TABLE OF CONTENTS
Volume 16, Issue 1 (January 2008)
In This Issue |
Research Highlights |
Commentary |
Reviews |
Original Articles |
Erratum
Editorial
Converging Paths of Viral and Non-viral Vector Engineering FREE
Ernst Wagner
Mol Ther 16: 1-2; doi:10.1038/sj.mt.6300378
See also: Review by Wolff & RozemaSee also: Review by Kreppel & KochanekIn This Issue
In This Issue FREE
Mol Ther 16: 4; doi:10.1038/sj.mt.6300385
See also: Original Article by Yin et al. See also: Original Article by Cortés et al. See also: Original Article by Murphy et al. See also: Original Article by Altomonte et al. See also: Original Article by Li et al.Research Highlights
Top of pageCommentary
Genetic Vaccination: One-Shot Shopping for Immediate and Sustained Protection FREE
Elmieke PJ Boot and Paul WHI Parren
Mol Ther 16: 6-7; doi:10.1038/sj.mt.6300368
See also: Original Article by De et al.Reviews
Vector Engineering and Delivery
Breaking the Bonds: Non-viral Vectors Become Chemically Dynamic FREE
Jon A Wolff and David B Rozema
Mol Ther 16: 8-15; advance online publication, October 23, 2007; doi:10.1038/sj.mt.6300326
See also: Editorial by WagnerModification of Adenovirus Gene Transfer Vectors With Synthetic Polymers: A Scientific Review and Technical Guide FREE
Florian Kreppel and Stefan Kochanek
Mol Ther 16: 16-29; advance online publication, October 2, 2007; doi:10.1038/sj.mt.6300321
See also: Editorial by WagnerOriginal Articles
Monogenic Disease
Biochemical, Pathological, and Skeletal Improvement of Mucopolysaccharidosis VI After Gene Transfer to Liver but Not to Muscle FREE
Alessandra Tessitore, Armida Faella, Thomas O'Malley, Gabriella Cotugno, Monica Doria, Tetsuo Kunieda, Giuseppe Matarese, Mark Haskins and Alberto Auricchio
Mol Ther 16: 30-37; advance online publication, October 23, 2007; doi:10.1038/sj.mt.6300325
Effective Exon Skipping and Restoration of Dystrophin Expression by Peptide Nucleic Acid Antisense Oligonucleotides in mdx Mice FREE
Haifang Yin, Qilong Lu and Matthew Wood
Mol Ther 16: 38-45; advance online publication, October 30, 2007; doi:10.1038/sj.mt.6300329
Acquired and Multigenic Disease
Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication FREE
Jason A Taylor, Lucia Vojtech, Ingrid Bahner, Donald B Kohn, Dorothee Von Laer, David W Russell and Robert E Richard
Mol Ther 16: 46-51; advance online publication, October 23, 2007; doi:10.1038/sj.mt.6300335
Myxoma Virus Oncolysis of Primary and Metastatic B16F10 Mouse Tumors In Vivo FREE
Marianne M Stanford, Mae Shaban, John W Barrett, Steven J Werden, Philippe-Alexandre Gilbert, Joe Bondy-Denomy, Lisa MacKenzie, Kevin C Graham, Ann F Chambers and Grant McFadden
Mol Ther 16: 52-59; advance online publication, November 13, 2007; doi:10.1038/sj.mt.6300348
Lentiviral-mediated GATA-3 RNAi Decreases Allergic Airway Inflammation and Hyperresponsiveness FREE
Chen-Chen Lee, Hsin-Ying Huang and Bor-Luen Chiang
Mol Ther 16: 60-65; advance online publication, September 18, 2007; doi:10.1038/sj.mt.6300309
RNA Aptamer-targeted Inhibition of NF-
B Suppresses Non-small Cell Lung Cancer Resistance to Doxorubicin FREE
Jing Mi, Xiuwu Zhang, Zahid N Rabbani, Yingmiao Liu, Srinevas K Reddy, Zhen Su, Fawzia K Salahuddin, Kristi Viles, Paloma H Giangrande, Mark W Dewhirst, Bruce A Sullenger, Christopher D Kontos and Bryan M Clary
Mol Ther 16: 66-73; advance online publication, October 2, 2007; doi:10.1038/sj.mt.6300320
In Vivo Reprogramming of hTERT by Trans-splicing Ribozyme to Target Tumor Cells FREE
Seung-Hee Hong, Jin-Sook Jeong, Yoon-Jong Lee, Haeng-Im Jung, Kyoung-Sook Cho, Chang-Min Kim, Byung-Su Kwon, Bruce A Sullenger, Seong-Wook Lee and In-Hoo Kim
Mol Ther 16: 74-80; advance online publication, August 14, 2007; doi:10.1038/sj.mt.6300282
Vector Engineering and Delivery
Targeted Integration of Functional Human ATM cDNA Into Genome Mediated by HSV/AAV Hybrid Amplicon Vector FREE
Maria L Cortés, Angelika Oehmig, Okay Saydam, Jocelyn D Sanford, Katherine F Perry, Cornel Fraefel and Xandra O Breakefield
Mol Ther 16: 81-88; advance online publication, November 13, 2007; doi:10.1038/sj.mt.6300338
AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method FREE
Ronald L Klein, Robert D Dayton, Jason B Tatom, Karen M Henderson and Phillip P Henning
Mol Ther 16: 89-96; advance online publication, October 23, 2007; doi:10.1038/sj.mt.6300331
Durable, Safe, Multi-gene Lentiviral Vector Expression in Feline Trabecular Meshwork FREE
Pranay D Khare, Nils Loewen, Wulin Teo, Román A Barraza, Dyana T Saenz, Douglas H Johnson and Eric M Poeschla
Mol Ther 16: 97-106; advance online publication, October 2, 2007; doi:10.1038/sj.mt.6300318
Cell-penetrating Peptide for Enhanced Delivery of Nucleic Acids and Drugs to Ocular Tissues Including Retina and Cornea FREE
Leslie N Johnson, Siobhan M Cashman and Rajendra Kumar-Singh
Mol Ther 16: 107-114; advance online publication, October 9, 2007; doi:10.1038/sj.mt.6300324
Characterization of a Novel Cytotoxic Cell-penetrating Peptide Derived From p14ARF Protein FREE
Henrik J Johansson, Samir El-Andaloussi, Tina Holm, Maarja Mäe, Jaak Jänes, Toivo Maimets and Ülo Langel
Mol Ther 16: 115-123; advance online publication, November 6, 2007; doi:10.1038/sj.mt.6300346
A Hybrid Vector System Expands Adeno-associated Viral Vector Packaging Capacity in a Transgene-independent Manner FREE
Arkasubhra Ghosh, Yongping Yue, Yi Lai and Dongsheng Duan
Mol Ther 16: 124-130; advance online publication, November 6, 2007; doi:10.1038/sj.mt.6300322
Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter FREE
Masayuki Endo, Philip W Zoltick, William H Peranteau, Antoneta Radu, Nidal Muvarak, Mayumi Ito, Zaixin Yang, George Cotsarelis and Alan W Flake
Mol Ther 16: 131-137; advance online publication, October 9, 2007; doi:10.1038/sj.mt.6300332
Vector Toxicology, Immunogenicity and Safety
Prolonged Susceptibility to Antibody-mediated Neutralization for Adeno-associated Vectors Targeted to the Liver FREE
Samuel L Murphy, Hojun Li, Shangzhen Zhou, Alexander Schlachterman and Katherine High
Mol Ther 16: 138-145; advance online publication, October 23, 2007; doi:10.1038/sj.mt.6300334
Exponential Enhancement of Oncolytic Vesicular Stomatitis Virus Potency by Vector-mediated Suppression of Inflammatory Responses In Vivo FREE
Jennifer Altomonte, Lan Wu, Li Chen, Marcia Meseck, Oliver Ebert, Adolfo García-Sastre, John Fallon and Savio LC Woo
Mol Ther 16: 146-153; advance online publication, December 11, 2007; doi:10.1038/sj.mt.6300343
Fully Detargeted Polyethylene Glycol-coated Adenovirus Vectors Are Potent Genetic Vaccines and Escape from Pre-existing Anti-adenovirus Antibodies FREE
Andreas Wortmann, Sabine Vöhringer, Tatjana Engler, Stephanie Corjon, Reinhold Schirmbeck, Jörg Reimann, Stefan Kochanek and Florian Kreppel
Mol Ther 16: 154-162; advance online publication, September 11, 2007; doi:10.1038/sj.mt.6300306
Oligonucleotide Therapy
Tumor-targeted Delivery of siRNA by Self-assembled Nanoparticles FREE
Shyh-Dar Li, Yun-Ching Chen, Michael J Hackett and Leaf Huang
Mol Ther 16: 163-169; advance online publication, October 9, 2007; doi:10.1038/sj.mt.6300323
Expression of Long Anti-HIV-1 Hairpin RNAs for the Generation of Multiple siRNAs: Advantages and Limitations FREE
Masayuki Sano, Haitang Li, Mahito Nakanishi and John J Rossi
Mol Ther 16: 170-177; advance online publication, August 28, 2007; doi:10.1038/sj.mt.6300298
Complete In Vivo Reversal of the Multidrug Resistance Phenotype by Jet-injection of Anti-MDR1 Short Hairpin RNA-encoding Plasmid DNA FREE
Ulrike Stein, Wolfgang Walther, Alexandra Stege, Alexander Kaszubiak, Iduna Fichtner and Hermann Lage
Mol Ther 16: 178-186; advance online publication, September 18, 2007; doi:10.1038/sj.mt.6300304
Cell Therapy
Gene Targeting of Mutant COL1A2 Alleles in Mesenchymal Stem Cells From Individuals With Osteogenesis Imperfecta FREE
Joel R Chamberlain, David R Deyle, Ulrike Schwarze, Peirong Wang, Roli K Hirata, Yi Li, Peter H Byers and David W Russell
Mol Ther 16: 187-193; advance online publication, October 23, 2007; doi:10.1038/sj.mt.6300339
Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3 FREE
Sarah E Allan, Alicia N Alstad, Natacha Merindol, Natasha K Crellin, Mario Amendola, Rosa Bacchetta, Luigi Naldini, Maria Grazia Roncarolo, Hugo Soudeyns and Megan K Levings
Mol Ther 16: 194-202; advance online publication, November 6, 2007; doi:10.1038/sj.mt.6300341
Vaccine Technology
Rapid/Sustained Anti-anthrax Passive Immunity Mediated by Co-administration of Ad/AAV FREE
Bishnu P De, Neil R Hackett, Ronald G Crystal and Julie L Boyer
Mol Ther 16: 203-209; advance online publication, December 4, 2007; doi:10.1038/sj.mt.6300344
See also: Commentary by Boot & ParrenVaccination Against Hepatitis C Virus With Dendritic Cells Transduced With an Adenovirus Encoding NS3 Protein FREE
Aintzane Zabaleta, Diana Llopiz, Laura Arribillaga, Leyre Silva, José Ignacio Riezu-Boj, Juan José Lasarte, Francisco Borrás-Cuesta, Jesús Prieto and Pablo Sarobe
Mol Ther 16: 210-217; advance online publication, October 9, 2007; doi:10.1038/sj.mt.6300333
