TABLE 1

FROM:

Helper-Independent Sleeping Beauty Transposon–Transposase Vectors for Efficient Nonviral Gene Delivery and Persistent Gene Expression in Vivo

Jacob Giehm Mikkelsen, Stephen R. Yant, Leonard Meuse, Zan Huang, Hui Xu and Mark A. Kay

Table 1. Partial phenotypic correction in hemophilia B mice treated once with HITT-vector plasmids

Group	Mouse strain	Vector treatment	Mouse	hFIX (ng/ml) Day 110	Bleeding times (min)
1	C57Bl/6	No DNA injection	1	ND	14
			2	ND	13
			3	ND	10
2	Hemophilia	42 g pT/EF1-hFIX.PGK-SB	4	322	20
	C57Bl/6	"active transposase"	5	187	18
			6	303	19
			7	221	22
3	Hemophilia	42 g pT/EF1-hFIX.PGK-mSB	8	UD	>30
	C57Bl/6	"inactive transposase"	9	UD	>30
			10	UD	>30
			11	UD	>30
			12	UD	>30

 ND, not done; UD, undetectable by ELISA.