TABLE OF CONTENTS
Volume 16, Issue 10 (October 2008)
Editorial
The ASGT and Ethical Codes for Clinical Research FREE
Theodore Friedmann
Mol Ther 16: 1643-1644; doi:10.1038/mt.2008.193
In This Issue
In This Issue FREE
Mol Ther 16: 1646; doi:10.1038/mt.2008.195
See also: Original Article by Patil et al. See also: Review by McCartySee also: Original Article by Thomas et al. See also: Original Article by Suzuki et al. See also: Original Article by Maguire et al.Research Highlights
Top of pageReview
Vector Engineering and Delivery
Self-complementary AAV Vectors; Advances and Applications FREE
Douglas M McCarty
Mol Ther 16: 1648-1656; advance online publication, August 5, 2008; doi:10.1038/mt.2008.171
Original Articles
Acquired and Multigenic Disease
Targeting mRNA Stability Arrests Inflammatory Bone Loss FREE
Chetan S Patil, Min Liu, Wenpu Zhao, Derek D Coatney, Fei Li, Elizabeth A VanTubergen, Nisha J D'Silva and Keith L Kirkwood
Mol Ther 16: 1657-1664; advance online publication, August 5, 2008; doi:10.1038/mt.2008.163
Immunosuppression Enhances Oncolytic Adenovirus Replication and Antitumor Efficacy in the Syrian Hamster Model FREE
Maria A Thomas, Jacqueline F Spencer, Karoly Toth, John E Sagartz, Nancy J Phillips and William SM Wold
Mol Ther 16: 1665-1673; advance online publication, July 29, 2008; doi:10.1038/mt.2008.162
Gene-eluting Stents: Adenovirus-mediated Delivery of eNOS to the Blood Vessel Wall Accelerates Re-endothelialization and Inhibits Restenosis FREE
Faisal Sharif, Sean O Hynes, Ronan Cooney, Linda Howard, Jill McMahon, Kieran Daly, James Crowley, Frank Barry and Timothy O'Brien
Mol Ther 16: 1674-1680; advance online publication, August 19, 2008; doi:10.1038/mt.2008.165
Dual Therapeutic Effects of Interferon-
Gene Therapy in a Rat Hepatocellular Carcinoma Model With Liver Cirrhosis FREE
Kai-Wen Huang, Yung-Chi Huang, Kuo-Feng Tai, Bo-Hua Chen, Po-Huang Lee and Lih-Hwa Hwang
Mol Ther 16: 1681-1687; advance online publication, July 29, 2008; doi:10.1038/mt.2008.160
Downregulation of p22phox in Retinal Pigment Epithelial Cells Inhibits Choroidal Neovascularization in Mice FREE
Qiuhong Li, Astra Dinculescu, Zhiying Shan, Rehae Miller, Jijing Pang, Alfred S Lewin, Mohan K Raizada and William W Hauswirth
Mol Ther 16: 1688-1694; advance online publication, July 29, 2008; doi:10.1038/mt.2008.164
Vector Engineering and Delivery
Preventing Growth of Brain Tumors by Creating a Zone of Resistance FREE
Casey A Maguire, Dimphna H Meijer, Stanley G LeRoy, Laryssa A Tierney, Marike LD Broekman, Fabricio F Costa, Xandra O Breakefield, Anat Stemmer-Rachamimov and Miguel Sena-Esteves
Mol Ther 16: 1695-1702; advance online publication, August 19, 2008; doi:10.1038/mt.2008.168
DNA Shuffling of Adeno-associated Virus Yields Functionally Diverse Viral Progeny FREE
James T Koerber, Jae-Hyung Jang and David V Schaffer
Mol Ther 16: 1703-1709; advance online publication, August 26, 2008; doi:10.1038/mt.2008.167
Expanded Repertoire of AAV Vector Serotypes Mediate Unique Patterns of Transduction in Mouse Brain FREE
Cassia N Cearley, Luk H Vandenberghe, Michael K Parente, Erin R Carnish, James M Wilson and John H Wolfe
Mol Ther 16: 1710-1718; advance online publication, August 19, 2008; doi:10.1038/mt.2008.166
Vector Toxicology, Immunogenicity and Safety
miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy FREE
Takayuki Suzuki, Fuminori Sakurai, Shin-ichiro Nakamura, Emi Kouyama, Kenji Kawabata, Masuo Kondoh, Kiyohito Yagi and Hiroyuki Mizuguchi
Mol Ther 16: 1719-1726; advance online publication, July 29, 2008; doi:10.1038/mt.2008.159
Stable Transgene Expression From HSV Amplicon Vectors in the Brain: Potential Involvement of Immunoregulatory Signals FREE
Masataka Suzuki, E. Antonio Chiocca and Yoshinaga Saeki
Mol Ther 16: 1727-1736; advance online publication, August 26, 2008; doi:10.1038/mt.2008.175
Transgene Expression, Bioactivity, and Safety of CERE-120 (AAV2-Neurturin) Following Delivery to the Monkey Striatum FREE
Christopher D Herzog, Biplob Dass, Mehdi Gasmi, Roy Bakay, James E Stansell, Mark Tuszynski, Krystof Bankiewicz, Er-Yun Chen, Yaping Chu, Kathie Bishop, Jeffrey H Kordower and Raymond T Bartus
Mol Ther 16: 1737-1744; advance online publication, August 26, 2008; doi:10.1038/mt.2008.170
Cell Therapy
Erythroid-specific Human Factor IX Delivery From In Vivo Selected Hematopoietic Stem Cells Following Nonmyeloablative Conditioning in Hemophilia B Mice FREE
Alex H Chang, Matthias T Stephan, Leszek Lisowski and Michel Sadelain
Mol Ther 16: 1745-1752; advance online publication, August 5, 2008; doi:10.1038/mt.2008.161
Vaccine Technology
Chemotherapy Targeted to Cancer Tissue Potentiates Antigen-specific Immune Response Induced by Vaccine for In Vivo Antigen Loading and Activation of Dendritic Cells FREE
Hakan Akbulut, Yucheng Tang, K. Gonca Akbulut, Jonathan Maynard and Albert Deisseroth
Mol Ther 16: 1753-1760; advance online publication, August 26, 2008; doi:10.1038/mt.2008.158
Clinical Trials
Phase I Study of Noninvasive Imaging of Adenovirus-mediated Gene Expression in the Human Prostate FREE
Kenneth N Barton, Hans Stricker, Stephen L Brown, Mohamed Elshaikh, Ibrahim Aref, Mei Lu, Jan Pegg, Yingshu Zhang, Kastytis C Karvelis, Farzan Siddiqui, Jae Ho Kim, Svend O Freytag and Benjamin Movsas
Mol Ther 16: 1761-1769; advance online publication, August 19, 2008; doi:10.1038/mt.2008.172
