TABLE OF CONTENTS
Volume 17, Issue 8 (August 2009)
In This Issue |
Research Highlights |
Letters to the Editor |
Commentary |
Reviews |
Original Articles |
Errata
Editorial
Gene Therapy Continues to Mature and to Face Challenges FREE
David A Williams
Mol Ther 17: 1305-1306; doi:10.1038/mt.2009.162
In This Issue
In This Issue FREE
Mol Ther 17: 1308; doi:10.1038/mt.2009.164
See also: Original Article by Policastro et al. See also: Original Article by Han et al. See also: Original Article by Chang et al. See also: Original Article by D'Apolito et al. See also: Original Article by Kiuru et al.Research Highlights
Top of pageLetters to the Editor
Rapid Tumor Cell Swelling and Bursting: Beware of Collateral Damage
Mathieu Lemaire and Mitchell L Halperin
Mol Ther 17: 1310-1311; doi:10.1038/mt.2009.161
Tannous et al. Respond:
Bakhos A Tannous, E Antonio Chiocca, Andreas H Jacobs, David P Corey and Xandra O Breakefield
Mol Ther 17: 1311-1312; doi:10.1038/mt.2009.166
Commentary
Genetic Correction of Hematopoiesis in Fanconi Anemia: The Case for a Non-HSC-Autonomous Defect
Amy M Skinner and Peter Kurre
Mol Ther 17: 1313-1315; doi:10.1038/mt.2009.138
See also: by Jacome et al.Reviews
Vector Engineering and Delivery
Integration-deficient Lentiviral Vectors: A Slow Coming of Age
Klaus Wanisch and Rafael J Yáñez-Muñoz
Mol Ther 17: 1316-1332; advance online publication, June 2, 2009; doi:10.1038/mt.2009.122
Vaccine Technology
New Insights on Adenovirus as Vaccine Vectors
Marcio O Lasaro and Hildegund CJ Ertl
Mol Ther 17: 1333-1339; advance online publication, June 9, 2009; doi:10.1038/mt.2009.130
Original Articles
Monogenic Disease
AAV2/8-mediated Correction of OTC Deficiency Is Robust in Adult but Not Neonatal Spf ash Mice
Sharon C Cunningham, Afroditi Spinoulas, Kevin H Carpenter, Bridget Wilcken, Philip W Kuchel and Ian E Alexander
Mol Ther 17: 1340-1346; advance online publication, April 21, 2009; doi:10.1038/mt.2009.88
AAV-mediated Tyrosinase Gene Transfer Restores Melanogenesis and Retinal Function in a Model of Oculo-cutaneous Albinism Type I (OCA1)
Annagiusi Gargiulo, Ciro Bonetti, Sandro Montefusco, Simona Neglia, Umberto Di Vicino, Elena Marrocco, Michele Della Corte, Luciano Domenici, Alberto Auricchio and Enrico M Surace
Mol Ther 17: 1347-1354; advance online publication, May 12, 2009; doi:10.1038/mt.2009.112
Acquired and Multigenic Disease
Suppression of Cancer Growth by Nonviral Gene Therapy Based on a Novel Reactive Oxygen Species-responsive Promoter
Lucía L Policastro, Irene L Ibañez, Hebe A Durán, Gastón Soria, Vanesa Gottifredi and Osvaldo L Podhajcer
Mol Ther 17: 1355-1364; advance online publication, May 12, 2009; doi:10.1038/mt.2009.103
Treatment With Cyclooxygenase-2 Inhibitors Enables Repeated Administration of Vaccinia Virus for Control of Ovarian Cancer
Chih-Long Chang, Barbara Ma, Xiaowu Pang, T-C Wu and Chien-Fu Hung
Mol Ther 17: 1365-1372; advance online publication, May 26, 2009; doi:10.1038/mt.2009.118
Abrogation of Microsatellite-instable Tumors Using a Highly Selective Suicide Gene/Prodrug Combination
Cristina Ferrás, Joachim AF Oude Vrielink, Johan WA Verspuy, Hein te Riele, Anastasia Tsaalbi-Shtylik and Niels de Wind
Mol Ther 17: 1373-1380; advance online publication, May 26, 2009; doi:10.1038/mt.2009.114
Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease
Yinxing Liu, Christa Studzinski, Tina Beckett, Hanjun Guan, Matthew A Hersh, M Paul Murphy, Ronald Klein and Louis B Hersh
Mol Ther 17: 1381-1386; advance online publication, May 26, 2009; doi:10.1038/mt.2009.115
Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma
Elie Hadchity, Marie-Thérèse Aloy, Christian Paulin, Emma Armandy, Emmanuel Watkin, Robert Rousson, Martin Gleave, Olivier Chapet and Claire Rodriguez-Lafrasse
Mol Ther 17: 1387-1394; advance online publication, May 12, 2009; doi:10.1038/mt.2009.90
Vector Engineering and Delivery
Converting Tumor-specific Markers Into Reporters of Oncolytic Virus Infection
Ianko D Iankov, Matthew L Hillestad, Allan B Dietz, Stephen J Russell and Evanthia Galanis
Mol Ther 17: 1395-1403; advance online publication, May 26, 2009; doi:10.1038/mt.2009.92
Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles
Muri Han, Makoto Oba, Nobuhiro Nishiyama, Mitsunobu R Kano, Shinae Kizaka-Kondoh and Kazunori Kataoka
Mol Ther 17: 1404-1410; advance online publication, May 26, 2009; doi:10.1038/mt.2009.119
Fluid Phase Endocytosis Contributes to Transfection of DNA by PEI-25
Hansjörg Hufnagel, Parvez Hakim, Aline Lima and Florian Hollfelder
Mol Ther 17: 1411-1417; advance online publication, June 16, 2009; doi:10.1038/mt.2009.121
Rational Design of Antisense Oligomers to Induce Dystrophin Exon Skipping
Chalermchai Mitrpant, Abbie M Adams, Penny L Meloni, Francesco Muntoni, Sue Fletcher and Steve D Wilton
Mol Ther 17: 1418-1426; advance online publication, March 17, 2009; doi:10.1038/mt.2009.49
Evaluation of Vascular Delivery Methodologies to Enhance rAAV6-mediated Gene Transfer to Canine Striated Musculature
Paul Gregorevic, Brian R Schultz, James M Allen, Jeffrey B Halldorson, Michael J Blankinship, Norman A Meznarich, Christian S Kuhr, Caitlin Doremus, Eric Finn, Denny Liggitt and Jeffrey S Chamberlain
Mol Ther 17: 1427-1433; advance online publication, May 26, 2009; doi:10.1038/mt.2009.116
Vector Toxicology, Immunogenicity and Safety
The Sea Urchin sns5 Insulator Protects Retroviral Vectors From Chromosomal Position Effects by Maintaining Active Chromatin Structure
Danilo D'Apolito, Elena Baiamonte, Mariella Bagliesi, Rosalba Di Marzo, Roberta Calzolari, Leda Ferro, Vito Franco, Giovanni Spinelli, Aurelio Maggio and Santina Acuto
Mol Ther 17: 1434-1441; advance online publication, April 7, 2009; doi:10.1038/mt.2009.74
Cell Therapy
Sonic Hedgehog Expands Diaphyseal Trabecular Bone Altering Bone Marrow Niche and Lymphocyte Compartment
Maija Kiuru, Chisa Hidaka, Ralf-Harto Hubner, Jason Solomon, Anja Krause, Philip L Leopold and Ronald G Crystal
Mol Ther 17: 1442-1452; advance online publication, May 12, 2009; doi:10.1038/mt.2009.102
Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo
Michael C. Milone, Jonathan D. Fish, Carmine Carpenito, Richard G. Carroll, Gwendolyn K. Binder, David Teachey, Minu Samanta, Mehdi Lakhal, Brian Gloss, Gwenn Danet-Desnoyers, Dario Campana, James L. Riley, Stephan A. Grupp and Carl H. June
Mol Ther 17: 1453-1464; advance online publication, April 21, 2009; doi:10.1038/mt.2009.83
Vaccine Technology
Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive Antitumor Immunity
Jeanette E Boudreau, Byram W Bridle, Kyle B Stephenson, Kristina M Jenkins, Jérôme Brunellière, Jonathan L Bramson, Brian D Lichty and Yonghong Wan
Mol Ther 17: 1465-1472; advance online publication, April 28, 2009; doi:10.1038/mt.2009.95
DNA/Amphiphilic Block Copolymer Nanospheres Promote Low-dose DNA Vaccination
Dorian McIlroy, Benoît Barteau, Jeannette Cany, Peggy Richard, Clothilde Gourden, Sophie Conchon and Bruno Pitard
Mol Ther 17: 1473-1481; advance online publication, May 5, 2009; doi:10.1038/mt.2009.84
Errata
Erratum to "Efficient Transduction of Skeletal Muscle Using Vectors Based on Adeno-associated Virus Serotype 6" FREE
Michael J Blankinship, Paul Gregorevic, James M Allen, Scott Q Harper, Hollie Harper, Christine L Halbert, A Dusty Miller and Jeffrey S Chamberlain
Mol Ther 17: 1482; doi:10.1038/mt.2009.135
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