TABLE OF CONTENTS
Volume 17, Issue 2 (February 2009)
In This Issue |
Research Highlights |
Commentaries |
Reviews |
Original Articles |
Erratum |
Corrigendum
Editorial
New Approaches in the Potential Treatment of HIV–acquired Immunodeficiency Disease FREE
David A Williams
Mol Ther 17: 209-210; doi:10.1038/mt.2008.302
In This Issue
In This Issue FREE
Mol Ther 17: 212; doi:10.1038/mt.2008.304
See also: Review by Park et al. See also: Review by Evans et al. See also: Original Article by Liu et al. See also: Original Article by Hoshiya et al. See also: Original Article by Laporte et al.Research Highlights
Top of pageCommentaries
Intersection of Gene Therapy and Progenitor Cell Biology in the Lung
Daniel J Weiss
Mol Ther 17: 214-216; doi:10.1038/mt.2008.285
See also: Original Article by Liu et al.Casting Doubt on the Safety of "Off-the-shelf" Mesenchymal Stem Cells for Cell Therapy
Pranela Rameshwar
Mol Ther 17: 216-218; doi:10.1038/mt.2008.296
See also: Original Article by Campeau et al.Reviews
CELL THERAPY
Cancer Stem Cell–Directed Therapies: Recent Data From the Laboratory and Clinic
Christopher Y Park, Diane Tseng and Irving L Weissman
Mol Ther 17: 219-230; advance online publication, December 9, 2008; doi:10.1038/mt.2008.254
ACQUIRED AND MULTIGENIC DISEASE
Orthopedic Gene Therapy in 2008
Christopher H Evans, Steven C Ghivizzani and Paul D Robbins
Mol Ther 17: 231-244; advance online publication, December 9, 2008; doi:10.1038/mt.2008.265
Original Articles
MONOGENIC DISEASE
Correction of Murine Sickle Cell Disease Using 
-Globin Lentiviral Vectors to Mediate High-level Expression of Fetal Hemoglobin
Tamara I Pestina, Phillip W Hargrove, Dennis Jay, John T Gray, Kelli M Boyd and Derek A Persons
Mol Ther 17: 245-252; advance online publication, December 2, 2008; doi:10.1038/mt.2008.259
Cardiac Expression of a Mini-dystrophin That Normalizes Skeletal Muscle Force Only Partially Restores Heart Function in Aged Mdx Mice
Brian Bostick, Yongping Yue, Chun Long, Nate Marschalk, Deborah M Fine, Jing Chen and Dongsheng Duan
Mol Ther 17: 253-261; advance online publication, December 9, 2008; doi:10.1038/mt.2008.264
ACQUIRED AND MULTIGENIC DISEASE
Direct Injection of Kit Ligand-2 Lentivirus Improves Cardiac Repair and Rescues Mice Post–myocardial Infarction
Koji Higuchi, Bilal Ayach, Takeya Sato, Manyin Chen, Sean P Devine, Vanessa I Rasaiah, Fayez Dawood, Teruyuki Yanagisawa, Chuwa Tei, Toshihiro Takenaka, Peter P Liu and Jeffrey A Medin
Mol Ther 17: 262-268; advance online publication, November 11, 2008; doi:10.1038/mt.2008.244
Targeting Hypoxia-inducible Factor-1
With Tf–PEI–shRNA Complex via Transferrin Receptor–mediated Endocytosis Inhibits Melanoma Growth
Yeqiang Liu, Juan Tao, Yan Li, Jing Yang, Yan Yu, Min Wang, Xiaoyuan Xu, Changzheng Huang, Wei Huang, Jing Dong, Li Li, Jing Liu, Guanxin Shen and Yating Tu
Mol Ther 17: 269-277; advance online publication, December 9, 2008; doi:10.1038/mt.2008.266
Antiangiogenic Gene Therapy With Soluble VEGFR-1, -2, and -3 Reduces the Growth of Solid Human Ovarian Carcinoma in Mice
Hanna Sallinen, Maarit Anttila, Johanna Narvainen, Jonna Koponen, Kirsi Hamalainen, Ivana Kholova, Tommi Heikura, Pyry Toivanen, Veli-Matti Kosma, Seppo Heinonen, Kari Alitalo and Seppo Yla-Herttuala
Mol Ther 17: 278-284; advance online publication, December 2, 2008; doi:10.1038/mt.2008.258
VECTOR ENGINEERING AND DELIVERY
Analysis of Adeno-associated Virus Progenitor Cell Transduction in Mouse Lung
Xiaoming Liu, Meihui Luo, Chenhong Guo, Ziying Yan, Yujiong Wang, Diana CM Lei-Butters and John F Engelhardt
Mol Ther 17: 285-293; advance online publication, November 25, 2008; doi:10.1038/mt.2008.248
Abstract | Full Text | PDF | Supplementary information
See also: Commentaries by WeissTransduction Efficiencies of Novel AAV Vectors in Mouse Airway Epithelium In Vivo and Human Ciliated Airway Epithelium In Vitro
Maria P Limberis, Luk H Vandenberghe, Liqun Zhang, Raymond J Pickles and James M Wilson
Mol Ther 17: 294-301; advance online publication, December 9, 2008; doi:10.1038/mt.2008.261
Microporation Is a Valuable Transfection Method for Gene Expression in Human Adipose Tissue–derived Stem Cells
Yan-Hsiung Wang, Mei-Ling Ho, Je-Ken Chang, Hai-Chang Chu, Shu-Chin Lai and Gwo-Jaw Wang
Mol Ther 17: 302-308; advance online publication, December 9, 2008; doi:10.1038/mt.2008.267
A highly Stable and Nonintegrated Human Artificial Chromosome (HAC) Containing the 2.4 Mb Entire Human Dystrophin Gene
Hidetoshi Hoshiya, Yasuhiro Kazuki, Satoshi Abe, Masato Takiguchi, Naoyo Kajitani, Yoshinori Watanabe, Toko Yoshino, Yasuaki Shirayoshi, Katsumi Higaki, Graziella Messina, Giulio Cossu and Mitsuo Oshimura
Mol Ther 17: 309-317; advance online publication, November 25, 2008; doi:10.1038/mt.2008.253
Plasmid Releasing Multiple Channel Bridges for Transgene Expression After Spinal Cord Injury
Laura De Laporte, Yang Yang, Marina L Zelivyanskaya, Brian J Cummings, Aileen J Anderson and Lonnie D Shea
Mol Ther 17: 318-326; advance online publication, December 2, 2008; doi:10.1038/mt.2008.252
Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates
Nicola Brunetti-Pierri, Gary E Stapleton, Mark Law, John Breinholt, Donna J Palmer, Yu Zuo, Nathan C Grove, Milton J Finegold, Karen Rice, Arthur L Beaudet, Charles E Mullins and Philip Ng
Mol Ther 17: 327-333; advance online publication, December 2, 2008; doi:10.1038/mt.2008.257
Delivery of Therapeutic Proteins as Secretable TAT Fusion Products
Marcella Flinterman, Farzin Farzaneh, Nagy Habib, Farooq Malik, Joop Gäken and Mahvash Tavassoli
Mol Ther 17: 334-342; advance online publication, December 2, 2008; doi:10.1038/mt.2008.256
Trans-splicing Into Highly Abundant Albumin Transcripts for Production of Therapeutic Proteins In Vivo
Jun Wang, S Gary Mansfield, Colette A Cote, Ping Du Jiang, Ke Weng, Marcelo JA Amar, Bryan H Brewer Jr, Alan T Remaley, Gerard J McGarrity, Mariano A Garcia-Blanco and M Puttaraju
Mol Ther 17: 343-351; advance online publication, December 9, 2008; doi:10.1038/mt.2008.260
VECTOR TOXICOLOGY, IMMUNOGENICITY AND SAFETY
Comparative Study of Anti-hepatitis B Virus RNA Interference by Double-stranded Adeno-associated Virus Serotypes 7, 8, and 9
Chun-Chi Chen, Cheng-Pu Sun, Hsin-I Ma, Cheng-Chieh Fang, Pin-Yi Wu, Xiao Xiao and Mi-Hua Tao
Mol Ther 17: 352-359; advance online publication, December 9, 2008; doi:10.1038/mt.2008.245
OLIGONUCLEOTIDE THERAPEUTICS
Mobilization-competent Lentiviral Vector–mediated Sustained Transcriptional Modulation of HIV-1 Expression
Anne-Marie W Turner, Justin De La Cruz and Kevin V Morris
Mol Ther 17: 360-368; advance online publication, December 9, 2008; doi:10.1038/mt.2008.268
CELL THERAPY
Mesenchymal Stromal Cells Engineered to Express Erythropoietin Induce Anti-erythropoietin Antibodies and Anemia in Allorecipients
Philippe M Campeau, Moutih Rafei, Moïra François, Elena Birman, Kathy-Ann Forner and Jacques Galipeau
Mol Ther 17: 369-372; advance online publication, December 16, 2008; doi:10.1038/mt.2008.270
See also: Commentaries by RameshwarVACCINE TECHNOLOGY
Genetic Vaccines for Anthrax Based on Recombinant Adeno-associated Virus Vectors
Te-Hui Liu, Jon Oscherwitz, Bruce Schnepp, Jana Jacobs, Fen Yu, Kemp B Cease and Philip R Johnson
Mol Ther 17: 373-379; advance online publication, November 11, 2008; doi:10.1038/mt.2008.242
Local IL-21 Promotes the Therapeutic Activity of Effector T cells by Decreasing Regulatory T Cells Within the Tumor Microenvironment
Seunghee Kim-Schulze, Hong Sung Kim, Qing Fan, Dae Won Kim and Howard L Kaufman
Mol Ther 17: 380-388; advance online publication, November 25, 2008; doi:10.1038/mt.2008.249
clinical trials
A Herpes Oncolytic Virus Can Be Delivered Via the Vasculature to Produce Biologic Changes in Human Colorectal Cancer
Yuman Fong, Teresa Kim, Amit Bhargava, Larry Schwartz, Karen Brown, Lynn Brody, Anne Covey, Matthias Karrasch, George Getrajdman, Axel Mescheder, William Jarnagin and Nancy Kemeny
Mol Ther 17: 389-394; advance online publication, November 18, 2008; doi:10.1038/mt.2008.240
Erratum
Erratum to "Efficient Modulation of T–cell Response by Dual–mode, Single–carrier Delivery of Cytokine–targeted siRNA and DNA Vaccine to Antigen–presenting Cells" FREE
Mol Ther 17: 395; doi:10.1038/mt.2008.247
