TABLE OF CONTENTS
Volume 15, Issue 6 (June 2007)
In This Issue |
Research Highlights |
Commentary |
Reviews |
Original Articles |
Corrigenda
Editorial
Happy Anniversary FREE
Theodore Friedmann ASGT President, 2006–2007
Mol Ther 15: 1035-1036; doi:10.1038/sj.mt.6300191
In This Issue
In This Issue FREE
Mol Ther 15: 1038; doi:10.1038/sj.mt.6300205
See also: Original Article by Howarth et al. See also: Original Article by Lee et al. See also: Original Article by Gouze et al. See also: Original Article by Ivics et al. See also: Original Article by Lim et al.Research Highlights
Top of pageCommentary
The Role of Immunosuppression in Gene- and Cell-Based Treatments for Duchenne Muscular Dystrophy FREE
Valder R Arruda
Mol Ther 15: 1040-1041; doi:10.1038/sj.mt.6300194
See also: Original Article by Wang et al.Reviews
Clinical Trials
Prostate Cancer Gene Therapy Clinical Trials FREE
Svend O Freytag, Hans Stricker, Benjamin Movsas and Jae Ho Kim
Mol Ther 15: 1042-1052; advance online publication, April 3, 2007; doi:10.1038/sj.mt.6300162
Acquired and Multigenic Disease
Advances in Preclinical Investigation of Prostate Cancer Gene Therapy FREE
Marxa L Figueiredo, Chinghai Kao and Lily Wu
Mol Ther 15: 1053-1064; advance online publication, April 24, 2007; doi:10.1038/sj.mt.6300181
Recent Advances and Current Challenges in Tumor Immunology and Immunotherapy FREE
Barbara-ann Guinn, Noriyuki Kasahara, Farzin Farzaneh, Nagy A Habib, James S Norris and Albert B Deisseroth
Mol Ther 15: 1065-1071; advance online publication, March 20, 2007; doi:10.1038/sj.mt.6300138
Original Articles
Monogenic Disease
Functional Recovery in a Friedreich's Ataxia Mouse Model by Frataxin Gene Transfer Using an HSV-1 Amplicon Vector FREE
Filip Lim, Gloria M Palomo, Christina Mauritz, Alfredo Giménez-Cassina, Belen Illana, Francisco Wandosell and Javier Díaz-Nido
Mol Ther 15: 1072-1078; advance online publication, March 20, 2007; doi:10.1038/sj.mt.6300143
Metabolic Basis of Sexual Dimorphism in PKU Mice After Genome-targeted PAH Gene Therapy FREE
Li Chen, Swan N Thung and Savio LC Woo
Mol Ther 15: 1079-1085; advance online publication, April 3, 2007; doi:10.1038/sj.mt.6300137
Systemic Administration of Micro-dystrophin Restores Cardiac Geometry and Prevents Dobutamine-induced Cardiac Pump Failure FREE
DeWayne Townsend, Michael J Blankinship, James M Allen, Paul Gregorevic, Jeffrey S Chamberlain and Joseph M Metzger
Mol Ther 15: 1086-1092; advance online publication, April 17, 2007; doi:10.1038/sj.mt.6300144
Hematopoietic Stem Cells Encoding Porcine Factor VIII Induce Pro-coagulant Activity in Hemophilia A Mice with Pre-existing Factor VIII Immunity FREE
Christopher B Doering, Bagirath Gangadharan, Hillary Z Dukart and H Trent Spencer
Mol Ther 15: 1093-1099; advance online publication, March 27, 2007; doi:10.1038/sj.mt.6300146
Acquired and Multigenic Disease
Hsp40 Molecules That Target to the Ubiquitin-proteasome System Decrease Inclusion Formation in Models of Polyglutamine Disease FREE
JL Howarth, S Kelly, MP Keasey, CPJ Glover, Y-B Lee, K Mitrophanous, JP Chapple, JM Gallo, ME Cheetham and JB Uney
Mol Ther 15: 1100-1105; advance online publication, April 10, 2007; doi:10.1038/sj.mt.6300163
Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy FREE
Irene Kanter-Schlifke, Biljana Georgievska, Deniz Kirik and Merab Kokaia
Mol Ther 15: 1106-1113; advance online publication, March 27, 2007; doi:10.1038/sj.mt.6300148
Vector Engineering and Delivery
Transgene Persistence and Cell Turnover in the Diarthrodial Joint: Implications for Gene Therapy of Chronic Joint Diseases FREE
Elvire Gouze, Jean-Noel Gouze, Glyn D Palmer, Carmencita Pilapil, Christopher H Evans and Steven C Ghivizzani
Mol Ther 15: 1114-1120; advance online publication, April 17, 2007; doi:10.1038/sj.mt.6300151
Carrier Cell–mediated Delivery of a Replication-competent Adenovirus for Cancer Gene Therapy FREE
Katsuyuki Hamada, Junzo Desaki, Kou Nakagawa, Ting Zhang, Toshiro Shirakawa, Akinobu Gotoh and Masatoshi Tagawa
Mol Ther 15: 1121-1128; advance online publication, March 27, 2007; doi:10.1038/sj.mt.6300128
An Efficient and Safe Herpes Simplex Virus Type 1 Amplicon Vector for Transcriptionally Targeted Therapy of Human Hepatocellular Carcinomas FREE
Paula YP Lam, Kian Chuan Sia, Jenn H Khong, Bart De Geest, Kar S Lim, Ivy AW Ho, Grace Y Wang, Lv Miao, H Huynh and Kam M Hui
Mol Ther 15: 1129-1136; advance online publication, April 10, 2007; doi:10.1038/sj.mt.6300165
Targeted Sleeping Beauty Transposition in Human Cells FREE
Zoltán Ivics, Andrea Katzer, Eva E Stüwe, Dora Fiedler, Siegne Knespel and Zsuzsanna Izsvák
Mol Ther 15: 1137-1144; advance online publication, April 10, 2007; doi:10.1038/sj.mt.6300169
Systemic and Specific Delivery of Small Interfering RNAs to the Liver Mediated by Apolipoprotein A-I FREE
Soo In Kim, Duckhyang Shin, Tae Hyun Choi, Jong Chan Lee, Gi-Jeong Cheon, Ki-Yong Kim, Mahnhoon Park and Meehyein Kim
Mol Ther 15: 1145-1152; advance online publication, April 17, 2007; doi:10.1038/sj.mt.6300168
An Antibody Delivery System for Regulated Expression of Therapeutic Levels of Monoclonal Antibodies In Vivo FREE
Jianmin Fang, Saili Yi, Andrew Simmons, Guang Huan Tu, Minh Nguyen, Thomas C Harding, Melinda VanRoey and Karin Jooss
Mol Ther 15: 1153-1159; advance online publication, March 20, 2007; doi:10.1038/sj.mt.6300142
Vector Toxicology, Immunogenicity and Safety
Sustained AAV-mediated Dystrophin Expression in a Canine Model of Duchenne Muscular Dystrophy with a Brief Course of Immunosuppression FREE
Zejing Wang, Christian S Kuhr, James M Allen, Michael Blankinship, Paul Gregorevic, Jeffrey S Chamberlain, Stephen J Tapscott and Rainer Storb
Mol Ther 15: 1160-1166; advance online publication, April 10, 2007; doi:10.1038/sj.mt.6300161
Abstract | Full Text | PDF | Supplementary information
See also: Commentary by ArrudaImproving Transcriptional Termination of Self-inactivating Gamma-retroviral and Lentiviral Vectors FREE
Axel Schambach, Melanie Galla, Tobias Maetzig, Rainer Loew and Christopher Baum
Mol Ther 15: 1167-1173; advance online publication, April 3, 2007; doi:10.1038/sj.mt.6300152
Anti-CD25 Targeted Killing of Bicistronically Transduced Cells: A Novel Safety Mechanism Against Retroviral Genotoxicity FREE
Shobha Ramsubir, Makoto Yoshimitsu and Jeffrey A Medin
Mol Ther 15: 1174-1181; advance online publication, March 27, 2007; doi:10.1038/sj.mt.6300147
Cell Therapy
Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes—CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy—in SCID-hu Mouse–Derived T Cells FREE
Joseph Anderson, Ming-Jie Li, Brent Palmer, Leila Remling, Shirley Li, Priscilla Yam, Jiing-Kuan Yee, John Rossi, John Zaia and Ramesh Akkina
Mol Ther 15: 1182-1188; advance online publication, April 3, 2007; doi:10.1038/sj.mt.6300157
Thermosensitive Hydrogel PEG–PLGA–PEG Enhances Engraftment of Muscle-derived Stem Cells and Promotes Healing in Diabetic Wound FREE
Pui Yan Lee, Erin Cobain, Johnny Huard and Leaf Huang
Mol Ther 15: 1189-1194; advance online publication, April 3, 2007; doi:10.1038/sj.mt.6300156
Engineered Enteroendocrine Cells Secrete Insulin in Response to Glucose and Reverse Hyperglycemia in Diabetic Mice FREE
Jaeseok Han, Hyune-Hwan Lee, Hyokjoon Kwon, Seungjin Shin, Ji-Won Yoon and Hee-Sook Jun
Mol Ther 15: 1195-1202; advance online publication, February 13, 2007; doi:10.1038/sj.mt.6300117
Vaccine Technology
Lentiviral Vectors Encoding HIV-1 Polyepitopes Induce Broad CTL Responses In Vivo FREE
Maria Candela Iglesias, Karine Mollier, Anne-Sophie Beignon, Philippe Souque, Olivier Adotevi, François Lemonnier and Pierre Charneau
Mol Ther 15: 1203-1210; advance online publication, March 20, 2007; doi:10.1038/sj.mt.6300135
DNA Vaccines Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-Cell Immune Responses and Enhances Vaccine Potency FREE
Chien-Fu Hung, Ya-Chea Tsai, Liangmei He and T-C Wu
Mol Ther 15: 1211-1219; advance online publication, March 13, 2007; doi:10.1038/sj.mt.6300121
Corrigenda
Efficient Whole-body Transduction with Trans-splicing Adeno-associated Viral Vectors FREE
Arkasubhra Ghosh, Yongping Yue, Chun Long, Brian Bostick and Dongsheng Duan
Mol Ther 15: 1220; doi:10.1038/sj.mt.6300153
