Commentaries

Tomorrow, Interrupted?: Risk, Ethics, and Medical Advance in Gene Transfer

Jonathan Kimmelman

Mol Ther 17: 1838-1839; doi:10.1038/mt.2009.240

Abstract | Full Text | PDF

Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals FREE

Arkadi Zintchenko, Andrei S Susha, Massimo Concia, Jochen Feldmann, Ernst Wagner, Andrey L Rogach and Manfred Ogris

Mol Ther 17: 1849-1856; advance online publication, August 25, 2009; doi:10.1038/mt.2009.201

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Tight Long-term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector

Fredric P Manfredsson, Corinna Burger, Aaron C Rising, Kheir Zuobi-Hasona, Layla F Sullivan, Alfred S Lewin, Julia Huang, Emily Piercefield, Nicholas Muzyczka and Ronald J Mandel

Mol Ther 17: 1857-1867; advance online publication, August 25, 2009; doi:10.1038/mt.2009.196

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Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis

Ikuhiko Nakase, Hisaaki Hirose, Gen Tanaka, Akiko Tadokoro, Sachiko Kobayashi, Toshihide Takeuchi and Shiroh Futaki

Mol Ther 17: 1868-1876; advance online publication, August 25, 2009; doi:10.1038/mt.2009.192

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Computational Design and Application of Endogenous Promoters for Transcriptionally Targeted Gene Therapy for Rheumatoid Arthritis

Jeroen Geurts, Leo AB Joosten, Nozomi Takahashi, Onno J Arntz, Anton Glück, Miranda B Bennink, Wim B van den Berg and Fons AJ van de Loo

Mol Ther 17: 1877-1887; advance online publication, August 18, 2009; doi:10.1038/mt.2009.182

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A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells

Richard H Smith, Justin R Levy and Robert M Kotin

Mol Ther 17: 1888-1896; advance online publication, June 16, 2009; doi:10.1038/mt.2009.128

Abstract | Full Text | PDF

Identification of Protein Cofactors Necessary for Sequence-specific Plasmid DNA Nuclear Import

Aaron M Miller, Felix M Munkonge, Eric WFW Alton and David A Dean

Mol Ther 17: 1897-1903; advance online publication, June 16, 2009; doi:10.1038/mt.2009.127

Abstract | Full Text | PDF | Supplementary information

Transgene Expression Levels Determine the Immunogenicity of Transduced Hematopoietic Grafts in Partially Myeloablated Mice FREE

Herena Eixarch, Alba Gómez, Elisabeth Kádár, Mónica George, Nuria Martínez, Carmen Espejo, Jordi Pétriz, Ramon Gimeno and Jordi Barquinero

Mol Ther 17: 1904-1909; advance online publication, August 25, 2009; doi:10.1038/mt.2009.198

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Self-inactivating Retroviral Vector-mediated Gene Transfer Induces Oncogene Activation and Immortalization of Primary Murine Bone Marrow Cells

Marita Bosticardo, Amrita Ghosh, Yang Du, Nancy A Jenkins, Neal G Copeland and Fabio Candotti

Mol Ther 17: 1910-1918; advance online publication, July 28, 2009; doi:10.1038/mt.2009.172

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Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

Ute Modlich, Susana Navarro, Daniela Zychlinski, Tobias Maetzig, Sabine Knoess, Martijn H. Brugman, Axel Schambach, Sabine Charrier, Anne Galy, Adrian J. Thrasher, Juan Bueren and Christopher Baum

Mol Ther 17: 1919-1928; advance online publication, August 11, 2009; doi:10.1038/mt.2009.179

Abstract | Full Text | PDF | Supplementary information

Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the -Globin Locus Control Region

Paritha I Arumugam, Tomoyasu Higashimoto, Fabrizia Urbinati, Ute Modlich, Shawna Nestheide, Ping Xia, Catherine Fox, Andrea Corsinotti, Christopher Baum and Punam Malik

Mol Ther 17: 1929-1937; advance online publication, August 25, 2009; doi:10.1038/mt.2009.183

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CD133 Identifies a Human Bone Marrow Stem/Progenitor Cell Sub-population With a Repertoire of Secreted Factors That Protect Against Stroke

Benjamin Bakondi, Issei S Shimada, Anthony Perry, James R Munoz, Joni Ylostalo, Alan B Howard, Carl A Gregory and Jeffrey L Spees

Mol Ther 17: 1938-1947; advance online publication, August 18, 2009; doi:10.1038/mt.2009.185

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Aldehyde Dehydrogenase Activity Identifies a Population of Human Skeletal Muscle Cells With High Myogenic Capacities

Karine Vauchez, Jean-Pierre Marolleau, Michel Schmid, Patricia Khattar, Alain Chapel, Cyril Catelain, Séverine Lecourt, Jérôme Larghéro, Marc Fiszman and Jean-Thomas Vilquin

Mol Ther 17: 1948-1958; advance online publication, September 8, 2009; doi:10.1038/mt.2009.204

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Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic Differentiation and Stimulation of Endogenous Cells

Fan Yang, Victor YL Leung, Keith DK Luk, Danny Chan and Kenneth MC Cheung

Mol Ther 17: 1959-1966; advance online publication, July 7, 2009; doi:10.1038/mt.2009.146

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Determination of the Fate and Contribution of Ex Vivo Expanded Human Bone Marrow Stem and Progenitor Cells for Bone Formation by 2.3ColGFP

Dezhong Yin, Zhuo Wang, Qinghong Gao, Renuka Sundaresan, Chris Parrish, Qingfen Yang, Paul H Krebsbach, Alexander C Lichtler, David W Rowe, Janet Hock and Peng Liu

Mol Ther 17: 1967-1978; advance online publication, July 14, 2009; doi:10.1038/mt.2009.151

Abstract | Full Text | PDF | Supplementary information