TABLE OF CONTENTS
Volume 16, Issue 6 (June 2008)
Editorial
The Growing Clinical Impact of Gene Therapy FREE
Arthur Nienhuis
Mol Ther 16: 995-996; doi:10.1038/mt.2008.94
In This Issue
In This Issue FREE
Mol Ther 16: 998; doi:10.1038/mt.2008.106
See also: Original Article by Niwano et al. See also: Commentaries by Periasamy & KalyanasundaramSee also: Original Article by Dodge et al. See also: Original Article by Scherschel et al. See also: Original Article by Tian et al. See also: Original Article by Zincarelli et al.Research Highlights
Top of pageCommentaries
Challenging the Cardiac Differentiation of Bone Marrow Cells: A Clinical Perspective FREE
Philippe Menasché
Mol Ther 16: 1000-1001; doi:10.1038/mt.2008.75
SERCA2a Gene Therapy for Heart Failure: Ready for Primetime? FREE
Muthu Periasamy and Anuradha Kalyanasundaram
Mol Ther 16: 1002-1004; doi:10.1038/mt.2008.89
With a Little Help From My f(X)riends!: The Basis of Ad5-Mediated Transduction of the Liver Revealed FREE
Pedro R Lowenstein
Mol Ther 16: 1004-1006; doi:10.1038/mt.2008.80
Translation of Targeted Oncolytic Virotherapeutics from the Lab into the Clinic, and Back Again: A High-Value Iterative Loop FREE
Ta-Chiang Liu, Tae-Ho Hwang, John C Bell and David H Kirn
Mol Ther 16: 1006-1008; doi:10.1038/mt.2008.70
Lentivector Targeting to Dendritic Cells FREE
Alexander Ageichik, Mary K Collins and Marie Dewannieux
Mol Ther 16: 1008-1009; doi:10.1038/mt.2008.95
Original Articles
Monogenic Disease
Effect of Late-stage Therapy on Disease Progression in AAV-mediated Rescue of Photoreceptor Cells in the Retinoschisin-deficient Mouse FREE
Andreas Janssen, Seok H Min, Laurie L Molday, Naoyuki Tanimoto, Mathias W Seeliger, William W Hauswirth, Robert S Molday and Bernhard HF Weber
Mol Ther 16: 1010-1017; advance online publication, March 25, 2008; doi:10.1038/mt.2008.57
Systemic AAV6 Delivery Mediating RNA Interference Against SOD1: Neuromuscular Transduction Does Not Alter Disease Progression in fALS Mice FREE
Chris Towne, Cédric Raoul, Bernard L Schneider and Patrick Aebischer
Mol Ther 16: 1018-1025; advance online publication, April 15, 2008; doi:10.1038/mt.2008.73
Acquired and Multigenic Disease
Lentiviral Vector–mediated SERCA2 Gene Transfer Protects Against Heart Failure and Left Ventricular Remodeling After Myocardial Infarction in Rats FREE
Kazuo Niwano, Masashi Arai, Norimichi Koitabashi, Atai Watanabe, Yasuhiro Ikeda, Hiroyuki Miyoshi and Masahiko Kurabayashi
Mol Ther 16: 1026-1032; advance online publication, March 25, 2008; doi:10.1038/mt.2008.61
Novel Cancer Antiangiotherapy Using the VEGF Promoter-targeted Artificial Zinc-finger Protein and Oncolytic Adenovirus FREE
Yoon-A Kang, Hyun-Chul Shin, Ji Young Yoo, Joo-Hang Kim, Jin-Soo Kim and Chae-Ok Yun
Mol Ther 16: 1033-1040; advance online publication, April 8, 2008; doi:10.1038/mt.2008.63
Trichostatin A and Oncolytic HSV Combination Therapy Shows Enhanced Antitumoral and Antiangiogenic Effects FREE
Ta-Chiang Liu, Pedro Castelo-Branco, Samuel D Rabkin and Robert L Martuza
Mol Ther 16: 1041-1047; advance online publication, April 1, 2008; doi:10.1038/mt.2008.58
Vector Engineering and Delivery
HSP70 and Constitutively Active HSF1 Mediate Protection Against CDCrel-1-mediated Toxicity FREE
Alisha E Jung, Helen L Fitzsimons, Ross J Bland, Matthew J During and Deborah Young
Mol Ther 16: 1048-1055; advance online publication, April 8, 2008; doi:10.1038/mt.2008.68
Acquired and Multigenic Disease
Delivery of AAV-IGF-1 to the CNS Extends Survival in ALS Mice Through Modification of Aberrant Glial Cell Activity FREE
James C Dodge, Amanda M Haidet, Wendy Yang, Marco A Passini, Mark Hester, Jennifer Clarke, Eric M Roskelley, Christopher M Treleaven, Liza Rizo, Heather Martin, Soo H Kim, Rita Kaspar, Tatyana V Taksir, Denise A Griffiths, Seng H Cheng, Lamya S Shihabuddin and Brian K Kaspar
Mol Ther 16: 1056-1064; advance online publication, April 1, 2008; doi:10.1038/mt.2008.60
Therapeutic Effect of Recombinant Adenovirus Encoding Interferon-
in a Murine Model of Progressive Pulmonary Tuberculosis FREE
Dulce A Mata-Espinosa, Valentin Mendoza-Rodríguez, Diana Aguilar-León, Ricardo Rosales, Fernando López-Casillas and Rogelio Hernández-Pando
Mol Ther 16: 1065-1072; advance online publication, April 22, 2008; doi:10.1038/mt.2008.69
Vector Engineering and Delivery
Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection FREE
Carmela Zincarelli, Stephen Soltys, Giuseppe Rengo and Joseph E Rabinowitz
Mol Ther 16: 1073-1080; advance online publication, April 15, 2008; doi:10.1038/mt.2008.76
Gene Delivery to the Juvenile Mouse Liver Using AAV2/8 Vectors FREE
Sharon C Cunningham, Allison P Dane, Afroditi Spinoulas and Ian E Alexander
Mol Ther 16: 1081-1088; advance online publication, April 15, 2008; doi:10.1038/mt.2008.72
Extended Transgene Expression From a Nonintegrating Adenoviral Vector Containing Retroviral Elements FREE
Changyu Zheng, Joseph M Vitolo, Weitian Zhang, Fumi Mineshiba, John A Chiorini and Bruce J Baum
Mol Ther 16: 1089-1097; advance online publication, March 25, 2008; doi:10.1038/mt.2008.56
Computer-assisted Hydrodynamic Gene Delivery FREE
Takeshi Suda, Kieko Suda and Dexi Liu
Mol Ther 16: 1098-1104; advance online publication, April 8, 2008; doi:10.1038/mt.2008.66
Oligonucleotide Therapy
Expressed Anti-HBV Primary MicroRNA Shuttles Inhibit Viral Replication Efficiently In Vitro and In Vivo FREE
Abdullah Ely, Tanusha Naidoo, Steven Mufamadi, Carol Crowther and Patrick Arbuthnot
Mol Ther 16: 1105-1112; advance online publication, April 22, 2008; doi:10.1038/mt.2008.82
Use of A U16 snoRNA-containing Ribozyme Library to Identify Ribozyme Targets in HIV-1 FREE
Hoshang J Unwalla, Haitang Li, Shi-Yang Li, Danny Abad and John J Rossi
Mol Ther 16: 1113-1119; advance online publication, April 1, 2008; doi:10.1038/mt.2008.54
Inhibition of Respiratory Syncytial Virus Infections With Morpholino Oligomers in Cell Cultures and in Mice FREE
Shen-Hao Lai, David A Stein, Antonieta Guerrero-Plata, Sui-Ling Liao, Teodora Ivanciuc, Chao Hong, Patrick L Iversen, Antonella Casola and Roberto P Garofalo
Mol Ther 16: 1120-1128; advance online publication, April 29, 2008; doi:10.1038/mt.2008.81
Cell Therapy
Adult Bone Marrow–derived Cells Do Not Acquire Functional Attributes of Cardiomyocytes When Transplanted into Peri-infarct Myocardium FREE
John A Scherschel, Mark H Soonpaa, Edward F Srour, Loren J Field and Michael Rubart
Mol Ther 16: 1129-1137; advance online publication, April 22, 2008; doi:10.1038/mt.2008.64
Treatment of Obesity and Diabetes in Mice by Transplant of Gut Cells Engineered to Produce Leptin FREE
Sarah N Oosman, Ada W Lam, George Harb, Suraj Unniappan, Ni T Lam, Travis Webber, Daniel Bruch, Qiu-Xia Zhang, Gregory S Korbutt and Timothy J Kieffer
Mol Ther 16: 1138-1145; advance online publication, April 15, 2008; doi:10.1038/mt.2008.62
Regulated Insulin Delivery From Human Epidermal Cells Reverses Hyperglycemia FREE
Jun Tian, Pedro Lei, Suzanne G Laychock and Stelios T Andreadis
Mol Ther 16: 1146-1153; advance online publication, April 22, 2008; doi:10.1038/mt.2008.79
Rapid Lentiviral Transduction Preserves the Engraftment Potential of Fanca –/– Hematopoietic Stem Cells FREE
Lars UW Müller, Michael D Milsom, Mi-Ok Kim, Axel Schambach, Todd Schuesler and David A Williams
Mol Ther 16: 1154-1160; advance online publication, April 8, 2008; doi:10.1038/mt.2008.67
Vaccine Technology
Heterologous Boosting of Recombinant Adenoviral Prime Immunization With a Novel Vesicular Stomatitis Virus–vectored Tuberculosis Vaccine FREE
Elizabeth K Roediger, Kapilan Kugathasan, XiZhong Zhang, Brian D Lichty and Zhou Xing
Mol Ther 16: 1161-1169; advance online publication, March 25, 2008; doi:10.1038/mt.2008.59
Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA FREE
Aude Bonehill, Sandra Tuyaerts, An MT Van Nuffel, Carlo Heirman, Tomas J Bos, Karel Fostier, Bart Neyns and Kris Thielemans
Mol Ther 16: 1170-1180; advance online publication, April 22, 2008; doi:10.1038/mt.2008.77
