TABLE OF CONTENTS
Volume 16, Issue 8 (August 2008)
In This Issue |
Research Highlights |
Letter to the Editor |
Commentary |
Original Articles
Editorial
On Target: New Envelopes for Lentiviral Vectors FREE
Christopher Baum
Mol Ther 16: 1349-1350; doi:10.1038/mt.2008.151
See also: Original Article by Funke et al.In This Issue
In This issue FREE
Mol Ther 16: 1352; doi:10.1038/mt.2008.150
See also: Original Article by Edge et al. See also: Original Article by Muro et al. See also: Original Article by Benjelloun et al. See also: Commentary by Yan & EllingtonSee also: Editorial by BaumResearch Highlights
Top of pageLetter to the Editor
Does Retroviral Insertional Mutagenesis Play a Role in the Generation of Induced Pluripotent Stem Cells? FREE
Robert G Hawley
Mol Ther 16: 1354-1355; doi:10.1038/mt.2008.142
Commentary
A Hitchhiker's Guide to HIV FREE
Amy Yan and Andrew Ellington
Mol Ther 16: 1356-1358; doi:10.1038/mt.2008.131
See also: Original Article by Zhou et al.Original Articles
Monogenic Disease
Phenotypic Correction of Hemophilia A by Ectopic Expression of Activated Factor VII in Platelets FREE
Tsukasa Ohmori, Akira Ishiwata, Yuji Kashiwakura, Seiji Madoiwa, Katsuyuki Mitomo, Hidenori Suzuki, Mamoru Hasegawa, Jun Mimuro and Yoichi Sakata
Mol Ther 16: 1359-1365; advance online publication, June 3, 2008; doi:10.1038/mt.2008.117
Correction of Multiple Striated Muscles in Murine Pompe Disease Through Adeno-associated Virus–mediated Gene Therapy FREE
Baodong Sun, Sarah P Young, Ping Li, Chunhui Di, Talmage Brown, Maja Z Salva, Songtao Li, Andrew Bird, Zhen Yan, Richard Auten, Stephen D Hauschka and Dwight D Koeberl
Mol Ther 16: 1366-1371; advance online publication, June 17, 2008; doi:10.1038/mt.2008.133
Gene Transfer May Be Preventive But Not Curative for a Lysosomal Transport Disorder FREE
Claire Hippert, Grégor Dubois, Carole Morin, Olivier Disson, Sandy Ibanes, Chantal Jacquet, Reto Schwendener, Corinne Antignac, Eric J Kremer and Vasiliki Kalatzis
Mol Ther 16: 1372-1381; advance online publication, June 24, 2008; doi:10.1038/mt.2008.126
Acquired and Multigenic Disease
Oncolytic HSV-1 Infection of Tumors Induces Angiogenesis and Upregulates CYR61 FREE
Kazuhiko Kurozumi, Jayson Hardcastle, Roopa Thakur, Joshua Shroll, Michal Nowicki, Akihiro Otsuki, E Antonio Chiocca and Balveen Kaur
Mol Ther 16: 1382-1391; advance online publication, June 10, 2008; doi:10.1038/mt.2008.112
Human Interleukin-10 Gene Transfer Is Protective in a Rat Model of Parkinson's Disease FREE
Louisa C Johnston, Xiaomin Su, Kathleen Maguire-Zeiss, Karen Horovitz, Irina Ankoudinova, Dmitry Guschin, Piotr Hadaczek, Howard J Federoff, Krystof Bankiewicz and John Forsayeth
Mol Ther 16: 1392-1399; advance online publication, June 10, 2008; doi:10.1038/mt.2008.113
Systemic Insulin-like Growth Factor-1 Reverses Hypoalgesia and Improves Mobility in a Mouse Model of Diabetic Peripheral Neuropathy FREE
Qiuming Chu, Rod Moreland, Nelson S Yew, Joseph Foley, Robin Ziegler and Ronald K Scheule
Mol Ther 16: 1400-1408; advance online publication, June 10, 2008; doi:10.1038/mt.2008.115
AAV8-mediated Gene Transfer of Interleukin-4 to Endogenous 
-Cells Prevents the Onset of Diabetes in NOD Mice FREE
Khaja K Rehman, Massimo Trucco, Zhong Wang, Xiao Xiao and Paul D Robbins
Mol Ther 16: 1409-1416; advance online publication, June 17, 2008; doi:10.1038/mt.2008.116
Intranasal HGF Administration Ameliorates the Physiologic and Morphologic Changes in Lung Emphysema FREE
Ahmed E Hegab, Hiroshi Kubo, Mutsuo Yamaya, Masanori Asada, Mei He, Naoya Fujino, Shinya Mizuno and Toshikazu Nakamura
Mol Ther 16: 1417-1426; advance online publication, June 17, 2008; doi:10.1038/mt.2008.137
Vector Engineering and Delivery
Targeted Cell Entry of Lentiviral Vectors FREE
Sabrina Funke, Andrea Maisner, Michael D Mühlebach, Ulrike Koehl, Manuel Grez, Roberto Cattaneo, Klaus Cichutek and Christian J Buchholz
Mol Ther 16: 1427-1436; advance online publication, June 24, 2008; doi:10.1038/mt.2008.128
A let-7 MicroRNA-sensitive Vesicular Stomatitis Virus Demonstrates Tumor-specific Replication FREE
Robert E Edge, Theresa J Falls, Christopher W Brown, Brian D Lichty, Harold Atkins and John C Bell
Mol Ther 16: 1437-1443; advance online publication, June 17, 2008; doi:10.1038/mt.2008.130
Repeat Administration of Proteins to the Eye With a Single Intraocular Injection of an Adenovirus Vector FREE
Duncan McVey, Melissa M Hamilton, Chi Hsu, C Richter King, Douglas E Brough and Lisa L Wei
Mol Ther 16: 1444-1449; advance online publication, June 10, 2008; doi:10.1038/mt.2008.124
Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers FREE
Silvia Muro, Carmen Garnacho, Julie A Champion, John Leferovich, Christine Gajewski, Edward H Schuchman, Samir Mitragotri and Vladimir R Muzykantov
Mol Ther 16: 1450-1458; advance online publication, June 17, 2008; doi:10.1038/mt.2008.127
Targeting of the CNS in MPS-IH Using a Nonviral Transferrin-
-L-iduronidase Fusion Gene Product FREE
Mark J Osborn, Ron T McElmurry, Brandon Peacock, Jakub Tolar and Bruce R Blazar
Mol Ther 16: 1459-1466; advance online publication, June 3, 2008; doi:10.1038/mt.2008.119
Site-specific Modification of AAV Vector Particles With Biophysical Probes and Targeting Ligands Using Biotin Ligase FREE
Matthew D Stachler, Irwin Chen, Alice Y Ting and Jeffrey S Bartlett
Mol Ther 16: 1467-1473; advance online publication, June 17, 2008; doi:10.1038/mt.2008.129
Vector Toxicology, Immunogenicity and Safety
Substitution of Hexon Hypervariable Region 5 of Adenovirus Serotype 5 Abrogates Blood Factor Binding and Limits Gene Transfer to Liver FREE
Frédéric Vigant, Delphyne Descamps, Betsy Jullienne, Stéphanie Esselin, Elisabeth Connault, Paule Opolon, Thierry Tordjmann, Emmanuelle Vigne, Michel Perricaudet and Karim Benihoud
Mol Ther 16: 1474-1480; advance online publication, June 17, 2008; doi:10.1038/mt.2008.132
Oligonucleotide Therapy
Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy FREE
Jiehua Zhou, Haitang Li, Shirley Li, John Zaia and John J Rossi
Mol Ther 16: 1481-1489; advance online publication, May 6, 2008; doi:10.1038/mt.2008.92
Abstract | Full Text | PDF | Supplementary information
See also: Commentary by Yan & EllingtonCell Therapy
Stable and Functional Lymphoid Reconstitution in Artemis-deficient Mice Following Lentiviral Artemis Gene Transfer Into Hematopoietic Stem Cells FREE
Fatine Benjelloun, Alexandrine Garrigue, Corinne Demerens-de Chappedelaine, Pauline Soulas-Sprauel, Michele Malassis-Séris, Daniel Stockholm, Julia Hauer, Johanna Blondeau, Julie Rivière, Annick Lim, Marc Le Lorc'h, Serge Romana, Nicole Brousse, Frederique Pâques, Anne Galy, Pierre Charneau, Alain Fischer, Jean-Pierre de Villartay and Marina Cavazzana-Calvo
Mol Ther 16: 1490-1499; advance online publication, June 17, 2008; doi:10.1038/mt.2008.118
Vaccine Technology
Enhancement of Cytotoxic T-lymphocyte Response in Aged Mice by a Novel Treatment with Recombinant AdIL-12 and Wild-type Adenovirus in Rapid Succession FREE
Jian Chen, John Wang, Jun Li, Qi Wu, Fei Chu Lim, PingAr Yang, Hui-Chen Hsu, David T Curiel and John D Mountz
Mol Ther 16: 1500-1506; advance online publication, June 10, 2008; doi:10.1038/mt.2008.121
Efficient MHC Class I Presentation by Controlled Intracellular Trafficking of Antigens in Octaarginine-modified Liposomes FREE
Takashi Nakamura, Rumiko Moriguchi, Kentaro Kogure, Nilabh Shastri and Hideyoshi Harashima
Mol Ther 16: 1507-1514; advance online publication, June 17, 2008; doi:10.1038/mt.2008.122
