TABLE OF CONTENTS
Volume 16, Issue 7 (July 2008)
In This Issue |
Research Highlights |
Letter to the Editor |
Reviews |
Original Articles |
Corrigenda
Editorial
Progress Reported in Two Studies of Clinical Gene Transfer Into the Retina FREE
David A Williams
Mol Ther 16: 1181; doi:10.1038/mt.2008.123
In This Issue
In This Issue FREE
Mol Ther 16: 1183; doi:10.1038/mt.2008.139
See also: Original Article by Li et al. See also: Original Article by Shen et al. See also: Original Article by Parker et al. See also: Original Article by Ritprajak et al. See also: Original Article by Doré-Savard et al.Research Highlights
Top of pageLetter to the Editor
International Efforts for Recombinant Adeno-associated Viral Vector Reference Standards FREE
Philippe Moullier and Richard O Snyder
Mol Ther 16: 1185-1188; doi:10.1038/mt.2008.125
Reviews
Vector Engineering and Delivery
Recombinant Adeno-associated Virus Transduction and Integration FREE
Brian R Schultz and Jeffrey S Chamberlain
Mol Ther 16: 1189-1199; advance online publication, May 20, 2008; doi:10.1038/mt.2008.103
Zinc-finger Nucleases: The Next Generation Emerges FREE
Toni Cathomen and J Keith Joung
Mol Ther 16: 1200-1207; advance online publication, June 10, 2008; doi:10.1038/mt.2008.114
Original Articles
Acquired and Multigenic Disease
MicroRNAs Regulate Ocular Neovascularization FREE
JiKui Shen, Xiaoru Yang, Bing Xie, Yangjian Chen, Mara Swaim, Sean F Hackett and Peter A Campochiaro
Mol Ther 16: 1208-1216; advance online publication, May 20, 2008; doi:10.1038/mt.2008.104
Treg Depletion–enhanced IL-2 Treatment Facilitates Therapy of Established Tumors Using Systemically Delivered Oncolytic Virus FREE
Timothy Kottke, Feorillo Galivo, Phonphimon Wongthida, Rosa Maria Diaz, Jill Thompson, Dragan Jevremovic, Glen N Barber, Geoff Hall, John Chester, Peter Selby, Kevin Harrington, Alan Melcher and Richard G Vile
Mol Ther 16: 1217-1226; advance online publication, April 22, 2008; doi:10.1038/mt.2008.83
Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene FREE
Shourong Wu, Nobuhiro Nishiyama, Mitsunobu R Kano, Yasuyuki Morishita, Kohei Miyazono, Keiji Itaka, Ung-il Chung and Kazunori Kataoka
Mol Ther 16: 1227-1234; advance online publication, May 20, 2008; doi:10.1038/mt.2008.90
Hepatic Insulin Gene Therapy Normalizes Diurnal Fluctuation of Oxidative Metabolism in Diabetic BB/Wor Rats FREE
Darin E Olson, Adam G Campbell, Marty H Porter, Kimberly G Freeman, Emily Kelso, William P Flatt and Peter M Thulé
Mol Ther 16: 1235-1242; advance online publication, May 20, 2008; doi:10.1038/mt.2008.97
Bone-protective Effects of Nonviral Gene Therapy With Folate–Chitosan DNA Nanoparticle Containing Interleukin-1 Receptor Antagonist Gene in Rats With Adjuvant-induced Arthritis FREE
Julio C Fernandes, Huijie Wang, Christian Jreyssaty, Mohamed Benderdour, Patrick Lavigne, Xingpin Qiu, Francoise M Winnik, Xiaoling Zhang, Kerong Dai and Qin Shi
Mol Ther 16: 1243-1251; advance online publication, May 20, 2008; doi:10.1038/mt.2008.99
Vector Engineering and Delivery
Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles FREE
Wuping Li, Aravind Asokan, Zhijian Wu, Terry Van Dyke, Nina DiPrimio, Jarrod S Johnson, Lakshmanan Govindaswamy, Mavis Agbandje-McKenna, Stefan Leichtle, D Eugene Redmond Jr, Thomas J McCown, Kimberly B Petermann, Norman E Sharpless and Richard J Samulski
Mol Ther 16: 1252-1260; advance online publication, May 20, 2008; doi:10.1038/mt.2008.100
Mannose 6-Phosphate Receptor–mediated Transport of Sulfamidase Across the Blood–brain Barrier in the Newborn Mouse FREE
Akihiko Urayama, Jeffrey H Grubb, William S Sly and William A Banks
Mol Ther 16: 1261-1266; advance online publication, April 29, 2008; doi:10.1038/mt.2008.84
Biodistribution of Adeno-associated Virus Type-2 in Nonhuman Primates after Convection-enhanced Delivery to Brain FREE
Janet Cunningham, Philip Pivirotto, John Bringas, Brian Suzuki, Sharmila Vijay, Laura Sanftner, Marina Kitamura, Curtis Chan and Krystof S Bankiewicz
Mol Ther 16: 1267-1275; advance online publication, June 3, 2008; doi:10.1038/mt.2008.111
Modification of Adenoviral Vectors With Polyethylene Glycol Modulates In Vivo Tissue Tropism and Gene Expression FREE
Sean E Hofherr, Elena V Shashkova, Eric A Weaver, Reeti Khare and Michael A Barry
Mol Ther 16: 1276-1282; advance online publication, May 6, 2008; doi:10.1038/mt.2008.86
Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes FREE
Lee A Davies, Gerry McLachlan, Stephanie G Sumner-Jones, David Ferguson, Alison Baker, Peter Tennant, Catherine Gordon, Christina Vrettou, Eilidh Baker, Jie Zhu, Eric WFW Alton, David DS Collie, David J Porteous, Stephen C Hyde and Deborah R Gill
Mol Ther 16: 1283-1290; advance online publication, May 20, 2008; doi:10.1038/mt.2008.96
Vector Toxicology, Immunogenicity and Safety
Safety and Efficacy of Regional Intravenous (RI) Versus Intramuscular (IM) Delivery of rAAV1 and rAAV8 to Nonhuman Primate Skeletal Muscle FREE
Alice Toromanoff, Yan Chérel, Mickaël Guilbaud, Magalie Penaud-Budloo, Richard O Snyder, Mark E Haskins, Jack-Yves Deschamps, Lydie Guigand, Guillaume Podevin, Valder R Arruda, Katherine A High, Hansell H Stedman, Fabienne Rolling, Ignacio Anegon, Philippe Moullier and Caroline Le Guiner
Mol Ther 16: 1291-1299; advance online publication, May 6, 2008; doi:10.1038/mt.2008.87
A Critical Role for Type I IFN–dependent NK Cell Activation in Innate Immune Elimination of Adenoviral Vectors In Vivo FREE
Jiangao Zhu, Xiaopei Huang and Yiping Yang
Mol Ther 16: 1300-1307; advance online publication, April 29, 2008; doi:10.1038/mt.2008.88
In Vivo Biosafety Model to Assess the Risk of Adverse Events From Retroviral and Lentiviral Vectors FREE
Gerhard Bauer, Mo A Dao, Scott S Case, Todd Meyerrose, Louisa Wirthlin, Ping Zhou, Xiuli Wang, Phillip Herrbrich, Jesusa Arevalo, Susie Csik, Dianne C Skelton, Jon Walker, Karen Pepper, Donald B Kohn and Jan A Nolta
Mol Ther 16: 1308-1315; advance online publication, May 6, 2008; doi:10.1038/mt.2008.93
Oligonucleotide Therapy
An Endogenous TNF-
Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models FREE
Maria A Graziewicz, Teresa K Tarrant, Brian Buckley, Jennifer Roberts, LeShara Fulton, Henrik Hansen, Henrik Ørum, Ryszard Kole and Peter Sazani
Mol Ther 16: 1316-1322; advance online publication, May 6, 2008; doi:10.1038/mt.2008.85
Topical Application of Cream-emulsified CD86 siRNA Ameliorates Allergic Skin Disease by Targeting Cutaneous Dendritic Cells FREE
Patcharee Ritprajak, Masaaki Hashiguchi and Miyuki Azuma
Mol Ther 16: 1323-1330; advance online publication, May 6, 2008; doi:10.1038/mt.2008.91
Central Delivery of Dicer-substrate siRNA: A Direct Application for Pain Research FREE
Louis Doré-Savard, Geneviève Roussy, Marc-André Dansereau, Michael A Collingwood, Kim A Lennox, Scott D Rose, Nicolas Beaudet, Mark A Behlke and Philippe Sarret
Mol Ther 16: 1331-1339; advance online publication, June 3, 2008; doi:10.1038/mt.2008.98
Cell Therapy
Hematopoietic Cell Transplantation Provides an Immune-tolerant Platform for Myoblast Transplantation in Dystrophic Dogs FREE
Maura H Parker, Christian Kuhr, Stephen J Tapscott and Rainer Storb
Mol Ther 16: 1340-1346; advance online publication, May 27, 2008; doi:10.1038/mt.2008.102
Corrigenda
Corrigendum to "Remission of Diabetes by 
-Cell Regeneration in Diabetic Mice Treated With a Recombinant Adenovirus Expressing Betacellulin" FREE
Mol Ther 16: 1347; doi:10.1038/mt.2008.105
