Molecular Therapy

FIGURE 3

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Improvement of Migratory Defects in a Murine Model of Wiskott–Aldrich Syndrome Gene Therapy

Michael P Blundell, Gerben Bouma, Yolanda Calle, Gareth E Jones, Christine Kinnon and Adrian J Thrasher

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Figure 3.

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Enhancement of migration in eGFP–WASp transduced splenocytes. Splenocytes from reconstituted mice were incubated in transwells and allowed to migrate for 3 hours at 37 °C. After surface staining, (a) B cell (b) dendritic cell (DC), and (c) T-cell migration were measured by flow cytometry for both the enhanced green fluorescent protein (eGFP) positive (eGFP+) and negative (eGFP- ) fractions. Plots shown are the total number of transduced cells migrated compared to the total number of transduced cells added, expressed as a percentage of the input cells. SEW n = 3, SEWW n = 4. Error shown is plusminus1 SD. * P < 0.01, ** P < 0.02 Students t-test. WASp, Wiskott–Aldrich syndrome protein.

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