TABLE OF CONTENTS
Volume 16, Issue 3 (March 2008)
In This Issue |
Research Highlights |
Commentary |
Reviews |
Original Articles |
Corrigendum
Editorial
NIH Recombinant DNA Advisory Committee Continues to Ponder Adverse Event Associated With AAV Gene Therapy Trial FREE
David A Williams
Mol Ther 16: 427-428; doi:10.1038/mt.2008.2
In This Issue
In This Issue FREE
Mol Ther 16: 430; doi:10.1038/mt.2008.27
See also: Original Article by Basile et al. See also: Original Article by Zhou et al. See also: Original Article by Hargrove et al. See also: Original Articles by Cheng et al. See also: Original Article by Lim et al.Research Highlights
Top of pageCommentary
En Route to Ethical Recommendations for Gene Transfer Clinical Trials FREE
Nancy MP King and Odile Cohen-Haguenauer
Mol Ther 16: 432-438; doi:10.1038/mt.2008.13
Reviews
Vector Toxicology, Immunogenicity and Safety
The MDS1–EVI1 Gene Complex as a Retrovirus Integration Site: Impact on Behavior of Hematopoietic Cells and Implications for Gene Therapy FREE
Jean-Yves Métais and Cynthia E Dunbar
Mol Ther 16: 439-449; advance online publication, January 29, 2008; doi:10.1038/sj.mt.6300372
Cell Therapy
Genetic Modification of Neural Stem Cells FREE
Rahul Jandial, Ilyas Singec, Christopher P Ames and Evan Y Snyder
Mol Ther 16: 450-457; advance online publication, February 5, 2008; doi:10.1038/sj.mt.6300402
Original Articles
Monogenic Disease
Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer FREE
Jeannette Bennicelli, John Fraser Wright, Andras Komaromy, Jonathan B Jacobs, Bernd Hauck, Olga Zelenaia, Federico Mingozzi, Daniel Hui, Daniel Chung, Tonia S Rex, Zhangyong Wei, Guang Qu, Shangzhen Zhou, Caroline Zeiss, Valder R Arruda, Gregory M Acland, Lou F Dell'Osso, Katherine A High, Albert M Maguire and Jean Bennett
Mol Ther 16: 458-465; advance online publication, January 22, 2008; doi:10.1038/sj.mt.6300389
Acquired and Multigenic Disease
Freeze-dried Tendon Allografts as Tissue-engineering Scaffolds for Gdf5 Gene Delivery FREE
Patrick Basile, Tulin Dadali, Justin Jacobson, Sys Hasslund, Michael Ulrich-Vinther, Kjeld Søballe, Yasuhiko Nishio, M Hicham Drissi, Howard N Langstein, David J Mitten, Regis J O'Keefe, Edward M Schwarz and Hani A Awad
Mol Ther 16: 466-473; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300395
Protection Against Aminoglycoside-induced Ototoxicity by Regulated AAV Vector–mediated GDNF Gene Transfer Into the Cochlea FREE
Yuhe Liu, Takashi Okada, Kuniko Shimazaki, Kianoush Sheykholeslami, Tatsuya Nomoto, Shin-Ichi Muramatsu, Hiroaki Mizukami, Akihiro Kume, Shuifang Xiao, Keiichi Ichimura and Keiya Ozawa
Mol Ther 16: 474-480; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300379
CNS Delivery of Vectored Prion-specific Single-chain Antibodies Delays Disease Onset FREE
Charles A Wuertzer, Mark A Sullivan, Xing Qiu and Howard J Federoff
Mol Ther 16: 481-486; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300387
Delta-24-RGD in Combination With RAD001 Induces Enhanced Anti-glioma Effect via Autophagic Cell Death FREE
Marta M Alonso, Hong Jiang, Tomohisa Yokoyama, Jing Xu, Nebiyou B Bekele, Frederick F Lang, Seiji Kondo, Candelaria Gomez-Manzano and Juan Fueyo
Mol Ther 16: 487-493; advance online publication, February 5, 2008; doi:10.1038/sj.mt.6300400
Vector Engineering and Delivery
Adeno-associated Virus of a Single-polarity DNA Genome Is Capable of Transduction In Vivo FREE
Xiaohuai Zhou, Xinghua Zeng, Zhenghong Fan, Chengwen Li, Thomas McCown, R Jude Samulski and Xiao Xiao
Mol Ther 16: 494-499; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300397
Inducible Packaging Cells for Large-scale Production of Lentiviral Vectors in Serum-free Suspension Culture FREE
Sophie Broussau, Nadine Jabbour, Guillaume Lachapelle, Yves Durocher, Rosanne Tom, Julia Transfiguracion, Rénald Gilbert and Bernard Massie
Mol Ther 16: 500-507; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300383
Receptor-targeted Nanocomplexes optimized for Gene Transfer to Primary Vascular Cells and Explant Cultures of Rabbit Aorta FREE
Scott A Irvine, Qing-Hai Meng, Faiza Afzal, Jimmy Ho, John B Wong, Helen C Hailes, Alethea B Tabor, Jean R McEwan and Stephen L Hart
Mol Ther 16: 508-515; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300381
Development of Peptide-targeted Lipoplexes to CXCR4-expressing Rat Glioma Cells and Rat Proliferating Endothelial Cells FREE
Wouter HP Driessen, Nobutaka Fujii, Hirokazu Tamamura and Sean M Sullivan
Mol Ther 16: 516-524; advance online publication, January 15, 2008; doi:10.1038/sj.mt.6300388
Vector Toxicology, Immunogenicity and Safety
Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in 
-thalassemic Hematopoietic Cells FREE
Phillip W Hargrove, Steven Kepes, Hideki Hanawa, John C Obenauer, Deiqing Pei, Cheng Cheng, John T Gray, Geoffrey Neale and Derek A Persons
Mol Ther 16: 525-533; advance online publication, January 15, 2008; doi:10.1038/sj.mt.6300394
A Rapid and Quantitative Assay for Measuring Neighboring Gene Activation by Vector Proviruses FREE
Paul C Hendrie, Yunwen Huo, Raisa B Stolitenko and David W Russell
Mol Ther 16: 534-540; advance online publication, January 22, 2008; doi:10.1038/sj.mt.6300398
Transient Immunomodulation Allows Repeated Injections of AAV1 and Correction of Muscular Dystrophy in Multiple Muscles FREE
Stéphanie Lorain, David-Alexandre Gross, Aurélie Goyenvalle, Olivier Danos, Jean Davoust and Luis Garcia
Mol Ther 16: 541-547; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300377
Silencing of Episomal Transgene Expression in Liver by Plasmid Bacterial Backbone DNA Is Independent of CpG Methylation FREE
Zhi-Ying Chen, Efren Riu, Chen-Yi He, Hui Xu and Mark A Kay
Mol Ther 16: 548-556; advance online publication, February 5, 2008; doi:10.1038/sj.mt.6300399
Oligonucleotide Therapy
Lentiviral Vector Design for Multiple shRNA Expression and Durable HIV-1 Inhibition FREE
Olivier ter Brake, Karen 't Hooft, Ying Poi Liu, Mireille Centlivre, Karin Jasmijn von Eije and Ben Berkhout
Mol Ther 16: 557-564; advance online publication, January 15, 2008; doi:10.1038/sj.mt.6300382
Promoter-targeted siRNAs Induce Gene Silencing of Simian Immunodeficiency Virus (SIV) Infection In Vitro FREE
Heidi GW Lim, Kazuo Suzuki, David A Cooper and Anthony D Kelleher
Mol Ther 16: 565-570; advance online publication, January 29, 2008; doi:10.1038/sj.mt.6300380
Cell Therapy
Targeted Migration of Mesenchymal Stem Cells Modified With CXCR4 Gene to Infarcted Myocardium Improves Cardiac Performance FREE
Zhaokang Cheng, Lailiang Ou, Xin Zhou, Fei Li, Xiaohua Jia, Yinguo Zhang, Xiaolei Liu, Yuming Li, Christopher A Ward, Luis G Melo and Deling Kong
Mol Ther 16: 571-579; advance online publication, February 5, 2008; doi:10.1038/sj.mt.6300374
Sleeping Beauty Transposon-mediated Engineering of Human Primary T Cells for Therapy of CD19+ Lymphoid Malignancies FREE
Xin Huang, Hongfeng Guo, Johnthomas Kang, Suet Choi, Tom C Zhou, Syam Tammana, Christopher J Lees, Zhong-Ze Li, Michael Milone, Bruce L Levine, Jakub Tolar, Carl H June, R Scott McIvor, John E Wagner, Bruce R Blazar and Xianzheng Zhou
Mol Ther 16: 580-589; advance online publication, January 29, 2008; doi:10.1038/sj.mt.6300404
Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined Immunodeficiency FREE
Susannah I Thornhill, Axel Schambach, Steven J Howe, Meera Ulaganathan, Elke Grassman, David Williams, Bernhard Schiedlmeier, Neil J Sebire, H Bobby Gaspar, Christine Kinnon, Christopher Baum and Adrian J Thrasher
Mol Ther 16: 590-598; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300393
Engineering Human Tumor-specific Cytotoxic T Cells to Function in a Hypoxic Environment FREE
Hongsung Kim, Guangyong Peng, John M Hicks, Heidi L Weiss, Erwin G Van Meir, Malcolm K Brenner and Patricia Yotnda
Mol Ther 16: 599-606; advance online publication, January 29, 2008; doi:10.1038/sj.mt.6300391
Vaccine Technology
Tumor Protection Following Vaccination With Low Doses of Lentivirally Transduced DCs Expressing the Self-antigen erbB2 FREE
Miriam E Mossoba, Jagdeep S Walia, Vanessa I Rasaiah, Nicole Buxhoeveden, Renee Head, Chuyan Ying, Jason E Foley, Jonathan L Bramson, Daniel H Fowler and Jeffrey A Medin
Mol Ther 16: 607-617; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300390
Clinical Trials
A Phase I Trial of Ad.hIFN- Gene Therapy for Glioma FREE
E Antonio Chiocca, Katie M Smith, Byron McKinney, Cheryl A Palmer, Steven Rosenfeld, Kevin Lillehei, Allan Hamilton, Betty K DeMasters, Kevin Judy and David Kirn
Mol Ther 16: 618-626; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300396
A Phase I Trial of Intratumoral Administration of Reovirus in Patients With Histologically Confirmed Recurrent Malignant Gliomas FREE
Peter Forsyth, Gloria Roldán, David George, Carla Wallace, Cheryl Ann Palmer, Don Morris, Gregory Cairncross, Maureen Vallee Matthews, James Markert, Yancey Gillespie, Matt Coffey, Brad Thompson and Mark Hamilton
Mol Ther 16: 627-632; advance online publication, February 5, 2008; doi:10.1038/sj.mt.6300403
