TABLE OF CONTENTS
Volume 17, Issue 1 (January 2009)
In This Issue |
Research Highlights |
Commentaries |
Meeting Report |
Review |
Original Articles
Editorial
ESCGT 2008: Progress in Clinical Gene Therapy FREE
David A Williams
Mol Ther 17: 1-2; doi:10.1038/mt.2008.277
In This Issue
In This Issue FREE
Mol Ther 17: 4; doi:10.1038/mt.2008.274
See also: Original Article by Puymirat et al. See also: Original Article by Puttini et al. See also: Original Article by Ohshima et al. See also: Original Article by Crombez et al. See also: Original Article by Dalsgaard et al.Research Highlights
Top of pageCommentaries
Can Type VII Collagen Injections Cure Dystrophic Epidermolysis Bullosa? FREE
Leena Bruckner-Tuderman
Mol Ther 17: 6-7; doi:10.1038/mt.2008.262
See also: Original Article by Remington et al.Phase Ib Trial of Oncolytic Herpes Virus G207 Shows Safety of Multiple Injections and Documents Viral Replication FREE
Manish K Aghi and E Antonio Chiocca
Mol Ther 17: 8-9; doi:10.1038/mt.2008.275
See also: Original Article by Markert et al.Meeting Report
TAGTC meets across the pond FREE
Robert M Frederickson
Mol Ther 17: 10-12; doi:10.1038/mt.2008.276
Review
ACQUIRED AND MULTIGENIC DISEASE
Herpes Vector–mediated Gene Transfer in the Treatment of Chronic Pain FREE
Joseph C Glorioso and David J Fink
Mol Ther 17: 13-18; advance online publication, October 7, 2008; doi:10.1038/mt.2008.213
Original Articles
MONOGENIC DISEASE
Gene-mediated Restoration of Normal Myofiber Elasticity in Dystrophic Muscles FREE
Stefania Puttini, Ma
gorzata Lekka, Olivier M Dorchies, Damien Saugy, Tania Incitti, Urs T Ruegg, Irene Bozzoni, Andrzej J Kulik and Nicolas Mermod
Mol Ther 17: 19-25; advance online publication, November 11, 2008; doi:10.1038/mt.2008.239
Injection of Recombinant Human Type VII Collagen Corrects the Disease Phenotype in a Murine Model of Dystrophic Epidermolysis Bullosa FREE
Jennifer Remington, Xinyi Wang, Yingpin Hou, Hui Zhou, Julie Burnett, Trevor Muirhead, Jouni Uitto, Douglas R Keene, David T Woodley and Mei Chen
Mol Ther 17: 26-33; advance online publication, November 18, 2008; doi:10.1038/mt.2008.234
See also: Commentaries by Bruckner-TudermanCorrection of ADAMTS13 Deficiency by In Utero Gene Transfer of Lentiviral Vector encoding ADAMTS13 Genes FREE
Masami Niiya, Masayuki Endo, Dezhi Shang, Philip W Zoltick, Nidal E Muvarak, Wenjing Cao, Sheng-Yu Jin, Christopher G Skipwith, David G Motto, Alan W Flake and X Long Zheng
Mol Ther 17: 34-41; advance online publication, October 28, 2008; doi:10.1038/mt.2008.223
ACQUIRED AND MULTIGENIC DISEASE
Nonviral Retrograde Gene Transfer of Human Hepatocyte Growth Factor Improves Neuropathic Pain-related Phenomena in Rats FREE
Toyokazu Tsuchihara, Sho Ogata, Koichi Nemoto, Takatoshi Okabayashi, Kuniaki Nakanishi, Naoki Kato, Ryuichi Morishita, Yasufumi Kaneda, Maki Uenoyama, Shinya Suzuki, Masatoshi Amako, Toshiaki Kawai and Hiroshi Arino
Mol Ther 17: 42-50; advance online publication, October 21, 2008; doi:10.1038/mt.2008.214
Hypoxia Enhances the Replication of Oncolytic Herpes Simplex Virus FREE
Manish K Aghi, Ta-Chiang Liu, Samuel Rabkin and Robert L Martuza
Mol Ther 17: 51-56; advance online publication, October 28, 2008; doi:10.1038/mt.2008.232
Enhanced Therapeutic Efficacy by Simultaneously Targeting Two Genetic Defects in Tumors FREE
He Zhang, Haibo Wang, Jianjun Zhang, Guanxiang Qian, Beibei Niu, Xianqun Fan, Jian Lu, Andrew R. Hoffman, Ji-Fan Hu and Shengfang Ge
Mol Ther 17: 57-64; advance online publication, November 18, 2008; doi:10.1038/mt.2008.236
Tissue-resident Macrophages Protect the Liver From Ischemia Reperfusion Injury via a Heme Oxygenase-1-Dependent Mechanism FREE
Luke Devey, David Ferenbach, Elodie Mohr, Kathryn Sangster, Christopher O Bellamy, Jeremy Hughes and Stephen J Wigmore
Mol Ther 17: 65-72; advance online publication, November 11, 2008; doi:10.1038/mt.2008.237
VECTOR ENGINEERING AND DELIVERY
Transduction Efficiency and Immune Response Associated With the Administration of AAV8 Vector Into Dog Skeletal Muscle FREE
Sachiko Ohshima, Jin-Hong Shin, Katsutoshi Yuasa, Akiyo Nishiyama, Junichi Kira, Takashi Okada and Shin'ichi Takeda
Mol Ther 17: 73-80; advance online publication, October 21, 2008; doi:10.1038/mt.2008.225
Recombinant AAV Serotype and Capsid Mutant Comparison for Pulmonary Gene Transfer of 
-1-Antitrypsin Using Invasive and Noninvasive Delivery FREE
Rejean Liqun Wang, Thomas McLaughlin, Travis Cossette, Qiushi Tang, Kevin Foust, Martha Campbell-Thompson, Ashley Martino, Pedro Cruz, Scott Loiler, Christian Mueller and Terence R Flotte
Mol Ther 17: 81-87; advance online publication, October 21, 2008; doi:10.1038/mt.2008.217
Intrathecal Injection of Naked Plasmid DNA Provides Long-term Expression of Secreted Proteins FREE
Travis S Hughes, Stephen J Langer, Kirk W Johnson, Raymond A Chavez, Linda R Watkins, Erin D Milligan and Leslie A Leinwand
Mol Ther 17: 88-94; advance online publication, October 21, 2008; doi:10.1038/mt.2008.230
A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells FREE
Laurence Crombez, Gudrun Aldrian-Herrada, Karidia Konate, Quan N Nguyen, Gary K McMaster, Robert Brasseur, Frederic Heitz and Gilles Divita
Mol Ther 17: 95-103; advance online publication, October 28, 2008; doi:10.1038/mt.2008.215
Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity FREE
Eva-Maria Händel, Stephen Alwin and Toni Cathomen
Mol Ther 17: 104-111; advance online publication, November 11, 2008; doi:10.1038/mt.2008.233
Mutational Derivatives of PhiC31 Integrase With Increased Efficiency and Specificity FREE
Annahita Keravala, Solomon Lee, Bhaskar Thyagarajan, Eric C Olivares, Vanessa E Gabrovsky, Lauren E Woodard and Michele P Calos
Mol Ther 17: 112-120; advance online publication, November 11, 2008; doi:10.1038/mt.2008.241
VECTOR TOXICOLOGY, IMMUNOGENICITY AND SAFETY
Shielding of Sleeping Beauty DNA Transposon-delivered Transgene Cassettes by Heterologous Insulators in Early Embryonal Cells FREE
Trine Dalsgaard, Brian Moldt, Nynne Sharma, Gernot Wolf, Alexander Schmitz, Finn S Pedersen and Jacob G Mikkelsen
Mol Ther 17: 121-130; advance online publication, November 4, 2008; doi:10.1038/mt.2008.224
Stem Cell Marking With Promotor-deprived Self-inactivating Retroviral Vectors Does Not Lead to Induced Clonal Imbalance FREE
Kerstin Cornils, Claudia Lange, Axel Schambach, Martijn H Brugman, Regine Nowak, Michael Lioznov, Christopher Baum and Boris Fehse
Mol Ther 17: 131-143; advance online publication, November 11, 2008; doi:10.1038/mt.2008.238
Undetectable Transcription of cap in a Clinical AAV Vector: Implications for Preformed Capsid in Immune Responses FREE
Bernd Hauck, Samuel L Murphy, Peter H Smith, Guang Qu, Xingge Liu, Olga Zelenaia, Federico Mingozzi, Jürg M Sommer, Katherine A High and J. Fraser Wright
Mol Ther 17: 144-152; advance online publication, October 21, 2008; doi:10.1038/mt.2008.227
OLIGONUCLEOTIDE THERAPEUTICS
RNA Aptamer Blockade of Osteopontin Inhibits Growth and Metastasis of MDA-MB231 Breast Cancer Cells FREE
Zhiyong Mi, Hongtao Guo, M Benjamin Russell, Yingmiao Liu, Bruce A Sullenger and Paul C Kuo
Mol Ther 17: 153-161; advance online publication, November 4, 2008; doi:10.1038/mt.2008.235
Chitosan/siRNA Nanoparticle–mediated TNF- Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model FREE
Kenneth A Howard, Søren R Paludan, Mark A Behlke, Flemming Besenbacher, Bent Deleuran and Jørgen Kjems
Mol Ther 17: 162-168; advance online publication, September 30, 2008; doi:10.1038/mt.2008.220
Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo FREE
Ryan L Boudreau, Inês Martins and Beverly L Davidson
Mol Ther 17: 169-175; advance online publication, November 11, 2008; doi:10.1038/mt.2008.231
CELL THERAPY
Can Mesenchymal Stem Cells Induce Tolerance to Cotransplanted Human Embryonic Stem Cells? FREE
Etienne Puymirat, Raghed Geha, André Tomescot, Valérie Bellamy, Jérôme Larghero, Ludovic Trinquart, Patrick Bruneval, Michel Desnos, Albert Hagège, Michel Pucéat and Philippe Menasché
Mol Ther 17: 176-182; advance online publication, October 7, 2008; doi:10.1038/mt.2008.208
Bone Marrow Multipotent Mesenchymal Stroma Cells Act as Pericyte-like Migratory Vehicles in Experimental Gliomas FREE
Daniel Bexell, Salina Gunnarsson, Ariane Tormin, Anna Darabi, David Gisselsson, Laurent Roybon, Stefan Scheding and Johan Bengzon
Mol Ther 17: 183-190; advance online publication, November 4, 2008; doi:10.1038/mt.2008.229
Transplantation of PC1/3-Expressing -cells Improves Glucose Handling and Cold Tolerance in Leptin-resistant Mice FREE
Rhonda D Wideman, Sarah L Gray, Scott D Covey, Gene C Webb and Timothy J Kieffer
Mol Ther 17: 191-198; advance online publication, October 21, 2008; doi:10.1038/mt.2008.219
clinical trials
Phase Ib Trial of Mutant Herpes Simplex Virus G207 Inoculated Pre-and Post-tumor Resection for Recurrent GBM FREE
James M Markert, Peter G Liechty, Wenquan Wang, Shanna Gaston, Eunice Braz, Matthias Karrasch, Louis B Nabors, Michael Markiewicz, Alfred D Lakeman, Cheryl A Palmer, Jacqueline N Parker, Richard J Whitley and George Y Gillespie
Mol Ther 17: 199-207; advance online publication, October 28, 2008; doi:10.1038/mt.2008.228
Abstract | Full Text | PDF | Supplementary information
See also: Commentaries by Aghi & Chiocca
