TABLE OF CONTENTS
Volume 16, Issue 2 (February 2008)
Editorial
Why Bother?: Is In Utero Gene Therapy Worth the Effort? FREE
Charles Coutelle
Mol Ther 16: 219-220; doi:10.1038/sj.mt.6300401
In This Issue
In This Issue FREE
Mol Ther 16: 222; doi:10.1038/sj.mt.6300406
See also: Original Article by Morrison et al. See also: Original Article by Wu et al. See also: Original Article by Zhong et al. See also: Original Article by Cornu et al. See also: Original Article by Lagresle-Peyrou et al.Research Highlights
Top of pageReviews
Vector Engineering and Delivery
Advances in Molecular and Cellular Therapies for Hearing Loss FREE
Michael S Hildebrand, Stephen S Newton, Samuel P Gubbels, Abraham M Sheffield, Amit Kochhar, Michelle G de Silva, Hans-Henrik M Dahl, Scott D Rose, Mark A Behlke and Richard JH Smith
Mol Ther 16: 224-236; advance online publication, November 27, 2007; doi:10.1038/sj.mt.6300351
Clinical Trials
Current Status of Gene Therapy in Asia FREE
Sunyoung Kim, Zhaohui Peng and Yasufumi Kaneda
Mol Ther 16: 237-243; advance online publication, December 11, 2007; doi:10.1038/sj.mt.6300336
Original Articles
Acquired and Multigenic Disease
Virotherapy of Ovarian Cancer With Polymer-cloaked Adenovirus Retargeted to the Epidermal Growth Factor Receptor FREE
Joanne Morrison, Simon S Briggs, Nicola Green, Kerry Fisher, Vladimir Subr, Karel Ulbrich, Sean Kehoe and Leonard W Seymour
Mol Ther 16: 244-251; advance online publication, December 11, 2007; doi:10.1038/sj.mt.6300363
Telomerase Transcriptional Targeting of Inducible Bax/TRAIL Gene Therapy Improves Gemcitabine Treatment of Pancreatic Cancer FREE
Séverine Wack, Soukaina Rejiba, Céline Parmentier, Marc Aprahamian and Amor Hajri
Mol Ther 16: 252-260; advance online publication, November 6, 2007; doi:10.1038/sj.mt.6300340
Induction of Natural Killer Cell-dependent Antitumor Immunity by the Autographa californica Multiple Nuclear Polyhedrosis Virus FREE
Masayuki Kitajima, Takayuki Abe, Naoko Miyano-Kurosaki, Masaru Taniguchi, Toshinori Nakayama and Hiroshi Takaku
Mol Ther 16: 261-268; advance online publication, December 4, 2007; doi:10.1038/sj.mt.6300364
Overcoming Immune Tolerance Against Multiple Myeloma With Lentiviral Calnexin-engineered Dendritic Cells FREE
Shuhong Han, Bei Wang, Matthew J Cotter, Li-Jun Yang, James Zucali, Jan S Moreb and Lung-Ji Chang
Mol Ther 16: 269-279; advance online publication, December 11, 2007; doi:10.1038/sj.mt.6300369
Vector Engineering and Delivery
Optimization of Self-complementary AAV Vectors for Liver-directed Expression Results in Sustained Correction of Hemophilia B at Low Vector Dose FREE
Zhijian Wu, Junjiang Sun, Taiping Zhang, Chaoying Yin, Fang Yin, Terry Van Dyke, Richard J Samulski and Paul E Monahan
Mol Ther 16: 280-289; advance online publication, December 4, 2007; doi:10.1038/sj.mt.6300355
Single-polarity Recombinant Adeno-associated Virus 2 Vector-mediated Transgene Expression In Vitro and In Vivo: Mechanism of Transduction FREE
Li Zhong, Xiaohuai Zhou, Yanjun Li, Keyun Qing, Xiao Xiao, Richard Jude Samulski and Arun Srivastava
Mol Ther 16: 290-295; advance online publication, December 18, 2007; doi:10.1038/sj.mt.6300376
Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1 FREE
Edmund R Hollis II, Ken Kadoya, Matthew Hirsch, Richard J Samulski and Mark H Tuszynski
Mol Ther 16: 296-301; advance online publication, November 27, 2007; doi:10.1038/sj.mt.6300367
Modulation of Adrenal Catecholamine Secretion by In Vivo Gene Transfer and Manipulation of G Protein–coupled Receptor Kinase-2 Activity FREE
Anastasios Lymperopoulos, Giuseppe Rengo, Carmela Zincarelli, Stephen Soltys and Walter J Koch
Mol Ther 16: 302-307; advance online publication, November 27, 2007; doi:10.1038/sj.mt.6300371
Engineering of a Stable Retroviral Gene Delivery Vector by Directed Evolution FREE
Halong N Vu, Joshua D Ramsey and Daniel W Pack
Mol Ther 16: 308-314; advance online publication, November 6, 2007; doi:10.1038/sj.mt.6300350
Input DNA Ratio Determines Copy Number of The 33 kb Factor IX Gene on De Novo Human Artificial Chromosomes FREE
Amy M Breman, Camie M Steiner, Roger B Slee and Brenda R Grimes
Mol Ther 16: 315-323; advance online publication, December 4, 2007; doi:10.1038/sj.mt.6300361
Quantitative Comparison of Intracellular Unpacking Kinetics of Polyplexes by a Model Constructed From Quantum Dot-FRET FREE
Hunter H Chen, Yi-Ping Ho, Xuan Jiang, Hai-Quan Mao, Tza-Huei Wang and Kam W Leong
Mol Ther 16: 324-332; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300392
Cell Surface Nucleolin Serves as Receptor for DNA Nanoparticles Composed of Pegylated Polylysine and DNA FREE
Xuguang Chen, Dianne M Kube, Mark J Cooper and Pamela B Davis
Mol Ther 16: 333-342; advance online publication, December 4, 2007; doi:10.1038/sj.mt.6300365
Vector Toxicology, Immunogenicity and Safety
Immunization Against the Transgene but not the TetON Switch Reduces Expression From Gutless Adenoviral Vectors in the Brain FREE
Weidong Xiong, Marianela Candolfi, Kurt M Kroeger, Mariana Puntel, Sonali Mondkar, Daniel Larocque, Chunyan Liu, James F Curtin, Donna Palmer, Philip Ng, Pedro R Lowenstein and Maria G Castro
Mol Ther 16: 343-351; advance online publication, January 8, 2008; doi:10.1038/sj.mt.6300375
DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases FREE
Tatjana I Cornu, Stacey Thibodeau-Beganny, Eva Guhl, Stephen Alwin, Magdalena Eichtinger, JK Joung and Toni Cathomen
Mol Ther 16: 352-358; advance online publication, November 20, 2007; doi:10.1038/sj.mt.6300357
Transcriptional Activities of the Sleeping Beauty Transposon and Shielding Its Genetic Cargo With Insulators FREE
Oliver Walisko, Andrea Schorn, Frank Rolfs, Anantharam Devaraj, Csaba Miskey, Zsuzsanna Izsvák and Zoltán Ivics
Mol Ther 16: 359-369; advance online publication, December 11, 2007; doi:10.1038/sj.mt.6300366
Several Serum Proteins Significantly Decrease Inflammatory Response to Lipid-based Non-viral Vectors FREE
Christine C Conwell, Feng Liu and Leaf Huang
Mol Ther 16: 370-377; advance online publication, November 20, 2007; doi:10.1038/sj.mt.6300356
Oligonucleotide Therapy
Titers of HIV-based Vectors Encoding shRNAs are Reduced by a Dicer-dependent Mechanism FREE
Ananthalakshmi Poluri and Richard E. Sutton
Mol Ther 16: 378-386; advance online publication, December 11, 2007; doi:10.1038/sj.mt.6300370
Downregulation of Monocyte Chemoattractant Protein-1 Involving Short Interfering RNA Attenuates Hapten-induced Contact Hypersensitivity FREE
Takuji Ishimoto, Yoshifumi Takei, Yukio Yuzawa, Koji Hanai, Shunji Nagahara, Yuzo Tarumi, Seiichi Matsuo and Kenji Kadomatsu
Mol Ther 16: 387-395; advance online publication, December 4, 2007; doi:10.1038/sj.mt.6300360
Cell Therapy
Restoration of Human B-cell Differentiation Into NOD-SCID Mice Engrafted With Gene-corrected CD34+ Cells Isolated From Artemis or RAG1-deficient Patients FREE
Chantal Lagresle-Peyrou, Fatine Benjelloun, Christophe Hue, Isabelle Andre-Schmutz, Delphine Bonhomme, Monique Forveille, Kheira Beldjord, Salima Hacein-Bey-Abina, Jean-Pierre De Villartay, Pierre Charneau, Anne Durandy, Alain Fischer and Marina Cavazzana-Calvo
Mol Ther 16: 396-403; advance online publication, November 27, 2007; doi:10.1038/sj.mt.6300353
Lentivirus Mediated HO-1 Gene Transfer Enhances Myogenic Precursor Cell Survival After Autologous Transplantation in Pig FREE
Thomas Laumonier, Sheng Yang, Stephane Konig, Christine Chauveau, Ignacio Anegon, Pierre Hoffmeyer and Jacques Menetrey
Mol Ther 16: 404-410; advance online publication, November 20, 2007; doi:10.1038/sj.mt.6300354
Vaccine Technology
Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines Is a Result of Their Ability to Engage Both CTL and IFN
-producing NK Cells FREE
Khalil Karimi, Jeanette E Boudreau, Katie Fraser, Hongju Liu, Jordan Delanghe, Jack Gauldie, Zhou Xing, Jonathan L Bramson and Yonghong Wan
Mol Ther 16: 411-418; advance online publication, December 4, 2007; doi:10.1038/sj.mt.6300347
DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo FREE
Michael A Chattergoon, Karuppiah Muthumani, Yutaka Tamura, Mathura Ramanathan, Jason P Shames, Vera Saulino, Tara M Robinson, Luis J Montaner and David B Weiner
Mol Ther 16: 419-426; advance online publication, December 18, 2007; doi:10.1038/sj.mt.6300373
