TABLE OF CONTENTS
Volume 16, Issue 9 (September 2008)
Editorial
Sleeping Beauty Vector System Moves Toward Human Trials in the United States FREE
David A Williams
Mol Ther 16: 1515-1516; doi:10.1038/mt.2008.169
In This Issue
In This Issue FREE
Mol Ther 16: 1518; doi:10.1038/mt.2008.179
See also: Original Article by Otsuki et al. See also: Original Article by Allen et al. See also: Original Article by Smith & SchuchmanSee also: Original Article by McCoy et al. See also: Original Article by Barker & DiamondResearch Highlights
Top of pageCommentaries
The Clone Ranger? FREE
Helen E Heslop and Malcolm K Brenner
Mol Ther 16: 1520-1521; doi:10.1038/mt.2008.154
Fighting Fire With Fire: Effects of Oncolytic Virotherapy on Underlying Viral Hepatitis in Hepatocellular Carcinoma FREE
Tony Reid
Mol Ther 16: 1521-1523; doi:10.1038/mt.2008.176
See also: Original Article by Liu et al.Peptide-Conjugated Antisense Therapy Takes a Skip Ahead FREE
Dominic J Wells
Mol Ther 16: 1523-1524; doi:10.1038/mt.2008.157
See also: Original Article by Jearawiriyapaisarn et al.Reviews
Vector Engineering and Delivery
Advances in High-capacity Extrachromosomal Vector Technology: Episomal Maintenance, Vector Delivery, and Transgene Expression FREE
Michele MP Lufino, Pauline AH Edser and Richard Wade-Martins
Mol Ther 16: 1525-1538; advance online publication, July 15, 2008; doi:10.1038/mt.2008.156
Original Articles
Monogenic Disease
Microutrophin Delivery Through rAAV6 Increases Lifespan and Improves Muscle Function in Dystrophic Dystrophin/Utrophin-deficient Mice FREE
Guy L Odom, Paul Gregorevic, James M Allen, Eric Finn and Jeffrey S Chamberlain
Mol Ther 16: 1539-1545; advance online publication, July 29, 2008; doi:10.1038/mt.2008.149
Acquired and Multigenic Disease
Histone Deacetylase Inhibitors Augment Antitumor Efficacy of Herpes-based Oncolytic Viruses FREE
Akihiro Otsuki, Ankita Patel, Kazue Kasai, Masataka Suzuki, Kazuhiko Kurozumi, E Antonio Chiocca and Yoshinaga Saeki
Mol Ther 16: 1546-1555; advance online publication, July 22, 2008; doi:10.1038/mt.2008.155
Interleukin-13 Displaying Retargeted Oncolytic Measles Virus Strains Have Significant Activity Against Gliomas With Improved Specificity FREE
Cory Allen, Georgia Paraskevakou, Ianko Iankov, Caterina Giannini, Mark Schroeder, Jann Sarkaria, Mark Schroeder, Raj K Puri, Stephen J Russell and Evanthia Galanis
Mol Ther 16: 1556-1564; advance online publication, July 29, 2008; doi:10.1038/mt.2008.152
Acid Sphingomyelinase Overexpression Enhances the Antineoplastic Effects of Irradiation In Vitro and In Vivo FREE
Eric L Smith and Edward H Schuchman
Mol Ther 16: 1565-1571; advance online publication, July 15, 2008; doi:10.1038/mt.2008.145
Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian rats FREE
Melissa K McCoy, Kelly A Ruhn, Terina N Martinez, Fiona E McAlpine, Armin Blesch and Malú G Tansey
Mol Ther 16: 1572-1579; advance online publication, July 15, 2008; doi:10.1038/mt.2008.146
Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces A
Deposits in APP + PS1 Transgenic Mice FREE
Niki C Carty, Kevin Nash, Daniel Lee, Mary Mercer, Paul E Gottschall, Craig Meyers, Nicholas Muzyczka, Marcia N Gordon and Dave Morgan
Mol Ther 16: 1580-1586; advance online publication, July 29, 2008; doi:10.1038/mt.2008.148
Viral Vector–mediated Delivery of Estrogen Receptor-
to the Hippocampus Improves Spatial Learning in Estrogen Receptor- Knockout Mice FREE
Thomas C Foster, Asha Rani, Ashok Kumar, Li Cui and Susan L Semple-Rowland
Mol Ther 16: 1587-1593; advance online publication, July 1, 2008; doi:10.1038/mt.2008.140
Vector Engineering and Delivery
Double Oxygen–sensing Vector System for Robust Hypoxia/Ischemia-regulated Gene Induction in Cardiac Muscle In Vitro and In Vivo FREE
Ekaterina V Fomicheva, Immanuel I Turner, Terri G Edwards, Janet Hoff, Eric Arden, Louis G D'Alecy and Joseph M Metzger
Mol Ther 16: 1594-1601; advance online publication, June 24, 2008; doi:10.1038/mt.2008.136
RNA Interference Screen to Identify Pathways That Enhance or Reduce Nonviral Gene Transfer During Lipofection FREE
Gregory A Barker and Scott L Diamond
Mol Ther 16: 1602-1608; advance online publication, July 15, 2008; doi:10.1038/mt.2008.147
Vector Toxicology, Immunogenicity and Safety
The Immunogenicity of Adenovirus Vectors Limits the Multispecificity of CD8 T-cell Responses to Vector-encoded Transgenic Antigens FREE
Reinhold Schirmbeck, Jörg Reimann, Stefan Kochanek and Florian Kreppel
Mol Ther 16: 1609-1616; advance online publication, July 8, 2008; doi:10.1038/mt.2008.141
Reduced Genotoxicity of Avian Sarcoma Leukosis Virus Vectors in Rhesus Long-term Repopulating Cells Compared to Standard Murine Retrovirus Vectors FREE
Jingqiong Hu, Gabriel Renaud, Theotonius Golmes, Andrea Ferris, Paul C Hendrie, Robert E Donahue, Stephen H Hughes, Tyra G Wolfsberg, David W Russell and Cynthia E Dunbar
Mol Ther 16: 1617-1623; advance online publication, June 24, 2008; doi:10.1038/mt.2008.135
Oligonucleotide Therapy
Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice FREE
Natee Jearawiriyapaisarn, Hong M Moulton, Brian Buckley, Jennifer Roberts, Peter Sazani, Suthat Fucharoen, Patrick L Iversen and Ryszard Kole
Mol Ther 16: 1624-1629; advance online publication, June 10, 2008; doi:10.1038/mt.2008.120
Abstract | Full Text | PDF | Supplementary information
See also: Commentaries by ReidExpression of shRNA From a Tissue-specific pol II Promoter Is an Effective and Safe RNAi Therapeutic FREE
Jeffery C Giering, Dirk Grimm, Theresa A Storm and Mark A Kay
Mol Ther 16: 1630-1636; advance online publication, July 29, 2008; doi:10.1038/mt.2008.144
Clinical Trials
The Targeted Oncolytic Poxvirus JX-594 Demonstrates Antitumoral, Antivascular, and Anti-HBV Activities in Patients With Hepatocellular Carcinoma FREE
Ta-Chiang Liu, Taeho Hwang, Byeong-Ho Park, John Bell and David H Kirn
Mol Ther 16: 1637-1642; advance online publication, July 15, 2008; doi:10.1038/mt.2008.143
See also: Commentaries by Wells
