TABLE 1

FROM:

Targeted Inflammation During Oncolytic Virus Therapy Severely Compromises Tumor Blood Flow

Caroline J Breitbach, Jennifer M Paterson, Chantal G Lemay, Theresa J Falls, Allison McGuire, Kelley A Parato, David F Stojdl, Manijeh Daneshmand, Kelly Speth, David Kirn, J Andrea McCart, Harold Atkins and John C Bell

Table 1. Genes up-regulated in CT-26 tumor 24 hours after infection with VSV, as compared with genes expressed in tumor treated with UV-inactivated VSV

Category and probe set	Fold increasea	Description
Chemotaxis
NM008176	127	Chemokine (C-X-C motif) ligand 1
NM009114	86	S100 calcium binding protein A9 (calgranulin B)
NM013653	38	Chemokine (C-C motif) ligand 5
BC024392	37	Chemokine (C-X-C motif) ligand 5
NM013650	29	S100 calcium binding protein A8 (calgranulin A)
NM017466	21	Chemokine (C-C motif) receptor-like 2
NM009140	14	Chemokine (C-X-C motif) ligand 2
NM011333	14	Chemokine (C-C motif) ligand 2
NM011337	11	Chemokine (C-C motif) ligand 3
NM021274	9	Chemokine (C-X-C motif) ligand 10
NM013654	4	Chemokine (C-C motif) ligand 7
NM019494	4	Chemokine (C-X-C motif) ligand 11
Inflammation
BC020275	624b	Neutrophil gelatinase associated lipocalin 1
NM010510	294	Interferon-, fibroblast
NM031168	52	Interleukin 6
NP034099	40b	Colony stimulating factor (granulocyte-macrophage)
NM011198	35	Prostaglandin-endoperoxide synthetase 2 (COX-2)
AB185896	18	Tumor necrosis factor alpha
NM009778	12	Complement component 3

  Abbreviations: COX, cyclooxygenase; UV, ultraviolet; VSV, vesicular stomatitis virus.

^a Values taken from microarray experiment, quantitative real-time polymerase chain reaction analysis shown in Figure S3. ^bSignals for these genes were absent in UV-inactivated sample. Changes in up-regulation, expressed as multiples, were calculated using an arbitrary signal value of 600 for the UV-inactivated sample.