TABLE OF CONTENTS
Volume 15, Issue 9 (September 2007)
In This Issue |
Research Highlights |
Commentary |
Review |
Original Articles |
Corrigenda
Editorial
Humility and Clinical Trials FREE
James Wilson Associate Editor
Mol Ther 15: 1571-1572; doi:10.1038/sj.mt.6300279
In This Issue
In This Issue FREE
Mol Ther 15: 1574; doi:10.1038/sj.mt.6300288
See also: Original Article by Appaiahgari & VratiSee also: Original Article by Breitbach et al. See also: Original Article by Larcher et al. See also: Original Article by Robbins et al. See also: Original Article by Sabatino et al.Research Highlights
Top of pageCommentary
A Decade of Accomplishments: Gene Therapy and the ASGT FREE
Theodore Friedmann
Mol Ther 15: 1576-1578; doi:10.1038/sj.mt.6300284
Review
Vector Engineering and Delivery
Non-invasive Imaging in Gene Therapy FREE
Jani Kristian Räty, Timo Liimatainen, Minna Unelma Kaikkonen, Olli Gröhn, Kari Jumani Airenne and Seppo Ylä-Herttuala
Mol Ther 15: 1579-1586; advance online publication, June 19, 2007; doi:10.1038/sj.mt.6300233
Original Articles
Monogenic Disease
Morpholino Oligomer–Mediated Exon Skipping Averts the Onset of Dystrophic Pathology in the mdx Mouse FREE
Sue Fletcher, Kaite Honeyman, Abbie M Fall, Penny L Harding, Russell D Johnsen, Joshua P Steinhaus, Hong M Moulton, Patrick L Iversen and Stephen D Wilton
Mol Ther 15: 1587-1592; advance online publication, June 19, 2007; doi:10.1038/sj.mt.6300245
Acquired and Multigenic Disease
DNAzyme-mediated Inhibition of Japanese Encephalitis Virus Replication in Mouse Brain FREE
Mohan Babu Appaiahgari and Sudhanshu Vrati
Mol Ther 15: 1593-1599; advance online publication, June 19, 2007; doi:10.1038/sj.mt.6300231
Replication-competent Adenovirus-mediated Suicide Gene Therapy with Radiation in a Preclinical Model of Pancreatic Cancer FREE
Svend O Freytag, Kenneth N Barton, Stephen L Brown, Vinod Narra, Yingshu Zhang, Don Tyson, Colleen Nall, Mei Lu, Munther Ajlouni, Benjamin Movsas and Jae Ho Kim
Mol Ther 15: 1600-1606; advance online publication, June 12, 2007; doi:10.1038/sj.mt.6300212
Systemic Toxicity–Efficacy Profile of ICOVIR-5, a Potent and Selective Oncolytic Adenovirus Based on the pRB Pathway FREE
Manel Cascallo, Marta M Alonso, Juan J Rojas, Anna Perez-Gimenez, Juan Fueyo and Ramon Alemany
Mol Ther 15: 1607-1615; advance online publication, June 19, 2007; doi:10.1038/sj.mt.6300239
Decorin Gene Transfer Promotes Muscle Cell Differentiation and Muscle Regeneration FREE
Yong Li, Juan Li, Jinghong Zhu, Bin Sun, Maria Branca, Ying Tang, William Foster, Xiao Xiao and Johnny Huard
Mol Ther 15: 1616-1622; advance online publication, July 3, 2007; doi:10.1038/sj.mt.6300250
Peripheral Transgene Expression of Plasma Gelsolin Reduces Amyloid in Transgenic Mouse Models of Alzheimer's Disease FREE
Aaron C Hirko, Edwin M Meyer, Michael A King and Jeffery A Hughes
Mol Ther 15: 1623-1629; advance online publication, July 3, 2007; doi:10.1038/sj.mt.6300253
Vector Engineering and Delivery
Functional Analysis of Various Promoters in Lentiviral Vectors at Different Stages of In Vitro Differentiation of Mouse Embryonic Stem Cells FREE
Sunghoi Hong, Dong-Youn Hwang, Soonsang Yoon, Ole Isacson, Ali Ramezani, Robert G Hawley and Kwang-Soo Kim
Mol Ther 15: 1630-1639; advance online publication, July 3, 2007; doi:10.1038/sj.mt.6300251
Improved Retinal Transduction In Vivo and Photoreceptor-specific Transgene Expression Using Adenovirus Vectors With Modified Penton Base FREE
Siobhan M Cashman, Laura McCullough and Rajendra Kumar-Singh
Mol Ther 15: 1640-1646; advance online publication, May 15, 2007; doi:10.1038/sj.mt.6300203
Development of Renal-targeted Vectors Through Combined In Vivo Phage Display and Capsid Engineering of Adenoviral Fibers From Serotype 19p FREE
Laura Denby, Lorraine M Work, Dan J Von Seggern, Eugene Wu, John H McVey, Stuart A Nicklin and Andrew H Baker
Mol Ther 15: 1647-1654; advance online publication, June 5, 2007; doi:10.1038/sj.mt.6300214
Bone Regeneration by Regulated In Vivo Gene Transfer Using Biocompatible Polyplex Nanomicelles FREE
Keiji Itaka, Shinsuke Ohba, Kanjiro Miyata, Hiroshi Kawaguchi, Kozo Nakamura, Tsuyoshi Takato, Ung-Il Chung and Kazunori Kataoka
Mol Ther 15: 1655-1662; advance online publication, June 5, 2007; doi:10.1038/sj.mt.6300218
Vector Toxicology, Immunogenicity and Safety
2'-O-methyl-modified RNAs Act as TLR7 Antagonists FREE
Marjorie Robbins, Adam Judge, Lisa Liang, Kevin McClintock, Ed Yaworski and Ian MacLachlan
Mol Ther 15: 1663-1669; advance online publication, June 19, 2007; doi:10.1038/sj.mt.6300240
Long-term Engraftment of Single Genetically Modified Human Epidermal Holoclones Enables Safety Pre-assessment of Cutaneous Gene Therapy FREE
Fernando Larcher, Elena Dellambra, Laura Rico, Sergio Bondanza, Rodolfo Murillas, Claudia Cattoglio, Fulvio Mavilio, José L Jorcano, Giovanna Zambruno and Marcela Del Rio
Mol Ther 15: 1670-1676; advance online publication, June 19, 2007; doi:10.1038/sj.mt.6300238
Persistent Expression of hF.IX After Tolerance Induction by In Utero or Neonatal Administration of AAV-1-F.IX in Hemophilia B Mice FREE
Denise E Sabatino, Tippi C MacKenzie, William Peranteau, Shyrie Edmonson, Cesare Campagnoli, Yi-Lin Liu, Alan W Flake and Katherine A High
Mol Ther 15: 1677-1685; advance online publication, June 12, 2007; doi:10.1038/sj.mt.6300219
Targeted Inflammation During Oncolytic Virus Therapy Severely Compromises Tumor Blood Flow FREE
Caroline J Breitbach, Jennifer M Paterson, Chantal G Lemay, Theresa J Falls, Allison McGuire, Kelley A Parato, David F Stojdl, Manijeh Daneshmand, Kelly Speth, David Kirn, J Andrea McCart, Harold Atkins and John C Bell
Mol Ther 15: 1686-1693; advance online publication, June 19, 2007; doi:10.1038/sj.mt.6300215
Activation of CFTR-specific T Cells in Cystic Fibrosis Mice Following Gene Transfer FREE
Maria P Limberis, Joanita Figueredo, Roberto Calcedo and James M Wilson
Mol Ther 15: 1694-1700; advance online publication, June 19, 2007; doi:10.1038/sj.mt.6300210
Cell Therapy
Long-term Correction of 
-Thalassemia With Minimal Cellular Requirement and Transplantation Modalities FREE
Hady Felfly and Marie Trudel
Mol Ther 15: 1701-1709; advance online publication, May 22, 2007; doi:10.1038/sj.mt.6300204
Transplanted Hepatocytes Over-expressing FoxM1B Efficiently Repopulate Chronically Injured Mouse Liver Independent of Donor Age FREE
Nicolas Brezillon, Martine Lambert-Blot, Serban Morosan, Dominique Couton, Claudia Mitchell, Dina Kremsdorf, Robert H Costa, Helene Gilgenkrantz and Jacques-Emmanuel Guidotti
Mol Ther 15: 1710-1715; advance online publication, June 12, 2007; doi:10.1038/sj.mt.6300232
Vaccine Technology
Successful Immunization with a Single Injection of Non-integrating Lentiviral Vector FREE
Donatella RM Negri, Zuleika Michelini, Silvia Baroncelli, Massimo Spada, Silvia Vendetti, Viviana Buffa, Roberta Bona, Pasqualina Leone, Mary E Klotman and Andrea Cara
Mol Ther 15: 1716-1723; advance online publication, June 26, 2007; doi:10.1038/sj.mt.6300241
A New Multi-clade DNA Prime/Recombinant MVA Boost Vaccine Induces Broad and High Levels of HIV-1-specific CD8+ T-cell and Humoral Responses in Mice FREE
Andreas Bråve, Andreas Boberg, Lindvi Gudmundsdotter, Erik Rollman, Kristian Hallermalm, Karl Ljungberg, Pontus Blomberg, Richard Stout, Staffan Paulie, Eric Sandström, Gunnel Biberfeld, Patricia Earl, Bernard Moss, Josephine H. Cox and Britta Wahren
Mol Ther 15: 1724-1733; advance online publication, June 19, 2007; doi:10.1038/sj.mt.6300235
Corrigenda
Corrigendum to "Intranasal Administration of the Growth-compromised HSV-2 Vector 
RR Prevents Kainate-induced Seizures and Neuronal Loss in Rats and Mice" FREE
Jennifer M Laing, Michael D Gober, Erin K Golembewski, Scott M Thompson, Kymberly A Gyure, Paul J Yarowsky and Laure Aurelian
Mol Ther 15: 1734; doi:10.1038/sj.mt.6300211
Corrigendum to "Cellular Dynamics of EGF Receptor–targeted Synthetic Viruses" FREE
Karla de Bruin, Nadia Ruthardt, Katharina von Gersdorff, Ralf Bausinger, Ernst Wagner, Manfred Ogris and Christoph Bräuchle
Mol Ther 15: 1735; doi:10.1038/sj.mt.6300247
Corrigendum to "Avian Influenza Virus Hemagglutinin Display on Baculovirus Envelope: Cytoplasmic Domain Affects Virus Properties and Vaccine Potential" FREE
Ding-Gang Yang, Yao-Chi Chung, Yiu-Kay Lai, Chia-Wei Lai, Hung-Jen Liu and Yu-Chen Hu
Mol Ther 15: 1736; doi:10.1038/sj.mt.6300236
