FIGURE 5
FROM:
Helper-Independent and AAV-ITR-Independent Chromosomal Integration of Double-Stranded Linear DNA Vectors in Mice
Hiroyuki Nakai, Eugenio Montini, Sally Fuess, Theresa A. Storm, Leonard Meuse, Milton Finegold, Markus Grompe and Mark A. Kay
BACK TO ARTICLEFigure 5.
Plasma human F.IX levels in ds linear or circular DNA vector-injected mice. (A) Plasma human F.IX levels after tail vein injection of human F.IX-expressing naked linear or circular DNA vector hF.IX-L+, hF.IX-L-, or hF.IX-C+. The amount of each vector (
g per mouse) and number of animals per group are shown. Each dose of vector was determined based on the molecular weight so that mice would receive the same number of, or four times more, molecules. (B) Plasma human F.IX levels after 2/3 partial hepatectomy performed 6 weeks postinjection in each individual mouse. The y axis represents averages of human F.IX levels relative to those at the time of hepatectomy in individual mice, shown as a percentage. Vertical bars indicate mean values 
standard errors.
