S. Soifer, Reena Vishwanath, James Kim, Bret Heale, Lisa J. Scherer and John J. Rossi

Mol Ther 9: S206-S207; doi:10.1016/j.ymthe.2004.06.500

549. Nonconserved Sequence Motifs outside the Catalytic Core Improve the Trans-Splicing Efficiency of Anti-HIV Hammerhead Ribozymes

Marc Weinberg and John J. Rossi

Mol Ther 9: S207-S207; doi:10.1016/j.ymthe.2004.06.466

550. Use of Plant Polysaccharides as Topically Applied Adjuvants for Enhancing Immune Responses Via Transdermal Gene Vaccination

Jeng-Hwan Wang, Su-Jane Wang, Wen-Chi Wei, Chih-Chien Hsu, Chin-Jin Li and Ning-Sun Yang

Mol Ther 9: S207-S207; doi:10.1016/j.ymthe.2004.06.467

551. Enhanced Immune Stimulation and Antigen Presentation of i.m. Injected Plasmid DNA Vaccines by Electroporation

Baowei Peng, Yonggang Zhao and Yuhong Xu

Mol Ther 9: S207-S208; doi:10.1016/j.ymthe.2004.06.469

552. Single-Chain Antibodies for Viral-Based Passive Immuno-Therapy for Prion Disease: Linear Epitope Mapping and Clearance from Thalamic Injection

Charles A. Wuertzer, Mark A. Sullivan and Howard J. Federoff

Mol Ther 9: S208-S208; doi:10.1016/j.ymthe.2004.06.471

553. Silencing HBV Gene Expression with Pol II and Pol III Promoter-Derived Short Hairpin RNA

Sergio Carmona, Abdullah Ely, Naazneen Moolla, Marc Weinberg and Patrick Arbuthnot

Mol Ther 9: S208-S208; doi:10.1016/j.ymthe.2004.06.475

554. A Candidate SARS-Associated Coronavirus Vaccine Elicits Broad Immunity in Monkeys

Wentao Gao, Azaibi Tamin, Adam Soloff, Leonardo D'Aiuto, Edward Nwanegbo, Paul D. Robbins, William J. Bellini, Simon Barratt-Boyes and Andrea Gambotto

Mol Ther 9: S208-S208; doi:10.1016/j.ymthe.2004.06.480

555. Langerhans cells modified by gene transfer of full length CMV pp65 are more potent inducers of cytolytic T lymphocytes in a CD4-dependent manner than either CMV p495 gene-modified or p495 peptide-pulsed langerhans cells

Jianda Yuan, Jean-Baptiste Latouche, Joanna Hodges, Glenn Heller, Isabelle Riviere, Michel Sadelain and James W. Young

Mol Ther 9: S209-S209; doi:10.1016/j.ymthe.2004.06.482

556. Toward the Development of Electroporation for Delivery of DNA Vaccines to Humans

Dietmar Rabussay, Georg Widera, Lei Zhang, Gillis R. Otten, Barbara Doe, Mary Schaefer, Hong Liu and Jeffrey B. Ulmer

Mol Ther 9: S209-S209; doi:10.1016/j.ymthe.2004.06.483

557. Co-administration of an adenovirus encoding the B cell stimulating factor BAFF with heat-inactivated Pseudomonas aeruginosa leads to increased anti-pseudomonal humoral immunity

Christine Tertilt, Stefan Worgall, Michael C. Rivara and Ronald G. Crystal

Mol Ther 9: S210-S210; doi:10.1016/j.ymthe.2004.06.484

558. Anti-SARS Humoral and Cellular Immunity Evoked by an Adenovirus Vector Expressing Spike Glycoprotein from SARS Coronavirus

Julie Boyer, Anja Krause, Jianping Qiu, Neil Hackett, Gary Kobinger, Yan Zhi, James M. Wilson and Ronald G. Crystal

Mol Ther 9: S210-S210; doi:10.1016/j.ymthe.2004.06.485

559. Generating Powerful Immune Responses Against Lentiviral Antigens: Using rSV40 Vector-Delivered Proinflammatory Cytokines to Potentiate Immune Responses vs. rSV40-Delivered Lentiviral Antigens

Hayley J. McKee and David S. Strayer

Mol Ther 9: S211-S211; doi:10.1016/j.ymthe.2004.06.498

560. Induction of Prion Protein-Specific Antibody Responses Using PrP-Retroparticles

Daphne Nikles, Patricia Bach, Klaus Boller, Christoph A. Merten, Fabio Montrasio, Ulrich Kalinke, Klaus Cichutek and Christian J. Buchholz

Mol Ther 9: S211-S211; doi:10.1016/j.ymthe.2004.06.486

561. Recombinant Adenovirus Carrying Spike Gene Induces Effective Humoral and Cellular Immunity Against SARS-CoV in Rats

Ranyi Liu, Lizhe Wu, Bijun Huang, Jialin Huang and Wenlin Huang

Mol Ther 9: S211-S212; doi:10.1016/j.ymthe.2004.06.487

562. Human T-Cells Modified as Antigen Presenting Cells Are Superior to Professional APC in Stimulating T-Cell Responses

Eleni C. Adamopoulou, Christian Sinzger, Gabriele Kuntz, Christina Neff, Hermann Einsele, Hans G. Rammensee and Max S. Topp

Mol Ther 9: S212-S212; doi:10.1016/j.ymthe.2004.06.497

563. Determinants of a Humoral Immune Response Against the Transgene Product after Adenoviral Gene Transfer

Bart De Geest, Sophie Van Linthout, Jan Snoeys, Joke Lievens and D|[eacute]|sir|[eacute]| Collen

Mol Ther 9: S212-S212; doi:10.1016/j.ymthe.2004.06.496

564. T Cell Immunity Using Transgenic B Lymphocytes

Mara Gerloni, Marta Rizzi, Paola Castiglioni and Maurizio Zanetti

Mol Ther 9: S213-S213; doi:10.1016/j.ymthe.2004.06.488

565. Modulation of the Acute Phase Response by Recombinant Adeno-Associated Viral Expression of the IL-1 Type 1 Soluble Receptor

Gregory G. Simon, Barry J. Byrne and Mark A. Atkinson

Mol Ther 9: S213-S213; doi:10.1016/j.ymthe.2004.06.489

566. Inactivation of a Bacterial Quorum-Sensing Signal by Expression of Bacterial Autoinducer Inhibitor, aiiA, in Mammalian Cells

Egon A. Ozer and Joseph Zabner

Mol Ther 9: S213-S214; doi:10.1016/j.ymthe.2004.06.490

567. Effective Boosting of Protective Immunity Via Repeated Intramuscular Administration of a Human Adenovirus-Based Anthrax Vaccine

Yadi Tan, Julie L. Boyer, Neil R. Hackett and Ronald G. Crystal

Mol Ther 9: S214-S214; doi:10.1016/j.ymthe.2004.06.495

568. Comparison of Antigen-Specific Immune Responses Elicited by Recombinant Simian Adenoviral Vectors with Deletions in Either E1, or E1/E3, or E1/E4 Regions

Yan Zhi, Gary P. Kobinger, Heather Jordan, Guangping Gao and James M. Wilson

Mol Ther 9: S214-S214; doi:10.1016/j.ymthe.2004.06.491

569. Increased Antigen-Specific Humoral Response by Adenoviral Vector Prime and Adeno-Associated Viral Vector Boost

Yan Zhi, Lili Wang, Guangping Gao and James M. Wilson

Mol Ther 9: S214-S214; doi:10.1016/j.ymthe.2004.06.492

570. Genetic Vaccination Against Yersinia pestis Using Recombinant Adenovirus Vectors Expressing the V Antigen

Maria Chiuchiolo, Barry Shea, Julie L. Boyer, Neil R. Hackett and Ronald G. Crystal

Mol Ther 9: S215-S215; doi:10.1016/j.ymthe.2004.06.494

571. Expression of IL-27 in Murine Carcinoma Cells Produces T Cell-Dependent and -Independent Antitumor Effects

Masatoshi Tagawa, Masako Chiyo, Osamu Shimozato, Ling Yu and Takehiko Fujisawa

Mol Ther 9: S215-S215; doi:10.1016/j.ymthe.2004.06.501

572. Augmentation of Immuno-Gene Therapy for Lung Cancer Using Chemotherapy

Eiji Suzuki, Veena Kapoor, Arminder S. Jassar, Andrew Haas, Larry R. Kaiser and Steven M. Albelda

Mol Ther 9: S215-S216; doi:10.1016/j.ymthe.2004.06.502

573. Immuno Gene Therapy of Feline Fibrosarcoma Using Intratumoral Magnetofection for Gene Delivery |[ndash]| Preliminary Results of a Veterinary Clinical Study

Ulrike Schillinger, Niels Kjaergaard, Kathrin Wiedmann, Anne Loecher, Stefanie Schlemmer, Bianca Schwarz, Tina Kempf, Johannes Hirschberger, Roberto Koestlin, Christian Plank, Bernd Gansbacher and Thomas Brill

Mol Ther 9: S216-S216; doi:10.1016/j.ymthe.2004.06.503

574. Systemic IL-12 Eliminates Pre-Established Leukemia in a Murine Model of Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Tanja A. Gruber, Dianne C. Skelton, Karen Pepper, Denise Peterson and Donald B. Kohn

Mol Ther 9: S216-S217; doi:10.1016/j.ymthe.2004.06.504

575. Dendritic Cells Modified Using an Adenovirus Expressing Murine IL-12 Inhibits Development of Tumors in a Mouse Colon Cancer Model

Yoshio Sakai, Brian J. Morrison, John E. Janik and John C. Morris

Mol Ther 9: S217-S217; doi:10.1016/j.ymthe.2004.06.505

576. Antitumoral Effect Mediated by Two SFV-IL-12 Expression Vectors in a Murine Model of Colon Adenocarcinoma

Juan R. Rodriguez-Madoz, Erkuden Casales, Min Guan, Jesus Prieto and Cristian Smerdou

Mol Ther 9: S217-S218; doi:10.1016/j.ymthe.2004.06.506

577. MVA-MUC1-IL2 Vaccine Immunotherapy for Patients Post-Prostatectomy with Rising PSA and No Evident Metastases

Robert Dreicer, Frederick Ahman, Allan Pantuck, Caroline Beunkens, Nadine Bizouarne, Bruce Acres, Teresa Maciejewska and Patrick Squiban

Mol Ther 9: S218-S218; doi:10.1016/j.ymthe.2004.06.507

578. Enhancement of GM-CSF secreting tumor cell vaccines by docetaxel through immune-dependent and independent mechanisms

Rodney A. Prell, Lisa Sampson, Melinda VanRoey and Karin U. Jooss

Mol Ther 9: S218-S218; doi:10.1016/j.ymthe.2004.06.508

579. Generation of potent cellular immune responses induced by intradermal delivery of plasmid DNA coexpressing Flt3 ligand and GM-CSF

Yi-Te Yo, Chao-Liang Wu, Chi-Wen Lo and Ai-Li Shiau

Mol Ther 9: S219-S219; doi:10.1016/j.ymthe.2004.06.509

580. Inducible expression of interleukin-12 for the treatment of liver metastases using a high-capacity adenoviral vector

Ruben Hernandez-Alcoceba, Itsaso Mauleon, Maider Zabala, Vijay Shankar, Stefan Kochanek, Jesus Prieto and Cheng Qian

Mol Ther 9: S219-S219; doi:10.1016/j.ymthe.2004.06.510

581. Enhanced antitumor effect of interleukin-12 and B7.1 expressing oncolytic adenovirus in immunocompetent mouse

Young-Sook Lee, Kyung-Ju Cho, Sungae Cho, Chae-Ok Yun and Joo-Hang Kim

Mol Ther 9: S219-S220; doi:10.1016/j.ymthe.2004.06.511

582. Detection of enhanced serum antibody production to renal cell cancer proteins and identification of serological tumor antigens in patients treated with the GM-CSF-gene transduced-autologous tumor vaccines (GVAX|[reg]|)

Takao Hashiguchi, Yukoh Nakazaki, Shirley Clift, Dale G. Ando, Shigetaka Asano and Kenzaburo Tani

Mol Ther 9: S220-S220; doi:10.1016/j.ymthe.2004.06.512

583. Efficient Non-Viral Gene Delivery to Primary, Leukemia B Cells by mRNA Transfection

Linhong Li, Cornell Allen, Rama Shivakumar, Jonathan M. Weiss, Joseph C. Fratantoni and Linda N. Liu

Mol Ther 9: S220-S220; doi:10.1016/j.ymthe.2004.06.513

584. Intratumoral Electrotransfer of Interleukin-12 Gene and Bleomycin Synergistically Induced Therapeutic Immunity and Suppressed Subcutaneous and Metastatic Melanomas in Mice

Tsunao Kishida, Hidetsugu Asada, Hiroshi Nakano, Kakei S. Yasutomi, Masaharu Shin-ya, Takashi Shinomiya, Feng-De Cui, Yasuo Hisa, Jiro Imanishi and Osam Mazda

Mol Ther 9: S221-S221; doi:10.1016/j.ymthe.2004.06.514

585. Anti-Angiogenic Drugs Synergize with a Membrane Macrophage Colony Stimulating Factor (mM-CSF) Based Tumor Vaccine to Therapeutically Treat Rats with an Established Intracranial Glioma

Martin R. Jadus, Edward W. B. Jeffes, Ramon Sanchez, Christina Delgado, Jian G. Zhang, Sakineh Khalaghizadeh, Tetyana Khomenko, Animesh Petkar, Chirag Shah, Brandon Knight, Seema Vohra, Reza Jahroudi and Terry Wepsic

Mol Ther 9: S221-S221; doi:10.1016/j.ymthe.2004.06.515

586. Gene transfer of IP10, IP10+CD154 or IP10+IL12 cDNA induces an anti-leukemic immunity in a murine model of acute leukemia

Aurore Saudemont and Bruno Quesnel

Mol Ther 9: S221-S222; doi:10.1016/j.ymthe.2004.06.531

587. Further advances in immuno-gene therapy against human papillomavirus by adeno-associated virus gene transfer into dendritic cells

Yong Liu, Maurizio Chiriva-Internati, Hong You, Jawahar L. Mehta and Paul L. Hermonat

Mol Ther 9: S222-S222; doi:10.1016/j.ymthe.2004.06.557

588. A central role of RNA in developing therapeutic vaccines for cancer and infectious diseases

Eli Gilboa, Sandra Santulli-Marotto, Smita K. Nair, David Boczkowski and Yanbing Zhao

Mol Ther 9: S222-S222; doi:10.1016/j.ymthe.2004.06.558

589. Therapeutic efficacy and cellular mechanism mediated by intratumoral and intramuscular IL-12 electrogenetherapy

Shulin Li, Francesca Mellieon and Robin Barret

Mol Ther 9: S222-S222; doi:10.1016/j.ymthe.2004.06.559

590. SuperCD enables low dose 5-FC application for effective suicide gene therapy in a rat hepatoma model both in vitro and in vivo

Marie-Luise Lemken, Florian Graepler, Wolfgang A. Wybranietz, Ulrike Schmidt, Irina Smirnow, Christine D. Gross, Martin Spiegel, Andrea Schenk, Hansjoerg Graf, Ulrike A. Lauer, Michael Gregor, Sorin Armeanu, Michael Bitzer and Ulrich M. Lauer

Mol Ther 9: S223-S223; doi:10.1016/j.ymthe.2004.06.517

591. Comparison of plant-TK/AZT versus HSV-TK/ganciclovir enzyme/prodrug systems in a human glioma cell line

Mette Willer, Peter Kristoffersen and Zoran Gojkovic

Mol Ther 9: S223-S223; doi:10.1016/j.ymthe.2004.06.516

592. Transfection of human oral cancer cells mediated by transferrin-associated lipoplexes: mechanisms of cell death induced by herpes simplex virus thimidine kinase/ganciclovir therapy

Silvia S. Neves, Sergio M. Simoes and Maria C. Pedroso de Lima

Mol Ther 9: S223-S224; doi:10.1016/j.ymthe.2004.06.518

593. Recombinant measles viruses encoding suicide genes for oncolytic therapy

Christoph Springfeld, von Messling Veronika, Frenzke Marie and Cattaneo Roberto

Mol Ther 9: S224-S224; doi:10.1016/j.ymthe.2004.06.519

594. Gene-directed enzyme therapy with carboxylesterase/CPT-11, but not thymidine kinase/GCV, enhances the efficacy of the conditionally replicating adenovirus Ad|[Delta]|24

Dinja Oosterhoff, Herbert M. Pinedo, M. Adhiambo Witlox, Jan E. Carette, Winald R. Gerritsen and Victor W. van Beusechem

Mol Ther 9: S224-S225; doi:10.1016/j.ymthe.2004.06.520

595. Combination tissue specific SCC antigen promoter with cd/5-fc gene therapy enhances killing of human uterine cervical cancer cells by radiation

Keng-Fu Hsu, Cheng-Yang Chou, Helen H. W. Chen, Che-Hsin Lee, Ai-Li Shiau and Chao-Liang Wu

Mol Ther 9: S225-S225; doi:10.1016/j.ymthe.2004.06.521

596. Radiosensitization of gliomas using lentiviral vectors expressing antisense ATM

Teong L. Chuah, David G. Walker, Ming Q. Wei, Shaun P. Scott and Martin F. Lavin

Mol Ther 9: S225-S225; doi:10.1016/j.ymthe.2004.06.522

597. Combined suicide/cytokine gene therapy of hepatocellular carcinoma

Anna-Lisa Stefani, Luisa Barzon, Ignazio Castagliuolo, Maria Guido, Fabio Farinati and Giorgio Pal|[ugrave]|

Mol Ther 9: S226-S226; doi:10.1016/j.ymthe.2004.06.554

598. Interleukin-2 enhanced the anti-tumor effect of adenoviral-mediated HSV-tk gene therapy in a murine bladder cancer model

Shiji Terao, Toshiro Sirakawa, Nobuyuki Hinata, Sadao Kamidono and Akinobu Gotoh

Mol Ther 9: S226-S226; doi:10.1016/j.ymthe.2004.06.523

599. Low-dose etoposide enhances tumor-specific adenovirus-mediated cytosine deaminase gene therapy through induction of integrin |[alpha]|v|[beta]|3 and |[alpha]|v|[beta]|5 overexpression and upregulation of human telomerase reverse transcriptase promoter

Gia-Shing Shieh, Tzong-Shin Tzai, Yi-Te Yo, Ai-Li Shiau and Chao-Liang Wu

Mol Ther 9: S226-S227; doi:10.1016/j.ymthe.2004.06.555

600. Fusion of HSV-1 thymidine kinase to an 11 aa-peptide from the HIV-1 tat protein promotes intercellular trafficking and enhances anti-tumoral activity in vivo

Ennio Tasciotti and Mauro Giacca

Mol Ther 9: S227-S227; doi:10.1016/j.ymthe.2004.06.524

601. HIV-1 TAT protein transduction domain-mediated enhancement of HSV-TK/ganciclovir suicide gene therapy

Outi Meril|[auml]|inen, Tanja Hakkarainen, Tiina Pasanen, Riikka Pellinen and Jarmo Wahlfors

Mol Ther 9: S227-S228; doi:10.1016/j.ymthe.2004.06.525

602. Utilization of VP22 in cancer gene therapy

Tanja Hakkarainen, Tiina Pasanen and Jarmo Wahlfors

Mol Ther 9: S228-S228; doi:10.1016/j.ymthe.2004.06.526

603. Prostate tumor regression following adenoviral delivery of Flp recombinase-regulated diphtheria toxin expression

Janet A. Sawicki and Weidan Peng

Mol Ther 9: S228-S228; doi:10.1016/j.ymthe.2004.06.556

604. Phase I/II clinical trial of Ad-OC-TK plus VAL for the patients with metastatic or local recurrent prostate cancer: initial experience in Japan

Toshiro Shirakawa, Nobuyuki Hinata, Shuji Terao, Katsumi Shigemura, Naonori Taniguch, Kazuhito Fukushima, Khoji Sugimoto, Kazuro Sugimura, Masafumi Matsuo, Sakan Maeda, Sadao Kamidono, Chinghai Kao, Thomas A. Gardner, Leland W. K. Chung and Akinobu Gotoh

Mol Ther 9: S228-S229; doi:10.1016/j.ymthe.2004.06.527

605. Cytokine profile assessment of mesothelioma patients treated with escalating doses of intrapleurally administered, genetically modified PA1STK cells and a twice daily regiment of ganciclovir. a Phase I clinical trial

Patrick S. Byrne, Paul O. Schwarzenberger, Lynn Harrison, Judy Norton and Jay K. Kolls

Mol Ther 9: S229-S229; doi:10.1016/j.ymthe.2004.06.528

606. The NOD-SCID |[beta]|2M null mouse xenograft model for studying activation, expansion and GvHD potential of gene transduced human t cells in vivo

Jon E. Walker, Gerhard Bauer, Phillip Herrbrich, David Hess, Todd Meyerrose, Bruno Nervi, Michael Rettig, Jan A. Nolta and John F. DiPersio

Mol Ther 9: S229-S229; doi:10.1016/j.ymthe.2004.06.1010

607. In vitro and in vivo monitoring of 5-fluorosytosine metabolism with 19F-NMR spectroscopy after adenoviral transduction of cells with bifunctional yeast CDUPRT fusion gene

Vera Simonenko, Huandong Pageant, Du Fei and Thian C. Ng

Mol Ther 9: S230-S230; doi:10.1016/j.ymthe.2004.06.530

608. VAI deleted adenovirus as an oncolytic agent targeting human EBV-associated tumours

Yaohe Wang, Shao-an Xue, Gunnel Hallden, Jennelle Francis, Beverly E. Griffin and Nick R. Lemoine

Mol Ther 9: S230-S230; doi:10.1016/j.ymthe.2004.06.532

609. Highly active, cancer specific promoters for gene therapy of small cell lung cancer

Nina Pedersen, Mikkel W. Pedersen, Thomas T. Poulsen and Hans S. Poulsen

Mol Ther 9: S230-S231; doi:10.1016/j.ymthe.2004.06.533

610. Elucidating the mechanism(s) for tumor specificity of attenuated measles virus

Bambi D. Anderson, Takafumi Nakamura, Stephen J. Russell and Kah-Whye Peng

Mol Ther 9: S231-S231; doi:10.1016/j.ymthe.2004.06.534

611. Group I intron-mediated trans-splicing revision of mutant p53 RNA transcripts

Daniel J. Catron, Takashi Watanabe, Kyung-Sook Shin, Eric M. Toloza, Seong-Wook Lee and Bruce A. Sullenger

Mol Ther 9: S231-S231; doi:10.1016/j.ymthe.2004.06.535

612. Effect of adenovirus dl520 as replicating agent in combination with fractionated radiotherapy in a glioma xenograft model

Alexa Bieler, Alexandra Bernshausen, Sybille Staerk, Anka Grosso, Bernd Gaensbacher and Per Sonne Holm

Mol Ther 9: S232-S232; doi:10.1016/j.ymthe.2004.06.536

613. Display of different protein scaffolds on envelope glycoprotein of avian leukosis virus

Pranay D. Khare, Stephen J. Russell and Mark J. Federspiel

Mol Ther 9: S232-S232; doi:10.1016/j.ymthe.2004.06.537

614. In vivo and in vitro characterisation of library selected matrix metalloprotease activatable retroviruses

Irene Hartl, Richard M. Schneider, Yuansheng Sun, Stephen J. Russell, Christian J. Buchholz and Klaus Cichutek

Mol Ther 9: S232-S233; doi:10.1016/j.ymthe.2004.06.538

615. Feasibility of hTERT-targeting trans-splicing ribozyme in tumor-targeted gene therapy

Seung-Hee Hong, Yoon-Jong Lee, Haeng-Im Jung, Byung-Su Kwon, Seong-Wook Lee, Jin-Sook Jeong, Chang-Min Kim and In-Hoo Kim

Mol Ther 9: S233-S233; doi:10.1016/j.ymthe.2004.06.539

616. Retargeted Selectively Replicating Adenoviruses for the Therapy of Colon Cancer

Krisztian Gy Homicsko, Christophe Fuerer and Richard Iggo

Mol Ther 9: S233-S233; doi:10.1016/j.ymthe.2004.06.540

617. Prostate Cancer Radiosensitization by Targeting Poly(ADP-ribose) Polymerase

Li Zhang, Prafulla Gokhale, Rajshree Mewani, Bihua Li, Anatoly Dritschilo and Viatcheslav Soldatenkov

Mol Ther 9: S234-S234; doi:10.1016/j.ymthe.2004.06.541

618. Coxsackie-Adenovirus Receptor (CAR) Levels Can Be Increased in Human Xenografts Followed by Treatment with FK228, a Histone Deacetylase Inhibitor

Alian Aguila, Merrill E. Goldsmith, Santhi J. Gollapalli, Michael C. Alley, William W. Waud, Susan Bates and Tito Fojo

Mol Ther 9: S234-S234; doi:10.1016/j.ymthe.2004.06.542

619. Augmentation of Anti-Tumor Activity of a Recombinant Adeno-Associated Virus 2 Carcinoembryonic Antigen Vaccine with Plasmid Adjuvants

Selvarangan Ponnazhagan, Gandham Mahendra, Jose Lima, Wayne Aldrich, Connie Jenkins, Changchun Ren, Sanjay Kumar, Lisa Kallman, Theresa V. Strong, Denise R. Shaw and Pierre L. Triozzi

Mol Ther 9: S234-S235; doi:10.1016/j.ymthe.2004.06.543

620. A Longer Human Telomerase Reverse Transcriptase Promoter-Based Conditionally Replicative Adenovirus Shows Oncolysis with Less Toxicity for Ovarian Cancer Treatment

Yosuke Kawakami, Koichi Takayama, Masato Yamamoto, Dirk M. Nettelbeck, Minghui Wang, Mack N. Barnes, Gene P. Siegal, Ronald D. Alvarez, David T. Curiel and Jerry L. Blackwell

Mol Ther 9: S235-S235; doi:10.1016/j.ymthe.2004.06.544

621. Translational Restriction of Protein Expression of a Modifed Suicide Gene and Cytotoxicity in Human Mammary Tumor Cells Expressing High Levels of the Translation Initiation Factor eIF4E

Don A. Sibley, James M. Mathis, Yoshi Odaka, B. J. Williams and Arrico DeBenedetti

Mol Ther 9: S235-S235; doi:10.1016/j.ymthe.2004.06.545

622. Discovery of Targeting Peptides for Selective Therapy of Medullary Thyroid Carcinoma

Miriam B|[ouml]|ckmann, Matthias Drosten and Brigitte M. P|[uuml]|tzer

Mol Ther 9: S236-S236; doi:10.1016/j.ymthe.2004.06.546

623. Transcriptional Targeting of Breast Cancer Employing the Heparanase Promoter

Martina Breidenbach, Daniel T. Rein, Yuko Tsuruta, Minghui Wang, Isabell Herrmann, Ronald D. Alvarez, Paul N. Reynolds and David T. Curiel

Mol Ther 9: S236-S236; doi:10.1016/j.ymthe.2004.06.547

624. Effect of an Oncolytic HSV Mutant Expressing ICP34.5 under Control of a Nestin Promoter for Brain Tumor Therapy

Hirokazu Kambara, Hideyuki Okano, E. Antonio Chiocca and Yoshinaga Saeki

Mol Ther 9: S236-S237; doi:10.1016/j.ymthe.2004.06.548

625. AAV Gene Therapy for Liver Metastatic Cancer

Ray A. Xu, Kevin Sun, Geoffrey W. Krissansen, Peter W. Fung, Sue Xu, Weidong Xiao, Juan Shi and Sheung-tat Fan

Mol Ther 9: S237-S237; doi:10.1016/j.ymthe.2004.06.549

626. A Novel Prostate-Specific Adenovirus for Gene Expression in Hormone-Sensitive and Hormone-Refractory Prostate Cancer Cells

Wing-Shing Cheng and Magnus Essand

Mol Ther 9: S237-S237; doi:10.1016/j.ymthe.2004.06.550

627. Widespread Intratumoral Viral Distribution Enables Local Control of Large Human Sarcoma Xenografts by Oncolytic Herpes Simplex Viruses

Mark A. Currier, Yoni H. Mahller, Lisa C. Adams, Brian Horsburgh, Frank Tufaro and Timothy P. Cripe

Mol Ther 9: S237-S237; doi:10.1016/j.ymthe.2004.06.551

628. An Oncolytic Adenovirus Armed with a GM-CSF Activating Designed Zinc-Finger Protein Transcription Factor: A Potential Cancer Vaccine Approach

Andreas Reik, Philip D. Gregory and Casey C. Case

Mol Ther 9: S238-S238; doi:10.1016/j.ymthe.2004.06.552

629. VEGF Promoter-Based Conditionally Replicative Adenoviruses Are Useful for the Treatment of Malignant Pleural Mesothelioma

Koichi Takayama, Akiko Ikegami, Hiroyuki Inoue, Lioudmila Kaliberova, Junji Uchino, David T. Curiel and Yoichi Nakanishi

Mol Ther 9: S238-S238; doi:10.1016/j.ymthe.2004.06.553

630. Tamoxifen-Inducible Expansion of Murine Hematopoietic Stem Cells by Retroviral-Mediated Transfer of a HOXB4-ERT2 Fusion Protein

Yan Shou, Lilia Stepanova and Brian P. Sorrentino

Mol Ther 9: S238-S239; doi:10.1016/j.ymthe.2004.06.560

631. Modulation of Immune Response to Gene Therapy Derived Products by CD4+ CD25+ T Regulatory Cells

Andrea Annoni, Manuela Battaglia, Antonia Follenzi, Angelo Lombardo, Luigi Naldini and Maria-Grazia Roncarolo

Mol Ther 9: S239-S239; doi:10.1016/j.ymthe.2004.06.561