TABLE OF CONTENTS
Volume 16, Issue 12 (December 2008)
Editorial
From "Gene Therapy" to "Gene and Cell Therapy": Why? FREE
Savio LC Woo
Mol Ther 16: 1899-1900; doi:10.1038/mt.2008.246
In This Issue
In This Issue FREE
Mol Ther 16: 1902; doi:10.1038/mt.2008.251
See also: Original Article by Kottke et al. See also: Original Article by Tal et al. See also: Commentaries by Nicklin & BakerSee also: Original Article by Bish et al. See also: Original Article by Murphy et al. See also: Original Article by Svensson et al.Research Highlights
Top of pageCommentaries
Efficient Vascular Endothelial Gene Transfer Following Intravenous Adenovirus Delivery
Stuart A Nicklin and Andrew H Baker
Mol Ther 16: 1904-1905; doi:10.1038/mt.2008.226
See also: Original Article by Tal et al.Mesenchymal Stem Cells as Trojan Horses for GDNF Delivery in ALS
Brian K Kaspar
Mol Ther 16: 1905-1906; doi:10.1038/mt.2008.216
See also: Original Article by Suzuki et al.Another New "Super Muscle Stem Cell" Leaves Unaddressed the Real Problems of Cell Therapy for Duchenne Muscular Dystrophy
Jacques P Tremblay and Daniel Skuk
Mol Ther 16: 1907-1909; doi:10.1038/mt.2008.243
Original Articles
ACQUIRED AND MULTIGENIC DISEASE
Use of Biological Therapy to Enhance Both Virotherapy and Adoptive T-Cell Therapy for Cancer
Timothy Kottke, Rosa M Diaz, Karen Kaluza, Jose Pulido, Feorillo Galivo, Phonphimon Wongthida, Jill Thompson, Candice Willmon, Glen N Barber, John Chester, Peter Selby, Scott Strome, Kevin Harrington, Alan Melcher and Richard G Vile
Mol Ther 16: 1910-1918; advance online publication, September 30, 2008; doi:10.1038/mt.2008.212
Potent Systemic Anticancer Activity of Adenovirally Expressed EGFR-Selective TRAIL Fusion Protein
Edwin Bremer, Gooitzen M van Dam, Marco de Bruyn, Manon van Riezen, Marike Dijkstra, Gera Kamps, Wijnand Helfrich and Hidde Haisma
Mol Ther 16: 1919-1926; advance online publication, September 23, 2008; doi:10.1038/mt.2008.203
Endothelial-targeted Gene Transfer of Hypoxia-inducible Factor-1
Augments Ischemic Neovascularization Following Systemic Administration
Reshef Tal, Aviv Shaish, Karen Rofe, Erez Feige, Nira Varda-Bloom, Arnon Afek, Iris Barshack, Livnat Bangio, Israel Hodish, Shoshana Greenberger, Michael Peled, Eyal Breitbart and Dror Harats
Mol Ther 16: 1927-1936; advance online publication, September 16, 2008; doi:10.1038/mt.2008.191
Abstract | Full Text | PDF | Supplementary information
See also: Commentaries by Nicklin & BakerBiological Pacemaker Engineered by Nonviral Gene Transfer in a Mouse Model of Complete Atrioventricular Block
Julien Piron, Khai Le Quang, François Briec, Jean-Christophe Amirault, Anne-Laure Leoni, Léa Desigaux, Denis Escande, Bruno Pitard and Flavien Charpentier
Mol Ther 16: 1937-1943; advance online publication, September 23, 2008; doi:10.1038/mt.2008.209
Vector Engineering and Delivery
A Single Intravenous Injection of Adeno-associated Virus Serotype-9 Leads to Whole Body Skeletal Muscle Transduction in Dogs
Yongping Yue, Arkasubhra Ghosh, Chun Long, Brian Bostick, Bruce F Smith, Joe N Kornegay and Dongsheng Duan
Mol Ther 16: 1944-1952; advance online publication, September 30, 2008; doi:10.1038/mt.2008.207
Percutaneous Transendocardial Delivery of Self-complementary Adeno-associated Virus 6 Achieves Global Cardiac Gene Transfer in Canines
Lawrence T Bish, Meg M Sleeper, Benjamin Brainard, Stephen Cole, Nicholas Russell, Elanor Withnall, Jason Arndt, Caryn Reynolds, Ellen Davison, Julio Sanmiguel, Di Wu, Guangping Gao, James M Wilson and H Lee Sweeney
Mol Ther 16: 1953-1959; advance online publication, September 23, 2008; doi:10.1038/mt.2008.202
High-throughput Screening and Biophysical Interrogation of Hepatotropic AAV
Samuel L Murphy, Anand Bhagwat, Shyrie Edmonson, Shangzhen Zhou and Katherine A High
Mol Ther 16: 1960-1967; advance online publication, September 30, 2008; doi:10.1038/mt.2008.210
A Large U3 Deletion Causes Increased In Vivo Expression From a Nonintegrating Lentiviral Vector
Matthew Bayer, Boris Kantor, Adam Cockrell, Hong Ma, Brian Zeithaml, Xiangping Li, Thomas McCown and Tal Kafri
Mol Ther 16: 1968-1976; advance online publication, September 16, 2008; doi:10.1038/mt.2008.199
Correction of Laminin-5 Deficiency in Human Epidermal Stem Cells by Transcriptionally Targeted Lentiviral Vectors
Francesca Di Nunzio, Giulietta Maruggi, Stefano Ferrari, Enzo Di Iorio, Valentina Poletti, Marta Garcia, Marcela Del Rio, Michele De Luca, Fernando Larcher, Graziella Pellegrini and Fulvio Mavilio
Mol Ther 16: 1977-1985; advance online publication, September 23, 2008; doi:10.1038/mt.2008.204
Persistent Expression of PEDF in the Eye Using High-capacity Adenovectors
Ping Chen, Melissa Hamilton, Charles A Thomas, Kurt Kroeger, Miguel Carrion, Randall S MacGill, Peter Gehlbach, Douglas E Brough, Lisa L Wei, C Richter King and Joseph T Bruder
Mol Ther 16: 1986-1994; advance online publication, September 30, 2008; doi:10.1038/mt.2008.211
VECTOR TOXICOLOGY, IMMUNOGENICITY AND SAFETY
Assessing siRNA Pharmacodynamics in a Luciferase-expressing Mouse
Robert U Svensson, Michael R Shey, Zuhair K Ballas, J Robert Dorkin, Michael Goldberg, Akin Akinc, Robert Langer, Daniel G Anderson, David Bumcrot and Michael D Henry
Mol Ther 16: 1995-2001; advance online publication, September 9, 2008; doi:10.1038/mt.2008.187
CELL THERAPY
Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS
Masatoshi Suzuki, Jacalyn McHugh, Craig Tork, Brandon Shelley, Antonio Hayes, Ilaria Bellantuono, Patrick Aebischer and Clive N Svendsen
Mol Ther 16: 2002-2010; advance online publication, September 16, 2008; doi:10.1038/mt.2008.197
Abstract | Full Text | PDF | Supplementary information
See also: Commentaries by KasparVaccine Technology
Efficient Modulation of T-cell Response by Dual-mode, Single-carrier Delivery of Cytokine-targeted siRNA and DNA Vaccine to Antigen-presenting Cells
Ankur Singh, Hui Nie, Bilal Ghosn, Hong Qin, Larry W Kwak and Krishnendu Roy
Mol Ther 16: 2011-2021; advance online publication, September 23, 2008; doi:10.1038/mt.2008.206
Clinical Trials
Phase I/II Study of GM-CSF DNA as an Adjuvant for a Multipeptide Cancer Vaccine in Patients With Advanced Melanoma
Miguel-Angel Perales, Jianda Yuan, Sarah Powel, Humilidad F Gallardo, Teresa S Rasalan, Christina Gonzalez, Gregor Manukian, Jian Wang, Yan Zhang, Paul B Chapman, Susan E Krown, Philip O Livingston, Samuel Ejadi, Katherine S Panageas, Manuel E Engelhorn, Stephanie L Terzulli, Alan N Houghton and Jedd D Wolchok
Mol Ther 16: 2022-2029; advance online publication, September 16, 2008; doi:10.1038/mt.2008.196
