TABLE OF CONTENTS
Volume 15, Issue 8 (August 2007)
Editorial
What Are the Consequences of the Fourth Case? FREE
Christopher Baum Associate Editor
Mol Ther 15: 1401-1402; doi:10.1038/sj.mt.6300263
In This Issue
In This Issue FREE
Mol Ther 15: 1404; doi:10.1038/sj.mt.6300265
See also: Original Article by Song & FriedmannSee also: Original Article by Alain et al. See also: Original Article by Marcato et al. See also: Original Article by Palfi et al. See also: Original Article by Zachos et al.Research Highlights
Top of pageCommentaries
Uncoating Reo: Uncovering the Steps Critical for Oncolysis FREE
Guy Lemay, Vanessa Tumilasci and John Hiscott
Mol Ther 15: 1406-1407; doi:10.1038/sj.mt.6300242
See also: Original Article by Alain et al. See also: Original Article by Marcato et al.Myostatin Blockade: A New Way to Enhance Skeletal Muscle Repair in Old Age? FREE
Zipora Yablonka-Reuveni
Mol Ther 15: 1407-1409; doi:10.1038/sj.mt.6300248
See also: Original Article by Siriett et al.Reviews
Vector Toxicology, Immunogenicity and Safety
The Influence of Blood on In Vivo Adenovirus Bio-distribution and Transduction FREE
Andrew H Baker, John H Mcvey, Simon N Waddington, Nelson C Di Paolo and Dmitry M Shayakhmetov
Mol Ther 15: 1410-1416; advance online publication, May 15, 2007; doi:10.1038/sj.mt.6300206
Toll-like Receptors Impact on Safety and Efficacy of Gene Transfer Vectors FREE
Scott E Hensley and Andrea Amalfitano
Mol Ther 15: 1417-1422; advance online publication, June 5, 2007; doi:10.1038/sj.mt.6300217
Original Articles
Monogenic Disease
Correction of Clinical Manifestations of Canine Mucopolysaccharidosis I with Neonatal Retroviral Vector Gene Therapy FREE
Anne M Traas, Ping Wang, Xiucui Ma, Mindy Tittiger, Laura Schaller, Patricia O'donnell, Meg M Sleeper, Charles Vite, Ramin Herati, Gustavo D Aguirre, Mark Haskins and Katherine P Ponder
Mol Ther 15: 1423-1431; advance online publication, May 22, 2007; doi:10.1038/sj.mt.6300201
Tissue-specific Aberrations of Gene Expression in HPRT-deficient Mice: Functional Complexity in a Monogenic Disease? FREE
Shaochun Song and Theodore Friedmann
Mol Ther 15: 1432-1443; advance online publication, May 15, 2007; doi:10.1038/sj.mt.6300199
Acquired and Multigenic Disease
Expression of Mutated Huntingtin Fragment in the Putamen Is Sufficient to Produce Abnormal Movement in Non-human Primates FREE
Stéphane Palfi, Emmanuel Brouillet, Béchir Jarraya, Jocelyne Bloch, Caroline Jan, Masahiro Shin, Françoise Condé, Xiao-Jiang Li, Patrick Aebischer, Philippe Hantraye and Nicole Déglon
Mol Ther 15: 1444-1451; advance online publication, May 1, 2007; doi:10.1038/sj.mt.6300185
Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs FREE
Christophe Chevalier, Aure Saulnier, Yann Benureau, Dorian Fléchet, David Delgrange, Florence Colbère-Garapin, Czeslaw Wychowski and Annette Martin
Mol Ther 15: 1452-1462; advance online publication, May 15, 2007; doi:10.1038/sj.mt.6300186
Antagonism of Myostatin Enhances Muscle Regeneration During Sarcopenia FREE
Victoria Siriett, Mônica Senna Salerno, Carole Berry, Gina Nicholas, Rob Bower, Ravi Kambadur and Mridula Sharma
Mol Ther 15: 1463-1470; advance online publication, June 5, 2007; doi:10.1038/sj.mt.6300182
Abstract | Full Text | PDF | Supplementary information
See also: Commentary by Yablonka-ReuveniVector Engineering and Delivery
Restoration of SMN Function: Delivery of a Trans-splicing RNA Re-directs SMN2 Pre-mRNA Splicing FREE
Tristan H Coady, Monir Shababi, Gregory E Tullis and Christian L Lorson
Mol Ther 15: 1471-1478; advance online publication, June 5, 2007; doi:10.1038/sj.mt.6300222
Spinal Muscular Atrophy: SMN2 Pre-mRNA Splicing Corrected by a U7 snRNA Derivative Carrying a Splicing Enhancer Sequence FREE
Julien Marquis, Kathrin Meyer, Larissa Angehrn, Sacha S Kämpfer, Barbara Rothen-Rutishauser and Daniel Schümperli
Mol Ther 15: 1479-1486; advance online publication, June 5, 2007; doi:10.1038/sj.mt.6300200
Characteristics of Lentiviral Vectors Harboring the Proximal Promoter of the vav Proto-oncogene: A Weak and Efficient Promoter for Gene Therapy FREE
Elena Almarza, Paula Río, Nestor W Meza, Montserrat Aldea, Xabier Agirre, Guillermo Guenechea, José C Segovia and Juan A Bueren
Mol Ther 15: 1487-1494; advance online publication, May 29, 2007; doi:10.1038/sj.mt.6300213
Androgen Receptor Attenuation of Ad5 Replication: Implications for the Development of Conditionally Replication Competent Adenoviruses FREE
Naseruddin Höti, Ying Li, Chien-Lun Chen, Wasim H Chowdhury, David C Johns, Qinghua Xia, Arup Kabul, Jer-Tsong Hsieh, Michael Berg, Gary Ketner, Shawn E Lupold and Ronald Rodriguez
Mol Ther 15: 1495-1503; advance online publication, June 12, 2007; doi:10.1038/sj.mt.6300223
Time Course of Transgene Expression After Intrastriatal Pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 Transduction in the Rat FREE
Sharon Reimsnider, Fredric P Manfredsson, Nicholas Muzyczka and Ronald J Mandel
Mol Ther 15: 1504-1511; advance online publication, June 12, 2007; doi:10.1038/sj.mt.6300227
Vector Toxicology, Immunogenicity and Safety
Proteolytic Disassembly Is a Critical Determinant for Reovirus Oncolysis FREE
Tommy Alain, Tom SY Kim, XueQing Lun, Adelhamid Liacini, Leslie A Schiff, Donna L Senger and Peter A Forsyth
Mol Ther 15: 1512-1521; advance online publication, May 22, 2007; doi:10.1038/sj.mt.6300207
See also: Commentary by Lemay et al.Ras Transformation Mediates Reovirus Oncolysis by Enhancing Virus Uncoating, Particle Infectivity, and Apoptosis-dependent Release FREE
Paola Marcato, Maya Shmulevitz, Da Pan, Don Stoltz and Patrick WK Lee
Mol Ther 15: 1522-1530; advance online publication, April 24, 2007; doi:10.1038/sj.mt.6300179
Abstract | Full Text | PDF | Supplementary information
See also: Commentary by Lemay et al.The RAS/Raf1/MEK/ERK Signaling Pathway Facilitates VSV-mediated Oncolysis: Implication for the Defective Interferon Response in Cancer Cells FREE
Josh A Noser, Amber A Mael, Ryuta Sakuma, Seiga Ohmine, Paola Marcato, Patrick WK Lee and Yasuhiro Ikeda
Mol Ther 15: 1531-1536; advance online publication, May 15, 2007; doi:10.1038/sj.mt.6300193
Antisense PNA Accumulates in Escherichia coli and Mediates a Long Post-antibiotic Effect FREE
Abbas Nikravesh, Rikard Dryselius, Omid R Faridani, Shan Goh, Majid Sadeghizadeh, Mehrdad Behmanesh, Anita Ganyu, Erik Jan Klok, Rula Zain and Liam Good
Mol Ther 15: 1537-1542; advance online publication, May 29, 2007; doi:10.1038/sj.mt.6300209
Cell Therapy
Mesenchymal Stem Cell-mediated Gene Delivery of Bone Morphogenetic Protein-2 in an Articular Fracture Model FREE
Terri Zachos, Alisha Diggs, Steven Weisbrode, Jeffrey Bartlett and Alicia Bertone
Mol Ther 15: 1543-1550; advance online publication, May 22, 2007; doi:10.1038/sj.mt.6300192
Foxp3-expressing CD4+T Cells Under the Control of IFN-
Promoter Prevent Diabetes in NOD Mice FREE
Renxi Wang, Gencheng Han, Jianan Wang, Lun Song, Guojiang Chen, Ruonan Xu, Ming Yu, Jiahua Qian, Beifen Shen and Yan Li
Mol Ther 15: 1551-1557; advance online publication, May 29, 2007; doi:10.1038/sj.mt.6300208
Vaccine Technology
Chemotherapy Enhances CD8+ T Cell-mediated Antitumor Immunity Induced by Vaccination With Vaccinia Virus FREE
Chung Kil Song, Hee Dong Han, Kyung Hee Noh, Tae Heung Kang, Yong Sung Park, Jin Hee Kim, Eun Suk Park, Byung Cheol Shin and Tae Woo Kim
Mol Ther 15: 1558-1563; advance online publication, June 5, 2007; doi:10.1038/sj.mt.6300221
Increased Sensitivity of Radiated Murine Cervical Cancer Tumors to E7 Subunit Vaccine–driven CTL-mediated Killing Induces Synergistic Anti-tumor Activity FREE
Gi Won Ye, Jae-Bok Park, Young-Ja Park, Youn Seok Choi and Jeong-Im Sin
Mol Ther 15: 1564-1570; advance online publication, May 1, 2007; doi:10.1038/sj.mt.6300149
