Molecular Therapy

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Freeze-dried Tendon Allografts as Tissue-engineering Scaffolds for Gdf5 Gene Delivery

Patrick Basile, Tulin Dadali, Justin Jacobson, Sys Hasslund, Michael Ulrich-Vinther, Kjeld Søballe, Yasuhiko Nishio, M Hicham Drissi, Howard N Langstein, David J Mitten, Regis J O'Keefe, Edward M Schwarz and Hani A Awad

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Figure 2.

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Kinetics and biodistribution of recombinant adeno-associated virus (rAAV)-mediated transduction through the use of processed tendon allografts. (a) Temporal bioluminescence images (BLIs) of a representative mouse grafted with a freeze-dried flexor digitorum longus tendon allograft loaded with rAAV-Luc, recorded over 21 days, show the localized biodistribution of rAAV-Luc transduction (heat map-yellow arrows) at the site of allograft implantation in the hind foot. (b) Kinetics of in vivo rAAV transduction, based on average BLI signal intensity, computed from measurements of total integrated light signal (photons emitted/cm2/s) emitted from a standardized region of interest in a standard 3-minute time interval (mean value plusminus SEM; n = 4).

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