TABLE OF CONTENTS
Volume 16, Issue 5 (May 2008)
Editorial
A "Vector Drain" in US Gene Therapy Development? FREE
Michel Sadelain and David A Williams
Mol Ther 16: 801-802; doi:10.1038/mt.2008.71
In This Issue
Top of pageResearch Highlights
Top of pageCommentaries
In Utero Efficacy of Cystic Fibrosis Gene Therapy: Difficult Studies, Positive or Negative FREE
Terence R Flotte
Mol Ther 16: 806-807; doi:10.1038/mt.2008.53
See also: Original Article by Davies et al. See also: Original Article by Buckley et al.Bovine Adenovirus Vectored Vaccine for Avian Influenza FREE
Dan H Barouch
Mol Ther 16: 807-808; doi:10.1038/mt.2008.47
See also: Original Article by Singh et al.Therapeutic Angiogenesis Gains a Leg to Stand On FREE
Andreas Rück and Christer Sylvén
Mol Ther 16: 808-810; doi:10.1038/mt.2008.65
See also: Original Article by Nikol et al.Realizing the Promise of RNAi FREE
John J Rossi
Mol Ther 16: 810-811; doi:10.1038/mt.2008.55
Original Articles
Monogenic Disease
Adenovirus-mediated In Utero Expression of CFTR Does Not Improve Survival of CFTR Knockout Mice FREE
Lee A Davies, Anusha Varathalingam, Hazel Painter, Anna E Lawton, Stephanie G Sumner-Jones, Graciela A Nunez-Alonso, Mario Chan, Felix Munkonge, Eric WFW Alton, Stephen C Hyde and Deborah R Gill
Mol Ther 16: 812-818; advance online publication, March 11, 2008; doi:10.1038/mt.2008.25
See also: Commentary by FlotteIntra-amniotic Delivery of CFTR-expressing Adenovirus Does Not Reverse Cystic Fibrosis Phenotype in Inbred CFTR-knockout Mice FREE
Suzanne MK Buckley, SN Waddington, S Jezzard, A Bergau, M Themis, LJ MacVinish, AW Cuthbert, WH Colledge and C Coutelle
Mol Ther 16: 819-824; advance online publication, March 25, 2008; doi:10.1038/mt.2008.26
See also: Commentary by FlotteTransduction of Full-length Dystrophin to Multiple Skeletal Muscles Improves Motor Performance and Life Span in Utrophin/Dystrophin Double Knockout Mice FREE
Ryoko Kawano, Masatoshi Ishizaki, Yasushi Maeda, Yuji Uchida, En Kimura and Makoto Uchino
Mol Ther 16: 825-831; advance online publication, March 4, 2008; doi:10.1038/mt.2008.23
Emergent Dilated Cardiomyopathy Caused by Targeted Repair of Dystrophic Skeletal Muscle FREE
DeWayne Townsend, Soichiro Yasuda, Sheng Li, Jeffrey S Chamberlain and Joseph M Metzger
Mol Ther 16: 832-835; advance online publication, April 15, 2008; doi:10.1038/mt.2008.52
Improvement of Migratory Defects in a Murine Model of Wiskott–Aldrich Syndrome Gene Therapy FREE
Michael P Blundell, Gerben Bouma, Yolanda Calle, Gareth E Jones, Christine Kinnon and Adrian J Thrasher
Mol Ther 16: 836-844; advance online publication, March 18, 2008; doi:10.1038/mt.2008.43
Acquired and Multigenic Disease
Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-
and Interleukin-4 FREE
Maria E Frazer, Jennifer E Hughes, Michael A Mastrangelo, Jennifer L Tibbens, Howard J Federoff and William J Bowers
Mol Ther 16: 845-853; advance online publication, March 11, 2008; doi:10.1038/mt.2008.39
Remission of Diabetes by -Cell Regeneration in Diabetic Mice Treated With a Recombinant Adenovirus Expressing Betacellulin FREE
Seungjin Shin, Na Li, Naoya Kobayashi, Ji-Won Yoon and Hee-Sook Jun
Mol Ther 16: 854-861; advance online publication, March 18, 2008; doi:10.1038/mt.2008.22
Double-blinded, Placebo-controlled Plasmid GHRH Trial for Cancer-associated Anemia in Dogs FREE
Angela M Bodles-Brakhop, Patricia A Brown, Melissa A Pope and Ruxandra Draghia-Akli
Mol Ther 16: 862-870; advance online publication, March 18, 2008; doi:10.1038/mt.2008.31
Systemic Osteoprotegerin Gene Therapy Restores Tumor-induced Bone Loss in a Therapeutic Model of Breast Cancer Bone Metastasis FREE
Diptiman Chanda, Tatyana Isayeva, Sanjay Kumar, Gene P Siegal, April A Szafran, Kurt R Zinn, Vishnu VB Reddy and Selvarangan Ponnazhagan
Mol Ther 16: 871-878; advance online publication, March 18, 2008; doi:10.1038/mt.2008.48
Efficacy and Safety of the Oncolytic Herpes Simplex Virus rRp450 Alone and Combined With Cyclophosphamide FREE
Mark A Currier, Rebecca A Gillespie, Nancy M Sawtell, Yonatan Y Mahller, Greg Stroup, Margaret H Collins, Hirokazu Kambara, E Antonio Chiocca and Timothy P Cripe
Mol Ther 16: 879-885; advance online publication, March 25, 2008; doi:10.1038/mt.2008.49
Therapeutic Molecular Targetingof 15-Lipoxygenase-1 in Colon Cancer FREE
Yuanqing Wu, Bingliang Fang, Xiulan Q Yang, Li Wang, Dongning Chen, Victor Krasnykh, Bing Z Carter, Jeffrey S Morris and Imad Shureiqi
Mol Ther 16: 886-892; advance online publication, March 18, 2008; doi:10.1038/mt.2008.44
Vector Engineering and Delivery
HIV TAT Peptide Modifies the Distribution of DNA Nanolipoparticles Following Convection-enhanced Delivery FREE
J Andrew MacKay, Weijun Li, Zhaohua Huang, Edward E Dy, Grace Huynh, Tarik Tihan, Rodney Collins, Dennis F Deen and Francis C Szoka Jr
Mol Ther 16: 893-900; advance online publication, March 11, 2008; doi:10.1038/mt.2008.36
Administering Plasmid DNA Encoding Tumor Vessel–anchored IFN-
for Localizing Gene Product Within or Into Tumors FREE
Ryan Craig, Jeffry Cutrera, Shiguo Zhu, Xueqing Xia, Yong-Hwan Lee and Shulin Li
Mol Ther 16: 901-906; advance online publication, March 18, 2008; doi:10.1038/mt.2008.40
A Receptor-targeted Nanocomplex Vector System Optimized for Respiratory Gene Transfer FREE
Aristides D Tagalakis, Robin J McAnulty, James Devaney, Stephen E Bottoms, John B Wong, Martin Elbs, Michele J Writer, Helen C Hailes, Alethea B Tabor, Christopher O'Callaghan, Adam Jaffe and Stephen L Hart
Mol Ther 16: 907-915; advance online publication, March 25, 2008; doi:10.1038/mt.2008.38
Subretinal Delivery of Recombinant AAV Serotype 8 Vector in Dogs Results in Gene Transfer to Neurons in the Brain FREE
Knut Stieger, Marie-Anne Colle, Laurence Dubreil, Alexandra Mendes-Madeira, Michel Weber, Guylène Le Meur, Jack Yves Deschamps, Nathalie Provost, Delphine Nivard, Yan Cherel, Philippe Moullier and Fabienne Rolling
Mol Ther 16: 916-923; advance online publication, March 11, 2008; doi:10.1038/mt.2008.41
Intron Splicing–mediated Expression of AAV Rep and Cap Genes and Production of AAV Vectors in Insect Cells FREE
Haifeng Chen
Mol Ther 16: 924-930; advance online publication, March 18, 2008; doi:10.1038/mt.2008.35
Vector Toxicology, Immunogenicity and Safety
The Host Response to Adenovirus, Helper-dependent Adenovirus, and Adeno-associated Virus in Mouse Liver FREE
Anton P McCaffrey, Paul Fawcett, Hiroyuki Nakai, Ramona L McCaffrey, Anja Ehrhardt, Thu-Thao T Pham, Kusum Pandey, Hui Xu, Sally Feuss, Theresa A Storm and Mark A Kay
Mol Ther 16: 931-941; advance online publication, March 18, 2008; doi:10.1038/mt.2008.37
Oligonucleotide Therapy
Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA FREE
Shyh-Dar Li, Sumio Chono and Leaf Huang
Mol Ther 16: 942-946; advance online publication, March 18, 2008; doi:10.1038/mt.2008.51
AAV Vector–mediated RNAi of Mutant Huntingtin Expression Is Neuroprotective in a Novel Genetic Rat Model of Huntington's Disease FREE
Nicholas R Franich, Helen L Fitzsimons, Dahna M Fong, Matthias Klugmann, Matthew J During and Deborah Young
Mol Ther 16: 947-956; advance online publication, March 25, 2008; doi:10.1038/mt.2008.50
Cell Therapy
Lentiviral Vectors Bearing the Cardiac Promoter of the Na+-Ca2+ Exchanger Report Cardiogenic Differentiation in Stem Cells FREE
Andreas S Barth, Eddy Kizana, Rachel R Smith, John Terrovitis, Peihong Dong, Michelle K Leppo, Yiqiang Zhang, Junichiro Miake, Eric N Olson, Jay W Schneider, M Roselle Abraham and Eduardo Marbán
Mol Ther 16: 957-964; advance online publication, March 18, 2008; doi:10.1038/mt.2008.30
Vaccine Technology
Bovine Adenoviral Vector–based H5N1 Influenza Vaccine Overcomes Exceptionally High Levels of Pre-existing Immunity Against Human Adenovirus FREE
Neetu Singh, Aseem Pandey, Lakshmi Jayashankar and Suresh K Mittal
Mol Ther 16: 965-971; advance online publication, February 26, 2008; doi:10.1038/mt.2008.12
See also: Commentary by BarouchClinical Trials
Therapeutic Angiogenesis With Intramuscular NV1FGF Improves Amputation-free Survival in Patients With Critical Limb Ischemia FREE
Sigrid Nikol, Iris Baumgartner, Eric Van Belle, Curt Diehm, Adriana Visoná, Maurizio C Capogrossi, Nicole Ferreira-Maldent, Augusto Gallino, Michael Graham Wyatt, Lasantha Dinesh Wijesinghe, Melissa Fusari, Dominique Stephan, Joseph Emmerich, Giulio Pompilio, Frank Vermassen, Emmanuel Pham, Vincent Grek, Michael Coleman and François Meyer
Mol Ther 16: 972-978; advance online publication, April 1, 2008; doi:10.1038/mt.2008.33
Abstract | Full Text | PDF | Supplementary information
See also: Commentary by Rück & SylvénPhase I Trial of a Pathotropic Retroviral Vector Expressing a Cytocidal Cyclin G1 Construct (Rexin-G) in Patients With Advanced Pancreatic Cancer FREE
Evanthia Galanis, Stephanie K Carlson, Nathan R Foster, Val Lowe, Fernando Quevedo, Robert R McWilliams, Axel Grothey, Aminah Jatoi, Steven R Alberts and Joseph Rubin
Mol Ther 16: 979-984; advance online publication, March 18, 2008; doi:10.1038/mt.2008.29
Intralesional Adenovirus-mediated Interleukin-2 Gene Transfer for Advanced Solid Cancers and Melanoma FREE
Reinhard Dummer, Christoph Rochlitz, Thierry Velu, Bruce Acres, Jean-Marc Limacher, Pascal Bleuzen, Gisèle Lacoste, Philippe Slos, Pedro Romero and Mirjana Urosevic
Mol Ther 16: 985-994; advance online publication, March 18, 2008; doi:10.1038/mt.2008.32
