TABLE OF CONTENTS
Volume 17, Issue 3 (March 2009)
Editorial
The RAC: Double, Double, Toil, and Trouble? FREE
Hildegund Ertl
Mol Ther 17: 397-399; doi:10.1038/mt.2009.19
In This Issue
In This Issue FREE
Mol Ther 17: 400; doi:10.1038/mt.2009.21
See also: Review by Kelly & RussellSee also: Original Article by Joo et al. See also: Original Article by Thomas-Virnig et al. See also: Original Article by Peden et al. See also: Original Article by Pande et al.Research Highlights
Top of pageCommentaries
AAV9: a potential blood-brain barrier buster
Fredric P Manfredsson, Aaron C Rising and Ronald J Mandel
Mol Ther 17: 403-405; doi:10.1038/mt.2009.15
Bioengineered Human Skin: Working the Bugs Out
L Steinstraesser, S Al-Benna, M Kesting and F Jacobsen
Mol Ther 17: 405-408; doi:10.1038/mt.2009.14
See also: Original Article by Thomas-Virnig et al.Review
VECTOR ENGINEERING AND DELIVERY
MicroRNAs and the Regulation of Vector Tropism
Elizabeth J Kelly and Stephen J Russell
Mol Ther 17: 409-416; advance online publication, December 23, 2008; doi:10.1038/mt.2008.288
Original Articles
MONOGENIC DISEASE
Enhanced Factor VIII Heavy Chain for Gene Therapy of Hemophilia A
Lingxia Chen, Hui Lu, Jinhui Wang, Rita Sarkar, Xiao Yang, Hongli Wang, Katherine A High and Weidong Xiao
Mol Ther 17: 417-424; advance online publication, January 6, 2009; doi:10.1038/mt.2008.292
Biochemical Correction of Very Long–chain Acyl-CoA Dehydrogenase Deficiency Following Adeno-associated Virus Gene Therapy
J. Lawrence Merritt II, Tien Nguyen, Jan Daniels, Dietrich Matern and David B. Schowalter
Mol Ther 17: 425-429; advance online publication, January 20, 2009; doi:10.1038/mt.2008.295
ACQUIRED AND MULTIGENIC DISEASE
Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer
Ayman EM Mahdy, Joseph C Cheng, Jun Li, Saeed Elojeimy, William D Meacham, Lorianne S Turner, Aiping Bai, Christopher R Gault, Alex S McPherson, Nicole Garcia, Thomas H Beckham, Antonio Saad, Alicja Bielawska, Jacek Bielawski, Yusuf A Hannun, Thomas E Keane, Mohhammed I Taha, Hisham M Hammouda, James S Norris and Xiang Liu
Mol Ther 17: 430-438; advance online publication, December 23, 2008; doi:10.1038/mt.2008.281
Activation of Akt as a Mechanism for Tumor Immune Evasion
Kyung Hee Noh, Tae Heung Kang, Jin Hee Kim, Sara I Pai, Ken Y Lin, Chien-Fu Hung, T-C Wu and Tae Woo Kim
Mol Ther 17: 439-447; advance online publication, December 23, 2008; doi:10.1038/mt.2008.255
Extracellular Superoxide Dismutase Is a Growth Regulatory Mediator of Tissue Injury Recovery
Juha P Laurila, Maria D Castellone, Antonio Curcio, Lilja E Laatikainen, Merja Haaparanta-Solin, Tove J Gronroos, Paivi Marjamaki, Satu Martikainen, Massimo Santoro and Mikko O Laukkanen
Mol Ther 17: 448-454; advance online publication, December 23, 2008; doi:10.1038/mt.2008.282
RNA Interference Targeting STIM1 Suppresses Vascular Smooth Muscle Cell Proliferation and Neointima Formation in the Rat
Fleur C Aubart, Yassine Sassi, Alain Coulombe, Nathalie Mougenot, Cédric Vrignaud, Pascal Leprince, Philippe Lechat, Anne-Marie Lompré and Jean-Sébastien Hulot
Mol Ther 17: 455-462; advance online publication, December 23, 2008; doi:10.1038/mt.2008.291
VECTOR ENGINEERING AND DELIVERY
High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors
Hilda Petrs-Silva, Astra Dinculescu, Qiuhong Li, Seok-Hong Min, Vince Chiodo, Ji-Jing Pang, Li Zhong, Sergei Zolotukhin, Arun Srivastava, Alfred S Lewin and William W Hauswirth
Mol Ther 17: 463-471; advance online publication, December 16, 2008; doi:10.1038/mt.2008.269
Efficient Intrathymic Gene Transfer Following In Situ Administration of a rAAV Serotype 8 Vector in Mice and Nonhuman Primates
Aurélie Moreau, Rita Vicente, Laurence Dubreil, Oumeya Adjali, Guillaume Podevin, Chantal Jacquet, Jack Yves Deschamps, David Klatzmann, Yan Cherel, Naomi Taylor, Philippe Moullier and Valérie S Zimmermann
Mol Ther 17: 472-479; advance online publication, December 16, 2008; doi:10.1038/mt.2008.272
Combinatorial Evaluation of Cations, pH-sensitive and Hydrophobic Moieties for Polymeric Vector Design
Sharon Y Wong, Nimil Sood and David Putnam
Mol Ther 17: 480-490; advance online publication, January 13, 2009; doi:10.1038/mt.2008.293
Image-guided, Lobe-specific Hydrodynamic Gene Delivery to Swine Liver
Kenya Kamimura, Takeshi Suda, Wei Xu, Guisheng Zhang and Dexi Liu
Mol Ther 17: 491-499; advance online publication, January 20, 2009; doi:10.1038/mt.2008.294
Selective Enhancement of the Uptake and Bioactivity of a TAT-conjugated Peptide Inhibitor of Glycogen Synthase Kinase-3
Aziza P Manceur, Brandon D Driscoll, Wei Sun and Julie Audet
Mol Ther 17: 500-507; advance online publication, December 23, 2008; doi:10.1038/mt.2008.271
VECTOR TOXICOLOGY, IMMUNOGENICITY AND SAFETY
Cancer-induced Expansion and Activation of CD11b+Gr-1+ Cells Predispose Mice to Adenoviral-triggered Anaphylactoid-type Reactions
Kalyan Pande, Roanna Ueda, Todd Machemer, Manjiri Sathe, Van Tsai, Elena Brin, Matthew J Delano, Nico Van Rooijen, Terrill K McClanahan, James E Talmadge, Lyle L Moldawer, Joseph H Phillips and Drake M LaFace
Mol Ther 17: 508-515; advance online publication, January 6, 2009; doi:10.1038/mt.2008.280
Detection of Intact rAAV Particles up to 6 Years After Successful Gene Transfer in the Retina of Dogs and Primates
Knut Stieger, Josef Schroeder, Nathalie Provost, Alexandra Mendes-Madeira, Brahim Belbellaa, Guylène Le Meur, Michel Weber, Jack-Yves Deschamps, Birgit Lorenz, Philippe Moullier and Fabienne Rolling
Mol Ther 17: 516-523; advance online publication, December 23, 2008; doi:10.1038/mt.2008.283
Striatal Readministration of rAAV Vectors Reveals an Immune Response Against AAV2 Capsids That Can Be Circumvented
Carmen S Peden, Fredric P Manfredsson, Sharon K Reimsnider, Amy E Poirier, Corinna Burger, Nicholas Muzyczka and Ronald J Mandel
Mol Ther 17: 524-537; advance online publication, January 13, 2009; doi:10.1038/mt.2008.284
OLIGONUCLEOTIDE THERAPEUTICS
Rational Design Leads to More Potent RNA Interference Against Hepatitis B Virus: Factors Effecting Silencing Efficiency
Kathy Keck, Esther M Volper, Ryan M Spengler, Dang D Long, Chi Y Chan, Ye Ding and Anton P McCaffrey
Mol Ther 17: 538-547; advance online publication, December 16, 2008; doi:10.1038/mt.2008.273
Guidelines for Antisense Oligonucleotide Design and Insight Into Splice-modulating Mechanisms
Annemieke Aartsma-Rus, Laura van Vliet, Marscha Hirschi, Anneke AM Janson, Hans Heemskerk, Christa L de Winter, Sjef de Kimpe, Judith CT van Deutekom, Peter AC 't Hoen and Gert-Jan B van Ommen
Mol Ther 17: 548-553; advance online publication, September 23, 2008; doi:10.1038/mt.2008.205
Design of Phosphorodiamidate Morpholino Oligomers (PMOs) for the Induction of Exon Skipping of the Human DMD Gene
Linda J Popplewell, Capucine Trollet, George Dickson and Ian R Graham
Mol Ther 17: 554-561; advance online publication, January 13, 2009; doi:10.1038/mt.2008.287
CELL THERAPY
Inhibition of Multidrug-resistant Acinetobacter baumannii by Nonviral Expression of hCAP-18 in a Bioengineered Human Skin Tissue
Christina L Thomas-Virnig, John M Centanni, Colette E Johnston, Li-Ke He, Sandy J Schlosser, Kelly F Van Winkle, Ruibing Chen, Angela L Gibson, Andrea Szilagyi, Lingjun Li, Ravi Shankar and B Lynn Allen-Hoffmann
Mol Ther 17: 562-569; advance online publication, February 3, 2009; doi:10.1038/mt.2008.289
Abstract | Full Text | PDF | Supplementary information
See also: Commentaries by Steinstraesser et al.Human Neural Stem Cells Can Target and Deliver Therapeutic Genes to Breast Cancer Brain Metastases
Kyeung Min Joo, In H Park, Ji Y Shin, Juyoun Jin, Bong Gu Kang, Mi Hyun Kim, Se Jeong Lee, Mi-young Jo, Seung U Kim and Do-Hyun Nam
Mol Ther 17: 570-575; advance online publication, January 6, 2009; doi:10.1038/mt.2008.290
